Journal
NATURAL PRODUCT RESEARCH
Volume 34, Issue 5, Pages 726-730Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2018.1495636
Keywords
Fridericia chica; Arrabidaea chica; leaf extract; cytotoxicity; anti-inflammatory activity; 4 ',6,7-trihydroxy-5-methoxyflavone; 5-O-methylscutellarein
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Funding
- CNPq/Bionorte [551737/2010-7]
- INAU/CNPq/MCTI [704792/2009]
- FAPEMAT [205978/2011]
- CAPES
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Rede de Biodiversidade e Biotecnologia da Amazonia Legal (Bionorte)
- Fundacao de Amparo a Pesquisa do Estado de Mato Grosso (FAPEMAT)
- Instituto Nacional de Ciencia e Tecnologia em Areas Umidas (INAU)
- Ministerio da Ciencia, Tecnologia e Inovacao (MCTI)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
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Fridericia chica, Bignoniaceae, is a tropical tree-creeper used as a traditional remedy for a number of diseases, highlighting inflammation. Our objective was to corroborate the popular anti-inflammatory use of the hydroethanolic extract from the leaves (HEFc) and of its isolated 4 ',6,7-trihydroxy-5-methoxyflavone (5-O-methylscutellarein) [1], described here for the first time. Quantitative analysis indicated 8.77 +/- 0.23 mg/g of this compound in the extract. Neither HEFc nor [1] was cytotoxic in vitro. In LPS-induced peritonitis in mice, oral pre-treatment with HEFc or [1] led to decreased leukocyte migration to the peritoneal cavity and a reduction in the concentrations of pro-inflammatory cytokines (TNF alpha and IL-1 beta). Also, the anti-inflammatory cytokine IL-10 was enhanced following treatment with [1]. Overall, these results validate the traditional use of Fridericia chica as anti-inflammatory, and indicate that the compound 5-O-methylscutellarein may participate in this effect. [GRAPHICS] .
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