Article
Biochemistry & Molecular Biology
Jiaqi Sun, Fuyin Zhao, Zhenlei Wang, Weina Zhang, Xiudong Yang, Hongli Zhou, Peng Wan
Summary: This study aims to optimize the processing of Myristica fragrans Houtt. by talcum powder simmering, and the results show that the new process can reduce the content of toxic components and enhance the antioxidant and antibacterial activity of the essential oils.
Article
Biochemistry & Molecular Biology
Sudarat Kruakaew, Suriphon Singha, Ek Sangvichien, Jantana Yahuafai, Somyote Sutthivaiyakit
Summary: In this study, chromatographic purification of the CH2Cl2 extract of Myristica fragrans seeds resulted in the isolation of 19 known compounds, including four dihydrofuran neolignans. The absolute configuration of these compounds was thoroughly investigated and discrepancies between the use of an aromatic quadrant rule and time-dependent density function theory calculation for predicting absolute configurations were found. The antimicrobial and cytotoxic activities of the isolates and reduction products of these neolignans were also studied.
Article
Biochemistry & Molecular Biology
Yasukiyo Yoshioka, Ryunoshin Kono, Masaki Kuse, Yoko Yamashita, Hitoshi Ashida
Summary: This study investigated the active compounds in Myristica fragrans and their mechanism in promoting glucose uptake. The researchers found that myristicin, licarin B, ADDP, and ADTP were the active compounds that promoted GLUT4 translocation. Oral administration of Myristica fragrans extract suppressed post-prandial hyperglycemia in mice. Therefore, Myristica fragrans shows promise as a functional food for preventing post-prandial hyperglycemia and type 2 diabetes mellitus.
Article
Biology
Wahidah H. Al-Qahtani, Yuvaraj Dinakarkumar, Selvaraj Arokiyaraj, Vigneshwar Saravanakumar, Jothi Ramalingam Rajabathar, Kowsalya Arjun, P. K. Gayathri, Jimmy Nelson Appaturi
Summary: The use of plant-derived medications is safer and more secure than synthetic ones. Elemicin isolated from Myristica fragrans has significant antioxidant and antibacterial activity. It can be crucially utilized in the development of therapeutic agents and food preservatives.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Plant Sciences
Muhamad Aqmal Othman, Yasodha Sivasothy
Summary: The review aims to provide scientific evidence that the medicinal properties of the genus Myristica could be attributed to the acylphenols and dimeric acylphenols present in its various parts, and highlight the potential in the development of these compounds as pharmaceutical products.
Article
Cell Biology
Mahsa Rastegar Moghaddam Poorbagher, Ehsan Karimi, Ehsan Oskoueian
Summary: In this study, nanoniosome-loaded Myristica fragrans' phenolic compounds (NLMP) were synthesized and characterized. The NLMP showed hepatoprotective effects on mice with liver toxicity induced by L-asparaginase injection. NLMP treatment increased the weight and feed intake of mice, decreased the blood levels of triglyceride, cholesterol, liver enzymes, and total bilirubin, and increased the levels of the antioxidant defence system. NLMP also downregulated the expression of inflammatory-related genes and upregulated the expression of SOD in the liver.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Engineering, Environmental
Teema Thomas, Arun Kumar Thalla
Summary: In this study, silver nanoparticles were synthesized from silver nitrate using Myristica fragrans seed shells aqueous extract. The synthesized nanoparticles were characterized and found to have antibacterial and antioxidant properties. Furthermore, the nanoparticles showed better photocatalytic degradation of dyes.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Chemistry, Applied
Xiaohui Xi, Jialing Huang, Shengyang Zhang, Qian Lu, Zhengfeng Fang, Cheng Li, Qing Zhang, Yuntao Liu, Hong Chen, Aiping Liu, Shuxiang Liu, Caixia Wang, Shanshan Li, Bin Hu
Summary: This study prepared the inclusion complex (IC) of nutmeg essential oil (NEO) with 2-hydroxypropyl ss-cyclodextrin (HP-ss-CD) by the coprecipitation method, overcoming the poor stability and low aqueous solubility of NEO in food. The optimal conditions were an inclusion temperature of 36 degrees C, time of 247 min, stirring speed of 520 r/min, and wall-core ratio of 12:1, resulting in a recovery of 80.63%. The formation of IC was confirmed by various techniques, and it was found that encapsulation improved the thermal stability, antioxidant, and nitrite scavenging activities of NEO. Moreover, the release of NEO from IC can be controlled by regulating the temperature and relative humidity. Overall, NEO/HP-ss-CD IC has great potential for application in the food industry.
Article
Chemistry, Multidisciplinary
Arezoo Rastegari, Azadeh Manayi, Mahdi Rezakazemi, Mahdieh Eftekhari, Mahnaz Khanavi, Tahmineh Akbarzadeh, Mina Saeedi
Summary: This study found that the ethyl acetate fraction of Myristica fragrans has inhibitory activity against BChE and neuroprotective effects against H2O2-induced cell death. Compound 2 from Myristica fragrans showed the best inhibitory activity against both AChE and BChE.
Article
Chemistry, Physical
Suresh Sagadevan, J. Anita Lett, Selvaraj Vennila, P. Varun Prasath, Gobi Saravanan Kaliaraj, Is Fatimah, Estelle Leonard, Faruq Mohammad, Hamad A. Al-Lohedan, Solhe F. Alshahateet, C. T. Lee
Summary: In this study, titanium dioxide (TiO2) nanoparticles were successfully synthesized via green synthesis routes, and their photocatalytic activity was evaluated. The TiO2 nanoparticles demonstrated excellent photocatalytic degradation of methylene blue and congo red, indicating superior photocatalytic performance.
CHEMICAL PHYSICS LETTERS
(2021)
Article
Plant Sciences
Vesna Nikolic, Ljubisa Nikolic, Ana Dinic, Ivana Gajic, Maja Urosevic, Ljiljana Stanojevic, Jelena Stanojevic, Bojana Danilovic
Summary: This study successfully isolated essential oil from nutmeg seeds, determined its chemical composition and antioxidant, antimicrobial activities. The essential oil demonstrated good antioxidant and antimicrobial properties, particularly showing significant inhibition against fungi and certain bacteria.
JOURNAL OF ESSENTIAL OIL BEARING PLANTS
(2021)
Article
Food Science & Technology
Suthiwat Khamnuan, Ampai Phrutivorapongkul, Pornsiri Pitchakarn, Pensiri Buacheen, Jirarat Karinchai, Chuda Chittasupho, Mingkwan Na Takuathung, Tinnakorn Theansungnoen, Kannika Thongkhao, Aekkhaluck Intharuksa, Renato Bruni, Manuela Mandrone, Laura Righetti
Summary: The aril and seed of nutmeg have significant value in various industries and exist in two morphological variations, namely globose and oval shape. By employing different analytical methods, the distinct characteristics of these two shapes were identified, and a comparative study was conducted in terms of morphological, chemical, and molecular aspects.
Article
Biochemistry & Molecular Biology
Ramya Perumalsamy, Lavanya Krishnadhas
Summary: This study synthesized silver nanoparticles from Myristica fragrans seeds and evaluated their anti-diabetic properties, demonstrating that these nanoparticles have therapeutic potential for the treatment of diabetes mellitus.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jurga Andreja Kazlauskaite, Inga Matulyte, Mindaugas Marksa, Raimundas Lelesius, Alvydas Pavilonis, Jurga Bernatoniene
Summary: This study aimed to investigate the biological activity of selected plant extracts and essential oil and to produce microcapsules. The main compounds in extracts and oil were determined, and antioxidant and antimicrobial activities were evaluated. Microcapsules with extracts and oil showed stability and size changes in different media.
Article
Multidisciplinary Sciences
Emeka Godwin Anaduaka, Innocent Uzochukwu Okagu, Nene Orizu Uchendu, Lawrence Uchenna Sunday Ezeanyika, Benneth Chima Nwanguma
Summary: The study demonstrated that long-term administration of high doses of Myristica fragrans seed extracts can cause hepato-renal toxicities, including abnormal liver function and kidney damage.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
