Review
Nanoscience & Nanotechnology
Shabnam Sattari, Mohsen Adeli, Siamak Beyranvand, Mohammad Nemati
Summary: Two-dimensional nanomaterials, such as graphene, are promising candidates for various biomedical applications due to their high surface area and efficient cellular uptake. Functionalization of graphene is essential to improve its dispersion in water and functionality for future nanomedicine applications. Techniques involving covalent or non-covalent methods have been explored to enhance the physicochemical properties of graphene and graphene oxide.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Chemistry, Multidisciplinary
Asif Mohd Itoo, Sree Lakshmi Vemula, Mahima Tejasvni Gupta, Mahesh Vilasrao Giram, Sangishetty Akhil Kumar, Balaram Ghosh, Swati Biswas
Summary: This review discusses the potential applications of two-dimensional graphene oxide nanoparticles in cancer therapy, including drug delivery, chemo-photothermal therapy, bioimaging, etc. It also examines the challenges and opportunities associated with these applications.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Nanoscience & Nanotechnology
Tingting Xu, Sufang Guo, Miaomiao Li, Zhen Zhang, Baobao Pang, Yingmo Hu
Summary: This study presents a composite film exhibiting multibending behaviors under UV/vis and NIR light irradiation. The reversible bending and recovery reactions of the AZO-GO/PVA composite film upon light exposure are achieved by the trans-cis-photoisomerization of azobenzene groups. The film also curls slightly away from the NIR light source due to the photothermal effect of the GO component, showing enhanced mechanical properties with low-cost and facile manufacturing.
ACS APPLIED NANO MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Xianbin Ma, Shu-Jin Li, Yuantong Liu, Tian Zhang, Peng Xue, Yuejun Kang, Zhi-Jun Sun, Zhigang Xu
Summary: Nanogels, as a versatile drug delivery system, play a crucial role in cancer immunotherapy, offering advantages such as enhanced drug bioavailability and reduced immune-related adverse events.
CHEMICAL SOCIETY REVIEWS
(2022)
Article
Pharmacology & Pharmacy
Mirian A. Gonzalez-Ayon, Jacob Licea-Rodriguez, Eugenio R. Mendez, Angel Licea-Claverie
Summary: Dual-function nanogels synthesized via surfactant-free emulsion polymerization can act as smart carriers for synergistic chemo- and photothermal therapy. Galacto-functionalized nanogels exhibit efficient drug release ability in in vitro experiments. Additionally, the presence of gold nanorods leads to enhanced drug release under laser irradiation.
Article
Polymer Science
Emanuel A. Glitscher, Julian Bergueiro, Marcelo Calderon
Summary: The novel strategy of incorporating anisotropic gold nanoparticles into polymeric thermoresponsive nanogels has expanded their potential applications in the field of nanomedicine.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Chemistry, Physical
Nuran Isiklan, Nizamudin Awel Hussien, Mustafa Turk
Summary: A multifunctional gelatin-decorated magnetic graphene oxide nanoplatform was developed for efficient delivery of paclitaxel in chemotherapy and photothermal therapy. The nanosheets exhibited pH-dependent drug release behavior and demonstrated high toxicity towards MCF-7 cancer cells. Overall, the results suggest that this nanostructure has potential for chemo-photothermal therapy and drug delivery.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Chemistry, Multidisciplinary
Elena Giusto, Ludmila Zarska, Darren Fergal Beirne, Arianna Rossi, Giada Bassi, Andrea Ruffini, Monica Montesi, Diego Montagner, Vaclav Ranc, Silvia Panseri
Summary: This study developed a graphene oxide-based nanocarrier to overcome the limitations of platinum-based chemotherapeutics. The results demonstrated that this nanoplatform has good anti-tumor effects in various cancer cells and potential for inhibiting cell migration.
Article
Chemistry, Physical
Nuran Isiklan, Nizamudin Awel Hussien, Mustafa Turk
Summary: In this study, graphene oxide nanosheets were functionalized with Fe3O4 nanoparticles and hydroxypropyl cellulose for chemo/phototherapy. The resulting nanobiocomposite exhibited improved biocompatibility, stability, and drug release, and displayed good photothermal features for cancer cell killing. Combined chemotherapy and phototherapy showed synergistic anticancer effects, making the nanobiocomposite a promising candidate for future cancer treatment.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Materials Science, Multidisciplinary
Yuan Zhan, Haiping Wang, Mingji Su, Zhengguang Sun, Yuhong Zhang, Peixin He
Summary: A novel biodegradable hybrid nanogel was developed for multistage delivery of anticancer drug, with the ability to control release through remote heating and function within cells. These nanogels showed high intracellular drug accumulation capacity, indicating their potential as an effective nanoplatform for delivery of therapeutic agents.
JOURNAL OF MATERIALS SCIENCE
(2021)
Article
Nanoscience & Nanotechnology
Maria P. Romero, Hilde H. Buzza, Mirian D. Stringasci, Bianca M. Estevao, Cecilia C. C. Silva, Marcelo A. Pereira-da-Silva, Natalia M. Inada, Vanderlei S. Bagnato
Summary: This study presents the application of nanocomposites based on graphene oxide (nc-GO) with surface modifications for in vivo Photodynamic Therapy (PDT) and Photothermal Therapy (PTT) in the treatment of Ehrlich tumors in mice using NIR light. The study demonstrates the use of nc-GO as a promising theranostic nanomedicine for cancer treatments, with simultaneous in vivo fluorescence diagnostic and combined PDT-PTT effects.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Chemistry, Multidisciplinary
Le Minh Tu Phan, Thuy Anh Thu Vo, Thi Xoan Hoang, Sungbo Cho
Summary: This review summarizes the current development of graphene-integrated hydrogel composites and their application in photothermal biomedicine, highlighting their unique advantages and potential contributions, providing important references to further advance photothermal biomedicine.
Article
Pharmacology & Pharmacy
Heba K. Mohammed-Ahmed, Mustafa Nakipoglu, Aysen Tezcaner, Dilek Keskin, Zafer Evis
Summary: Graphene quantum dots (GQDs) have been widely used in biomedical applications, particularly in anticancer drug delivery. This study investigated the use of graphene oxide quantum dots conjugated with glucosamine and boric acid (GOQDs-GlcN-BA) for cancer therapy. The nanocomposite showed enhanced loading and release of the anticancer drug doxorubicin, as well as increased cytotoxicity against breast cancer cells.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Asghar Taheri-Kafrani, Hamidreza Shirzadfar, Abolghasem Abbasi Kajani, Bassam K. Kudhair, Layth Jasim Mohammed, Shima Mohammadi, Fatemeh Lotfi
Summary: The study presented a simple method for synthesizing superparamagnetic graphene oxide (SPMGO) nanocomposite using a chemical precipitation method as efficient drug carriers, functionalized with cyanuric chloride as a linker for drug loading. Characterization techniques including FTIR spectroscopy, TEM, AFM, TGA, XRD, and XPS confirmed the successful synthesis. In vitro assays demonstrated that the SPMGO/CC/MTX nanocarrier system showed high biocompatibility, enhanced drug efficiency against various cell lines, and controlled drug release, indicating great potential for targeted drug delivery in chemotherapy with methotrexate.
JOURNAL OF BIOTECHNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Cuiping Jiang, Haiyue Zhao, Haiyan Xiao, Yuan Wang, Li Liu, Huoji Chen, Chunyan Shen, Hongxia Zhu, Qiang Liu
Summary: Despite still being in the preclinical stage, rational modification of GFNs with functional elements or utilizing GFNs-based multimodal combination therapy may hold great potential in biomedicine for clinical applications.
EXPERT OPINION ON DRUG DELIVERY
(2021)
Article
Materials Science, Multidisciplinary
Yuan Zhan, Haiping Wang, Mingji Su, Zhengguang Sun, Yuhong Zhang, Peixin He
Summary: A novel biodegradable hybrid nanogel was developed for multistage delivery of anticancer drug, with the ability to control release through remote heating and function within cells. These nanogels showed high intracellular drug accumulation capacity, indicating their potential as an effective nanoplatform for delivery of therapeutic agents.
JOURNAL OF MATERIALS SCIENCE
(2021)
Article
Polymer Science
Hanhong Li, Zhenqi Cheng, Yang Wang, Dong Zhou, Mingji Su, Xianxun Wang, Peixin He, Yuhong Zhang
Summary: A novel drug delivery vehicle, the sPP nanomicelles, has been developed with high encapsulation efficiency, pH responsiveness, and sustainable drug release behavior, showing great potential for therapeutic applications.
MACROMOLECULAR CHEMISTRY AND PHYSICS
(2021)
Article
Engineering, Environmental
Li-Bo Jiang, Sheng-Long Ding, Wang Ding, Di-Han Su, Fang-Xue Zhang, Tai-Wei Zhang, Xiao-Fan Yin, Lan Xiao, Yu-Lin Li, Feng-Lai Yuan, Jian Dong
Summary: The study demonstrated that the crosslinked Alg/Ser/GO hydrogel combined with macrophages and BMSCs has a significant promoting effect on bone regeneration, especially for irregular bone defects.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Kaikai Zheng, Yu Tong, Shihao Zhang, Ruiying He, Lan Xiao, Zoya Iqbal, Yuhong Zhang, Jie Gao, Lei Zhang, Libo Jiang, Yulin Li
Summary: The study presents multifunctional hydrogels for real-time monitoring of wound healing, which can detect pH level, reduce bacterial infection, and promote wound healing simultaneously. The hybridization of CQDs and pH indicator with the hydrogels allows for high responsiveness and accurate indication of pH variability, enabling real-time evaluation of wound conditions. These hydrogels have potential as a smart and flexible wound dressing platform for theranostic skin regeneration.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Engineering, Multidisciplinary
Jianyu Yin, Chengcheng Lu, Chenghui Li, Zhenkun Yu, Chang Shen, Yuanyuan Yang, Xueliang Jiang, Yuhong Zhang
Summary: Multifunctional hydrogel sensors are important for flexible wearable devices, but it is challenging to fabricate sensors with high strength, transparency, UV filterability, environmental stability, self-healing capability, and easy recyclability. This paper successfully prepared a multifunctional composite ionic hydrogel (PGETA) by incorporating tannic acid-coated cellulose nanocrystals (TA@CNC) into a hydrogel. The PGETA hydrogel showed high tensile strength, stretchability, transparency, UV-filtering property, low-temperature tolerance, and moisturizing performance, as well as good self-healing capability and recyclability. It can be used as a wearable device to monitor deformations and physiological signals in different body parts.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Materials Science, Multidisciplinary
Meng Xia, Xiao Yi, Shenxin Pan, Yong Liu, Hanhong Li, Zhengguang Sun, Xueliang Jiang, Yuhong Zhang
Summary: Oil/water separation is essential for sustainable development and ecological protection. A dual-sensitive heterogeneity organohydrogel was developed in this study, capable of super-wettability conversion under temperature stimuli.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Nanoscience & Nanotechnology
Wenbing Cao, Yuhan Wu, Xin Li, Xuanfeng Jiang, Yuhong Zhang, Yuan Zhan, Zhengguang Sun
Summary: In this study, a series of double silane-functionalized carbon dots (DSiCDs) were prepared, and the influence of the organic functional group of the silane and the number of alkoxy group on the optical and coating properties were investigated. The optimized DSiCDs showed excellent optical properties under 570 nm excitation and could be completely cured within 1 h at room temperature to form fluorescent coating with high stability and strong adhesion. These DSiCDs can be directly coated on LED chips to prepare efficient white light-emitting diodes.
Article
Engineering, Biomedical
Shihao Zhang, Yamin Li, Xiaofeng Qiu, Anqi Jiao, Wei Luo, Xiajie Lin, Xiaohui Zhang, Zeren Zhang, Jiachan Hong, Peihao Cai, Yuhong Zhang, Yan Wu, Jie Gao, Changsheng Liu, Yulin Li
Summary: The study successfully developed bioabsorbable materials with ROS regulation capacity, showing great potential in wound healing. The materials can improve cell adhesion and proliferation, promote the wound healing process, and achieve higher healing efficacy by adjusting the ROS levels in the wound area.
BIOACTIVE MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Xiaohui Fan, Yang Wang, Bo Li, Chang Shen, Zhengguang Sun, Yuan Zhan, Yuhong Zhang
Summary: In this study, highly luminescent pH-responsive carbon quantum dots (Si-CDs) were synthesized using a one-step hydrothermal method. The optical properties of the Si-CDs can be controlled by adjusting the pH, making them promising candidates for biomedical and pH-sensitive sensors. These Si-CDs also exhibit good biocompatibility and chemical inertness in vitro cell system simulation.
Article
Materials Science, Multidisciplinary
Zhenkun Yu, Yuanyuan Yang, Chang Shen, Linhan Mao, Congcong Cui, Zhaoxia Chen, Yuhong Zhang
Summary: In this study, a thermochromic hydrogel smart window with adjustable response temperature and excellent transparency was developed. The window allows visible and ultraviolet light to pass through in high-temperature environments while blocking light in low-temperature environments to protect privacy. The hydrogel-based smart windows also have the ability to transition from transparent to opaque through electrical regulation, and show excellent cycling stability and solar modulation characteristics.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)
Article
Nanoscience & Nanotechnology
Yanwen Xiao, Chengcheng Lu, Zhenkun Yu, Yue Lian, Yulin Ma, Zhaoxia Chen, Xueliang Jiang, Yuhong Zhang
Summary: This study prepared a multifunctional ionic conductive hydrogel with high tensile strength, fast self-recovery and fatigue resistance, and high transparency. The strain sensor based on this hydrogel can respond to mechanical stimulation and generate accurate and stable electrical signals. Additionally, it can be used as a flexible wearable device and a capacitive pen for writing and drawing on screens.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Polymer Science
Linhan Mao, Di Chen, Congcong Cui, Yue Lian, Yulin Ma, Zhaoxia Chen, Yuhong Zhang
Summary: This research utilizes a multi-functional superhydrophobic sponge to address the issue of offshore oil spills. The sponge exhibits good absorption properties, chemical stability, and flame retardancy, while also demonstrating superior photothermal conversion capability. With the aid of sunlight, it efficiently separates viscous oils from water mixtures, showing promising potential for oily wastewater treatment and water ecosystem remediation.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Zhenkun Yu, Yulin Ma, Linhan Mao, Yue Lian, Yanwen Xiao, Zhaoxia Chen, Yuhong Zhang
Summary: This article introduces the development of a novel bidirectional optically responsive smart window with adjustable temperature and privacy protection. The smart window has high transparency and excellent solar modulation, providing lighting and landscape appreciation at comfortable temperatures while protecting privacy at low temperatures.
MATERIALS HORIZONS
(2023)
Article
Nanoscience & Nanotechnology
Chuang Li, Ying Zhou, Siju Liu, Renqi Guo, Cuifen Lu, Dan Yin, Yuhong Zhang, Xu Xu, Nianguo Dong, Jiawei Shi
Summary: In this study, a composite scaffold was prepared by introducing POSS nanoparticles into a PEG hydrogel and coating it on the surface of a decellularized heart valve (DHV). The experimental results showed that the composite scaffold had good biocompatibility and anti-calcification properties, making it a potential material for artificial heart valves.
ACS APPLIED BIO MATERIALS
(2022)
Article
Materials Science, Biomaterials
Bozhen Wu, Mingpei Li, Liudi Wang, Zoya Iqbal, Kaiqi Zhu, Yuhao Yang, Yulin Li
Summary: This study developed a biodegradable nanohybrid drug delivery system with pH/redox/enzymatic sensitivity that can release drugs in the tumor microenvironment to enhance anti-tumor bioactivity.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)