Article
Pharmacology & Pharmacy
Hassan Maleki, Mohammad Reza Hosseini Najafabadi, Thomas J. Webster, Mahmoud Reza Hadjighassem, Esmaeil Sadroddiny, Hossein Ghanbari, Masood Khosravani, Mahdi Adabi
Summary: The study aimed to co-load paclitaxel and etoposide in mPEG-PLGA NPs for enhanced therapeutic efficacy in treating intracranial glioblastoma, showing improved cytotoxic effects and anti-glioma activity without inducing blood-related issues.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Multidisciplinary Sciences
Jovany J. Franco, Tatsuo Nagata, Takayuki Okamoto, Shizuo Mukai
Summary: We have designed the CentREUSE, an ultra-low-cost, portable, discarded material-based, human-powered centrifuge for therapeutic applications. It demonstrates reliable centrifugal force and comparable performance to commercial devices. Templates and instructions for construction are provided in this open-source publication.
SCIENTIFIC REPORTS
(2023)
Article
Biology
Pradip Nirbhavane, Laxmi Moksha, Gajanand Sharma, Thirumurthy Velpandian, Bhupinder Singh, O. P. Katare
Summary: This study evaluated a novel nano-lipoidal eye drop formulation of triamcinolone acetonide (TA) for the topical treatment of uveitis. The developed triamcinolone acetonide-loaded nanostructured lipid carriers (cTA-NLC) showed sustained release and enhanced efficacy in vitro. In vivo efficacy was tested on Wistar rats and a pharmacokinetic study was conducted in rabbits. The results demonstrated that the cTA-NLC formulation effectively managed uveitis with minimal signs of inflammation.
Article
Engineering, Biomedical
Bo-Bae Seo, Youngjoong Kwon, Jun Kim, Ki Hyun Hong, Sung-Eun Kim, Hae-Ryong Song, Young-Min Kim, Soo-Chang Song
Summary: In this study, an injectable anti-OA drug depot system for sustained drug release was developed. The system showed long-term effective therapeutic advantages in reducing pain and cartilage degeneration, and exhibited a significant inhibitory effect against further OA progression.
BIOACTIVE MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Shiyi Xu, Xinyu Zhang, Xingyu Zhu, Hui Su, Xueying Yan
Summary: Co-loading nanoparticle encapsulation is an effective strategy for anti-tumor treatment. The combination of arsenic trioxide and tetrandrine synergistically inhibits tumor growth and metastasis. This study developed co-loading nanoparticle formulations and demonstrated their improved drug distribution and anti-tumor activity.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Ophthalmology
Muhammad Usman Jamil, Uzma Naz, Saliha Naz
Summary: This study compared the efficacy of a single intraoperative intravitreal injection of 4 mg triamcinolone acetonide (IVTA) with oral steroids for inflammation control in patients with complicated uveitic cataracts. The results showed that IVTA had similar efficacy to peri-operative oral steroid administration.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Ophthalmology
Steven Yeh, Christopher R. Henry, Barry Kapik, Thomas A. Ciulla
Summary: The results of this study demonstrate the effectiveness and tolerability of SCS-TA in the treatment of macular edema secondary to noninfectious uveitis.
OPHTHALMOLOGY AND THERAPY
(2023)
Article
Multidisciplinary Sciences
Kyle Battiston, Ian Parrag, Matthew Statham, Dimitra Louka, Hans Fischer, Gillian Mackey, Adam Daley, Fan Gu, Emily Baldwin, Bingqing Yang, Ben Muirhead, Emily Anne Hicks, Heather Sheardown, Leonid Kalachev, Christopher Crean, Jeffrey Edelman, J. Paul Santerre, Wendy Naimark
Summary: This study presented a strategy for controlled delivery of corticosteroids using corticosteroid dimer implants, which exhibited surface erosion and tightly controlled drug release kinetics. These implants effectively inhibited inflammation and demonstrated predictable pharmacokinetics in animal models, surpassing the limitations of traditional polymer-based systems.
NATURE COMMUNICATIONS
(2021)
Article
Dermatology
Mi Yeon Cho, Ahreum Song, Kee Yang Chung, Mi Ryung Roh
Summary: This study demonstrates the superiority of the tunneling method over the conventional method in terms of therapeutic effect and side effect occurrence in the treatment of keloids.
DERMATOLOGIC SURGERY
(2022)
Article
Pharmacology & Pharmacy
Pengfei Zhao, Ying Qi
Summary: In this study, a reliable UPLCESI-MS/MS method was developed for the quantification of TA in human plasma after a single intramuscular injection. The method was validated and shown to accurately determine TA concentrations in plasma with high precision and accuracy. The results indicated that the test and reference formulations of TA exhibited bioequivalence in healthy Chinese volunteers.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cell Biology
Wenkai Ni, Shengli Lin, Saiyan Bian, Mingbing Xiao, Yongjun Wang, Yumin Yang, Cuihua Lu, Wenjie Zheng, Pinghong Zhou
Summary: A novel porous composite scaffold, ChCo-TAMS, composed of chitosan, collagen-I and triamcinolone acetonide loaded into poly (lactic-co-glycolic) acid microspheres, displayed unique properties in inhibiting the activation of macrophages, chemokine-mediated cell recruitment and fibrogenesis of fibroblasts, providing a promising clinical medical device for the prevention of post-operative oesophageal stricture.
CELL PROLIFERATION
(2021)
Article
Pharmacology & Pharmacy
Yanhai Xi, Weiheng Wang, Liang Ma, Ning Xu, Changgui Shi, Guohua Xu, Hailong He, Wenming Pan
Summary: A novel nano-carrier with bone targeting, AS-AL-mPEG-PLGA, was successfully prepared to enhance the oral bioavailability, bone targeting, and anti-osteoporotic effect of AS.
Article
Ophthalmology
Carlos Pavesio, Carsten Heinz
Summary: The study findings suggest that in patients with bilateral non-infectious uveitis of the posterior segment (NIU-PS), the use of 0.2 µg/day fluocinolone acetonide implant (FAi) can effectively reduce recurrence rates, decrease the need for adjunctive medications, and improve visual acuity over a 36-month period.
Article
Immunology
Yijun Xia, Youbin Wang, Yan Hao, Mengjie Shan, Hao Liu, Zhengyun Liang, Xinwen Kuang
Summary: Single-cell RNA sequencing analysis revealed that TAC+5-FU injections interrupted the differentiation trajectory of fibroblasts and induced keloid atrophy by inhibiting the FGF signaling pathway. These findings provide new insights into the mechanism of action and potential therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Madhuri Dandamudi, Peter McLoughlin, Gautam Behl, Sweta Rani, Lee Coffey, Anuj Chauhan, David Kent, Laurence Fitzhenry
Summary: The study developed a nanoparticulate system for topically applied corticosteroids, aiming to reduce the treatment burden for patients and doctors. Surface-modified nanoparticles showed controlled drug release and improved bioavailability, making them potential candidates for treating acquired retinal vasculopathies.
Article
Biochemistry & Molecular Biology
Xuewei Yin, Qin Li, Huixia Wei, Ninghong Chen, Shanshan Wu, Yue Yuan, Bin Liu, Chen Chen, Hongsheng Bi, Dadong Guo
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2019)
Article
Cell Biology
Xuewei Yin, Bin Liu, Huixia Wei, Shanshan Wu, Lijie Guo, Furu Xu, TingTing Liu, Hongsheng Bi, Dadong Guo
INFLAMMATION RESEARCH
(2019)
Article
Biotechnology & Applied Microbiology
Dadong Guo, Meihua Ding, Xiaoli Song, Yuanyuan Sun, Guoping Li, Zonghong Li, Huixia Wei, Jianfeng Wu, Wenjun Jiang, Hongsheng Bi
Article
Immunology
Beibei Wang, Qingmei Tian, Dadong Guo, Wei Lin, Xiaofeng Xie, Hongsheng Bi
Summary: This study showed that activated gamma delta T cells may promote DCs maturation to exacerbate EAU development, while blocking IFN-gamma could decrease DCs maturation. In KO EAU mice, the decrease in percentage of IFN-gamma- and IL-17-producing CD4(+) T cells was greater compared to WT EAU mice. The levels of IFN-gamma/IL-17 in serum were consistent with those of CD4(+) T cells, indicating the potential role of gamma delta T cells in Th1/Th17 cell generation in EAU.
IMMUNOLOGICAL INVESTIGATIONS
(2021)
Article
Immunology
Xuewei Yin, Huixia Wei, Shanshan Wu, Zhe Wang, Bin Liu, Lijie Guo, Hongsheng Bi, Dadong Guo
INTERNATIONAL IMMUNOPHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Shanshan Wu, Dadong Guo, Huixia Wei, Xuewei Yin, Liwei Zhang, Bin Guo, Furu Xu, Yixian Hao, Wenjun Jiang, Hongsheng Bi
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2020)
Article
Immunology
H. Wei, X. Yin, H. Tang, Y. Gao, B. Liu, Q. Wu, Q. Tian, Y. Hao, H. Bi, D. Guo
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2020)
Article
Ophthalmology
Zheng-Feng Liu, Feng Zhang, Da-Doug Guo, Xue-Mei Pan, Hong-Sheng Bi
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
(2020)
Article
Biochemical Research Methods
Bin Liu, Xuewei Yin, Huixia Wei, Zhe Wang, Hongying Tang, Yan Qiu, Yixian Hao, Xiuyan Zhang, Hongsheng Bi, Dadong Guo
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2020)
Article
Ophthalmology
Qiuxin Wu, Zhongen Li, Xiuzhen Lu, Jike Song, Hui Wang, Dongmei Liu, Dadong Guo, Hongsheng Bi
Summary: The study demonstrated that EGCG enhances cell viability and protects against UVB-induced apoptosis in HLECs by reducing ROS generation, maintaining mitochondrial membrane potential, increasing total antioxidant capacity, and inhibiting expression of AIF and Endo G. These findings suggest that EGCG acts through AIF/Endo G signaling pathways to mitigate UVB-induced oxidative stress in HLECs.
CUTANEOUS AND OCULAR TOXICOLOGY
(2021)
Article
Mathematical & Computational Biology
Tao Zhang, Qian Jiang, Furu Xu, Ruixue Zhang, Dezheng Liu, Dadong Guo, Jianfeng Wu, Ying Wen, Xingrong Wang, Wenjun Jiang, Hongsheng Bi
Summary: The study investigated the role of electroacupuncture (EA) in treating glucocorticoid (GC)-enhanced myopia by increasing resting-state functional connectivity (FC) between the left and right visual cortices. EA at acupoints was found to improve symptoms, suppress myopia, and enhance recovery in guinea pigs with GC-enhanced myopia compared to those in the sham EA group.
FRONTIERS IN NEUROINFORMATICS
(2021)
Article
Medicine, Research & Experimental
Xuewei Yin, Yan Qiu, Zonghong Li, Lijie Guo, Huixia Wei, Bin Liu, Mengxian Zhou, Tuling Li, Lihan Wang, Wenjun Jiang, Hongsheng Bi, Dadong Guo
Summary: In this study, it was found that LXD could effectively inhibit Th17 cell differentiation by suppressing the activation of the Notch signaling pathway, restoring the balance of CD4(+)/CD8(+) and Th17/Treg, consequently alleviating eye inflammation and positively regulating the immune state overall.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Dadong Guo, Zhe Wang, Lijie Guo, Xuewei Yin, Zonghong Li, Mengxian Zhou, Tuling Li, Chen Chen, Hongsheng Bi
Summary: The study demonstrated that zinc oxide (ZnO) nanoparticles can efficiently inhibit the proliferation of human tenon fibroblasts (HTFs) by activating autophagy signaling and inducing oxidative stress. This mechanism also includes disrupting mitochondrial function, attenuating ATP production, and damaging nuclear morphology.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Ophthalmology
Jike Song, Dadong Guo, Qingmei Tian, Qiuxin Wu, Xiuyan Zhang, Hongsheng Bi
Summary: The study found that chronic unpredictable mild stress (CUMS) may protect rats with experimental autoimmune uveitis (EAU) from harmful effects by suppressing immune disorder of T lymphocyte and related cytokine responses.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2022)
Article
Ophthalmology
Yang Li, Jie Liu, Qingmei Tian, Dadong Guo, Dongmei Liu, Xianzhen Ma, Hongsheng Bi
Summary: This case report identified a thelazia callipaeda infection discovered during phacoemulsification cataract surgery, highlighting the importance of carefully asking for the patient's medical history before surgery. It also emphasized the necessity of health education, maintaining a clean environment, and personal eye hygiene.
