Isoxazole Derivatives as Regulators of Immune Functions

The recent progress of isoxazole in medicinal chemistry

(2018) Jie Zhu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Indolyl-isoxazolidines attenuate LPS-stimulated pro-inflammatory cytokines and increase survival in a mouse model of sepsis: Identification of potent lead

(2018) Gagandeep Singh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, Immunosuppressive Properties, and Mechanism of Action of a New Isoxazole Derivative

(2018) Marcin Mączyński et al.   MOLECULES

Synthesis, anti-inflammatory, cyclooxygenases inhibitions assays and histopathological study of poly-substituted 1,3,5-triazines: Confirmation of regiospecific pyrazole cyclization by HMBC

(2017) Heba A.H. Elshemy et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Isoxazole ring as a useful scaffold in a search for new therapeutic agents

(2017) Angelika Sysak et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Analgesic, anti-inflammatory, and antimicrobial activities of novel isoxazole/pyrimidine/pyrazole substituted benzimidazole analogs

(2017) Krishna Veni Chikkula et al.   MEDICINAL CHEMISTRY RESEARCH

The safety profile of parecoxib for the treatment of postoperative pain: a pooled analysis of 28 randomized, double-blind, placebo-controlled clinical trials and a review of over 10 years of postauthorization data

(2017) Stephan Schug et al.   Journal of Pain Research

5-Amino-3-methyl-4-isoxazolecarboxylic acid hydrazide derivatives with in vitro immunomodulatory activities

(2016) Angelika Drynda et al.   Chemical Biology & Drug Design

1, 2-Benzisoxazole: A Privileged Structure with a Potential for Polypharmacology

(2016) Yoshikazu Uto   CURRENT PHARMACEUTICAL DESIGN

Medicinal Chemistry Perspective of Fused Isoxazole Derivatives

(2016) Mahesh A. Barmade et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Synthesis and biological evaluation of salicylic acid conjugated isoxazoline analogues on immune cell proliferation and angiogenesis

(2016) Naveen Puttaswamy et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

4,5-Diarylisoxazol-3-carboxylic acids: A new class of leukotriene biosynthesis inhibitors potentially targeting 5-lipoxygenase-activating protein (FLAP)

(2016) Erden Banoglu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Influence of 5-amino-3-methyl-4-isoxazolecarbohydrazide on selective gene expression in Caco-2 cultured cells

(2016) Paulina Płoszaj et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Immunoregulatory effects of 4-(4-chlorophenyl)-1-(5-amino-3-methylisoxazole-4-carbonyl)-thiosemicarbazide (06K) in non-immunized and SRBC-immunized mice

(2016) Angelika Drynda et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Anti-inflammatory properties of an isoxazole derivative – MZO-2

(2016) Marcin Mączyński et al.   Pharmacological Reports

The MIF Antagonist ISO-1 Attenuates Corticosteroid-Insensitive Inflammation and Airways Hyperresponsiveness in an Ozone-Induced Model of COPD

(2016) Kirsty E. Russell et al.   PLoS One

Comparative effectiveness of granulocyte colony-stimulating factors to prevent febrile neutropenia and related complications in cancer patients in clinical practice: A systematic review

(2016) Sarah Mitchell et al.   JOURNAL OF ONCOLOGY PHARMACY PRACTICE

The effect of 5-amino-3-methyl-4-isoxazolecarboxylic acid hydrazide on lymphocyte subsets and humoral immune response in SRBC-immunized mice

(2015) Angelika Drynda et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

3,5-Disubstituted Isoxazole Derivatives: Potential Inhibitors of Inflammation and Cancer

(2015) Kodagahalli Sathya Rakesh et al.   INFLAMMATION

Discovery of a novel isoxazoline derivative of prednisolone endowed with a robust anti-inflammatory profile and suitable for topical pulmonary administration

(2015) E. Ghidini et al.   STEROIDS

In vitroimmunomodulatory effects of 5-amino-3-methyl-4-isoxazolecarboxylic acid hydrazide on the cellular immune response

(2014) Angelika Drynda et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Immune function in cyclophosphamide-treated mice is restored by the T-cell-tropic isoxazole derivative R-13

(2014) Michał Zimecki et al.   Journal of Immunotoxicology

Restoration of immune system function is accelerated in immunocompromised mice by the B-cell-tropic isoxazole R-11

(2014) Michał Zimecki et al.   Pharmacological Reports

Regioselective synthesis of isoxazole–mercaptobenzimidazole hybrids and their in vivo analgesic and anti-inflammatory activity studies

(2013) Shravankumar Kankala et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

New FAAH inhibitors based on 3-carboxamido-5-aryl-isoxazole scaffold that protect against experimental colitis

(2011) Virginie Andrzejak et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A Small-Molecule Macrophage Migration Inhibitory Factor Antagonist Protects against Glomerulonephritis in Lupus-Prone NZB/NZW F1 and MRL/lpr Mice

(2010) L. Leng et al.   JOURNAL OF IMMUNOLOGY

Use of Filgrastim and Pegfilgrastim to Support Delivery of Chemotherapy

(2009) William Renwick et al.   BIODRUGS

Synthesis and pharmacological screening of derivatives of isoxazolo[4,5-d]pyrimidine

(2008) Edwin Wagner et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY