Article
Nanoscience & Nanotechnology
Mustafa K. Shehata, Assem A. Ismail, Maher A. Kamel
Summary: This study aimed to prepare nanostructured lipid carriers (NLCs) co-loaded with donepezil and astaxanthin and evaluate their in vivo efficacy in an AD-like rat model. The results showed that the DPL/AST-NLCs had significant effects in improving AD-related biomarkers and histopathological changes. Nose-to-brain delivery of DPL/AST-NLCs is a promising strategy for the management of AD.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Review
Agricultural Engineering
Yuanyua Ren, Jinquan Deng, Junchao Huang, Zhaoming Wu, Lanbo Yi, Yuge Bi, Feng Chen
Summary: Astaxanthin, an important antioxidant and nutraceutical compound, is widely used in dietary supplements and cosmetics. The refinery of astaxanthin from Haematococcus pluvialis is a growing industrial sector, as it can accumulate astaxanthin up to 5% of dry weight. Further research on production optimization and joint-production with lipids could make algal-derived astaxanthin more accessible for various applications.
BIORESOURCE TECHNOLOGY
(2021)
Article
Food Science & Technology
Juan Huang, Wenjing Xie, Lu Liu, Yucong Song, Fang Pan, Hua Bai, Ting Pan, Yiwen Lv, Jianchu Chen, Jianqiang Shi, Xiaojia Hu
Summary: This study aimed to enhance the stability and bioavailability of astaxanthin by incorporating it into nanostructured lipid carriers (NLCs) and then into alginate microgels. The slow dissolution of astaxanthin in alginate microgels compared to NLCs was observed in vitro. The NLC-alginate microgels offer potential for encapsulating astaxanthin in the food industry for improved chemical stability and controlled release.
EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY
(2021)
Article
Biology
Ngoc-Bich-Dao Vu, Ngoc-Duy Pham, Thi-Ngoc-Mai Tran, Xuan-Hai Pham, Dai-Nghiep Ngo, Minh-Hiep Nguyen
Summary: This study aimed to protect patients' skin during radiotherapy by using astaxanthin-encapsulated nanostructured lipid carriers (NLC-ATX). Results showed that NLC-ATX exhibited significant radioprotective effects in both in vitro and in vivo experiments.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2023)
Review
Biophysics
Maxius Gunawan, Veerakiet Boonkanokwong
Summary: Lipid nanoparticles have been used to enhance the delivery of antioxidants in the gastrointestinal tract, overcoming challenges such as low solubility and stability. These nanoparticles can improve the bioavailability and effectiveness of antioxidant compounds, making them valuable in nutraceutical formulations.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biochemical Research Methods
Eman Gomaa, Heba A. Fathi, Noura G. Eissa, Mahmoud Elsabahy
Summary: Construction of nanocarriers, such as NLCs, has great potential in drug delivery systems. NLCs, as a new generation of solid lipid nanoparticles, have higher drug loading efficiency compared to SLNs and offer advantages in terms of preparation and scalability.
Article
Nanoscience & Nanotechnology
Mustafa K. Shehata, Assem A. Ismail, Maher A. Kamel
Summary: This study aimed to prepare and evaluate AST-loaded nanostructured lipid carriers (NLCs) for nose-to-brain drug delivery in rat model of AD. The optimized AST-NLCs showed improved therapeutic properties and significantly reduced oxidative stress, amyloidogenic pathway, neuroinflammation, and apoptosis in AD-like rats.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Engineering, Biomedical
Liyuan Gu, Wenjuan Wang, Bi Wu, Suping Ji, Qiang Xia
Summary: The aim of this study was to evaluate the astaxanthin-loaded nanostructured lipid carriers (ASX-NLC) for local application of astaxanthin. The effects of microencapsulation on the properties of ASX-NLC were studied using dynamic light scattering (DLS) and X-ray diffraction (XRD). The ASX-NLC showed a mean size of 108.43 +/- 0.26 nm and a high encapsulation efficiency of 95.69 +/- 0.13%. It exhibited good light stability and temperature stability, indicating its feasibility. The ASX-NLC could effectively release astaxanthin and increase astaxanthin retention in the skin.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Sandra Costa-Fernandez, Jenyffer K. R. Matos, Gaby S. Scheunemann, Giovanna C. Salata, Marlus Chorilli, Il-Sei Watanabe, Gabriel L. B. de Araujo, Marinilce F. Santos, Kelly Ishida, Luciana B. Lopes
Summary: The study developed bioadhesive nanostructured lipid carriers for the management of chronic wounds in elderly individuals, effectively delivering antioxidants and antimicrobial agents to improve treatment outcomes. The results demonstrated significant localization of the carriers in damaged skin, along with antimicrobial effects and stimulation of fibroblast migration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Agricultural Engineering
Hailiang Xing, Yongteng Zhao, Tao Li, Benyong Han, Peng Zhao, Xuya Yu
Summary: The combination of melatonin and putrescine enhances the production of astaxanthin (Asta) and lipids in Haematococcus pluvialis, increasing endogenous putrescine content and reducing oxidative stress levels. This strategy also upregulates carotenogenic, lipogenic, and antioxidant enzyme genes in the microalga.
BIORESOURCE TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rosa Calderon-Jacinto, Pietro Matricardi, Virginie Gueguen, Graciela Pavon-Djavid, Emmanuel Pauthe, Violeta Rodriguez-Ruiz
Summary: This study focuses on the development and evaluation of a dual nanostructured lipid carrier (NLC)/Carbopol(R)-based hydrogel system for the topical delivery of curcumin to the skin. The results demonstrate that CUR-NLCs have high curcumin antioxidant activity and moderate anti-migration/proliferation effect. The dual CUR-NLC/hydrogel system shows potential application in adjuvant treatment for topical dermatological applications.
Article
Engineering, Chemical
Aye Aye Myint, Sabrinna Wulandari, Jongho Choi, Sang Jun Sim, Jaehoon Kim
Summary: Efficient extraction of valuable bioactive compounds from wet Haematococcus pluvialis cysts was achieved using a green and sustainable strategy involving l-DME and DMSO extraction methods. The dry extract obtained had higher astaxanthin and fatty acid contents as well as greater antioxidant activity compared to the DMSO extract.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Environmental Sciences
Yanxia Zhu, Ze Zhang, Xiaodan Xu, Jun Cheng, Shutong Chen, Jianglei Tian, Weijuan Yang, Mark Crocker
Summary: Ammoniumferric citrate (AFC) was used to enhance biomass yield and astaxanthin content of Haematococcus pluvialis by stimulating light harvest in photosynthesis and oxidation induction in astaxanthin accumulation at different growth stages. This resulted in increased astaxanthin and lipid content in the algae cells, providing a new approach for reducing greenhouse gas emissions and producing high-value products.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Plant Sciences
Veno Jasa Grujic, Biljana Todorovic, Roman Kranvogl, Terezija Ciringer, Jana Ambrozic-Dolinsek
Summary: This study evaluated the composition and content of carotenoids and other pigments in both stages of H. pluvialis algae life cycle, finding that the content of carotenoids was significantly higher in the red vegetative stage compared to the green vegetative stage, with astaxanthin and its esters predominating. The results contribute to understanding the overall pigment composition and content of H. pluvialis algae, providing a basis for further cultivation improvements.
Article
Biochemistry & Molecular Biology
Xavier Llorente, Gerard Esteruelas, Lorena Bonilla, Mariana Garnica Agudelo, Ingrid Filgaira, Daniel Lopez-Ramajo, Ruoyi C. Gong, Concepcio Soler, Marta Espina, Maria Luisa Garcia, Joan Manils, Montserrat Pujol, Elena Sanchez-Lopez
Summary: Nanocarriers, including nanostructured lipid carriers (NLC), are highly effective for topical drug administration. Optimized NLCs loaded with the drug Riluzole (RLZ-NLCs) were developed as a potential treatment, featuring biodegradability, biocompatibility, and sustained drug release. RLZ-NLCs showed successful delivery of RLZ in a sustained manner, inhibition of keratinocyte cell proliferation, and non-angiogenic properties, making them a promising strategy for treating keratinocyte hyperproliferative conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Sina Jafari-Matanagh, Seyed Esmail Razavi, Mir Biuk Ehghaghi Bonab, Hossein Omidian, Yadollah Omidi
Summary: In this study, we investigated the extravasation of pharmaceutical inorganic nanoparticles from leaky tumor microvasculature into the tumor microenvironment using a new approach. We used a combination of macroscopic and microscopic methods to examine the effect of interstitial fluid retention on drug delivery. Our findings suggest that increasing interstitial fluid retention enhances drug delivery to solid tumors by increasing tumor interstitial fluid pressure.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Kwadwo Mfoafo, Rahul Mittal, Adrien Eshraghi, Yadollah Omidi, Hossein Omidian
Summary: The management of inner ear disorders is hindered by challenges in delivering drug molecules to the affected cells. Systemic therapy often results in sub-optimal concentration due to the blood-labyrinth barrier (BLB), while local drug delivery methods face issues with drainage. The use of hydrogels to deliver drugs to the inner ear offers significant potential, and this article discusses the impact of such formulations.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Hossein Omidian, Jafar Razmara, Sepideh Parvizpour, Hamed Tabrizchi, Yosef Masoudi-Sobhanzadeh, Yadollah Omidi
Summary: The life cycle of a drug starts from its discovery and ends when it is disposed. Various entities such as drug discovery companies, manufacturers, regulatory agencies, suppliers, pharmacies, patients, and healthcare providers are involved in this process. Transparency, traceability, automation, and data security play crucial roles in ensuring effective and safe transactions among all parties. However, challenges like scalability, energy consumption, regulations, standards, and complexity hinder the adoption of new technology that can fulfill these requirements. This article highlights how blockchain technology can track, accelerate, and enhance the efficiency of complex operations like pharmaceutical development.
DRUG DISCOVERY TODAY
(2023)
Article
Pharmacology & Pharmacy
Kwadwo Mfoafo, Yadollah Omidi, Hossein Omidian
Summary: Thermoresponsive polymers have been widely used for the development of stimuli-responsive drug formulations in various routes of administration. However, their use has been limited by obstacles such as high polymer concentration, wide gelation temperature, low gel strength, poor mucoadhesiveness, and short retention. In-situ thermoresponsive mucoadhesive hydrogel blends or hybrids have been suggested as a solution to improve drug bioavailability and efficacy. This article highlights the development and assessment of such hydrogels in different administration routes.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Engineering, Biomedical
Parvin Shokrollahi, Yadollah Omidi, Luigi X. Cubeddu, Hossein Omidian
Summary: Cardiovascular diseases, including myocardial infarction, are a major global burden and the leading cause of death. Cell-based tissue engineering and regeneration may be the only viable option for restoring normal heart function since damaged cardiac tissue cannot self-repair. Various techniques, such as the incorporation of cells into conductive polymers (CPs) and biomaterials, have been used to transport cells to damaged cardiac tissues. The success of tissue engineering for the damaged heart depends on factors like cell source, growth factors, and scaffolds.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2023)
Article
Pharmacology & Pharmacy
Minoo Ghanavi, Ali Khoshandam, Shaghayegh Aslzad, Marziyeh Fathi, Abolfazl Barzegari, Elaheh Dalir Abdolahinia, Khosro Adibkia, Jaleh Barar, Yadollah Omidi
Summary: Due to the unique structure of the human eye, ocular drug delivery faces challenges such as low bioavailability. In-situ gel-forming mucoadhesive hydrogels can improve ocular bioavailability. Chitosan has been used in the preparation of these hydrogels. Water-soluble chitosan was obtained and gel formation was accomplished using sodium beta-glycerophosphate and sodium bicarbonate. The prepared hydrogel showed sustained-release and antibacterial activity in vitro.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Nazanin Amiryaghoubi, Marziyeh Fathi, Jaleh Barar, Nader Noroozi-Pesyan, Hossein Omidian, Yadollah Omidi
Summary: Graphene-based composites have garnered significant attention in biomedical engineering due to their excellent characteristics. These composites, when combined with different biomolecules, show promise as scaffolds for cartilage tissue regeneration. The success of cartilage tissue engineering depends on the compatibility of the scaffold with cells, chondrogenic factors, and biomechanical behavior. This review provides insights into the recent progress in the bioengineering of graphene-based hybrid scaffolds for cartilage tissue engineering and chondrogenic differentiation.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Analytical
Ghasem Ebrahimi, Parvin Samadi Pakchin, Ali Mota, Hossein Omidian, Yadollah Omidi
Summary: Microfluidic paper-based analytical devices (μPADs) provide a cost-effective, portable, and rapid detection method for a wide range of molecules and microorganisms. Electrochemical detection methods are key for qualitative analysis of different ligands. 2D μPADs are transformed into 3D through folding or twisting of paper, with microfluidic channels and connections created within the paper layers. Wax printing is the most common method for creating hydrophilic channels in μPADs. This review discusses the fabrication, design strategies, detection modes, and applications of affinity-based electrochemical μPADs for the detection of oncomarkers.
Review
Gastroenterology & Hepatology
Hassan Shokri Garjan, Yadollah Omidi, Mehdi Poursheikhali Asghari, Reza Ferdousi
Summary: Thanks to advancements in sequencing technology and microbiology, microorganisms have been linked to a range of critical human diseases. The understanding of human microbe-disease relationships from a pathogen's perspective has provided valuable insights for pathogenesis research, early diagnosis, precision medicine, and therapy. Microbe-based analysis in terms of diseases and related drug discovery has the potential to predict new connections and mechanisms, while providing new concepts. This review highlights the computational approaches, databases, potential prospects, and obstacles in this field, along with recommendations for enhancing predictive capabilities.
Article
Engineering, Biomedical
Camille Le Guilcher, Gregory Merlen, Alessandra Dellaquila, Marie-Noeurolle Labour, Rachida Aid, Thierry Tordjmann, Didier Letourneur, Teresa Simon-Yarza
Summary: Porous pullulan-dextran hydrogel can be used to self-assemble hepatocytes and biliary-like cells into functional 3D microtissues, showing potential value in clinical applications.
MATERIALS TODAY BIO
(2023)
Review
Multidisciplinary Sciences
Sajini D. Hettiarachchi, Young M. Kwon, Yadollah Omidi, Robert C. Speth
Summary: The renin-angiotensin system (RAS) plays a role in several disorders and drugs that target this system are limited in their efficacy. Nanoparticle-mediated drug delivery systems offer a potential solution to overcome these limitations.
Review
Pharmacology & Pharmacy
Kwadwo Mfoafo, Rahul Mittal, Adrien Eshraghi, Yadollah Omidi, Hossein Omidian
Summary: Thiolated polymers, known as thiomers, have unique mucoadhesive properties and can form strong covalent bonds with cysteine-rich subdomains of mucus glycoproteins. This makes them suitable for drug delivery systems (DDSs) for dry mucosal surface diseases. Thiomers offer higher adhesion and retention time compared to non-thiolated polymers, leading to increased bioavailability and reduced patient noncompliance. They can also inhibit enzymes, increase permeability, and protect protein and peptide drugs from digestive enzymes. Thiolated polymers have potential applications in adhesion, controlled drug release, and tissue engineering.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Naima Ahmed Omar, Jessica Roque, Paul Galvez, Robin Siadous, Olivier Chassande, Sylvain Catros, Joelle Amedee, Samantha Roques, Marlene Durand, Celine Bergeaut, Laurent Bidault, Paola Aprile, Didier Letourneur, Jean-Christophe Fricain, Mathilde Fenelon
Summary: This study developed and evaluated pullulan/dextran-based membranes for guided bone regeneration (GBR) procedures. The membranes showed cytocompatibility and biocompatibility, with the HA-containing membrane promoting significant bone formation in the early stage. These findings suggest the potential use of pullulan/dextran-based membranes for GBR procedures.
BIOENGINEERING-BASEL
(2023)
Article
Biotechnology & Applied Microbiology
Jerome Grenier, Bertrand David, Clement Journe, Iwona Cicha, Didier Letourneur, Herve Duval
Summary: In this study, researchers combined porous polysaccharide-based hydrogel scaffolds with a bioreactor-type perfusion device to provide biological and mechanical stimuli for in vitro cell culture. They found that cells organized into spheroids with a diameter of 30-100 μm and were not affected by hypoxia under the perfusion rate of 10 mL/min. These findings are important for future applications in organoid research.
BIOENGINEERING-BASEL
(2023)
Article
Food Science & Technology
Carlos Adelantado, Jose Angel Salatti-Dorado, Carlos Herrera, Lourdes Arce, Maria Jose Cardador
Summary: High-performance-ion mobility spectrometry (HPIMS) was used for the first time in the analysis of olive oil samples, following a simple liquid-liquid extraction procedure. The developed methodology is user-friendly, fast, and inexpensive, complying with the principles of green chemistry. The proposed approach, combined with multivariate analysis, showed potential in classifying olive oil samples based on their organoleptic quality, with high accuracy rates.