Article
Biochemistry & Molecular Biology
Chao Liu, Yining Li, Ren Sheng, Xiaowan Han, Li Bao, Chenyin Wang, Weizhi Wang, Xinhai Jiang, Jiangxue Han, Lijuan Lei, Ni Li, Jing Zhang, Minghua Chen, Yan Li, Yexiang Wu, Shunwang Li, Yu Ren, Yanni Xu, Shuyi Si
Summary: The study demonstrated that the N-methylpyridine-chlorofuranformamide analog 3i1 shows promise in upregulating OPG activity, inhibiting RANKL-induced osteoclastogenesis, and promoting osteoblast differentiation, potentially serving as a new therapeutic agent for osteoporosis.
BIOORGANIC CHEMISTRY
(2021)
Article
Immunology
Huanhuan Xu, Titi Liu, Yuankan Jia, Jin Li, Li Jiang, Caijiang Hu, Xuanjun Wang, Jun Sheng
Summary: EGCG in green tea can inhibit osteoclastogenesis by interfering with the interaction between RANK and RANKL, suppressing the phosphorylation of key regulatory factors, and negatively regulating NF-kappa B and MAPK signaling pathways.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Yukino Tsunekage, Masatoshi Takeiri, Yuri Yoshioka, Shinichi Matsumura, Yoshihide Kimura, Kohsuke Kataoka
Summary: Extract from watercress suppresses osteoclast differentiation and function through inhibition of key signaling pathways and gene expression, showing potential anti-osteoporosis effects.
NATURAL PRODUCT COMMUNICATIONS
(2021)
Review
Endocrinology & Metabolism
Jing-Yi Xue, Shiro Ikegawa, Long Guo
Summary: The RANKL/OPG/RANK signaling pathway plays a crucial role in bone metabolism and genetic mutations in associated genes can lead to various skeletal disorders. These disorders can be categorized into two types based on their effects on osteoclast formation and bone density.
JOURNAL OF BONE AND MINERAL METABOLISM
(2021)
Article
Oncology
Anuj Anuj, Nina Reuven, Stefan G. E. Roberts, Ari Elson
Summary: The cytokine RANKL is involved in the differentiation of monocytes/macrophages into bone-resorbing osteoclasts, and it down-regulates the expression of BASP1 which is a negative regulator of osteoclastogenesis. Knocking down or eliminating BASP1 enhances RANKL-induced osteoclastogenesis, promoting cell-cell fusion and increasing mineral degrading abilities of osteoclasts.
EXPERIMENTAL CELL RESEARCH
(2023)
Review
Oncology
Junjie Lu, Desheng Hu, Yan Zhang, Chen Ma, Lin Shen, Bo Shuai
Summary: Denosumab, a fully humanized monoclonal neutralizing antibody, inhibits bone resorption by competitively binding with RANKL and blocking the activation of the RANK/RANKL/OPG signaling pathway. It is used to treat metabolic bone diseases and has potential in the treatment of osteoarthritis, bone tumors, and other autoimmune diseases. However, more research is needed to understand its mechanism of action and optimize its clinical use for bone metastasis of malignant tumors.
FRONTIERS IN ONCOLOGY
(2023)
Article
Immunology
Jiachao Guo, Ranyue Ren, Zhou Guo, Kai Sun, Jinpeng He, Jingfan Shao, Xiaolin Wang
Summary: Osteoporosis is a systemic and endocrine bone disorder characterized by decreased bone mineral density, compromised bone strength, and destruction of trabecular structure. The excessive osteoclastogenesis and bone erosion contribute to the progression of the disease. However, existing medications have poor adherence and adverse reactions, highlighting the urgent need for novel therapies for osteoporosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Honglei Kang, Qian Guo, Yimin Dong, Renpeng Peng, Kehan Song, Jia Wang, Haiyang Liu, Meipeng Zhu, Hongjian Zhao, Hanfeng Guan, Feng Li
Summary: MAT2A is crucial for osteoclastogenesis and may be a potential therapeutic target for the treatment of osteoporosis.
Article
Cell Biology
Gang Wang, Kai Chen, Chao Ma, Chao Wang, Delong Chen, Jianbo He, Yuhao Liu, Tao Jiang, Jinbo Yuan, Leilei Chen, Wei He, Jiake Xu
Summary: RA is a natural compound that shows potential therapeutic effects by inhibiting osteoclast differentiation and reducing bone loss. It suppresses osteoclastogenesis without causing cell toxicity, making it a promising treatment option for skeletal diseases.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Review
Endocrinology & Metabolism
Yan Zhang, Jingqi Liang, Peilong Liu, Qiong Wang, Liang Liu, Hongmou Zhao
Summary: With the increasing incidence of cancer, tumor bone metastasis has become more common among patients. The RANK/RANKL/OPG system and osteoclasts play important roles in bone homeostasis and tumor bone metastasis formation, and inhibiting this system can prevent metastasis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yuria Jang, Hong Moon Sohn, Young Jong Ko, Hoon Hyun, Wonbong Lim
Summary: The mutant RANKL demonstrated the ability to inhibit osteoclastogenesis by competitively inhibiting RANKL, serving as a potential therapeutic agent for osteoporosis with fewer toxic side effects compared to traditional treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Gang Wang, Chao Ma, Kai Chen, Ziyi Wang, Heng Qiu, Delong Chen, Jianbo He, Cheng Zhang, Ding Guo, Boyong Lai, Shuangxiao Zhang, Linfeng Huang, Fan Yang, Jinbo Yuan, Leilei Chen, Wei He, Jiake Xu
Summary: This study demonstrates that cycloastragenol (CAG) inhibits the formation and function of osteoclasts by regulating intracellular signaling pathways. It has potential as an alternative treatment for osteoporosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Hao Qu, Yuankang Zhang, Rongxin He, Nong Lin, Cong Wang
Summary: Postmenopausal osteoporosis is a chronic systemic metabolic disease caused by excessive bone resorption and reduced bone formation. Anethole, a natural compound, shows potential in inhibiting osteoclast differentiation, reducing bone resorption, and suppressing osteoclast-specific gene expression through blocking ERK and AKT signaling pathways. Our study suggests that anethole may have osteoprotective effects and be a potential treatment for osteoporosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Yan Yang, Xiangxin Li
Summary: This study revealed the effects of SIRT1 on the OPG/RANKL signaling pathway and periodontitis progression. The results showed that overexpression of SIRT1 can activate the OPG/RANKL pathway, inhibit osteoclastogenesis, and attenuate periodontitis progression.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Biochemistry & Molecular Biology
Yizhen Huang, Yute Yang, Jianle Wang, Shasha Yao, Teng Yao, Yining Xu, Zizheng Chen, Putao Yuan, Jun Gao, Shuying Shen, Jianjun Ma
Summary: The study found that miR-21-5p regulates osteoclast differentiation by targeting SKP2, and treatment with miR-21-5p can inhibit bone resorption in vivo, suggesting that it may be a new therapeutic target for osteoporosis.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Mei-Ling Ho, Chin-Jung Hsu, Che-Wei Wu, Ling-Hua Chang, Jhen-Wei Chen, Chung-Hwan Chen, Kui-Chou Huang, Je-Ken Chang, Shun-Cheng Wu, Pei-Lin Shao
Summary: This study investigated the effect of adipose-derived stem cell (ADSC)-secreted extracellular vesicles (EVs) on osteoblast function. The results showed that ADSC-EVs can enhance osteoblast proliferation and activity, and may regulate osteoblast function through autophagy or signaling pathways.
Review
Biochemistry & Molecular Biology
Wei-Chun Kao, Jian-Chih Chen, Ping-Cheng Liu, Cheng-Chang Lu, Sung-Yen Lin, Shu-Chun Chuang, Shun-Cheng Wu, Ling-Hua Chang, Mon-Juan Lee, Chung-Da Yang, Tien-Ching Lee, Ying-Chun Wang, Jhong-You Li, Chun-Wang Wei, Chung-Hwan Chen
Summary: This review discusses the role of autophagy in osteoarthritis (OA) and the modulation of the autophagy pathway by drugs, key molecules, and non-coding RNAs. Further research is needed to identify therapeutic targets or diagnostic biomarkers related to autophagy, making it a more effective approach for OA treatment in the future.
Article
Endocrinology & Metabolism
Tien-Ching Lee, Jian-Chih Chen, Sung-Yen Lin, Pei-Shan Ho, Chung-Hwan Chen, Yin-Chih Fu, Je-Ken Chang, Mei-Ling Ho
Summary: This study examined the association between statin use and hip fracture risk in patients with type 2 diabetes mellitus. The results showed that statin use was associated with a decreased risk of hip fracture, and a dose-response relationship was observed.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Editorial Material
Emergency Medicine
Chih-Yao Lee, Cheng-Chang Lu
EMERGENCY MEDICINE JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Shun-Yi Jian, Chiu-Feng Lin, Tung-Lin Tsai, Pei-Hua Wang, Chung-Hwan Chen, Sung-Yen Lin, Chun-Chieh Tseng
Summary: This study aims to establish a surface modification technology for ZK60 magnesium alloy implants that can degrade uniformly over time and promote bone healing. It proposes a special micro-arc oxidation (MAO) treatment on ZK60 alloy to create a coating with better corrosion resistance and solve the problems of uneven and excessive degradation. The MAO-treated samples exhibited excellent corrosion resistance and electrochemical stability, and the deposited Ca ions were not cytotoxic and were beneficial for enhancing bone healing after implantation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Letter
Medicine, General & Internal
Chia-Hao Hsu, Chung-Hwan Chen, Nin-Chieh Hsu
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Cell & Tissue Engineering
C-C. Lu, C-J. Ho, S-J. Chen, Z-M. Liu, P. P-H. Chou, M-L. Ho, Y-C. Tien
Summary: The study found that preserving the remnant of the anterior cruciate ligament (ACL) has positive effects on ACL reconstruction. Co-culturing ACL remnant cells with bone marrow stromal cells (BMSCs) can reduce cell apoptosis and enhance the activity of hamstring tendons and tenocytes, thereby aiding ACL reconstruction.
BONE & JOINT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Lin Kang, Ai-Lun Yang, Chao-Han Lai, Tsan-Ju Chen, Sung-Yen Lin, Yan-Hsiung Wang, Chau-Zen Wang, Edward M. Conway, Hua-Lin Wu, Mei-Ling Ho, Je-Ken Chang, Chung-Hwan Chen, Tsung-Lin Cheng
Summary: The study found that thrombomodulin (TM) plays a crucial protective role in osteoarthritis (OA) by enhancing chondrocyte growth and migration, blocking inflammatory signaling, and protecting knee function and bone integrity. Increasing TM expression can effectively protect cartilage from damage. These findings contribute to the development of novel therapeutic approaches against OA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Ta-Wei Tai, Chun-Feng Huang, Huei-Kai Huang, Rong-Sen Yang, Jung-Fu Chen, Tien-Tsai Cheng, Fang-Ping Chen, Chung-Hwan Chen, Yin-Fan Chang, Wei-Chieh Hung, Der-Sheng Han, Ding-Cheng Chan, Ching-Chou Tsai, I-Wen Chen, Wing P. Chan, Husan-Jui Chang, Jawl-Shan Hwang, Chih-Hsing Wu
Summary: This updated guideline aims to reduce the risk of osteoporotic fractures and improve the quality of care for patients with osteoporosis in Taiwan by providing practical recommendations based on the latest evidence.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Biochemistry & Molecular Biology
Chih-Wei Lin, Chung-Hwan Chen, Meng-Hsing Wu, Fong-Ming Chang, Lin Kang
Summary: This study investigated the association between two promoter polymorphisms in the TNF genes and preeclampsia (PE). It found that the polymorphism at the -308 position in the TNF-a gene promoter region is associated with severe PE in Taiwanese Han populations.
Article
Immunology
Po-chih Shen, Shih-Hao Huang, Zi-Miao Liu, Cheng-Chang Lu, Shih-Hsiang Chou, Yin-Chun Tien
Summary: This study found that suramin significantly suppressed the expression of matrix destruction proteases and inflammatory mediators, while enhancing the synthesis of cartilage anabolic factors in IL-1 beta-induced chondrocytes. In a mouse model, suramin improved cartilage degeneration by activating Nrf2 and inhibiting NF-kappa B and MAPK pathways. Additionally, suramin repolarized M1 macrophages to the M2 phenotype, reducing chondrocyte apoptosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ling-Hua Chang, Shun-Cheng Wu, Chung-Hwan Chen, Jhen-Wei Chen, Wan-Chun Huang, Che-Wei Wu, Yi-Shan Lin, Yu-Ju Chen, Je-Ken Chang, Mei-Ling Ho
Summary: In this study, it was found that exosomes derived from adipose-derived stem cells cultured in a hypoxic environment can improve the function of human articular chondrocytes and alleviate chondrocyte inflammaging and osteoarthritis progression. The results suggest that hypoxia-cultured adipose-derived stem cell exosomes may offer a new strategy for future osteoarthritis therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Materials Science, Multidisciplinary
Y. H. Chen, W. Y. Chen, Y. S. Lin, C. H. Chen, Rui Zhou, T. H. Chou, Y. T. Zhu, W. P. Li, X. Wang, S. C. Chen, C. Y. Chen, J. C. Huang
Summary: The surface modification of Ti6Al4V using Ti-Ta-Nb films greatly enhances its corrosion resistance and biological properties. Higher Ta content in the Ti-Ta-Nb system leads to improved corrosion resistance and better surface conditions for cell viability and adhesion.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2023)
Article
Medicine, General & Internal
Ying-Chun Wang, Chia-Ling Lee, Yu-Jen Chen, Yin-Chun Tien, Sung-Yen Lin, Chung-Hwan Chen, Paul Pei-Hsi Chou, Hsuan-Ti Huang
Summary: This study compared the efficacy of intra-articular single-dose PRP versus novel crosslinked HA for treating early-stage knee OA. The results showed that both PRP and HA can significantly improve WOMAC scores at 6-month follow-up, without any differences between the two groups at 1-, 3-, and 6-month follow-ups. Therefore, both PRP and HA single-injection regimens can improve functional outcomes for early-stage knee OA.
MEDICINA-LITHUANIA
(2022)
Proceedings Paper
Engineering, Biomedical
Anupama Nair, Shu-Chun Chuang, Yi-Shan Lin, Chung-Hwan Chen, Chi-Hsiang Lien, Shean-Jen Chen
Summary: Distinguishing between type I and type II collagen is crucial for understanding collagen changes in cartilage and connective tissues. This study utilizes a non-invasive dual-liquid crystal based polarization resolved second harmonic microscopy to quantitatively characterize different types of collagen in fracture healing tissues. The results show that type II collagen dominates in the early stage of repair while type I collagen dominates in the later stage.
BIOMEDICAL SPECTROSCOPY, MICROSCOPY, AND IMAGING II
(2022)