Article
Chemistry, Multidisciplinary
Hao Su, Feihu Wang, Han Wang, Weijie Zhang, Caleb F. Anderson, Honggang Cui
Summary: The study aims to achieve precise control over the size and size distribution of supramolecular polymers, using self-limiting supramolecular polymerization chemistry to effectively control the length and polydispersity of molecular chains by grafting multi-armed OEG segments onto aromatic segments.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Biochemistry & Molecular Biology
Preeti Goyal, Mahak Singh, Pradeep Kumar, Alka Gupta
Summary: Core-shell structures formed by amphiphilic molecules in a medium are important in biomedical sciences. Cholesteryl-dextran amphiphiles were synthesized with high yields and different concentrations, forming nanomicelles with sustained drug release behavior for colon specific diseases.
CARBOHYDRATE RESEARCH
(2021)
Article
Immunology
Rainer Knoll, Lorenzo Bonaguro, Jessica C. dos Santos, Stefanie Warnat-Herresthal, Maartje C. P. Jacobs-Cleophas, Edda Bluemel, Nico Reusch, Arik Horne, Miriam Herbert, Melanie Nuesch-Germano, Twan Otten, Wouter A. Van der Heijden, Lisa Van de Wijer, Alex K. Shalek, Kristian Handler, Matthias Becker, Marc D. Beyer, Mihai G. Netea, Leo A. B. Joosten, Andre J. A. M. Van der Ven, Joachim L. Schultze, Anna C. Aschenbrenner
Summary: The study found that immune cells of PLHIV have altered transcriptomes, and single-cell RNA sequencing can identify drug candidates to reverse this state. These scientific findings and technological advancements provide the basis for further large-scale cohort studies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Physical
Y. Li, M. Kim, T. H. Pial, Y. Lin, H. Cui, M. Olvera de la Cruz
Summary: Electrostatic interactions play a critical role in the kinetic pathways and thermodynamic outcomes of peptide self-assembly. The aggregation of peptide units can alter their charged status and pK(a) values, resulting in different nanostructures.
JOURNAL OF PHYSICAL CHEMISTRY B
(2023)
Article
Immunology
Eline S. van der Valk, Daniel S. Mulder, Tessa Kouwenhoven, Nicole M. A. Nagtzaam, Elisabeth F. C. van Rossum, Willem A. Dik, Pieter J. M. Leenen
Summary: This study examined the monocyte subset composition and inflammatory marker profile of individuals with obesity during a 1.5 year lifestyle intervention. The results showed that while there were no changes in monocyte subset counts, there were significant changes in marker profiles. These findings suggest that long-term lifestyle intervention can lead to persistent immunophenotypic adaptations in blood monocytes of individuals with obesity, which is different from the phenotype observed in individuals with less severe obesity.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Adele Ruder, Suzan M. W. Wetzels, Lieve Temmerman, Erik A. L. Biessen, Pieter Goossens
Summary: Monocytes differentiate into macrophages at sites of inflammation and contribute to the development of cardiovascular disease. Different subtypes of monocytes, characterized by the expression of CD14 and CD16, have been identified. The middle subtype has been found to be associated with atherosclerosis, myocardial infarction, and heart failure. However, more research is needed to understand their exact role and predictive value in cardiovascular disease.
CARDIOVASCULAR RESEARCH
(2023)
Article
Immunology
Stephanie C. Talker, G. Tuba Barut, Heidi E. L. Lischer, Reto Rufener, Lilly von Munchow, Remy Bruggmann, Artur Summerfield
Summary: This study investigates the transcriptome profiles and functions of bovine monocytes. The findings reveal three subtypes of monocytes in bovine, each with distinct functional roles. Classical monocytes are involved in pro-inflammatory and antibacterial responses, while nonclassical and intermediate monocytes are specialized in regulatory/anti-inflammatory functions, tissue repair, antiviral responses, and T-cell immunomodulation. Furthermore, heterogeneity within classical monocytes is discovered, and intermediate monocytes are proposed as a transient differentiation stage between classical and nonclassical monocytes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Kevin W. O'Connor, Tiantian Liu, Sunkyung Kim, Carlos G. Briseno, Katia Georgopoulos, Theresa L. Murphy, Kenneth M. Murphy
Summary: This study investigates the impact of NOTCH2 signaling on the development of Ly6C(lo) monocytes and identifies transcription factors involved. The results show that NOTCH2 signaling can induce the transition of Ly6C(hi) monocytes into Ly6C(lo) monocytes, and that BCL6 and IRF2 are important for this development process.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Engineering, Biomedical
Bita Nasiri, Tai Yi, Yulun Wu, Randall J. Smith, Ashis Kumar Podder, Christopher K. Breuer, Stelios T. Andreadis
Summary: A strategy to recruit monocytes (MCs) from blood to regenerate vascular tissue from unseeded tissue engineered vascular grafts is presented. The fusion protein, H2R5, can capture blood-derived MC under static or flow conditions on the surface of vascular grafts. This bound MC then transforms into macrophages (M phi) expressing specific genes. When these functionalized grafts are implanted, they form a continuous endothelium expressing specific proteins and multiple cell layers expressing specific markers. Lineage tracing analysis provides direct evidence of MC/M phi recruitment to the graft lumen. Circulating MCs may potentially contribute to the endothelialization and vascular wall formation of acellular vascular grafts.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Biochemistry & Molecular Biology
Filippo Prencipe, Carlo Diaferia, Filomena Rossi, Luisa Ronga, Diego Tesauro
Summary: Precision medicine relies on innovative management methods for active components, delivering drugs to specific tissues to enhance therapeutic effects and reduce side effects. Utilizing drug-encapsulated micelles for active targeting marks a new frontier in precision medicine. By decorating micelles with targeting bioactive moieties like peptides, it is possible to direct drugs towards a range of molecular targets, particularly on cancer cells and vasculature.
Review
Nanoscience & Nanotechnology
Chelsea N. Fries, Elizabeth J. Curvino, Jui-Lin Chen, Sallie R. Permar, Genevieve G. Fouda, Joel H. Collier
Summary: Nanotechnology is being utilized to design new vaccines and facilitate their global implementation, particularly for globally devastating diseases such as HIV, malaria, and tuberculosis. Successful vaccines will need to trigger immune responses different from those raised by normal infection, and nanomaterials provide strategies for achieving this.
NATURE NANOTECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Michael A. Harris, Huihui Kuang, Zachary Schneiderman, Maple L. Shiao, Andrew T. Crane, Matthew R. Chrostek, Alexandru-Flaviu Tabaran, Thomas Pengo, Kevin Liaw, Beibei Xu, Lucy Lin, Clark C. Chen, M. Gerard O'Sullivan, Rangaramanujam M. Kannan, Walter C. Low, Efrosini Kokkoli
Summary: This study demonstrates the potential application of nanotubes formed from self-assembly of ssDNA-amphiphiles in the treatment of glioblastoma. These nanotubes preferentially accumulate in tumor tissue after local delivery, cross the blood-brain tumor barrier and internalize in cells after intravenous injection. Compared to traditional doxorubicin delivery methods, doxorubicin delivery by nanotubes shows no systemic toxicity and enhances mouse survival.
Article
Chemistry, Multidisciplinary
Sima Lashkari, Mahshid Chekini, Rajinder Pal, Michael A. Pope
Summary: In this study, aqueous systems of common nonionic surfactants were used to investigate the adsorption of ionic liquids onto graphene oxide surfaces. The results showed that a compact film can be formed through the spontaneous adsorption of the IL/surfactant complex. The addition of IL to the surfactant phase led to a reduction in micellar size and adsorbed layer thickness, suggesting significant interactions and nonideal mixing among the components.
Article
Chemistry, Physical
Yan Zhao, Shuo Liu, Zhishang Shi, Hangqi Zhu, Mingchun Li, Qilin Yu
Summary: In this study, a pathogen infection-responsive and macrophage endoplasmic reticulum-targeting nanoplatform was developed to alleviate systemic infections. The nanoplatform efficiently loaded and released an antimicrobial peptide, inhibited pathogen growth and macrophage stress, and protected against kidney dysfunction and inflammation in a systemic infection model.
Article
Medicine, Research & Experimental
P. Vishnyakova, A. Poltavets, E. Karpulevich, A. Maznina, V. Vtorushina, L. Mikhaleva, E. Kananykhina, A. Lokhonina, S. Kovalchuk, A. Makarov, A. Elchaninov, G. Sukhikh, T. Fatkhudinov
Summary: Macrophages play a crucial role in innate immunity and are activated by various factors. This study found that macrophages derived from CD14+ monocytes exhibit higher sensitivity to pro-inflammatory induction, showing increased levels of pro-inflammatory and anti-inflammatory cytokines compared to CD16+-derived macrophages. This data may be valuable for macrophage-based cell therapy applications, providing insights for manipulating donor monocytes for transplantation.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cell & Tissue Engineering
Nirmalya Tripathy, Jonathan Wang, Madelynn Tung, Claire Conway, Eun Ji Chung
CELLULAR AND MOLECULAR BIOENGINEERING
(2020)
Article
Biotechnology & Applied Microbiology
Yi Huang, Kairui Jiang, Xuting Zhang, Eun Ji Chung
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2020)
Review
Medicine, Research & Experimental
Noah Trac, Eun Ji Chung
Summary: Lymph nodes are crucial sites for cancer metastasis and immune activity, making them important clinical targets. Intravenous drug delivery, while advantageous for lymph node targeting, faces challenges such as rapid clearance and physical barriers, driving research into nanoparticle-based drug delivery systems to improve efficiency in lymph node drug delivery.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Article
Engineering, Biomedical
Deborah D. Chin, Christopher Poon, Jonathan Wang, Johan Joo, Victor Ong, Zhangjingyi Jiang, Kayley Cheng, Anastasia Plotkin, Gregory A. Magee, Eun Ji Chung
Summary: The delivery of miR-145 micelles to VSMCs shows promise in mitigating atherosclerosis progression by altering cell phenotypes and reducing plaque growth. In mouse experiments, miR-145 micelles significantly inhibited the advancement of atherosclerosis.
Review
Biochemistry & Molecular Biology
Alysia Cox, Siyoung A. Lim, Eun Ji Chung
Summary: The use of various types of RNA molecules for prevention and therapy of pathologies has shown great potential. However, limitations such as short in vivo half-life, lack of targeted delivery, and safety issues have hindered the therapeutic efficacy. Nanoparticle-mediated delivery has been successful in overcoming these limitations, with multiple formulations already in clinical trials and approved by FDA. This review summarizes the methods of modifying nanoparticles for optimal therapeutic effects in RNA delivery.
MOLECULAR ASPECTS OF MEDICINE
(2022)
Article
Medicine, Research & Experimental
Kuang-Yuh Chyu, Xiaoning Zhao, Jianchang Zhou, Paul C. Dimayuga, Nicole Wm Lio, Bojan Cercek, Noah T. Trac, Eun Ji Chung, Prediman K. Shah
Summary: This study explored the possibility of delivering apolipoprotein B-100 (ApoB-100) peptide P210 as an antigen using nanoparticles to reduce atherosclerosis. The researchers characterized the T cell responses to P210 in patients with atherosclerotic cardiovascular disease and demonstrated the potential mechanisms of action of P210-PAM in a mouse model. The study also showed the clinical relevance of P210-PAM immunization in reducing atherosclerosis.
Article
Cell & Tissue Engineering
Kairui Jiang, Yi Huang, Eun Ji Chung
Summary: This study demonstrates for the first time the drug synergy using drug-loaded nanoparticles and free MET for the treatment of ADPKD. The combination of MET with all drug-loaded nanoparticles significantly enhanced the efficacy in inhibiting cell proliferation and cyst growth. Synergistic effects were found for MET and nanoparticles loaded with either salsalate or rapamycin.
CELLULAR AND MOLECULAR BIOENGINEERING
(2023)
Review
Biotechnology & Applied Microbiology
Neil J. J. Patel, Anisa Ashraf, Eun Ji Chung
Summary: Extracellular vesicles (EVs) are small membrane-bound vesicles that are secreted by all cell types into the extracellular space. They transfer nucleic acids, proteins, and lipids to facilitate cell-to-cell communication. EVs interact with the extracellular matrix (ECM) and play a role in both its organization and degradation. Furthermore, they influence recipient cells to remodel the ECM in pathological and therapeutic contexts.
BIOENGINEERING-BASEL
(2023)
Article
Chemistry, Multidisciplinary
Noah Trac, Anisa Ashraf, Joshua Giblin, Supriya Prakash, Samir Mitragotri, Eun Ji Chung
Summary: Nanoparticles, as drug delivery carriers, have been effective in treating various diseases, including cancer, since the 1990s. Recently, their potential to combat global diseases like COVID-19 has been demonstrated. However, there is limited research on nanomedicine for chronic kidney diseases (CKDs) which affect a significant number of individuals worldwide. This article provides an overview of the clinical status of genetic kidney diseases, nanoparticle design for kidney targeting, and emerging technological strategies for treating genetic kidney diseases.
Article
Biochemical Research Methods
Alysia Cox, Madelynn Tung, Hui Li, Kenneth R. Hallows, Eun Ji Chung
Summary: Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic kidney disease characterized by renal cyst formation. Inhibition of the mTOR pathway has been proposed as a potential treatment approach. This study focused on encapsulating mTOR inhibitors in drug delivery carriers that target the kidneys. The results show promising efficacy of the encapsulated drugs in inhibiting cell proliferation in vitro. Encapsulation in peptide amphiphile micelle (PAM) nanoparticles could be a potential strategy for delivering mTOR inhibitors to treat ADPKD.
Article
Chemistry, Multidisciplinary
Noah Trac, Anisa Ashraf, Joshua Giblin, Supriya Prakash, Samir Mitragotri, Eun Ji Chung
Summary: Nanoparticles as drug delivery carriers have shown great potential in treating various diseases, including cancer, as well as in the fight against global pandemics like COVID-19. However, there is still limited research on nanomedicine for chronic kidney diseases, especially genetic kidney diseases. This perspective provides an overview of the clinical status of genetic kidney diseases, kidney physiology, nanoparticle design, and emerging technological strategies that can be applied to address this challenge.
Article
Pharmacology & Pharmacy
Deborah D. Chin, Christopher Poon, Noah Trac, Jonathan Wang, Johan Joo, Zhangjingyi Jiang, Naomi Sulit Sta Maria, Russell E. Jacobs, Eun Ji Chung, Jackson Cook
ADVANCED THERAPEUTICS
(2020)
Article
Materials Science, Biomaterials
Deborah D. Chin, Jonathan Wang, Margot Mel de Fontenay, Anastasia Plotkin, Gregory A. Magee, Eun Ji Chung
JOURNAL OF MATERIALS CHEMISTRY B
(2019)
Article
Engineering, Biomedical
Deborah D. Chin, Sampreeti Chowdhuri, Eun Ji Chung
REGENERATIVE ENGINEERING AND TRANSLATIONAL MEDICINE
(2019)