Article
Engineering, Biomedical
Pengli Zhang, Qinghe Wu, Jingxing Yang, Mengfei Hou, Benchao Zheng, Jia Xu, Yimin Chai, Liqin Xiong, Chunfu Zhang
Summary: In this study, a nanohybrid for the combination therapy of tumors using PDT and PTT was developed. The nanohybrid showed improved therapeutic efficacy by addressing the challenges of tumor hypoxia and limited tissue penetration depth. This study provides a promising strategy for phototherapy.
ACTA BIOMATERIALIA
(2022)
Article
Chemistry, Physical
Lan Yang, Yanpeng Zhu, Aijing Ma, Wei Gao, Zhaoyang Guo, Yujia Xin, Ruixue Ran, Xiaoying Yang
Summary: The study developed a multifunctional nanoparticle that can release CO and generate ROS in the tumor microenvironment, demonstrating desirable anticancer effect and therapeutic safety.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2023)
Review
Chemistry, Applied
Wen Zhou, Mingzhi Du, Jinghui Wang, Xuheng Zhang, Tingting Liang, Chen Xie, Quli Fan
Summary: Photothermal therapy (PTT) has shown outstanding efficacy in cancer treatment, but the overexpression of heat shock proteins (HSPs) within tumor cells can reduce the damage caused by high temperature, thereby limiting the therapeutic efficacy. To improve the efficacy, researchers are exploring the combination of PTT with other therapeutic modalities such as chemotherapy and immunotherapy. Recently, the oxygen-independent thermodynamic therapy (TDT) has shown great promise in combination with PTT, as it can enhance the efficacy without inducing additional side effects.
Article
Nanoscience & Nanotechnology
Jiawen Zhao, Liang Zhang, Yingjie Qi, Kui Liao, Zhigang Wang, Ming Wen, Di Zhou
Summary: The study successfully developed multifunctional nanoparticles with targeted therapeutic and diagnostic imaging capabilities for combination therapy of ovarian cancer. These nanoparticles showed excellent dispersity, stability, and optical properties, with a combination of photothermal conversion and chemotherapy achieving highly efficient therapy both in vitro and in vivo. The nanoparticles have the potential for therapeutic guidance and monitoring, with outstanding imaging capabilities for both photoacoustic and X-ray computed tomography imaging.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Lei Zhou, Chang Du, Rong Zhang, Changming Dong
Summary: The study developed a novel multifunctional nanocarrier PDOXCBs for combined photothermal-chemotherapy treatment, demonstrating a significant synergistic effect in vitro.
CHINESE CHEMICAL LETTERS
(2021)
Article
Pharmacology & Pharmacy
Qiang Gao, Jun Gao, Chengqiang Ding, Shangji Li, Linhong Deng, Yong Kong
Summary: The combination nanoplatform of graphene quantum dots and gold-silver nanoclusters shows significant efficacy in chemo-photothermal combination therapy for cancer cells, which can be modulated by adjusting pH and near-infrared irradiation for treatment.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Nanoscience & Nanotechnology
Sergiy Kyrylenko, Oleksiy Gogotsi, Ivan Baginskiy, Vitalii Balitskyi, Veronika Zahorodna, Yevheniia Husak, Ilya Yanko, Mykolay Pernakov, Anton Roshchupkin, Mykola Lyndin, Bernhard B. Singer, Volodymyr Buranych, Alexander Pogrebnjak, Oksana Sulaieva, Oleksandr Solodovnyk, Yury Gogotsi, Maksym Pogorielov
Summary: Innovative therapies, such as thermal ablation using MXenes for photothermal therapy, show potential for selectively targeting tumor cells. Pulsed 1064 nm lasers can effectively ablate tumor cells loaded with Ti3C2Tx MXene, demonstrating low toxicity and good biocompatibility. These studies lay the foundation for developing efficient and safe protocols for minimally invasive cancer therapies.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Medicine, Research & Experimental
Zhaomin Tang, Weijun Tian, Hongyu Long, Shuting Jiang, Jianqing Zhao, Jianren Zhou, Qian He, Xia Luo
Summary: Multidrug resistance is a significant challenge in cancer treatment, and combining chemotherapy with photothermal therapy has shown potential in overcoming MDR. In this study, a subcellular-targeted near-infrared-responsive nanomedicine was developed, which achieved improved photothermal stability and efficiency. This nanomedicine could enhance MDR cancer treatment by combining chemotherapy and photothermal therapy.
MOLECULAR PHARMACEUTICS
(2022)
Review
Chemistry, Multidisciplinary
Haitao Sun, Qin Zhang, Jingchao Li, Shaojun Peng, Xiaolin Wang, Rong Cai
Summary: Cancer nanomedicines offer promising treatment strategies, with photothermal therapy identified as a safe modality for achieving photothermal synergistic cancer therapy and significantly improved benefits.
Article
Chemistry, Physical
Shudi Mo, Yunhua Song, Meihong Lin, Jianling Wang, Ze Zhang, Jingyu Sun, Donggang Guo, Lu Liu
Summary: This study demonstrates the enhanced photocatalytic performance and strong antibacterial effects of CuS nanosheets with sulfur vacancies. The CuS nanosheets with the highest vacancy concentration showed a 99.9% bactericidal rate under laser irradiation, with increased temperature and high photothermal conversion efficiency. The induction of ROS production by CuS contributed to the effective bacterial eradication.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Review
Chemistry, Multidisciplinary
Hangqi Luo, Shuai Gao
Summary: Phototherapy, including photothermal therapy (PTT) and photodynamic therapy (PDT), is widely used for cancer treatment, but conventional PTT/PDT lack disease recognition ability, resulting in limited therapeutic effects. Integrating fluorescence imaging with PTT/PDT can reveal tumor locations in real-time, enabling early diagnosis and precision treatment. The use of NIR-II fluorescence imaging with PTT/PDT can significantly improve tumor theranostics accuracy and minimize damage to normal tissues.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Weiwei Wu, Yan Yang, Zhuoying Liang, Xiling Song, Yadong Huang, Lin Qiu, Xiaozhong Qiu, Siming Yu, Wei Xue
Summary: This study demonstrated the effective strategy of utilizing near-infrared laser-induced simultaneous release of NO and alkyl radicals to inhibit tumor growth, achieved through the elaborately fabricated biocompatible free radical nanogenerator. Under NIR II laser irradiation, the nanogenerator can precisely control the release profiles of NO and alkyl radicals, displaying synergistic anticancer effects on breast tumors.
Review
Chemistry, Inorganic & Nuclear
Chenxu Yan, Yutao Zhang, Zhiqian Guo
Summary: Recent advances in molecularly NIR fluorescent probes for nanotheranostics have attracted increasing attention due to their potential in bridging in vivo imaging and therapeutic capability within a unimolecular system. The unique advantages of near-infrared (NIR) fluorescence imaging, such as low background, deep penetration, and minimal tissue damage, make it a promising tool for in vivo chemotherapy and phototherapy. The focus is on design strategy and functionalization of high-performance fluorophores, with discussions on current challenges and future prospects in bringing forth clinical applications for personalized treatment.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Pharmacology & Pharmacy
Hugo A. L. Filipe, Andre F. Moreira, Sonia P. Miguel, Maximiano P. Ribeiro, Paula Coutinho
Summary: Cancer poses a significant global challenge for the next decade, and strategies for simultaneous diagnosis and treatment are promising for combatting this disease. Developing nanomaterials with near-infrared (NIR) light responsiveness, such as heptamethine cyanines, has shown great potential for tumor visualization and generating a photothermal/photodynamic effect. Molecular dynamics simulations were performed to understand the interaction between 12 NIR-light responsive probes and lipid membranes, providing valuable insights for selecting suitable molecules and guiding probe modifications to optimize interaction with tumor cell membranes.
Article
Chemistry, Multidisciplinary
Mengyuan Li, Zhuoting Lu, Jiaxin Zhang, Liying Chen, Xialian Tang, Quanheng Jiang, Qinglian Hu, Lin Li, Jie Liu, Wei Huang
Summary: This study reports the use of an organic fluorescent substance AS1, which has fluorescence, photothermal, and photodynamic functions in the near-infrared II window. The encapsulation of AS1 into nanostructures results in high-performance phototheranostics (AS1R) with superior brightness, photothermal effect, and photodynamic performance compared to other types of organic phototheranostics.
ADVANCED MATERIALS
(2023)