Review
Biochemistry & Molecular Biology
Ji Won Han, Eui-Cheol Shin
Summary: Tissue-resident memory CD8(+) T (T-RM) cells, a population that resides in peripheral tissues and does not recirculate, have important implications for the treatment of chronic HBV infection. Liver T-RM cells have distinct characteristics compared to T cells in peripheral blood or other tissues, possibly due to the unique microenvironment of the liver. Liver T-RM cells can be a potential immunotherapeutic target for chronic HBV infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Greta Acerbi, Ilaria Montali, Gennaro Domenico Ferrigno, Valeria Barili, Simona Schivazappa, Arianna Alfieri, Diletta Laccabue, Alessandro Loglio, Marta Borghi, Marco Massari, Marzia Rossi, Andrea Vecchi, Amalia Penna, Carolina Boni, Gabriele Missale, Pietro Lampertico, Daniele Del Rio, Carlo Ferrari, Paola Fisicaro
Summary: In chronic HBV infection, virus-specific CD8 T cells show impaired autophagic flux, while bioactive compounds such as resveratrol and oleuropein can improve mitochondrial and proteostasis functions in T cells. The combination of polyphenols with antioxidants represents a promising strategy for immune reconstitution in chronic HBV infection.
JOURNAL OF HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Ilenia Pacella, Ilenia Cammarata, Carmela Martire, Giuseppina Brancaccio, Giovanni Battista Gaeta, Vincenzo Barnaba, Silvia Piconese
Summary: The study revealed that in patients with chronic HBV infection receiving NUC therapy and having advanced hepatic fibrosis, the frequency of AE-specific CD8(+) T cells was significantly increased. Different specificities of CD8(+) T cells were found to populate distinct subpopulations, suggesting a link between AE-specific T cells and advanced liver fibrosis.
LIVER INTERNATIONAL
(2021)
Article
Immunology
Sara Ferrando-Martinez, Angie Snell Bennett, Elisabete Lino, Adam J. J. Gehring, Jordan Feld, Harry L. A. Janssen, Scott H. H. Robbins
Summary: The functionality of HBV-specific CD8 T cells is associated with a higher frequency of cells with low exhaustion phenotype, independently of the clinical parameters. PD-L1 blockade enhanced the HBV-specific CD8 T cell response only in patients with lower exhaustion levels, while response to PD-L1 blockade was abrogated in patients with higher frequencies of exhausted HBV-specific CD8 T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Shue Xiong, Dan Zhu, Boyun Liang, Mingyue Li, Wen Pan, Junyi He, Hua Wang, Kathrin Sutter, Ulf Dittmer, Mengji Lu, Di Liu, Dongliang Yang, Jia Liu, Xin Zheng
Summary: The desirable endpoint of treatment against chronic hepatitis B virus infection is to achieve a functional cure, characterized by HBsAg loss with or without anti-HBs seroconversion. This study found that cHBV patients with sAg-L display distinct CD4(+) and CD8(+) T cell phenotype fingerprints compared to sAg-R patients, with upregulated HLA-DR expression and potent HBcAg-specific CD8(+) T cell response. The onset of HBsAg decrease and subsequent loss in cHBV patients on treatment is associated with significant alterations of both CD4(+) and CD8(+) T cell phenotypes, which may serve as predictive factors for sAg-L.
Article
Immunology
Madhura G. Kelkar, Umair Ahmad Bargir, Reetika Malik-Yadav, Maya Gupta, Aparna Dalvi, Neha Jodhawat, Shweta Shinde, Manisha R. Madkaikar
Summary: The study found that CD8+ cytotoxic T lymphocytes from HLH patients exhibited high expression of exhaustion markers with overall impaired function. This is the first report suggesting functional exhaustion of CD8 T cells in both primary and secondary HLH. Further research is needed to understand the association between exhaustion and disease outcome for potential therapeutic implementation.
JOURNAL OF CLINICAL IMMUNOLOGY
(2021)
Article
Immunology
Xin Liu, Shu-xiang Chen, Hui Liu, Jin-li Lou
Summary: This study analyzed the differences in T-lymphocyte subsets, cytokine levels, and HBV S gene sequences between HBsAg-negative and HBsAg-positive patients. The results showed that HBsAg-negative patients had superior cellular immune function compared to HBsAg-positive patients, with possible mutations and amino acid replacement sites in the HBV S region.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Zhiqiang Zhu, Yuanyuan Qin, Qi Liang, Wei Xia, Tong Zhang, Wen Wang, Mengmeng Zhang, Taiyi Jiang, Hao Wu, Ye Tian
Summary: The coinfection rate of HBV in HIV patients increases as HIV disease progresses, possibly due to the reduced numbers of HBV-specific IFN-gamma-producing CD8+ T cells. Close monitoring of HBV serum markers from the early stage of HIV infection is necessary.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Raphael Kuhn, Ioana Sandu, Andreas Agrafiotis, Kai-Lin Hong, Danielle Shlesinger, Daniel Neimeier, Doron Merkler, Annette Oxenius, Sai T. Reddy, Alexander Yermanos
Summary: CD8+ T cells play a crucial role in viral infections and exhibit diverse phenotypes and effector functions. By analyzing the TCR repertoire and transcriptome of virus-specific CD8 T cells in murine models, we identified infection-specific populations corresponding to different phenotypes. Chronic and latent infections resulted in a higher proportion of clonally expanded T cells compared to acute infection. We also observed a relationship between transcriptional heterogeneity and clonal expansion.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Shokichi Takahama, Sachiyo Yoshio, Yuji Masuta, Hirotomo Murakami, Ryotaro Sakamori, Shun Kaneko, Takashi Honda, Miyako Murakawa, Masaya Sugiyama, Masayuki Kurosaki, Yasuhiro Asahina, Tetsuo Takehara, Victor Appay, Tatsuya Kanto, Takuya Yamamoto
Summary: This study explored the traits of activated CD8(+) T cells and HBV-specific CD8(+) T cells in patients with chronic hepatitis B undergoing NUC therapy. Results revealed that patients with higher HBsAg levels had CD8(+) T cell clusters with cytolytic functions, while HBcore-specific CD8(+) T cells exhibited greater polyfunctionality and a subset of these cells with lower cytolytic potential was negatively correlated with HBsAg levels.
FRONTIERS IN IMMUNOLOGY
(2023)
Editorial Material
Immunology
Jessica Wei, Jeffrey J. Ishizuka
Summary: The study reveals that tissue-resident memory CD8(+) T cells specific for hepatitis B virus-derived antigens demonstrate potent anti-tumor properties and are associated with relapse-free survival in patients with resected hepatocellular carcinoma.
Review
Immunology
Nengqi Lin, Wei Yin, Heather Miller, Maria G. Byazrova, Andres A. Herrada, Kamel Benlagha, Pamela Lee, Fei Guan, Jiahui Lei, Quan Gong, Youqing Yan, Alexander Filatov, Chaohong Liu
Summary: Hepatitis B has become a major health threat worldwide, particularly in developing countries and regions. Infection with hepatitis B virus significantly increases the risk of liver diseases such as cirrhosis and cancer. The immune response against hepatitis B is mainly regulated by CD8+ T cells, which play a key role in fighting viral infections, while regulatory T cells prevent excessive immune response. Additionally, follicular T helper cells have a critical role in B-cell activation, proliferation, differentiation, and the formation of germinal centers. The development of hepatitis B virus is generally associated with immune system disorders or dysfunctions. This review focuses on the important functions and biological processes of regulatory T cells and follicular T helper cells during HBV infection.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Laura Campisi, Shahab Chizari, Jessica S. Y. Ho, Anastasia Gromova, Frederick J. Arnold, Lorena Mosca, Xueyan Mei, Yesai Fstkchyan, Denis Torre, Cindy Beharry, Marta Garcia-Forn, Miguel Jimenez-Alcazar, Vladislav A. Korobeynikov, Jack Prazich, Zahi A. Fayad, Marcus M. Seldin, Silvia De Rubeis, Craig L. Bennett, Lyle W. Ostrow, Christian Lunetta, Massimo Squatrito, Minji Byun, Neil A. Shneider, Ning Jiang, Albert R. La Spada, Ivan Marazzi
Summary: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that affects motor neurons and muscle control, with different gene mutations defining subtypes. A specific immune signature has been identified in ALS4 patients, potentially serving as a biomarker for disease progression.
Article
Multidisciplinary Sciences
Laura Campisi, Shahab Chizari, Jessica S. Y. Ho, Anastasia Gromova, Frederic Arnold, Lorena Mosca, Xueyan Mei, Yesai Fstkchyan, Denis Torre, Cindy Beharry, Marta Garcia-Forn, Miguel Jimenez-Alcazar, Vladislav A. Korobeynikov, Jack Prazich, Zahi A. Fayad, Marcus M. Seldin, Silvia De Rubeis, Craig L. Bennett, Lyle W. Ostrow, Christian Lunetta, Massimo Squatrito, Minji Byun, Neil A. Shneider, Ning Jiang, Albert R. La Spada, Ivan Marazzi
Summary: This study describes the presence of clonally expanded T-EMRA CD8 T cells in ALS4 knock-in mice and ALS4 patients, which may be related to disease progression and anti-glioma immunity. The results provide evidence for unraveling the disease mechanisms and serve as a potential biomarker of ALS4.
Article
Multidisciplinary Sciences
Erietta Stelekati, Zhangying Cai, Sasikanth Manne, Zeyu Chen, Jean-Christophe Beltra, Lance Alec Buchness, Xuebing Leng, Svetlana Ristin, Kito Nzingha, Viktoriya Ekshyyan, Christina Niavi, Mohamed S. Abdel-Hakeem, Mohammed-Alkhatim Ali, Sydney Drury, Chi Wai Lau, Zhen Gao, Yuguang Ban, Simon K. Zhou, K. Mark Ansel, Makoto Kurachi, Martha S. Jordan, Alejandro V. Villarino, Shin Foong Ngiow, E. John Wherry
Summary: This study identifies miR-29a as a key regulator of exhausted CD8 T cells (TEX) during chronic viral infection. It shows that miR-29a improves CD8 T cell responses, inhibits exhaustion-driving transcriptional pathways, and regulates ribosomal biogenesis. As a result, miR-29a promotes a memory-like CD8 T cell differentiation state during chronic infection.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
Yu Song, Peishan Li, Liping Qin, Zhiliang Xu, Baichun Jiang, Chunhong Ma, Changshun Shao, Yaoqin Gong
Summary: CUL4B functions as an intrinsic negative regulator of the TLR-triggered inflammatory response, enhancing proinflammatory cytokine production and reducing anti-inflammatory cytokine IL-10 production when deleted in macrophages. Enhanced TLR-induced inflammatory responses in the absence of CUL4B are mediated by increased GSK3β activity. By regulating the PI3K-AKT-GSK3β pathway, CUL4B restricts TLR-triggered inflammatory responses.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Hematology
Xin Li, Zi Sheng, Yuanxin Sun, Yuanjian Wang, Miao Xu, Zhiyue Zhang, Hui Li, Linlin Shao, Yanqi Zhang, Jinming Yu, Chunhong Ma, Chengjiang Gao, Ming Hou, Heyu Ni, Jun Peng, Ji Ma, Qi Feng
Summary: The expression of HLA-G and immunoglobulin-like transcripts is found to be impaired in patients with ITP. Recombinant HLA-G can correct this abnormality by upregulating immunoglobulin-like transcripts, stimulating Th2 differentiation, and downregulating Th1 and Th17 immune responses, suggesting that HLA-G can be a potential diagnostic marker and therapeutic option for ITP.
Article
Immunology
Yunyun Guo, Fei Jiang, Lingli Kong, Haifeng Wu, Honghai Zhang, Xiaorong Chen, Jian Zhao, Baoshan Cai, Yanqi Li, Chunhong Ma, Fan Yi, Lei Zhang, Bingyu Liu, Yi Zheng, Lingqiang Zhang, Chengjiang Gao
Summary: STING is a critical adaptor protein for innate antiviral and antitumor immunity, regulated by protein ubiquitination, with OTUD5 identified as a key deubiquitinase that interacts with STING to maintain its stability. Knockout of OTUD5 resulted in impaired immune responses and increased susceptibility to viral infection and tumor development.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Editorial Material
Immunology
Tixiao Wang, Chunhong Ma
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Cell Biology
Baoshan Cai, Jian Zhao, Yuling Zhang, Yaxing Liu, Chunhong Ma, Fan Yi, Yi Zheng, Lei Zhang, Tian Chen, Huiqing Liu, Bingyu Liu, Chengjiang Gao
Summary: USP5 acts as a key scaffold protein in recruiting the E3 ligase MARCHF7 for autophagic degradation of NLRP3 independently of its deubiquitinating enzyme activity. Knockdown of USP5 promotes inflammatory signaling release, while overexpression has inhibitory effects.
Article
Biochemistry & Molecular Biology
Jian Zhao, Baoshan Cai, Zhugui Shao, Lei Zhang, Yi Zheng, Chunhong Ma, Fan Yi, Bingyu Liu, Chengjiang Gao
Summary: The study reveals that TRIM26 positively regulates TAK1 activation by ubiquitinating its binding partner TAB1. Trim26 deficiency reduces the induction of inflammatory cytokines, protecting mice from septic shock and attenuating the severity of colitis.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Cell Biology
Shuai Tan, Junhao Zhang, Yang Sun, Anton Gistera, Zi Sheng, Rickard E. Malmstrom, Ming Hou, Jun Peng, Chunhong Ma, Wangjun Liao, Nailin Li
Summary: Platelets enhance Th1 and Treg cell responses of CD4(+) central memory T cells through PF4-dependent mitochondrial biogenesis and proliferation of Tcm cells.
Article
Multidisciplinary Sciences
Jinxiu Hou, Lulu Han, Ze Zhao, Huiqing Liu, Lei Zhang, Chunhong Ma, Fan Yi, Bingyu Liu, Yi Zheng, Chengjiang Gao
Summary: Research demonstrates that deubiquitinase USP18 regulates MAVS-mediated antiviral signaling by promoting MAVS interaction with TRIM31, leading to increased production of type I interferon and enhanced resistance to RNA viruses.
NATURE COMMUNICATIONS
(2021)
Article
Biotechnology & Applied Microbiology
Tixiao Wang, Jie Zhang, Na Li, Mengzhen Li, Shuaiya Ma, Siyu Tan, Xiaowei Guo, Zehua Wang, Zhuanchang Wu, Lifen Gao, Chunhong Ma, Xiaohong Liang
Summary: The spatial organization of immune cells within the tumor microenvironment (TME) plays a crucial role in anti-tumor immunity, tumor progression, and therapeutic response. Tim-3 is an immune checkpoint with potential as an immunotherapy target. This study examined the spatial distribution of Tim-3/Tim-3L in the TME and found that CD4 T cells were more accumulated in the tumor region and had a closer association with patient survival. CD4 T cells surrounding Tim-3L(+) cells expressed higher levels of Tim-3. Depletion of CD4 T cells abrogated the inhibition of tumor growth and metastasis mediated by Tim-3 blockade. These findings highlight the importance of CD4 T cells in Tim-3/Tim-3L-mediated immunosuppression and provide insights for Tim-3 targeted cancer immunotherapy.
Article
Chemistry, Multidisciplinary
Yang Sun, Yan Teng, Liyuan Wang, Zhaoying Zhang, ChaoJia Chen, Yingchun Wang, Xiaodong Zhang, Peng Xiang, Xiaojia Song, Jinghui Lu, Nailin Li, Lifen Gao, Xiaohong Liang, Yuchen Xia, Zhuanchang Wu, Chunhong Ma
Summary: This study identifies LINC01431 as a novel host restriction factor for HBV transcription. It competitively binds with PRMT1 to inhibit the ubiquitination and degradation of PRMT1 mediated by HBx, thus repressing cccDNA transcription. In turn, HBV transcriptionally suppresses LINC01431 expression by inhibiting the transcription factor ZHX2.
Letter
Oncology
Yuming Ding, Chaojia Chen, Shuaiya Ma, Xue Sheng, Fangcheng Zhao, Jiali Peng, Haoqing Dong, Chunhong Ma, Chunyang Li
CANCER COMMUNICATIONS
(2022)
Letter
Biochemistry & Molecular Biology
Zhuanchang Wu, Xiaobo Lei, Xin Wang, Zhaoying Zhang, Yuming Li, Lifen Gao, Xiaohong Liang, Peihui Wang, Jianwei Wang, Chunhong Ma
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Immunology
Wanxin Zhuang, Lei Zhang, Yi Zheng, Bingyu Liu, Chunhong Ma, Wei Zhao, Suxia Liu, Feng Liu, Chengjiang Gao
Summary: Inflammasomes are crucial for the innate immune system, and dysregulation of their activation can have negative impacts on human health. This study reveals that USP3 acts as a key regulator of ASC ubiquitination, enhancing its stability and promoting inflammasome activation.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Article
Oncology
Haixia Shan, Bo Wang, Xiaodong Zhang, Hui Song, Xi Li, Yongxin Zou, Baichun Jiang, Huili Hu, Hao Dou, Changshun Shao, Lifen Gao, Chunhong Ma, Xiaoyun Yang, Xiaohong Liang, Yaoqin Gong
Summary: The study found that CUL4B enhances HBV replication by interacting with HBx and disrupting its ubiquitin-dependent proteasomal degradation. The results of this study are of great significance for the development of potential targets for anti-HBV therapy.
CANCER BIOLOGY & MEDICINE
(2022)
Letter
Biochemistry & Molecular Biology
Zhuanchang Wu, Zhaoying Zhang, Xin Wang, Jing Zhang, Caiyue Ren, Yuming Li, Lifen Gao, Xiaohong Liang, Peihui Wang, Chunhong Ma
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
