Review
Oncology
Bohan Wang, Yachong Liu, Zhibin Liao, Haofeng Wu, Bixiang Zhang, Lei Zhang
Summary: Hepatocellular carcinoma (HCC) is the leading cause of cancer-related death, and the accumulation of genetic and epigenetic changes plays a crucial role in its occurrence and development. Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase, is suggested to be a key factor in mediating oncogenesis through epigenetic alteration. Recent studies have shown that EZH2 is extensively involved in the proliferation and metastasis of HCC cells. This review summarizes the functions of EZH2 in HCC progression, its role in tumor immunity, and the application of EZH2-related inhibitors in HCC therapy.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2023)
Review
Cell Biology
Zetao Ma, Lei Chen, Yushun Wang, Sheng Zhang, Jianrui Zheng, Yuhong Luo, Chao Wang, Hui Zeng, Lixiang Xue, Zhen Tan, Deli Wang
Summary: Degenerative musculoskeletal diseases, such as osteoporosis, osteoarthritis, degenerative spinal disease, and sarcopenia, have a significant impact on bone, cartilage, and muscle tissues, leading to functional impairment and pain. Enhancer of zeste homolog 2 (EZH2), an epigenetic regulator, plays a crucial role in the development of these diseases through the epigenetic regulation of gene expression. The pharmacological inhibition of EZH2 holds promise as a potential therapeutic approach for improving the treatment of degenerative musculoskeletal diseases.
AGEING RESEARCH REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Hsiang-Hao Chuang, Ming-Shyan Huang, Yen-Yi Zhen, Cheng-Hao Chuang, Ying-Ray Lee, Michael Hsiao, Chih-Jen Yang
Summary: FAK inhibition not only elicits DNA-damage signaling but also downregulates EZH2 expression. Active FAK signaling corresponds with the activation of the EZH2-mediated signaling cascade in lung-cancer-cells-derived tumor tissues. Ectopic EZH2 expression attenuates FAK-inhibition-induced cellular senescence in lung cancer cells.
Article
Immunology
Chen Li, Jiagui Song, Zhengyang Guo, Yueqing Gong, Tengrui Zhang, Jiaqi Huang, Rui Cheng, Xiaotong Yu, Yanfang Li, Li Chen, Xiaojuan Ma, Yan Sun, Yan Wang, Lixiang Xue
Summary: This study investigates the role of EZH2 inhibitors in modulating macrophage polarization in the tumor microenvironment of colorectal cancer. The two different EZH2 inhibitors, EPZ6438 and GSK126, were compared. The findings suggest that EZH2 inhibitors not only suppress CRC cell proliferation directly, but also regulate macrophage polarization to exert a tumor suppressive effect.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Ke Wang, Xunliang Jiang, Yu Jiang, Jun Liu, Yongtao Du, Zecheng Zhang, Yunlong Li, Xinhui Zhao, Jipeng Li, Rui Zhang
Summary: This study revealed the role of the EZH2/miR-139-5p/TOP2A axis in regulating cellular senescence and cell proliferation in HCC, enriching the molecular mechanisms of EZH2-mediated epigenetic regulation in HCC. Therapeutically targeting EZH2 to induce cellular senescence and destroy senescent cells could be a potential treatment strategy for HCC.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Qiangsheng Zhang, Xi Hu, Lu Li, Lidan Zhang, Guoquan Wan, Qiang Feng, Yongxia Zhu, Ningyu Wang, Zhihao Liu, Luoting Yu
Summary: SKLB-0335 displays high paralog-selectivity on EZH2 by targeting its unique Cys663, covalently binding to EZH2 at its S-adenosylmethionine (SAM) pocket and inhibiting H3K27Me3. This compound could serve as an effective chemical probe to further investigate the specific biological functions of EZH2.
CHEMICAL COMMUNICATIONS
(2021)
Review
Oncology
Liu Zhaoyun, Jia Yue, Guo Yixuan, Wang Hao, Fu Rong
Summary: In this paper, we reviewed the role of EZH2 in regulating bone marrow mesenchymal stem cell differentiation and immune cell function in the tumor microenvironment, summarized existing EZH2 inhibitors and main clinical trials, and proposed relevant ideas for potential clinical applications.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Article
Medicine, General & Internal
Yusuke Niwa, Kenya Kamimura, Kohei Ogawa, Chiyumi Oda, Yuto Tanaka, Ryoko Horigome, Masato Ohtsuka, Hiromi Miura, Koichi Fujisawa, Naoki Yamamoto, Taro Takami, Shujiro Okuda, Masayoshi Ko, Takashi Owaki, Atsushi Kimura, Osamu Shibata, Shinichi Morita, Norihiro Sakai, Hiroyuki Abe, Takeshi Yokoo, Akira Sakamaki, Hiroteru Kamimura, Shuji Terai
Summary: This study focused on investigating the function of Cyclin D1 binding protein 1 (CCNDBP1) in the survival of cancer cells by rescuing them from DNA damage caused by chemotherapy. The research revealed that CCNDBP1, by inhibiting EZH2, contributes to the activation of the ATM-CHK2 pathway and alleviates DNA damage, leading to chemoresistance.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Yingze Li, Guojian Fang, Wei Cao, Jiali Yuan, Shuai Song, Hong Peng, Yuepeng Wang, Qunshan Wang
Summary: In the aged and fibrotic left atrium, replicative senescence of atrial fibroblasts (AFs) plays a significant role in the pathogenesis of atrial fibrillation. The downregulation of Ezh2, a histone methyltransferase, is identified as a key regulator of AFs' replicative senescence. This finding may have implications for future treatments of atrial fibrosis in the elderly.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Review
Cell Biology
Venturina Stagni, Alessandra Ferri, Claudia Cirotti, Daniela Barila
Summary: There is a strong interplay between autophagy and genomic stability, with recent evidence linking DNA Damage Response (DDR) and autophagy in influencing cell fate. ATM kinase plays a crucial role in balancing senescence and apoptosis in response to stimuli, and its aberrant deregulation is linked to the development of pathologies like cancer and neurodegeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Na-Lee Ka, Ga Young Lim, Sewon Hwang, Seung-Su Kim, Mi-Ock Lee
Summary: The role of IFI16 in DNA repair enhances STING-type-I IFN signaling, offering potential therapeutic strategies for triple-negative breast cancer patients.
Article
Oncology
Sebastian C. B. Bremer, Gabi Bittner, Omar Elakad, Helen Dinter, Jochen Gaedcke, Alexander O. Koenig, Ahmad Amanzada, Volker Ellenrieder, Alexander Freiherr von Hammerstein-Equord, Philipp Stroebel, Hanibal Bohnenberger
Summary: Neuroendocrine neoplasms in different locations have varying prognosis and treatment responses, requiring accurate distinctions. EZH2 may serve as a reliable biomarker for distinguishing different types of neuroendocrine neoplasms.
Article
Oncology
Florian Sperling, Danny Misiak, Stefan Huettelmaier, Patrick Michl, Heidi Griesmann
Summary: Translation: Neuroendocrine neoplasms (NENs) are a diverse group of tumors that have been increasing in prevalence. In this study, the researchers found that IGF2BP1 is highly expressed in NEN cells and promotes cell proliferation by increasing the expression of EZH2, a protein involved in gene repression. The researchers also discovered that targeting IGF2BP1, EZH2, and Myc together can induce cell apoptosis in NEN cells. These findings highlight the potential for targeted therapy in neuroendocrine neoplasms by disrupting the IGF2BP1-Myc-EZH2 pathway.
Article
Geriatrics & Gerontology
Zhengshuai Song, Qi Cao, Bin Guo, Ye Zhao, Xuechao Li, Ning Lou, Chenxi Zhu, Gang Luo, Song Peng, Guohao Li, Ke Chen, Yong Wang, Hailong Ruan, Yonglian Guo
Summary: In this study, the researchers identified RACGAP1 as a common differentially expressed gene associated with neuroendocrine prostate cancer (NEPC). They confirmed its expression in clinical prostate cancer samples and investigated its regulatory pathways and functions. They found that RACGAP1 promoted NE transdifferentiation of prostate cancer and resistance to hormone therapy. Patients with high tumor RACGAP1 expression had shorter relapse-free survival time. This study explored the molecular mechanism of NE differentiation and may provide new insights for targeted therapy of NEPC.
Article
Chemistry, Medicinal
Pei-Pei Kung, Connie Fan, Hovhannes J. Gukasyan, Buwen Huang, Susan Kephart, Manfred Kraus, Joseph H. Lee, Scott C. Sutton, Shinji Yamazaki, Luke Zehnder
Summary: A pyridone-derived phosphate prodrug was designed and synthesized to improve the aqueous solubility of an enhancer of zeste homolog 2 (EZH2) inhibitor, demonstrating efficient conversion to its parent compound in vivo and impressive tumor growth inhibition in a xenograft model. This prodrug strategy is expected to be generally applicable to poorly soluble pyridone-containing EZH2 inhibitors, offering a new option for achieving high exposures in vivo.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Urology & Nephrology
Di Niu, Qihang Xu, Hanjiang Xu, Shuiping Yin, Zongyao Hao, Haoqiang Shi, Jun Zhou, Sheng Tai, Zhihui Zou, Cheng Yang, Chaozhao Liang
Summary: A new wireless high-definition endoscopic system (WHES) was developed, which provides similar image resolution as a Storz laparoscopic system with acceptable colour resolution, at a lower cost. Expert evaluation showed no significant difference in resolution, brightness, and colour for cystoscopy between WHES and Storz system, but WHES scored higher in ergonomics. The overall cost of WHES was much lower compared to Storz system, and there was 100% general satisfaction in the survey.
Letter
Surgery
Hanjiang Xu, Song Fan, Chaozhao Liang, Zongyao Hao
ASIAN JOURNAL OF SURGERY
(2023)
Review
Oncology
Xiangbin Kong, Weiwei Hu, Zhilong Dong, Junqiang Tian, Yuhan Wang, Chen Jin, Chaozhao Liang, Zongyao Hao, Zhiping Wang
Summary: This systematic review and meta-analysis found that Li-ESWT, combined with or without medications, is an effective and safe treatment option for patients with Chronic prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS). The study included 12 randomized controlled trials with a total of 651 patients. The results showed significant improvements in symptom scores, including pain, quality of life, and erectile function, in the Li-ESWT group compared to the control group at various time points. The subgroup analysis also demonstrated longer-lasting and greater reductions in symptom scores when Li-ESWT was combined with medications. Overall, Li-ESWT should be recommended for widespread use in clinical practice for CP/CPPS patients.
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
Review
Andrology
Bing Zhao, Jing Wang, Li Chen, Hong Wang, Chao-Zhao Liang, Jiaoti Huang, Ling-Fan Xu
Summary: Reprogramming of metabolism is a characteristic of tumors and has been investigated for therapeutic purposes. Prostate cancer, especially advanced and therapy-resistant cases, exhibits unique metabolic properties. Targeting the metabolic vulnerabilities of prostate cancer, specifically focusing on glutamine metabolism alterations, may offer new treatment options and improve clinical outcomes. This review summarizes the metabolic landscape of prostate cancer, highlights the influence of glutamine metabolism on therapeutic resistance and disease progression, and proposes novel therapeutic strategies.
ASIAN JOURNAL OF ANDROLOGY
(2023)
Article
Cell Biology
Zhengyao Song, Chen Jin, Zichen Bian, Chaozhao Liang
Summary: In this study, researchers found that the combination treatment of radial extracorporeal shock wave therapy (rESWT) and Resveratrol (Res) derivative can effectively reduce inflammation and fibrosis in chronic nonbacterial prostatitis (CNP) rats. This combination treatment works by regulating the expression of SIRT1 and NF-kappa B.
Article
Cell Biology
Yang Su, Tianxiang Zhang, Jinsen Lu, Lei Qian, Yang Fei, Li Zhang, Song Fan, Jun Zhou, Jieqiong Tang, Haige Chen, Chaozhao Liang
Summary: The study aimed to identify key tumor-infiltrating immune cells (TIICs) affecting distant metastasis and prognosis in patients with clear cell renal cell carcinoma (ccRCC). A three-gene panel consisting of CFB, PPP1R18, and TOM1L1 was established and validated for predicting distant metastasis and immunotherapy response. High-risk patients exhibited lower infiltration of RMCs, higher tumor mutation burden (TMB), and worse prognosis. The panel provided new insights for the treatment of advanced ccRCC.
Article
Biochemistry & Molecular Biology
Zichen Bian, Jia Chen, Chang Liu, Qintao Ge, Meng Zhang, Jialin Meng, Chaozhao Liang
Summary: This study presents a classification system, called Bladder Cancer Immune Prognostic Index (BCIPI), based on the intratumoral microenvironment to predict the prognosis and immunotherapeutic response of bladder cancer patients. Analysis of expression profiles from 1554 bladder cancer cases established the BCIPI and showed its effectiveness in predicting overall survival. Patients in the BCIPI-High subgroup exhibited different immunophenotypic outcomes and increased sensitivity to anti-PD-L1 immunotherapy compared to the BCIPI-Low subgroup.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Review
Microbiology
Kunyu Zhang, Lei Chen, Chenyu Zhu, Meng Zhang, Chaozhao Liang
Summary: T helper 22 (Th22) cells, characterized by their distinct cytokine profile, play variable roles in human immunity. The main effector molecule secreted by Th22 cells is IL-22, which has both protective and deleterious effects on infectious diseases. Th22/IL-22 may be a promising therapeutic target and an effective treatment strategy for various infections.
Article
Chemistry, Multidisciplinary
Hui Wang, Yu Guan, Chun Li, Jia Chen, Shaoyu Yue, Jieying Qian, Bangshun Dai, Changqin Jiang, Chenghao Wen, Longping Wen, Chaozhao Liang, Yunjiao Zhang, Li Zhang
Summary: This study designed magnetic PEGylated manganese-zinc ferrite nanocrystals (PMZFNs) to actively attract and retain the drug in prostate cancer by implanting micromagnets into tumor tissues. The PMZFNs accumulate in prostate cancer and elicit potent ferroptosis and the activation of cGAS-STING pathway, achieving targeted therapy.
Article
Cell Biology
Yu-Ching Wen, Van Thi Ngoc Tram, Wei-Hao Chen, Chien-Hsiu Li, Hsiu-Lien Yeh, Phan Vu Thuy Dung, Kuo-Ching Jiang, Han-Ru Li, Jiaoti Huang, Michael Hsiao, Wei-Yu Chen, Yen-Nien Liu
Summary: Current treatment options for prostate cancer focus on targeting androgen receptor (AR) signaling, but inhibiting AR may promote the development of neuroendocrine prostate cancer (NEPC). Understanding the regulatory mechanisms of AR is crucial for the clinical management of NEPC. This study revealed the tumor-suppressive role of AR and identified its downregulation of CHRM4 expression. CHRM4 overexpression drives neuroendocrine differentiation in prostate cancer cells and is associated with immunosuppressive cytokine responses in the tumor microenvironment (TME). Targeting CHRM4 and evaluating IFNA17 secretion as a prognostic biomarker could be potential therapeutic strategies for NEPC.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Jialin Meng, Jingjing Gao, Xiao Li, Rui Gao, Xiaofan Lu, Jun Zhou, Fangrong Yan, Haitao Wang, Yi Liu, Zongyao Hao, Xiansheng Zhang, Chaozhao Liang
Summary: This study aims to investigate the prognosis and therapeutic targets for testicular germ cell tumors (TGCTs), and defined the tumor immune microenvironment activation status (TIMEAS). By classifying patients into immune-activated and immune-exhausted subgroups, different treatment strategies could be applied to achieve better outcomes.
Article
Urology & Nephrology
Junyue Tao, Qintao Ge, Jialing Meng, Chaozhao Liang, Zongyao Hao, Jun Zhou
Summary: This study reveals that high expression of DDX49 predicts a poor prognosis in prostate cancer. Knockdown of DDX49 inhibits cell proliferation and migration, induces cell cycle arrest, and promotes cell apoptosis. Therefore, DDX49 knockdown may be a promising novel therapy for treating patients with prostate cancer.
Article
Green & Sustainable Science & Technology
R. Zhong, R. Chu, J. Zhu, J. Ling, L. Zhang, Y. Zhou, M. Yin, Z. Hao, C. Liang, S. Cao, T. Xu, S. Ye, S. Fan
Summary: Prostate diseases are common in males, and nanomedicine provides opportunities for the biomedical field by designing and manufacturing biomaterials. Gels have various applications in drug delivery, anti-inflammation, tissue regeneration, and wound healing. This review focuses on the current research on gels-based nanocomposites in the diagnostics and therapy of prostate diseases, pointing out their shortcomings and suggesting a broader prospect for future clinical application.
MATERIALS TODAY SUSTAINABILITY
(2023)
Article
Urology & Nephrology
Hanjiang Xu, Di Niu, Cheng Yang, Zongyao Hao, Chaozhao Liang
Summary: This study introduced a new wireless endoscopic system based on fifth-generation transmission technology. The visual discomfort induced by this system was compared with that induced by a conventional endoscopic system during laparoscopic pelvic surgery. The results showed that experienced surgeons did not experience additional visual discomfort when using the wireless endoscopic system compared to the conventional system.
Article
Oncology
Wei Xu, Meiyi Lu, Siqi Xie, Dangui Zhou, Mei Zhu, Chaozhao Liang
Summary: Mounting evidence suggests that endoplasmic reticulum stress (ERS) plays a crucial role in modulating tumor-associated macrophages (TAMs) and shaping the immunosuppressive microenvironment. The communication between ER-stressed tumor cells and TAMs remains unclear, but exosomes have been identified as important mediators in intercellular communication. Therefore, this study aimed to investigate the impact of ER stress-related exosomes on prostate cancer cells in promoting macrophage infiltration and polarization. The findings demonstrated that TG-treated exosomes downregulated PD-L1 expression on macrophages and altered the expression of inflammatory cytokines and the PI3K/AKT pathway.