Epigenetically upregulated oncoprotein PLCE1 drives esophageal carcinoma angiogenesis and proliferation via activating the PI-PLCε-NF-κB signaling pathway and VEGF-C/ Bcl-2 expression

PLCE1 Promotes Esophageal Cancer Cell Progression by Maintaining the Transcriptional Activity of Snail

(2017) Shicong Zhai et al.   NEOPLASIA

Phospholipase Cϵ Activates Nuclear Factor-κB Signaling by Causing Cytoplasmic Localization of Ribosomal S6 Kinase and Facilitating Its Phosphorylation of Inhibitor κB in Colon Epithelial Cells

(2016) Masahiro Wakita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The tumor microenvironment in esophageal cancer

(2016) E W Lin et al.   ONCOGENE

Utility of intrapapillary capillary loops seen on magnifying narrow-band imaging in estimating invasive depth of esophageal squamous cell carcinoma

(2015) Hiroki Sato et al.   ENDOSCOPY

Microvessel density in hepatocellular carcinoma: Prognostic significance and review of the previous published work

(2015) Keigo Murakami et al.   HEPATOLOGY RESEARCH

PLCε signaling in cancer

(2015) Rui-Yan Zhang et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Golgi phosphoprotein 3 (GOLPH3) promotes hepatocellular carcinoma cell aggressiveness by activating the NF-κB pathway

(2015) Ting Dai et al.   JOURNAL OF PATHOLOGY

PLCE1 Suppresses p53 Expression in Esophageal Cancer Cells

(2014) Yun Li et al.   CANCER INVESTIGATION

Inactivation of miR-34a by aberrant CpG methylation in Kazakh patients with esophageal carcinoma

(2014) Xiaobin Cui et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Nuclear factor-κB signaling pathway is involved in phospholipase Cε-regulated proliferation in human renal cell carcinoma cells

(2014) Hong-fei Du et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Increased extracellular pressure stimulates tumor proliferation by a mechanosensitive calcium channel and PKC-β

(2014) Marc D. Basson et al.   Molecular Oncology

Overexpression of AKIP1 promotes angiogenesis and lymphangiogenesis in human esophageal squamous cell carcinoma

(2014) C Lin et al.   ONCOGENE

Src contributes to IL6-induced vascular endothelial growth factor-C expression in lymphatic endothelial cells

(2013) Yu-Han Huang et al.   ANGIOGENESIS

Overexpression ofPLCE1in Kazakh esophageal squamous cell carcinoma: implications in cancer metastasis and aggressiveness

(2013) Yun-Zhao Chen et al.   APMIS

Nkx2-8 Downregulation Promotes Angiogenesis and Activates NF- B in Esophageal Cancer

(2013) C. Lin et al.   CANCER RESEARCH

Phospholipase Cε-1 inhibits p53 expression in lung cancer

(2013) Xue-ping Luo   CELL BIOCHEMISTRY AND FUNCTION

Downregulation of miR-138 Sustains NF- B Activation and Promotes Lipid Raft Formation in Esophageal Squamous Cell Carcinoma

(2013) H. Gong et al.   CLINICAL CANCER RESEARCH

Multiple polymorphisms within the PLCE1 are associated with esophageal cancer via promoting the gene expression in a Chinese Kazakh population

(2013) Xiao-Bin Cui et al.   GENE

Heterozygote ofPLCE1rs2274223 increases susceptibility to human papillomavirus infection in patients with esophageal carcinoma among the Kazakh populations

(2013) Xiaobin Cui et al.   JOURNAL OF MEDICAL VIROLOGY

Elevated expression patterns and tight correlation of the PLCE1 and NF-κB signaling in Kazakh patients with esophageal carcinoma

(2013) Xiao-bin Cui et al.   MEDICAL ONCOLOGY

A sequence variant in the phospholipase C epsilon C2 domain is associated with esophageal carcinoma and esophagitis

(2013) Li-Dong Wang et al.   MOLECULAR CARCINOGENESIS

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Clinical Significance of GPR56, Transglutaminase 2, and NF-κB in Esophageal Squamous Cell Carcinoma

(2010) Tasneem Kausar et al.   CANCER INVESTIGATION

Overexpression of phospholipase Cε in keratinocytes upregulates cytokine expression and causes dermatitis with acanthosis and T-cell infiltration

(2010) Nobuyuki Takenaka et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma

(2010) Christian C Abnet et al.   NATURE GENETICS

Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies a susceptibility locus at PLCE1

(2010) Li-Dong Wang et al.   NATURE GENETICS

Phospholipase Cε promotes intestinal tumorigenesis of Apc Min/+ mice through augmentation of inflammation and angiogenesis

(2009) Mingzhen Li et al.   CARCINOGENESIS

Crucial Role of Phospholipase C  in Skin Inflammation Induced by Tumor-Promoting Phorbol Ester

(2008) S. Ikuta et al.   CANCER RESEARCH