Article
Reproductive Biology
Serkan Sayiner, Isfendiyar Darbaz, Osman Ergene, Selim Aslan
Summary: This study aimed to monitor the alterations in antioxidant enzyme activities and metabolic profile parameters in dairy cows during different reproductive stages. Results showed a relationship between blood antioxidant enzymes and metabolic parameters at different periods.
Article
Environmental Sciences
Fatemeh Fallah, Abasalt Hosseinzadeh Colagar, Hayder Abdulhadi Saleh, Mojtaba Ranjbar
Summary: This study investigated the association between enzymatic factors in semen, polymorphisms (SOD2 rs4880, GPX1 rs1050450, and CAT rs1001179), and male infertility. The results showed that the rs1050450 polymorphism was associated with a reduced risk of male infertility, asthenozoospermia, and teratozoospermia, while the rs4880 polymorphism was associated with an increased risk of male infertility and teratozoospermia.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Agriculture, Dairy & Animal Science
Cristina Palacin-Martinez, Mercedes Alvarez, Rafael Montes-Garrido, Marta Neila-Montero, Luis Anel-Lopez, Paulino de Paz, Luis Anel, Marta F. Riesco
Summary: Sperm cryopreservation plays a crucial role in optimizing artificial insemination protocols for rams. Previous efforts to improve ram sperm cryopreservation protocols have focused on different methods, such as using different cryoprotectants, antioxidants, or freezing-thawing rates. However, the influence of male sexual regimes on freezeability has not been studied until now. In this study, a multiparametric analysis was conducted to evaluate the quality of cooled and frozen-thawed semen after different sperm collection frequencies. The results showed that semen quality significantly decreased in the groups with zero and ten collections per week compared to the group with four collections per week. Additionally, the apoptosis rate significantly increased in the group with ten collections per week. Enzyme activity related to redox balance, such as glutathione peroxidase and superoxide dismutase, also showed significant decreases in the group with ten collections per week. This study highlights the importance of considering male sexual regimes in alternative strategies for sperm cryopreservation in order to improve frozen-thawed sperm quality.
Article
Pharmacology & Pharmacy
Yihai Liu, Xuan Wei, Mingyue Wu, Jiamin Xu, Biao Xu, Lina Kang
Summary: The study found that BHB could protect from DOX-induced cardiotoxicity by inhibiting cell apoptosis and oxidative stress, and maintaining mitochondrial membrane integrity.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Hosna Hajati, Mojtaba Zaghari, Omid Noori, Reza Negarandeh, Haniel Cedraz de Oliveira
Summary: The study showed that in ovo injection of Spirulina can improve hatchability, regulate antioxidant status, and enhance performance of Japanese quails and broilers.
ITALIAN JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Environmental Sciences
Minerva Najera-Martinez, Anabel Perez-Cruz, Ricardo Dzul-Caamal, Armando Vega-Lopez
Summary: This study aimed to evaluate the impact of heavy metals on freshwater phytoplankton communities and their relationships with biomarkers of oxidative stress response. The results from artificial lakes and a natural lake showed different influence patterns.
WATER AIR AND SOIL POLLUTION
(2021)
Article
Biochemistry & Molecular Biology
Dwi Ramadhani, Viria Agesti Suvifan, Sofiati Purnami, Nastiti Rahajeng, Yanti Lusiyanti, Septelia Inawati Wanandi, Heri Wibowo, Tomisato Miura, Mukh Syaifudin
Summary: The study aimed to evaluate the impact of radon exposure on endogenous antioxidants modulation in a population chronically exposed to high radon levels indoors. Despite no significant differences in SOD and GPX activities between populations, there was a significant positive correlation between the two. Factors such as gender, age, smoking habits, and BMI did not significantly affect SOD and GPX activities. Further studies with larger sample sizes and assessing antioxidant levels in serum are recommended for a more comprehensive analysis.
FREE RADICAL RESEARCH
(2021)
Article
Toxicology
Chanisa Thonusin, Wichwara Nawara, Thawatchai Khuanjing, Nanthip Prathumsup, Apiwan Arinno, Benjamin Ongnok, Busarin Arunsak, Sirawit Sriwichaiin, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: This study investigated the changes in blood and cardiac metabolome levels following treatment with doxorubicin and trastuzumab, and their association with cardiac dysfunction and injury. The study found that there were distinct patterns of metabolome alterations between the two treatment groups, and that the constituents of the blood metabolome may serve as non-invasive biomarkers for assessing the severity and prognosis of heart failure induced by these drugs.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Medicine, Research & Experimental
Lin Tan, Nikolay Bogush, Emmen Naqvi, John W. Calvert, Robert M. Graham, W. Robert Taylor, Nawazish Naqvi, Ahsan Husain
Summary: The study demonstrates that therapy with DUSP5 suppression plus T3 can rebuild cardiac muscle by increasing cardiomyocyte numbers, thereby reversing heart dysfunction and preventing progressive chamber dilatation.
Article
Nutrition & Dietetics
Maria Choleva, Chrysa Argyrou, Maria Detopoulou, Maria-Eleni Donta, Anastasia Gerogianni, Evanggelia Moustou, Androniki Papaemmanouil, Christina Skitsa, Genovefa Kolovou, Petros Kalogeropoulos, Elizabeth Fragopoulou
Summary: Research suggests that the bioactive compounds in wine may provide antioxidant effects that counteract oxidative damage caused by alcohol consumption in patients with coronary heart disease.
Article
Pharmacology & Pharmacy
Xuejun Wang, Li Zhang, Mengwen Feng, Zhongqing Xu, Zijie Cheng, Lingmei Qian
Summary: ELA-11 alleviated heart injury induced by DOX and inhibited apoptosis in cardiac tissues by regulating the PI3K/AKT and ERK/MAPK signaling pathways. It also protected cardiomyocytes from oxidative stress-induced apoptosis by interacting with the APJ receptor.
FRONTIERS IN PHARMACOLOGY
(2022)
Editorial Material
Agriculture, Dairy & Animal Science
Rupas Kumar Debbarma, M. Ayub Ali, M. C. Lallianchhunga, H. Das, G. Kalita, T. C. Tolenkhomba, R. Goswami, P. Mayengbam
Summary: The study investigated the effects of vitamin C supplementation on stress and antioxidative status in commercial layer birds during summer. Two groups were compared, one with basal diet and the other with vitamin C supplementation. Heat stress and decrease in antioxidative status were observed in the control group, while vitamin C supplementation stabilized markers of stress and improved antioxidative status. This study highlights the importance of vitamin C supplementation in mitigating stress and improving antioxidative status in commercial layer birds during summer.
INDIAN JOURNAL OF ANIMAL SCIENCES
(2023)
Article
Plant Sciences
Chenyue Yuan, Zong Wu, Cuiliu Jin, Weiwei Cao, Yaorong Dong, Jiahui Chen, Chenping Liu
Summary: This study aimed to investigate whether the Qiangxin recipe can induce glucose metabolism and inhibit cardiomyocyte apoptosis by promoting the activation of the transcription factor Kruppel like factor 5 (KLF5). The results showed that the Qiangxin recipe can improve congestive heart failure by enhancing glucose metabolism and reducing apoptosis. The KLF5-mediated signaling pathways play an important role in the treatment of congestive heart failure, and the Qiangxin recipe can be used as a novel targeted therapy.
Article
Nutrition & Dietetics
Xuan Wang, Yuting Ji, Dekui Jin, Jingyi Qi, Xuening Hou, Wenting Zhao, Shuaishuai Zhou, Chengying Zhang, Yongting Luo, Peng An, Junjie Luo
Summary: In this study, it was found that beta-glucan can prevent Doxorubicin-induced cardiotoxicity. Doxorubicin reduces the ATP production capacity of the heart and increases oxidative stress, while beta-glucan can restore heart function and reduce oxidative stress.
Article
Biochemistry & Molecular Biology
Amani M. T. Gusti, Safaa Y. Qusti, Eida M. Alshammari, Eman A. Toraih, Manal S. Fawzy
Summary: The study investigated the association of 12 SNPs related to antioxidants with obesity susceptibility in a Saudi population. Results suggest that genetic determinants related to oxidative stress could significantly associate with obesity risk in the study population.
Review
Cardiac & Cardiovascular Systems
Ilias K. Gartzonikas, Katerina K. Naka, Aris Anastasakis
Summary: Hypertrophic cardiomyopathy (HCM) is a genetically inherited cardiomyopathy with common mutations in the genes MYBPC3 and MYH7. Diagnosis requires ruling out secondary causes of left ventricular hypertrophy. HCM is characterized by various clinical manifestations, with diastolic dysfunction and increased ventricular arrhythmogenesis being commonly observed. Current therapies focus on symptom management and prevention of sudden cardiac death, but there is a need for improved treatments targeting heart failure and atrial fibrillation. With advancements in understanding the genetic and molecular basis of HCM, novel treatments are expected in the near future.
HELLENIC JOURNAL OF CARDIOLOGY
(2023)
Article
Urology & Nephrology
Davide Bolignano, Marta Greco, Pierangela Presta, Anila Duni, Caterina Vita, Ethymios Pappas, Maria Mirabelli, Lampros Lakkas, Katerina K. Naka, Antonio Brunetti, Daniela Patrizia Foti, Michele Andreucci, Giuseppe Coppolino, Evangelia Dounousi
Summary: Chronic HD patients with severe cardiac alterations have a higher risk of death and adverse CV outcomes. Imbalanced expression of certain miRNAs is related to pathological cardiac remodeling and worse CV outcomes. In this study, circulating levels of miRNA 30a-5p, 23a-3p, and 451a were found to be lower in HD patients and correlated with the severity of cardiac dysfunction. These miRNAs may serve as predictors of worse clinical outcomes.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Lampros Lakkas, Katerina K. Naka, Aris Bechlioulis, Anila Duni, Maria Moustakli, Olga Balafa, Ioanna Theodorou, Christos S. Katsouras, Evangelia Dounousi, Lampros K. Michalis
Summary: This study aimed to compare myocardial strain, echocardiographic indices, and coronary flow reserve (CFR) in younger and older CKD patients. The findings showed that younger CKD patients had impaired coronary microcirculation and left ventricular diastolic function, while myocardial strain abnormalities were not observed. These issues worsened with aging in CKD patients. The study suggests that assessing coronary microcirculation and ventricular function may be important in younger CKD patients.
ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES
(2023)
Article
Endocrinology & Metabolism
Aris Bechlioulis, Georgios Markozannes, Ifigeneia Chionidi, Evangelos Liberopoulos, Katerina K. Naka, Evangelia E. Ntzani, Stavros Liatis, Manfredi Rizzo, Evangelos C. Rizos
Summary: This study compared the effects of empagliflozin, liraglutide, and their sequential combination on arterial stiffness indices in patients with type 2 diabetes. The results showed that neither empagliflozin nor liraglutide, nor their combination, had a significant favorable impact on arterial stiffness indices.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2023)
Review
Oncology
Alexia Alexandraki, Elisavet Papageorgiou, Marina Zacharia, Kalliopi Keramida, Andri Papakonstantinou, Carlo M. Cipolla, Dorothea Tsekoura, Katerina Naka, Ketti Mazzocco, Davide Mauri, Manolis Tsiknakis, Georgios C. Manikis, Kostas Marias, Yiola Marcou, Eleni Kakouri, Ifigenia Konstantinou, Maria Daniel, Myria Galazi, Effrosyni Kampouroglou, Domen Ribnikar, Cameron Brown, Georgia Karanasiou, Athos Antoniades, Dimitrios Fotiadis, Gerasimos Filippatos, Anastasia Constantinidou
Summary: Cancer therapy-related cardiac dysfunction (CTRCD) is a pressing medical issue in breast cancer patients receiving specific treatments, and traditional biomarkers lack reliability in predicting CTRCD. Clinical studies are exploring new biomarkers as potential indicators and predictors of CTRCD. This systematic review aims to summarize human studies on traditional and novel biomarkers for early detection and prediction of CTRCD in breast cancer patients undergoing cardiotoxic-cancer therapies.
Article
Biochemistry & Molecular Biology
Anila Duni, Athanasios Kitsos, Aris Bechlioulis, Georgios S. Markopoulos, Lampros Lakkas, Gerasimos Baxevanos, Michail Mitsis, George Vartholomatos, Katerina K. Naka, Evangelia Dounousi
Summary: This study investigated differences in circulating immune cells between type 2 cardiorenal syndrome (CRS-2) patients and CKD patients without cardiovascular disease (CVD). The results showed that CRS-2 patients had higher levels of proinflammatory cells and T regulatory cells, as well as lower levels of lymphocytes and natural killer cells compared to CKD patients. Decreased lymphocytes, T-lymphocytes, and increased proinflammatory cells were associated with mortality. CD4+ T-lymphocytes independently predicted fatal cardiovascular events in the CRS-2 cohort.
Article
Health Care Sciences & Services
Paraskevi Zotou, Aris Bechlioulis, Spyridon Tsiouris, Katerina K. Naka, Xanthi Xourgia, Konstantinos Pappas, Lampros Lakkas, Aidonis Rammos, John Kalef-Ezra, Lampros K. Michalis, Andreas Fotopoulos
Summary: Myocardial perfusion imaging via single-photon emission computed tomography (SPECT MPI) is a well-established method for diagnosing coronary artery disease (CAD). However, the role of SPECT MPI in predicting major cardiovascular events remains uncertain. In this study, the presence of extensive perfusion defects in SPECT MPI was found to be independently associated with mortality at 1 year in high-risk patients with suspected stable CAD.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Savvas Kyriakidis, George Rigas, Vassiliki Kigka, Dimitris Zaridis, Georgia Karanasiou, Panagiota Tsompou, Gianna Karanasiou, Lampros Lakkas, Sotirios Nikopoulos, Katerina K. K. Naka, Lampros K. K. Michalis, Dimitrios I. I. Fotiadis, Antonis I. I. Sakellarios
Summary: Diagnosis of coronary artery disease relies mainly on invasive imaging modalities such as X-ray angiography, intravascular ultrasound (IVUS), and optical coherence tomography (OCT), with computed tomography coronary angiography (CTCA) as a non-invasive alternative. This study presents a novel tool for reconstructing 3D coronary arteries and characterizing plaques using these imaging modalities. Image processing and deep learning algorithms were used to determine lumen and adventitia borders, plaque properties, and strut detection. The tool combines X-ray angiography with IVUS/OCT analysis for hybrid 3D reconstruction, and uses a 3D level set approach for CTCA image processing. The tool was evaluated for efficiency and usability, achieving high agreement with manual annotations and a high System Usability Scale (SUS) score of 0.89, indicating excellent usability.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Christos Ballas, Lampros Lakkas, Olga Kardakari, Athanasios Konstantinidis, Konstantinos Exarchos, Stavroula Tsiara, Konstantinos Kostikas, Katerina K. Naka, Lampros K. Michalis, Christos S. Katsouras
Summary: This study evaluated non-conventional markers of right ventricular dysfunction in patients with acute pulmonary embolism. The results showed that a majority of patients had abnormal right ventricular function, which was associated with clinical and biochemical prognostic indices.
Article
Biology
Matthaios Didagelos, Vlasis Ninios, Charalampos Kakderis, Lampros Lakkas, Antonios Kouparanis, Dimitrios Nikas, Katerina K. Naka, Aidonis Rammos, Thomas Zegkos, Vasileios Kamperidis, Ilias Ninios, Sotirios Evangelou, Dimitrios G. Tsalikakis, Lampros Michalis, Antonios Ziakas
Summary: The study evaluated outcomes at 2 years after TAVI with the Portico valve for patients with severe aortic stenosis. The results showed that TAVI with the Portico valve is an effective and safe solution for high-risk surgical patients with severe aortic stenosis.
Article
Biology
Aidonis Rammos, Aris Bechlioulis, Petros Kalogeras, Chris J. Watson, Pietro Salvo, Tommaso Lomonaco, Olga Kardakari, Evanthia E. Tripoliti, Yorgos Goletsis, Dimitris I. Fotiadis, Christos S. Katsouras, Lampros K. Michalis, Katerina K. Naka
Summary: This study found that saliva NT-proBNP correlates with serum values in patients with acute decompensated HF, but cannot differentiate between HF and other causes of dyspnea.
Article
Biochemistry & Molecular Biology
Anila Duni, Marta Greco, Pierangela Presta, Roberta Arena, Ethymios Pappas, Lampros Lakkas, Katerina K. Naka, Antonio Brunetti, Daniela Patrizia Foti, Michele Andreucci, Giuseppe Coppolino, Evangelia Dounousi, Davide Bolignano
Summary: Patients undergoing chronic hemodialysis (HD) are at high risk of cardiovascular (CV) events, but risk prediction in this population is challenging. Recent research has shown that circulating miRNA 122-5p is related to the onset and progression of CV disease. This study found that HD patients had lower levels of circulating miRNA 122-5p compared to healthy controls. ALT, E/e', and CRP were identified as independent predictors of miRNA 122-5p levels. Additionally, higher baseline levels of circulating miRNA 122-5p predicted a significantly increased risk of composite endpoint occurrence in HD patients.
Article
Cardiac & Cardiovascular Systems
Jussi Schultz, Inge J. van den Hoogen, Jurrien H. Kuneman, Michiel A. de Graaf, Vasileios Kamperidis, Alexander Broersen, J. Wouter Jukema, Antonis Sakellarios, Sotirios Nikopoulos, Konstantina Tsarapatsani, Katerina Naka, Lampros Michalis, Dimitrios Fotiadis, Teemu Maaniitty, Antti Saraste, Jeroen J. Bax, Juhani Knuuti
Summary: This study evaluated CCTA-based ESS values in coronary arteries without atherosclerosis and identified factors affecting ESS values. The findings showed that ESS was highest in the left anterior descending artery and lower in men compared to women, even after adjusting for lumen diameter. ESS values were also highest in small segments and had a correlation with the distance from the ostium.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2023)
Meeting Abstract
Transplantation
Anila Duni, Lampros Lakkas, Georgios Markopoulos, Aris Bechlioulis, Vasileios Koutlas, Eirini Tzalavra, Vasileios Tatsis, Ioanna Theodorou, Haralambos Pappas, George Vartholomatos, Michael Mitsis, Katerina Naka, Evangelia Ntounousi
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Meeting Abstract
Transplantation
Anila Duni, Lampros Lakkas, Aris Bechlioulis, Georgios Markopoulos, Revekka Georgiou, John Alekos, Athanasios Kitsos, Olga Balafa, Ioanna Theodorou, George Vartholomatos, Michael Mitsis, Katerina Naka, Evangelia Ntounousi
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
