Acorus calamus gold nanoparticles as enhanced anti-microbial agents for transdermal patches

During the past 20 years, there has been a drastic advancement in the formulation and administration of drugs. In comparison to the conventional oral, traditional and invasive methods of drug delivery, the transdermal (TD) delivery system offers enhanced drug delivery through skin permeation. TD delivery market is contributing greatly to the medical field as it is as an alternate to all other medicinal intake approaches. Nanoparticles enhance the performance of biomaterials in cancer therapy, drug delivery and microbial management. This study involves the synthesis of gold nanoparticles using the aqueous extracts of Acorus calamus and the incorporation of Acorus gold nanoparticles with the biomaterial collagen extracted and isolated from soy seeds. Collagen exhibits biodegradability, low antigenicity and superior biocompatibility in addition to its physiological properties as a natural extracellular matrix component. Acorus calamus mediated gold nanoparticles were fabricated onto TD patches using sonication technique. The treatment of synthesised gold nanoparticles as anti-microbial agents for TD application against E. coli has been evaluated.