Article
Clinical Neurology
Shadab A. Rahman, Margo D. Nathan, Aleta Wiley, Sybil Crawford, Aviva Y. Cohn, Jessica A. Harder, Leilah K. Grant, Athena Erickson, Akanksha Srivastava, Kathleen McCormick, Suzanne M. Bertisch, John W. Winkelman, Hadine Joffe
Summary: This study suggests that suvorexant is a well-tolerated and effective treatment option for VMS-associated insomnia disorder, reducing nighttime VMS symptoms. However, it did not significantly improve daytime VMS symptoms or other sleep-related outcomes.
Article
Oncology
Ellen B. Gold, Sybil L. Crawford, Katherine Leung, Gail Greendale, Katherine W. Reeves, Hadine Joffe, Nancy E. Avis
Summary: The study revealed significant differences in the reporting patterns of prevalent VMS between breast cancer cases and controls, especially in the post-diagnosis period, with the latter only partially explained by tamoxifen use among cases. Risk factors for VMS largely did not differ between cases and controls.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Geriatrics & Gerontology
Ki-Jin Ryu, Hyuntae Park, Jin Seol Park, Yeon Woo Lee, Soo Young Kim, Hayun Kim, Yeon Ju Lee, Tak Kim
Summary: Moderate and severe vasomotor symptoms (VMS) are independently associated with increased carotid intima-media thickness (CIMT) in otherwise healthy Korean midlife women. Clinicians managing midlife women with bothersome VMS should consider screening for subclinical cardiovascular diseases.
Article
Obstetrics & Gynecology
Rebecca C. Thurston, Yuefang Chang
Summary: This study found that physiologically assessed vasomotor symptoms (VMS) were associated with lower levels of adiponectin, independent of factors such as age, race/ethnicity, education, insulin resistance, and waist circumference. However, adiponectin did not explain the relationship between VMS and carotid atherosclerosis.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2022)
Article
Clinical Neurology
Denisse Morales-Rodriguez, Annika Anderson, Alyssa Nylander, Stephanie Hsu, Jessica Singh, Will Rowles, Christine M. Walsh, Tiffany J. Braley, Riley Bove
Summary: This study explored the associations between mental health, sleep, and other quality of life metrics, and vasomotor symptoms (VMSs) in menopausal women with multiple sclerosis (MS). The results showed that improving sleep quality, mood, and hot flash quantity/interference could substantially improve mental health in menopausal women with MS, highlighting an important care gap in this population.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Rebecca C. Thurston, Minjie Wu, Yue-Fang Chang, Howard J. Aizenstein, Carol A. Derby, Emma A. Barinas-Mitchell, Pauline Maki
Summary: Research shows that more severe menopausal symptoms may be associated with greater white matter hyperintensity volume, especially for symptoms occurring during sleep. This finding is important for early intervention and prevention of brain health issues related to middle-aged women.
Article
Endocrinology & Metabolism
Hye Rin Choi, Yoosoo Chang, Yejin Kim, Yoosun Cho, Jeonggyu Kang, Min-Jung Kwon, Ria Kwon, Gayoung Lim, Kye-Hyun Kim, Hoon Kim, Yunsoo Hong, Jihwan Park, Di Zhao, Juhee Cho, Eliseo Guallar, Hyun-Young Park, Seungho Ryu
Summary: Unfavorable cardiovascular health metrics are significantly associated with an increased risk of early-onset vasomotor symptoms (VMSs) among premenopausal women.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Obstetrics & Gynecology
Margo D. Nathan, Aleta Wiley, Pamela B. Mahon, Julie Camuso, Kathryn Sullivan, Kathleen McCormick, Akanksha Srivastava, Kim Albert, Paul Newhouse, Hadine Joffe
Summary: This study found that women with vasomotor symptoms (VMS) exhibited differences in physiological and subjective stress responses following experimental stress paradigms compared to women without VMS, suggesting that VMS may represent a chronic stress condition.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2021)
Article
Obstetrics & Gynecology
Nicholas J. Andersen, Jessica L. Parker, Susanne Pettigrew, Diana Bitner
Summary: This study developed a short patient-centric Menopause Transition Scale (MTS) for accurate measurement of menopausal symptoms. The MTS was found to correlate with validated menopause symptom scales and can be used in outpatient settings.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2022)
Review
Geriatrics & Gerontology
Elaine M. Dennison
Summary: This article discusses the relationship between the development of osteoarthritis and hormonal status, highlighting the need for future research in this area.
Review
Obstetrics & Gynecology
Vivien Brown
Summary: Menopause is a critical period for preventive healthcare in older women. Immunizations play an important role in disease prevention. However, barriers to adult vaccination need to be addressed, and healthcare practitioners should recommend vaccines and provide education on vaccination guidelines and risks.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2022)
Article
Environmental Sciences
Genoa R. Warner, Zhong Li, Jodi A. Flaws, Rebecca Smith
Summary: This study aims to characterize the long-term variability in phthalate biomarker concentrations in midlife women and identify factors associated with increased variability. The results show that phthalate biomarker concentrations in midlife women exhibit significant variability over time, and annual sampling may not be sufficient to fully capture long-term exposure.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2023)
Article
Nutrition & Dietetics
Yoosun Cho, Yoosoo Chang, Hye Rin Choi, Jeonggyu Kang, Ria Kwon, Ga-Young Lim, Jiin Ahn, Kye-Hyun Kim, Hoon Kim, Yun Soo Hong, Di Zhao, Sanjay Rampal, Juhee Cho, Hyun-Young Park, Eliseo Guallar, Seungho Ryu
Summary: The study examined the prevalence of vasomotor symptoms (VMS) in premenopausal women with nonalcoholic fatty liver disease (NAFLD) and found that even lean individuals with NAFLD had an increased risk of developing VMS. Further research is needed to understand the longitudinal association between NAFLD and VMS risk.
Article
Environmental Sciences
Genoa R. Warner, Diana C. Pacyga, Rita S. Strakovsky, Rebecca Smith, Tamarra James-Todd, Paige L. Williams, Russ Hauser, Daryl D. Meling, Zhong Li, Jodi A. Flaws
Summary: The study revealed associations between phthalates and hot flashes in midlife women, suggesting a potential impact on hot flash risk. Factors such as menopause status, BMI, race/ethnicity, and depressive symptoms may influence these associations.
ENVIRONMENTAL RESEARCH
(2021)
Article
Geriatrics & Gerontology
Alanna De Mello, Augustine Chavez, Mahnoor Mukarram, Matthew R. Buras, Juliana M. Kling
Summary: Menopausal symptoms in women from different socioeconomic areas in Arizona showed significant differences, with uninsured or homeless women experiencing higher psychological and somatic symptoms.
Review
Obstetrics & Gynecology
F. Sultana, S. R. Davis, R. J. Bell, S. Taylor, R. M. Islam
Summary: The association between endogenous testosterone blood concentrations and cognitive performance among postmenopausal women remains inconclusive due to the imprecision of testosterone measurement and the methodological heterogeneity of the included studies.
Article
Obstetrics & Gynecology
Z. N. Azene, S. R. Davis, J. J. McNeil, A. M. Tonkin, D. J. Handelsman, R. M. Islam
Summary: This study investigated the association between estrone and sex hormone binding globulin (SHBG) concentrations with lipid concentrations in older postmenopausal women. The results showed that estrone and SHBG are associated with lipid concentrations in older women, with SHBG providing additional clinical predictive utility for the assessment of cardiometabolic disease risk.
Review
Obstetrics & Gynecology
S. R. Davis
Summary: This article summarizes some of the known information about testosterone in women, including its actions, consequences of depletion and replacement. It is not a comprehensive review of the literature in this field, but provides some informative insights.
Article
Obstetrics & Gynecology
F. Sultana, S. R. Davis, A. M. Murray, R. L. Woods, J. J. McNeil, R. M. Islam
Summary: This study aimed to explore the associations between sex hormones and cognitive performance in older women. The results showed no associations between sex hormones and cognitive performance, but a correlation was found between low sex hormone binding globulin concentrations and better processing speed.
Letter
Obstetrics & Gynecology
S. R. Davis
Review
Endocrinology & Metabolism
Sasha Taylor, Rakibul M. Islam, Robin J. Bell, Chandima Hemachandra, Susan R. Davis
Summary: This study aims to investigate the associations between endogenous testosterone blood concentrations and muscle mass, strength, and performance in community dwelling women. The review found that there is no association between total testosterone and muscle mass, strength, or performance in women. Although calculated free or bioavailable testosterone showed a positive association with lean muscle mass, no association was found for muscle strength or performance.
CLINICAL ENDOCRINOLOGY
(2023)
Review
Obstetrics & Gynecology
Scott M. Nelson, Susan R. Davis, Sophia Kalantaridou, Mary Ann Lumsden, Nick Panay, Richard A. Anderson
Summary: This systematic review aimed to determine the usefulness of serum anti-Mullerian hormone (AMH) in diagnosing menopause, predicting menopause, or predicting/diagnosing premature ovarian insufficiency (POI). The review found that lower age-specific AMH concentrations were associated with earlier menopause, but AMH alone could not accurately predict the age at menopause. However, undetectable or extremely low AMH levels may assist in the early diagnosis of POI in young women.
HUMAN REPRODUCTION UPDATE
(2023)
Review
Geriatrics & Gerontology
Chandima Hemachandra, Rakibul M. Islam, Robin J. Bell, Farhana Sultana, Susan R. Davis
Summary: This review examines the association between endogenous testosterone blood concentrations and depression in postmenopausal women. The results suggest no significant association between total testosterone or free testosterone and depression, except for one study which found a relationship between bioavailable testosterone and incident depressive symptoms in women at least 21 years postmenopause. However, due to methodological limitations in the included studies, further research using community-based samples and validated depression assessment tools is necessary to address this knowledge gap.
Review
Obstetrics & Gynecology
Chandima Hemachandra, Susan R. Davis, Robin J. Bell, Farhana Sultana, Rakibul M. Islam
Summary: This systematic review examines the association between endogenous DHEA/DHEAS and depression in postmenopausal women. The review concludes that there is no evidence to support a link between these hormones and depression in this population.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2023)
Article
Obstetrics & Gynecology
Robin J. Bell, Penelope J. Robinson, Marina A. Skiba, Rakibul M. Islam, Chandima Hemachandra, Susan R. Davis
Summary: A large-scale study found that endometriosis has a significant impact on sick leave and work ability in women, including those without severe symptoms.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2023)
Review
Obstetrics & Gynecology
M. Jahangirifar, E. Fooladi, S. R. Davis, R. M. Islam
Summary: Refugee and asylum seeker women at midlife and beyond face various health challenges, including menopausal symptoms, sexual dysfunctions, and pelvic floor disorders. However, there is limited global knowledge about the prevalence and risk factors of these neglected health issues in this population.
Article
Endocrinology & Metabolism
Jo Wrigglesworth, Ian H. Harding, Rakibul M. Islam, Phillip G. D. Ward, Robyn L. Woods, Robin J. Bell, John J. McNeil, Elsdon Storey, Gary Egan, Anne M. Murray, Ruth E. Trevaks, Stephanie A. Ward, Susan R. Davis, Joanne Ryan
Summary: This study investigated the relationship between circulating sex hormones and structural brain ageing in older women. The findings showed that women with higher levels of DHEA had higher baseline brain ageing, but this association was not significant after controlling for age and other potential confounding factors. Estrone, testosterone, and sex-hormone binding globulin were not associated with brain ageing. Further studies on circulating sex hormones and brain health in postmenopausal women are needed.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Susan R. Davis, Karen Magraith
MEDICAL JOURNAL OF AUSTRALIA
(2023)
Review
Obstetrics & Gynecology
S. R. Davis
Summary: Cardiovascular disease (CVD) is the leading cause of death in older women, and sex hormones, especially estrogens in women, play a crucial role in its development. Low testosterone levels in women may also have detrimental effects on cardiovascular function. Testosterone has been shown to have favorable effects on blood vessel function and blood pressure in postmenopausal women. Animal studies have demonstrated advantageous effects of testosterone on myocardial function and cardiac electrical signaling. However, there is limited human data, mainly consisting of observational and mechanistic studies, on the cardiovascular effects of testosterone in women.
Review
Obstetrics & Gynecology
S. R. Davis, S. Taylor, C. Hemachandra, K. Magraith, P. R. Ebeling, F. Jane, R. M. Islam
Summary: The Practitioner's Toolkit for Managing the Menopause has been revised to ensure that it reflects current best practice, with updated algorithms and supporting information.