Article
Oncology
Dengdeng Pan, Dongliang Liu, Lichuan Liang, Tongyi Shen, Chenzhang Shi, Huanlong Qin
Summary: This study demonstrates that PD-1 inhibitor plus apatinib shows better treatment efficacy and survival benefits compared to apatinib monotherapy in advanced colorectal cancer patients, with tolerable safety.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Dongxu Wang, Xu Yang, Junyu Long, Jianzhen Lin, Jinzhu Mao, Fucun Xie, Yunchao Wang, Yanyu Wang, Ziyu Xun, Yi Bai, Xiaobo Yang, Mei Guan, Jie Pan, Samuel Seery, Xinting Sang, Haitao Zhao
Summary: This study evaluated the safety and efficacy of apatinib plus camrelizumab in pretreated advanced biliary tract cancer patients. The results showed that this regimen has favorable therapeutic effects with relatively manageable toxicity, suggesting the need for further trials with a control arm to investigate.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Baohong Gu, Bofang Wang, Xuemei Li, Zedong Feng, Chenhui Ma, Lei Gao, Yang Yu, Jing Zhang, Peng Zheng, Yunpeng Wang, Haiyuan Li, Tao Zhang, Hao Chen
Summary: This study confirmed the effectiveness of PDT in patients with advanced CRC and demonstrated that it alters the tumor microenvironment by recruiting immune cells into tumor tissues.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Xuchen Huang, Xuhua Hu, Tongbo Yi
Summary: This study provides evidence supporting the reliable efficacy of apatinib monotherapy for advanced breast cancer. However, non-hematologic grade 3-4 adverse events, especially hypertension, are more frequently observed during apatinib treatment than during treatment with other tyrosine kinase inhibitors, such as sunitinib or sorafenib.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
E. Alouani, M. Mercier, C. Flecchia, E. Auclin, A. Hollebecque, T. Mazard, A. Turpin, S. Pernot, R. Cohen, M. Dutherage, S. Kim, F. Sclafani, M. Ben-Abdelghani, C. Herve, T. Aparicio, C. De La Fouchardiere, G. Perkins, V. Hautefeuille, M. Jaffrelot, C. Gallois, V. Bongard, D. Tougeron, J. Taieb, R. Guimbaud
Summary: This multicenter retrospective study confirms the efficacy and safety of immunotherapy in patients with advanced MMRd/MSI CRC and identifies markers associated with long-term benefit.
Article
Oncology
Yongli Ma, Jinghui Li, Liang Wen, Guosheng Zhang, Xueqing Yao
Summary: This study aimed to investigate the efficacy and safety of apatinib combined with radiotherapy in the treatment of advanced pancreatic cancer. A total of 7 randomized controlled trials were included, and the results showed that apatinib combined with radiotherapy was more effective in improving treatment response rate, disease control rate, and survival rate compared to radiotherapy alone. However, more large-sample, multicentre, and high-quality randomized controlled trials are needed to validate the conclusions due to limitations in the quantity and quality of the included studies.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Jijin Wang, Di Huang, Wenjing Yang, Qingxu Song, Yibin Jia, Pengxiang Chen, Yufeng Cheng
Summary: The study retrospectively analyzed the treatment of Apatinib in 128 patients with advanced NSCLC, and the results showed that Apatinib at a lower dose (≤500mg/d) had good efficacy and safety in the treatment after first-line chemotherapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Zhuangzhuang Zheng, Zijing Liu, Haifeng Zhang, Xiao Guo, Xiaojing Jia, Jianfeng Wang, Lingbin Meng, Ying Xin, Xin Jiang
Summary: This study retrospectively analyzed the efficacy and safety of apatinib mesylate in the treatment of advanced hepatocellular carcinoma (HCC). The results showed that apatinib mesylate is an effective treatment for advanced HCC, and its adverse reactions are relatively mild.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Longbo Yu, Yuanyuan Wang, Yingxue He, Haiqing Zhong, Shushan Ge, Yi Zou, Yisheng Lai, Qiang Xu, Jian Gao, Wen Liu, Wenjie Guo
Summary: The combination of apo-IDO1 inhibitor and apatinib showed significant inhibition of colorectal cancer growth, increased apoptosis of cancer cells, and reprogrammed the immune microenvironment to enhance immune killing ability.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Oncology
Chuanxiu Zeng, Mengchao Wang, Shuqi Xie, Na Wang, Zhen Wang, Dan Yi, Fanming Kong, Liwei Chen
Summary: Colorectal cancer, especially with BRAF V600E mutation, poses a serious threat to human health. Precision therapy, including molecularly targeted drugs and immune checkpoint inhibitors, has improved the outcome of colorectal cancer. However, there is still a need for more rational and effective drug combination regimens to provide longer survival for patients with genetic mutations in metastatic colorectal cancer (mCRC). This article reviews the progress of clinical research on targeted drugs, immune checkpoint inhibitors, first-line chemotherapeutic agents, and different combination therapy regimens for colorectal cancer patients with BRAF V600E mutation, providing a reference for further treatment exploration.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Caiyun Nie, Huifang Lv, Yishu Xing, Beibei Chen, Weifeng Xu, Jianzheng Wang, Xiaobing Chen
Summary: Apatinib monotherapy or combination therapy can improve PFS in patients with advanced or recurrent BTC, and adverse reactions can be well tolerated.
Article
Oncology
Ruyan Zhang, Yifei Chen, Xiaoran Liu, Xinyu Gui, Anjie Zhu, Hanfang Jiang, Bin Shao, Xu Liang, Ying Yan, Jiayang Zhang, Guohong Song, Huiping Li
Summary: This study evaluated the efficacy and safety of apatinib 250 mg combined with chemotherapy in patients with pretreated metastatic breast cancer. The results showed that this combination therapy provided favorable efficacy regardless of molecular types and treatment lines, and the toxicities were well tolerated and manageable.
FRONTIERS IN ONCOLOGY
(2023)
Review
Pharmacology & Pharmacy
Da Huang, Qionghua He, Lingyun Zhai, Jiayu Shen, Fei Jing, Huanhuan Chen, Xiaoqing Zhu, Jianwei Zhou
Summary: This meta-analysis demonstrated that apatinib has promising efficacy and safety for patients with advanced or recurrent cervical cancer. The tumor response rate and disease control rate were 22.9% and 68.6% respectively, while the PFS and OS were 5.19 months and 10.63 months. Common treatment-related adverse events include hand-foot syndrome, hypertension, and fatigue.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Xuetong Rong, Haiyi Liu, Hongmei Yu, Jian Zhao, Jie Wang, Yusheng Wang
Summary: This study evaluated the efficacy and safety of apatinib combined with FOLFIRI in the first-line treatment of advanced metastatic colorectal cancer. It found that baseline neutrophil and alkaline phosphatase levels were independent prognostic factors. The treatment regimen showed good efficacy and safety.
INVESTIGATIONAL NEW DRUGS
(2022)
Article
Pharmacology & Pharmacy
Zhiyuan Xu, Can Hu, Jianfa Yu, Yian Du, Ping Hu, Guofa Yu, Conggang Hu, Yu Zhang, Wei Mao, Shanqi Chen, Xiangdong Cheng
Summary: Chemotherapy combined with apatinib has shown to improve treatment response and resection rate in unresectable gastric cancer patients, leading to a survival benefit. Suspending apatinib for 4 weeks before gastrectomy is a safe practice.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Si Huang, Xiaoli Liao, Junyong Wu, Xiaojie Zhang, Yamin Li, Daxiong Xiang, Shilin Luo
Summary: This study identifies TREM2 receptor expressed on the membrane of microglial exosomes and shows its involvement in controlling exosome secretion and promoting A beta clearance through microglia phagocytosis. This novel exosome-mediated mechanism provides insights into the crosstalk between microglial cells and A beta.
Article
Food Science & Technology
Xiaoyan Yang, Xiaoli Liao, Li Yu, Shen Rao, Qiangwen Chen, Zhenzhou Zhu, Xin Cong, Weiwei Zhang, Jiabao Ye, Shuiyuan Cheng, Feng Xu
Summary: The study explores the effects of selenate on the growth and quality of cabbage, as well as the mechanisms of selenium absorption and conversion. It also discovers the impact of selenium on secondary metabolites and identifies the crucial genes involved in these processes.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Chemistry, Analytical
Han Wang, Xiaoya Zhao, Jiawen Xu, Peng Wang, Xinyan Chen, Xiaoli Liao, Chenyong Zhan
Summary: In this study, MIL-101(Cr)-NH2&GO-coated SiO2/Fe3O4 magnetic particles were used as sorbents for magnetic solid-phase extraction in combination with high-performance liquid chromatography-tandem mass spectrometry for the analysis of beta-blockers and beta 2-agonists. The developed method showed good results in the determination of these compounds in environmental and biological samples.
JOURNAL OF SEPARATION SCIENCE
(2022)
Article
Environmental Sciences
Yin Dong, Baishu Guo, Dawei He, Xiaoli Liao, Zhengyu Zhang, Xueqin Wu
Summary: This study analyzes the spatiotemporal correlation characteristics of industrial transformation and urban economic efficiency evolution in the Yangtze River economic belt and explains the path characteristics of urban development and industrial transformation. The findings show that economic efficiency in the Yangtze River economic belt has increased over time, and the range and intensity of industrial transformation have shown an increasing trend.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Pharmacology & Pharmacy
Yan Lin, Xiaoli Liao, Yumei Zhang, Guobin Wu, Jiazhou Ye, Shanshan Luo, Xinxin He, Min Luo, Mingzhi Xie, Jinyan Zhang, Qian Li, Yu Huang, Sina Liao, Yongqiang Li, Rong Liang
Summary: This study suggests that the mutant type (HR-MUT) of the Homologous recombination (HR) pathway may impact the chemotherapy sensitivity and prognosis of colorectal cancer (CRC) patients. HR-MUT patients have a lower probability of tumor metastasis after chemotherapy, and HR-MUT can be used as an independent predictor of chemotherapy prognosis for CRC patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Dongcheng Luo, Sina Liao, Qian Li, Youzhi Lin, Junbao Wei, Yongqiang Li, Xiaoli Liao
Summary: This article reports a case of locally advanced pancreatic cancer achieving good efficacy after switching to TS-1 chemotherapy combined with anlotinib targeted therapy. This suggests that patients with advanced pancreatic cancer may benefit from treatment with the anlotinib targeted therapy combined with TS-1 chemotherapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Ecology
Yude Wang, Xiao-Li Liao, KeJie Chen, Zhaohui Zhang, Yuxin Liu, JingPing Yang, DuanSheng Wu
Summary: Radiation can cause differential expression of biological miRNA molecules. This study focused on the laboratory red crucian carp (LRCC) and explored its potential in detecting low-dose ionizing radiation-induced biological damage in aquatic environments. By using RNA-seq and bioinformatics techniques, it was discovered that LRCC liver cells showed nuclear pyknosis after irradiation, and 34 differentially expressed miRNAs were identified, including 7 new crucian carp miRNAs. The predicted target genes were mainly involved in energy transfer and material catabolism, and the AMPK signalling pathway was the most active. These findings suggest that LRCC is sensitive to radiation and can be used as an experimental animal for studying the biological effects of radiation. Additionally, the screened miRNAs can serve as pre-selected biomarkers for radiation damage detection and environmental monitoring.
Retraction
Biotechnology & Applied Microbiology
Q. D. Ye, X. L. Liao, P. Fu, J. Y. Dou, K. Chen, H. Jiang
ONCOTARGETS AND THERAPY
(2023)
Article
Horticulture
Li Yu, Qiangwen Chen, Xiaoli Liao, Xiaoyan Yang, Wei Chao, Xin Cong, Weiwei Zhang, Yongling Liao, Jiabao Ye, Hua Qian, Yang Zhao, Shuiyuan Cheng, Feng Xu
Summary: Selenium is an important trace element for human and animal health. Approximately 0.5-1 billion people worldwide suffer from selenium deficiency, leading to various endemic diseases. Cabbage, as a popular vegetable, can accumulate selenium through biofortification. Therefore, producing selenium-enriched cabbage may be an effective solution to alleviate selenium deficiency.
Article
Forestry
Xiaokang Dai, Ying Lin, Tingting Zhou, Yue Li, Xiaoli Liao, Jianbo Cao, Jihua Ding
Summary: Seasonal phenology of trees in tropical/sub-tropical regions is not well understood. This study investigates the molecular mechanisms of seasonal regulation events and flowering phenology in Eucalyptus dunnii, a widely planted tropical/sub-tropical hardwood tree. Results suggest that low temperature triggers the seasonal flowering of E. dunnii. Comparative analysis with Populus reveals molecular basis for different shoot apex growth habits in trees from different regions. This study provides insights into the molecular mechanisms of seasonal phenology in tropical/sub-tropical trees.
Meeting Abstract
Oncology
Yan Lin, Jinyan Zhang, Xiaoli Liao, Yumei Zhang, Min Luo, Qian Li, Mingzhi Xie, Chaoyong Liang, Sina Liao, Yating Zheng, Xue Hu, Mengli Huang, Rong Liang, Yongqiang Li
Meeting Abstract
Oncology
Yan Lin, Jinyan Zhang, Xiaoli Liao, Yumei Zhang, Min Luo, Qian Li, Mingzhi Xie, Chaoyong Liang, Sina Liao, Yating Zheng, Xue Hu, Mengli Huang, Rong Liang, Yongqiang Li
Article
Horticulture
Yanna Gao, Ning Li, Jiaojiao Ruan, Ying Li, Xiaoli Liao, Changxian Yang
Summary: This study conducted a comprehensive bioinformatic analysis of RBZ genes in tomato, revealing their gene structure, protein conserved domains, and potential involvement in complex regulatory networks during plant growth and development. The study also found that these genes exhibit different response patterns to various phytohormones and abiotic stresses.
Article
Forestry
Qiangwen Chen, Li Yu, Wei Chao, Juan Xiang, Xiaoyan Yang, Jiabao Ye, Xiaoli Liao, Xian Zhou, Shen Rao, Shuiyuan Cheng, Xin Cong, Bo Xiao, Feng Xu
Summary: This study investigated the effects of sodium selenite and selenate on the selenium tolerance and accumulation mechanism in Broussonetia papyrifera. The results showed that both forms of selenium significantly increased the total selenium content, with higher organic selenium proportion in the sodium selenite treatment. Additionally, exogenous selenium increased soluble sugar, phenolic acid, flavonoid contents and antioxidant enzyme activities. The study also proposed a model of selenium metabolism in B. papyrifera. This study provides a foundation for further understanding the accumulation and tolerance mechanism of selenium in B. papyrifera.
Article
Oncology
Dongcheng Luo, Sina Liao, Yu Liu, Youzhi Lin, Yongqiang Li, XiaoLi Liao
Summary: The study explored the potential relationship between HJURP and the tumor microenvironment in hepatocellular carcinoma, finding that HJURP is significantly related to the immunosuppressive tumor microenvironment and immune cells. Additionally, HJURP expression was associated with the downregulation of immune bioprocesses in malignant hepatocytes.
PATHOLOGY & ONCOLOGY RESEARCH
(2022)