Article
Chemistry, Multidisciplinary
Zijie Luo, Gervase Ng, Yingzhu Zhou, Cyrille Boyer, Rona Chandrawati
Summary: Polymeric amines have been discovered to induce NO generation from RSNOs, and controlled NO release can be achieved by adjusting various factors. The NO-releasing feature can be integrated into different materials, and the potential of PVA/PEI hydrogels in Pseudomonas aeruginosa biofilm prevention has been demonstrated. The discovery in this study opens up new opportunities in NO-generating biomaterials for antibacterial, antiviral, anticancer, antithrombotic, and wound healing applications.
Article
Polymer Science
Graham Hayes, Ben Drain, C. Remzi Becer
Summary: Poly(2-oxazoline)s are promising for biomedical applications, but limited synthetic approaches exist for star-shaped polymers. A novel bis-oxazoline cross-linker was developed via a fast thiol click reaction, allowing the preparation of well-controlled core cross-linked star polymers. The synthesized star-shaped polymers were characterized extensively and showed potential for encapsulation of dihydroxyanthroquinone.
Article
Chemistry, Multidisciplinary
Ekkachai Martwong, Yvette Tran
Summary: The study reports on the synthesis and temperature-responsive properties of poly(PEGMA) hydrogel thin films. Surface-attached poly(PEGMA) hydrogel films were synthesized using a simple, versatile, and well-controlled thiol-ene click reaction method, with the transition temperature finely tunable by adjusting the number of PEG units. The LCST properties of the hydrogel films are not sensitive to salt, holding promise for applications in biology such as injectable hydrogels, drug delivery systems, microfluidic valves, and flow switches for biotechnologies.
Article
Chemistry, Multidisciplinary
Pinghua Ling, Xianping Gao, Xiaona Zang, Xinyu Sun, Feng Gao
Summary: This paper presents the catalytic activity and kinetic study of metal-organic frameworks (MOFs) on the modulation of NO release from RSNOs, showing that different MOFs exhibit varying catalytic activities towards RSNOs, with Cu-MOF(Pd) being the most active. Zr-MOF(Pd) was also demonstrated to have the ability to generate NO from RSNOs in cell experiment, suggesting potential applications in biological samples.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Materials Science, Textiles
Romina Sepehri, Payam Zahedi, Mahboubeh Kabiri, Chakavak Nojavan
Summary: Coating polymeric nanofibers with an anti-coagulant agent, heparin, can enhance their performance in blood interactions. In this study, PET/GO 3 nanofibers coated with heparin were investigated for their physicochemical properties and hemocompatibility. The results showed that the heparin-coated PET/GO 3 nanofibers exhibited good properties and promoted the proliferation of mesenchymal stem cells.
FIBERS AND POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Jessica Zarenkiewicz, Christina Perez-Ternero, Volga Kojasoy, Christopher McGinity, Vinayak S. Khodade, Joseph Lin, Dean J. Tantillo, John P. Toscano, Adrian J. Hobbs, Jon M. Fukuto
Summary: The generation and degradation mechanisms of S-Nitrosothiol (RS-NO) are important for their biological activity. The discovery of hydropersulfides (RSSH) provides a possible route for NO release from RS-NO.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Food Science & Technology
Xiaohan Ge, Xueying Huang, Liping Zhou, Yi Wang
Summary: The study investigates the use of active food packaging with antimicrobial compounds to prolong shelf life and improve product quality. Mixing PLA, zein, and PEG to create a composite film enhances water barrier properties and reduces brittleness of the film.
FOOD PACKAGING AND SHELF LIFE
(2022)
Article
Engineering, Chemical
Dinglei Zhong, Zhaogen Wang, Jiemei Zhou, Yong Wang
Summary: Hemodialysis membranes made from PSF-b-PEG exhibit excellent hemocompatibility and biocompatibility, with mesopores formed throughout the membrane during NIPS process to enhance hydrophilicity, showing superior dialysis performance compared to traditional membranes.
JOURNAL OF MEMBRANE SCIENCE
(2021)
Article
Polymer Science
Laura Brelle, Agustin Rios de Anda, Teoman Ozturk, Nathalie Didier, Estelle Renard, Valerie Langlois
Summary: Biocompatible gels based on PHAs were developed using radical polymerization in the presence of PEGDA. The microscopic structure varied depending on the mass proportions between the two polymers, and chemical crosslinking was observed between unsaturated PHA and PEGDA.
Article
Materials Science, Multidisciplinary
Peichuang Li, Wanhao Cai, Xin Li, Kebing Wang, Lei Zhou, Tengda Shang, Xianmang Xu, Yuancong Zhao, Jin Wang
Summary: A novel tellurium-functionalized polycarbonate-polyurethane (PCU-TeTe) was designed and synthesized, showing excellent catalytic activity in nitric oxide release and significantly reducing the probability of thrombosis in blood environment.
MATERIALS & DESIGN
(2022)
Article
Biochemistry & Molecular Biology
Ceren Cokca, Franz J. Hack, Daniel Costabel, Kira Herwig, Juliana Huelsmann, Patrick Then, Rainer Heintzmann, Dagmar Fischer, Kalina Peneva
Summary: This study describes the shielding of a high performing terpolymer using block copolymerization with various molecular weights of P(MEO(9)MA) and investigates its influence on cytotoxicity, pDNA binding, and transfection efficiency. The results show that higher molecular weight P(MEO(9)MA) blocks exhibit excellent biocompatibility and efficient transfection efficiency.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Nanoscience & Nanotechnology
Esther Marie JieRong Lin, Chee Leng Lay, Gomathy Sandhya Subramanian, Wui Siew Tan, Susanna Su Jan Leong, Lionel Chuan Hui Moh, Kaiyang Lim
Summary: The study developed an improved antimicrobial catheter coating with enhanced controlled-release functionality, demonstrating superior antimicrobial performance and sustainability compared to commercial antimicrobial catheters.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
David Pizzi, James Humphries, Joshua P. Morrow, Ayaat M. Mahmoud, Nicholas L. Fletcher, Stefan E. Sonderegger, Craig A. Bell, Kristofer J. Thurecht, Kristian Kempe
Summary: In this study, we synthesized a new water-soluble polymer and compared it with control polymers. The new polymer demonstrated a lower critical solution temperature behavior and a chiral secondary structure. Cellular association and mouse biodistribution studies confirmed the biocompatibility of this polymer and its higher immune cell association and organ accumulation compared to control polymers.
Article
Chemistry, Medicinal
Zhongyuan Zheng, Hui Liu, Xi Wang, Yu Zhang, Shuiqing Qu, Yuanmin Yang, Shuoqiu Deng, Lina Chen, Xiaoxin Zhu, Yujie Li
Summary: This study confirmed the effects of AS+TMP on cerebral blood flow and NO-related indicators, and explored the mechanism of NO through the S-nitrosoproteome. The results demonstrated that AS+TMP could improve ECM symptoms.
ACS INFECTIOUS DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Megan Douglass, Sean Hopkins, Rashmi Pandey, Priya Singha, Megan Norman, Hitesh Handa
Summary: The novel use of nanofibers coated with nitric oxide releasing biodegradable polymers provides a safe antimicrobial and hemocompatible coating for blood-contacting medical devices. The nanofibers exhibit improved mechanical properties, significant reduction in bacterial adhesion, and decreased platelet adhesion, making them suitable for various biomedical applications.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Engineering, Biomedical
Manjyot Kaur Chug, Hamed Massoumi, Yi Wu, Elizabeth J. Brisbois
Summary: This study evaluated the synergy of nitric oxide (NO) and chlorhexidine diacetate (CHXD) to create an antimicrobial medical-grade silicone rubber. The results showed that the dual-active SNAP-CHXD films were able to significantly reduce Escherichia coli and Staphylococcus aureus bacteria without toxicity towards mouse fibroblast cells.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2022)
Article
Nanoscience & Nanotechnology
Lori M. Estes Bright, Mark R. S. Garren, Morgan Ashcraft, Anil Kumar, Huzefa Husain, Elizabeth J. Brisbois, Hitesh Handa
Summary: In this study, a dual-function hydrogel capable of releasing nitric oxide and fluoride was developed for the treatment of dental caries. The hydrogel demonstrated effective antibacterial activity by releasing nitric oxide and prevented enamel demineralization by delivering fluoride ions. It also showed good biocompatibility with human gingival fibroblasts and human osteoblasts.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Environmental Sciences
Xin Zhang, Jianfeng Wu, Lauren M. Smith, Xin Li, Olivia Yancey, Alfred Franzblau, J. Timothy Dvonch, Chuanwu Xi, Richard L. Neitzel
Summary: This research examined the presence of SARS-CoV-2 in non-healthcare environments on a university campus and estimated the infection risks for people exposed to the virus. The findings showed a low positivity rate and highlighted the importance of protecting individuals from airborne transmission. This study reinforces the significance of environmental monitoring and risk assessment in understanding the transmission of highly infectious respiratory viruses.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Rajnish Kumar, Manjyot Kaur Chug, Elizabeth J. Brisbois
Summary: Physical incorporation of nitric oxide (NO) releasing materials into biomedical grade polymer matrices is an economically feasible method to fabricate antimicrobial coatings and devices. In this study, a penicillamine dipeptide NO-releasing molecule (SNAP-SNAP) was successfully incorporated into a biomedical grade silicone rubber (SR) to fabricate a NO-releasing coating (SNAP-SNAP/SR). The SNAP-SNAP/SR coatings exhibited sustained NO release and lower leaching of NO donors compared to coatings with a different NO-releasing molecule (SNAP). These coatings showed promising antibacterial properties and biocompatibility, making them suitable for long-term indwelling biomedical devices and implants.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Hamed Massoumi, Manjyot Kaur Chug, Grace H. Nguyen, Elizabeth J. Brisbois
Summary: The development of novel biomaterials is crucial in the field of undergraduate education. Interdisciplinary experiments allow undergraduate students to integrate knowledge from different fields to analyze multidisciplinary results, thereby gaining a better understanding of the influence of material properties on biological responses for biomaterial interfaces.
JOURNAL OF CHEMICAL EDUCATION
(2022)
Article
Chemistry, Multidisciplinary
Manjyot Kaur Chug, Elizabeth J. Brisbois
Summary: This study reports a novel medical device that utilizes the antimicrobial properties of light and nitric oxide to both prevent and treat catheter-related infections. By incorporating a photo-initiated nitric oxide donor molecule into the device, tunable levels of nitric oxide can be released, reducing microbial attachment and eradicating bacteria on pre-colonized catheters. This smart, mobile-operated device shows promise as a biocompatible solution for catheter-related bloodstream infections, eliminating the need for complex surgical interventions.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Engineering, Biomedical
Mark Garren, Morgan Ashcraft, Dagney Crowley, Elizabeth J. Brisbois, Hitesh Handa
Summary: Graphene oxide (GO) nanosheets are promising carbon-based materials for medical device construction. Chemical modification of GO nanosheets enables the introduction of new surface properties, enhancing biological effects. The immobilization of S-nitrosothiol (RSNO) moieties onto GO nanosheets allows for tunable nitric oxide (NO) release properties.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Article
Engineering, Biomedical
Aasma Sapkota, Arnab Mondal, Manjyot Kaur Chug, Elizabeth J. Brisbois
Summary: Infection of indwelling catheter is a common healthcare problem that can lead to higher morbidity and mortality. Nitric oxide-releasing materials, such as the proposed catheters prepared in this study, showed antibacterial properties without the risk of antibacterial resistance. These catheters demonstrated NO-releasing and NO-generating capability, significantly reducing bacterial adhesion and showing compatibility with sterilization and storage.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Article
Chemistry, Physical
Anil Kumar, Arnab Mondal, Megan E. Douglass, Divine J. Francis, Mark R. Garren, Lori M. Estes Bright, Sama Ghalei, Jin Xie, Elizabeth J. Brisbois, Hitesh Handa
Summary: Light-controlled therapies using porphyrin-based supramolecular nanostructure frameworks (SNFs) show promise in preventing and suppressing bacterial infections. The SNFs offer extended light absorption and release high yields of reactive oxygen intermediates under visible light irradiation, enhancing antimicrobial photodynamic therapy (APDT). Furthermore, the SNFs exhibit significant biofilm dispersion and can target pathogenic infections without harming mammalian cells, making them a potential treatment for microbial infections.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Review
Chemistry, Physical
Manjyot Kaur Chug, Elizabeth J. Brisbois
Summary: Implant-associated infections caused by biofilm development have a negative impact on patients' quality of life. Despite efforts in the biomaterials field to discourage bacterial and protein adhesion without affecting surrounding tissue and cell functions, the rate of infections associated with medical devices continues to increase. In response, current strategies focus on the development of dual antimicrobial surfaces that can eradicate attached bacteria and resist or release bacterial adhesion. This review outlines progress in biomedical engineering and biomaterials for the development of multifunctional antibacterial biomedical devices.
Article
Nanoscience & Nanotechnology
Hamed Massoumi, Rajnish Kumar, Manjyot Kaur Chug, Yun Qian, Elizabeth J. Brisbois
Summary: In this study, S-nitroso-N-acetylpenicillamine (SNAP) was covalently immobilized on titanium dioxide nanoparticles (TiNPs) to form NO-releasing nanoparticles. The TiNP-SNAP exhibited concentration-dependent antimicrobial efficacy against bacteria and showed no significant cytotoxicity to mouse fibroblast cells.
ACS APPLIED BIO MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Hamed Massoumi, Rajnish Kumar, Manjyot Kaur Chug, Yun Qian, Elizabeth J. Brisbois
Summary: TiNP-SNAP nanoparticles, which immobilize S-nitroso-N-acetylpenicillamine (SNAP) molecules as nitric oxide (NO) donors on titanium dioxide nanoparticles (TiNPs), exhibit concentration-dependent antimicrobial efficacy against both Gram-positive and Gram-negative bacteria, with no significant cytotoxicity to human cells.
ACS APPLIED BIO MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Yun Qian, Manjyot Kaur Chug, Elizabeth J. Brisbois
Summary: This study reports the development of a NO-releasing silicone oil based on S-nitrosothiol, which exhibits proactive antibacterial effects. The silicone oil can release NO without leaching and has potential applications in creating antimicrobial medical device surfaces and other antibacterial materials.
ACS APPLIED BIO MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Yun Qian, Manjyot Kaur Chug, Hamed Massoumi, Elizabeth J. Brisbois
Summary: Infection is a significant challenge in healthcare and medical devices. Researchers have developed a new therapy using nitric oxide (NO) to treat infection, inflammation, and thrombosis. However, the release of NO has been unstable. This study introduces a new NO-releasing silicone oil (SNAP-Si) that can effectively inhibit bacterial growth and has the potential to create antimicrobial medical device surfaces to reduce infection risks.
MATERIALS ADVANCES
(2022)
Article
Nanoscience & Nanotechnology
Megan Douglass, Sama Ghalei, Elizabeth Brisbois, Hitesh Handa
Summary: Catheter-associated urinary tract infections (CAUTIs) remain a major source of hospital-acquired infections. This study demonstrated the successful loading of a nitric oxide (NO) donor into latex catheters, which showed stable noncytotoxic release characteristics and broad-spectrum antimicrobial activity, offering great potential for reducing the impact of CAUTIs.
ACS APPLIED BIO MATERIALS
(2022)