Article
Immunology
Sandra Vols, Naomi Kaisar-Iluz, Merav E. Shaul, Arik Ryvkin, Haim Ashkenazy, Avishag Yehuda, Ronza Atamneh, Adina Heinberg, Meital Ben-David-Naim, Menucha Nadav, Shira Hirsch, Vera Mitesser, Seth J. Salpeter, Ron Dzikowski, Zvi Hayouka, Jonathan M. Gershoni, Zvi G. Fridlender, Zvi Granot
Summary: This article describes the discovery of peptides that specifically bind to neutrophils and the development of nanoparticles decorated with these peptides for neutrophil-specific targeting. The study also demonstrates the specific modulation of neutrophil function and longevity by encapsulating neutrophil modifying small molecules within these nanoparticles.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Inorganic & Nuclear
Neelam Thakur, Pritam Sadhukhan, Mousumi Kundu, Th. Abhishek Singh, Madushmita Hatimuria, Ashok Pabbathi, Joydeep Das, Parames C. Sil
Summary: In this study, folic acid-conjugated and amine-functionalized cerium oxide nanoparticles (CeO2-NH-FA) were synthesized for targeted and controlled delivery of Morin to breast cancer cells overexpressing folic acid. The resulting nanohybrids exhibited significant cytotoxicity against breast cancer cells and a potential antimigratory effect. In addition, the nanohybrids showed improved anticancer efficacy compared to free Morin and CeO2-NH-FA in tumor-bearing mice. The study highlights the potential of the Morin-CeO2-NH-FA nanohybrids as a drug delivery vehicle for cancer treatment.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Materials Science, Multidisciplinary
Yu Chen, Sheng Zhang, Tianjiao Cheng, Wei Lin, Linlin Mao, Zhonghui Chen, Yang Yang, Hanqing Huang, Jinqiu Li, Zhiyong Ke, Zhong-Kai Cui
Summary: Mitochondria are recognized as ideal targets for tumor therapy, and mitochondria-specific photosensitizers play a critical role in inducing cell apoptosis. In this study, a new aggregation-induced emission (AIE) photosensitizer with excellent properties was developed for mitochondrial targeting, exhibiting good biocompatibility, reactive oxygen species (ROS) stimulation ability, anticancer efficacy, and two-photon imaging properties.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Macarena Gonzalez, Tanisha Prashar, Haley Connaughton, Michael Barry, Rebecca Robker, Ryan Rose
Summary: This study investigated the potential of mitochondrial antioxidants to protect sperm quality during cryopreservation. The results showed that the addition of BGP-15 or L-carnitine to the cryopreservation medium improved sperm motility and prevented loss of viability. These antioxidants also reduced DNA oxidative damage, with BGP-15 significantly reducing DNA fragmentation. Overall, this study highlights the importance of mitochondrial antioxidants in improving long-term fertility preservation in males.
Article
Chemistry, Multidisciplinary
Haiyan Chen, Wendan Pu, Xiankang Hu, Cheng Yang, Guanli Zhao, Houyuan Hu, Jianxiang Zhang
Summary: This article reports a mitochondrial-mimetic therapy for dilated cardiomyopathy (DCM) that efficiently targets the heart, cardiomyocytes, and myocardial mitochondria, effectively regulating mitochondrial homeostasis. By synthesizing a bioactive conjugate TPT and delivering it intravenously, TPTN can accumulate in the heart and primarily localize in the cardiomyocytes and myocardial mitochondria, alleviating DCM. By packaging TPTN into outer mitochondrial membrane-derived vesicles, a mitochondrial-mimetic therapy with enhanced targeting capability is created, providing notable therapeutic effects in DCM mice.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Chenbin Bian, Zhuangzhuang Zheng, Jing Su, Huanhuan Wang, Sitong Chang, Ying Xin, Xin Jiang
Summary: Radiotherapy failure and poor tumor prognosis are mainly caused by radioresistance. The relationship and mechanisms between mitochondrial metabolism and cancer radioresistance are not fully understood. However, mitochondria play a crucial role in regulating various biological reactions and influencing the radiation effects of malignancies. Therefore, targeting mitochondrial signaling pathways for the development of novel anticancer drugs holds promise.
Article
Engineering, Environmental
Guoliang Chen, Mingxing Wang, Panpan Zhu, Guixue Wang, Tingzhang Hu
Summary: Pyraoxystrobin (SYP-3343), a newly-invented strobilurin fungicide, exhibits high toxicity to aquatic organisms, particularly in zebrafish embryos, through affecting cell cycle, mitochondrial membrane potential, and reactive oxygen species generation. This toxicity is dose- and time-dependent, inducing apoptosis in zebrafish embryos.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Biotechnology & Applied Microbiology
Wenjian Liu, Jing Su, Qiang Shi, Jinlei Wang, Xiao Chen, Shizhong Zhang, Mengkao Li, Jie Cui, Cundong Fan, Beibei Sun, Guojun Wang
Summary: The study demonstrated that Ag@Se@RGD NPs had stable particle size and morphology in physiological conditions and induced significant integrin-targeted intracellular uptake. In vitro experiments showed that Ag@Se@RGD NPs dose-dependently inhibited U251 human glioma cell growth by inducing cell apoptosis through triggering mitochondrial dysfunction and ROS-dependent MAPKs activation. In vivo administration of Ag@Se@RGD NPs effectively inhibited U251 tumor xenograft growth by inducing apoptosis through regulation of MAPKs activation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Jianmin Xiao, Miao Yan, Ke Zhou, Hui Chen, Zhaowei Xu, Yuehao Gan, Biao Hong, Geng Tian, Junchao Qian, Guilong Zhang, Zhengyan Wu
Summary: In this study, self-assembled Pseudomonas geniculate cell membranes were prepared as drug nanocarriers (BMMPs) with high biosafety and efficient internalization by cancer cells. Coated with nanoselenium and loaded with Mn2+ ions and doxorubicin, the functional nanoplatform (BMMP-Mn2+/Se/DOX) exhibited increased effectiveness in inducing cancer cell death through mitochondrial and nuclear targeting pathways. This nanoplatform holds promise as a safe and effective drug delivery system for cancer therapy.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Review
Immunology
Weiyao Jing, Cui Liu, Chenghong Su, Limei Liu, Ping Chen, Xiangjun Li, Xinghua Zhang, Bo Yuan, Haidong Wang, Xiaozheng Du
Summary: Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial inflammation, pannus formation, and bone and cartilage damage. The hypoxic microenvironment of RA joints can cause reactive oxygen species (ROS) accumulation and mitochondrial damage, which upregulate inflammatory pathways and contribute to angiogenesis and bone destruction, thereby accelerating RA progression. This review highlights the effects of ROS accumulation and mitochondrial damage on inflammation, angiogenesis, and bone and cartilage damage in RA, as well as discusses therapeutic approaches targeting ROS or mitochondria to alleviate symptoms and the current gaps and controversies in research.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Yinghui Shang, Qinghai Wang, Jian Li, Haiting Liu, Qiangqiang Zhao, Xueyuan Huang, Hang Dong, Wansong Chen, Rong Gui, Xinmin Nie
Summary: ZrO2 NPs induce cell death in HeLa cells through elevation of intracellular ROS, mitochondrial damage, promotion of autophagy and apoptosis.
FRONTIERS IN CHEMISTRY
(2021)
Article
Engineering, Environmental
Xiangrui Wang, Wen-Xiong Wang
Summary: The difference in toxicity mechanisms of Cu(I) and Cu(II) on mitochondrial function leads to their differential tolerance to accumulation. By designing Cu(x)S shells for Cu2O and CuO NPs, we uncovered the difference in cytotoxicity mechanisms, which can greatly benefit the green fabrication of engineered Cu-based NPs.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Review
Medicine, Research & Experimental
Tao Zhang, Yingli Nie, Jiliang Wang
Summary: Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease that can progress to liver fibrosis, cirrhosis, and hepatocellular carcinoma. It is associated with a higher risk of cardiovascular disease and extrahepatic cancers. Recent studies suggest that NAFLD may be a mitochondrial disease, and targeting mitochondrial dysfunction could be a potential therapeutic approach. This review explores the mechanisms of mitochondrial dysfunction in NAFLD progression and discusses various mitochondria-targeted compounds and medications currently being tested for NAFLD treatment.
Article
Cell Biology
Yanhong Wang, Xinyu Mang, Xuran Li, Zhengyu Cai, Fei Tan
Summary: This study investigated the effect and mechanism of cold atmospheric plasma (CAP) on the proliferation and apoptosis of lung cancer and colon cancer cells. The results showed that CAP treatment inhibited tumor cell proliferation and induced apoptosis through the activation of the mitochondrial pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Matthew A. Deragon, William D. McCaig, Phillip V. Truong, Kevin R. Metz, Katherine A. Carron, Keven J. Hughes, Angeleigh R. Knapp, Molly J. Dougherty, Timothy J. LaRocca
Summary: Apoptosis and necroptosis, two different forms of cell death, are influenced by high glucose levels. High glucose promotes necroptosis by affecting mitochondrial trafficking of key proteins, such as RIP1 and MLKL. Additionally, the induction of ROS replicates the effects of high glucose on mitochondrial trafficking. These findings provide insight into the molecular mechanisms underlying the hyperglycemic shift from apoptosis to necroptosis and highlight the role of mitochondrial permeability in this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Batakrishna Jana, Surajit Barman, Rajsekhar Roy, Gaurav Das, Nabanita Mukherjee, Anindyasundar Adak, Surajit Ghosh
Summary: The study investigates the effect of an exchangeable GTP/GDP binding antimitotic tetrapeptide on its binding affinity to tubulin and its anticancer potential, showing that the substitution of proline with multifluorine substituted proline enhances its effects.
JOURNAL OF PHYSICAL CHEMISTRY B
(2021)
Article
Chemistry, Organic
Shekaraiah Devari, Debmalya Bhunia, Dennis Bong
Summary: In this study, bifacial peptide nucleic acids (bPNAs) with novel diketopiperazine (DKP) backbones displaying unnatural melamine (M) bases and native bases were synthesized. The structure-function scope of DKP bPNAs was examined, and a set of bPNAs displaying different base-tripling motifs were prepared. Thermal denaturation studies revealed that the optimal side-chain linkage was four carbons, corresponding to the lysine derivative. With these building blocks, DKP bPNAs displaying a combination of native and synthetic bases were prepared. Preliminary melting studies indicate binding signatures of cytidine- and melamine-displaying bPNAs to T-rich DNAs of noncanonical structure. This convenient and potentially scalable method allows for the rapid generation of low molecular weight DNA-binding scaffolds with established cell permeability, enabling further studies on noncanonical nucleic acid hybridization.
Article
Chemistry, Applied
Samrat Dev, Souvik Pandey, Suvendu Maity, Debarpan Mitra, Gaurav Das, Nabendu Murmu, Chittaranjan Sinha
Summary: A phenylazo appended ortho-vanillin Schiff base scaffold (HAZ) has been utilized as a colorimetric sensor for selective detection of Cu2+ in semi-aqueous medium. The structure of HAZ and Cu (II) complex [Cu(AZ)(2)] is characterized using spectroscopic data and X-ray diffraction measurement. Additionally, the probe is tested for cytotoxicity on MDA-MB 231 breast cancer cells.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Channakeshava Sokke Umeshappa, Patricia Sole, Jun Yamanouchi, Saswat Mohapatra, Bas G. J. Surewaard, Josep Garnica, Santiswarup Singha, Debajyoti Mondal, Elena Cortes-Vicente, Charlotte D'Mello, Andrew Mason, Paul Kubes, Pau Serra, Yang Yang, Pere Santamaria
Summary: Invariant natural killer T (iNKT) cells in the liver exhibit plasticity and can differentiate into regulatory B cells to suppress liver and pancreas autoimmunity upon systemic treatment with lipid nanoparticles.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Mukul Bikash Maity, Debojit Talukdar, Basudeb Dutta, Gurupada Bairy, Nabendu Murmu, Gaurav Das, Chittaranjan Sinha
Summary: Strategic design of a Rhodamine-based chemosensor probe allowed for the highly sensitive recognition of ions/molecules at low concentrations, with implications for health and sustainability. The probe exhibited a significant increase in fluorescent intensity in the presence of Analytical Group IIIA ions, and was effective for cell imaging and inhibiting breast cancer cell proliferation.
INORGANICA CHIMICA ACTA
(2023)
Article
Biochemistry & Molecular Biology
Prabir Kumar Gharai, Juhee Khan, Rathnam Mallesh, Shubham Garg, Abhijit Saha, Subhajit Ghosh, Surajit Ghosh
Summary: The designed molecule VBD can transform into a fluorescent probe VBD-1, which has a high affinity for binding with Afi fibrillary aggregates. It can reduce the production of harmful hydrogen peroxide in AD brain cells.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Tanaya Chatterjee, Gaurav Das, Barun K. Chatterjee, Surajit Ghosh, Pinak Chakrabarti
Summary: The oligomeric form of amyloid-beta peptide (A beta 42) is crucial in Alzheimer's disease pathogenesis and cognitive deficits. It is believed that soluble oligomers are more toxic than fibrils. Protein-L-isoaspartyl methyltransferase (PIMT) repairs aberrant isoAsp residues and inhibits A beta 42 fibrillization. PIMT affects the conformation, size, and toxicity of A beta 42 oligomers, and has a neuroprotective role against A beta O-induced toxicity.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Nanoscience & Nanotechnology
Rousunara Khatun, Ritwik Modak, Abu Saleh Musha Islam, Dolan Moni, Nayim Sepay, Rimi Mukherjee, Gaurav Das, Nabendu Murmu, Mahammad Ali
Summary: A manganese(III) complex, [Mn-III(L)(SCN)(enH)](NO3)& BULL;H2O, was synthesized and characterized. The interaction of the complex with DNA was studied, and the binding constant of the complex with ct-DNA was determined. Competitive displacement reactions of dyes from dye-ct-DNA conjugates by the complex were analyzed. The complex showed anticancer potential in breast cancer cells through a minor groove binding interaction with ct-DNA.
ACS APPLIED BIO MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Mallayasamy Siva, Kiran Das, Subhabrata Guha, Subramaniyam Sivagnanam, Gaurav Das, Abhijit Saha, Adele Stewart, Biswanath Maity, Priyadip Das
Summary: In this study, we designed and synthesized two phenanthro[9,10-d]imidazole-based ligands and their corresponding zinc complexes. These complexes were encapsulated in liposomes for cellular uptake and showed potential for breast cancer treatment through inducing DNA fragmentation, arresting the cell cycle, decreasing proliferation, and promoting apoptosis. The study demonstrates the promise of liposomal formation for developing imaging probes and efficient anticancer drugs.
ACS APPLIED BIO MATERIALS
(2023)
Article
Plant Sciences
Michel-Gael F. Guefack, Debojit Talukdar, Rimi Mukherjee, Subhabrata Guha, Debarpan Mitra, Depanwita Saha, Gaurav Das, Francois Damen, Victor Kuete, Nabendu Murmu
Summary: Hypericum roeperianum, a traditional medicinal spice, has been found to possess anticancer properties. It inhibits breast cancer progression by regulating mitochondrial apoptosis and epithelial-mesenchymal transition (EMT). The crude extract induces apoptosis and inhibits cell migration by affecting multiple molecular markers. Additionally, it modulates the PI3K/Akt/mToR signaling pathway to suppress EMT. The in vitro and in vivo experiments support the potential use of Hypericum roeperianum in breast cancer therapy.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Chemistry, Medicinal
Anindyasundar Adak, Gaurav Das, Varsha Gupta, Juhee Khan, Nabanita Mukherjee, Prasenjit Mondal, Rajsekhar Roy, Surajit Barman, Prabir Kumar Gharai, Surajit Ghosh
Summary: Protein-protein interactions are crucial in microtubule dynamics and cancer therapeutics. The study found that para-fluorophenylalanine-modified stapled peptides are the most potent inhibitors of microtubule polymerization, with potential for inhibiting melanoma growth.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Guy Mechrez, Karthik Ananth Mani, Abhijit Saha, Oded Lachman, Neta Luria, Ori Molad, Liliya Kotliarevski, Einat Zelinger, Elisheva Smith, Noga Yaakov, Dalia Shabashov Stone, Meital Reches, Aviv Dombrovsky
Summary: This study developed a two-mode platform for enhancing epitope presentation of subunit vaccines and demonstrated its efficacy. The platform allowed stable attachment of SARS-CoV-2-S1 peptide epitopes to the surface of virus-like particles (VLPs) and subsequent administration through emulsions.
ACS APPLIED BIO MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Guy Mechrez, Karthik Ananth Mani, Abhijit Saha, Oded Lachman, Neta Luria, Ori Molad, Liliya Kotliarevski, Einat Zelinger, Elisheva Smith, Noga Yaakov, Dalia Shabashov Stone, Meital Reches, Aviv Dombrovsky
Summary: An efficient platform for enhancing the presentation of subunit vaccine epitopes has been developed, which involves attaching high concentrations of SARS-CoV-2-S1 peptide epitope to virus-like particles and assembling them on the surface of oil droplets in an emulsion. This synthetic approach significantly improves the efficacy of the vaccine.
ACS APPLIED BIO MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Prasenjit Mondal, Saswat Mohapatra, Debmalya Bhunia, Prabir Kumar Gharai, Nabanita Mukherjee, Varsha Gupta, Satyajit Ghosh, Surajit Ghosh
Summary: Cell proliferation is a crucial step that may lead to cancer if not properly regulated, with p16 protein often remaining inactive in cancer cells. Researchers have focused on restoring the activity of p16 protein using new viral vectors, small molecules, and peptides to control abnormal cell proliferation. By conjugating a nuclear-localized signal (NLS) sequence and a short peptide (AVPI), the efficiency of p16 peptide as an anti-leukemia therapeutic agent has been significantly enhanced.
RSC MEDICINAL CHEMISTRY
(2022)