Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 81, Issue 5, Pages 3314-3329Publisher
WILEY
DOI: 10.1002/mrm.27613
Keywords
Diffusion-compartment imaging; diffusion-weighted mri; image-based navigation; intra-volume motion; motion-robust; motion tracking; simultaneous multi-slice; slice registration Correspondence
Funding
- McKnight Foundation through a Technological Innovations in Neuroscience Award
- Intel IPCC
- National Institutes of Health (NIH) [R01 EB018988, R01 EB019483, R01 NS079788, U01 NS082320, U54 NS092090]
- NCATS
- NIMH
- NINDS
- NICHD
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Purpose: To achieve motion-robust diffusion compartment imaging (DCI) in near continuously moving subjects based on simultaneous multi-slice, diffusion-weighted brain MRI. Methods: Simultaneous multi-slice (SMS) acquisition enables fast and dense sampling of k- and q-space. We propose to achieve motion-robust DCI via slice-level motion correction by exploiting the rigid coupling between simultaneously acquired slices. This coupling provides 3D coverage of the anatomy that substantially constraints the slice-to-volume alignment problem. This is incorporated into an explicit model of motion dynamics that handles continuous and large subject motion in robust DCI reconstruction. Results: We applied the proposed technique, called Motion Tracking based on Simultanous Multislicc Registration (MT-SMR) to multi b-value SMS diffusion-weighted brain MRI of healthy volunteers and motion-corrupted scans of 20 pediatric subjects. Quantitative and qualitative evaluation based on fractional anisotropy in unidirectional fiber regions, and DCI in crossing-fiber regions show robust reconstruction in the presence of motion. Conclusion: The proposed approach has the potential to extend routine use of SMS DCI in very challenging populations, such as young children, newborns, and non-cooperative patients.
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