Article
Polymer Science
Jiahua Zhou, Dongjian Shi, Tatsuo Kaneko, Weifu Dong, Mingqing Chen
Summary: A novel thermoresponsive system based on electrostatic interactions is reported, which achieves reversible thermoresponsive behavior without any volume change by loading aluminum chloride (AlCl3) into poly(2-hydroxyethyl acrylate) (PHEA) hydrogels. The thermoresponsive hydrogel demonstrates high transparency and excellent luminous modulation capability.
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
Article
Polymer Science
Aleksey D. Drozdov, Jesper deClaville Christiansen
Summary: Thermoresponsive gels of the UCST type shrink below their critical temperature and swell above it, driven by thermally induced dissociation of hydrogen or ionic bonds between chains. A simple model developed for describing the equilibrium swelling of these gels can be applied to various structures and compositions of thermoresponsive gels.
POLYMER INTERNATIONAL
(2022)
Article
Materials Science, Multidisciplinary
Nikola Majstorovic, Jens Pechtold, Seema Agarwal
Summary: Functional thermoresponsive copolymers were synthesized and used to form water-soluble biohybrid nanogels through a reaction with an enzyme. The size of the nanogels increased with temperature, leading to an increase in enzyme activity. These reactive copolymer nanogels can be used to modulate enzyme activity and serve as initiation sites for further polymerization reactions.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Polymer Science
Jianlei Lu, Mengdi Xu, Yi Lei, Lihao Gong, Chuanzhuang Zhao
Summary: The authors reported a novel aqueous copolymerization strategy to prepare polymers with tunable upper critical solution temperature (UCST) or lower critical solution temperature (LCST) from non-responsive monomers. By simply replacing a monomer, the thermo-responsiveness of the copolymers can be converted from UCST-type to LCST-type. The cloud points of the copolymers can be rationally tuned with their monomer ratios and the condition of the solvent.
MACROMOLECULAR RAPID COMMUNICATIONS
(2021)
Article
Polymer Science
Elaine Halligan, Shuo Zhuo, Declan Mary Colbert, Mohamad Alsaadi, Billy Shu Hieng Tie, Gilberto S. N. Bezerra, Gavin Keane, Luke M. Geever
Summary: Four-dimensional (4D) printing is a form of 3D printing technology that utilizes additional stimulus and stimulus-responsive materials, such as temperature-sensitive polymers like poly-N-vinylcaprolactam. This study aims to alter the phase transition temperature of poly-N-vinylcaprolactam hydrogels by incorporating two additional monomers, vinylacetate and N-vinylpyrrolidone, through photopolymerization. The findings show that the inclusion of N-vinylpyrrolidone increases the lower critical solution temperature above the physiological range, while the incorporation of vinylacetate decreases it to allow for self-assembly of 4D-printed objects at room temperature.
Article
Chemistry, Applied
E. Suljovrujic, M. Krstic, Z. Rogic Miladinovic, S. Petrovic, A. Leskovac, G. Stamboliev
Summary: Hydrogels with OEG, OPG, and combined OEG/OPG pendant chains were synthesized and their properties were investigated. An optimized method for OPGMA synthesis was developed. PEG6MA, PPG5MA, and P(EG6/PG5)MA hydrogels were produced using gamma radiation-induced polymerization. The combination of OEG and OPG allowed easy tuning of the phase transition temperature, making it suitable for biomedical applications.
REACTIVE & FUNCTIONAL POLYMERS
(2023)
Article
Chemistry, Applied
Yong Ho Yeo, Kiramage Chathuranga, Jong Soo Lee, Jaseung Koo, Won Ho Park
Summary: Multifunctional and thermoresponsive hydrogels containing methylcellulose, tannic acid, and Fe3+ were prepared in this study with reversible thermogelation properties. The gelation rates and mechanical properties of the MC composite hydrogel were controlled by varying its TA and Fe3+ contents. The hydrogel with a TA-Fe chelating complex showed excellent photothermal effect and multifunctional properties.
CARBOHYDRATE POLYMERS
(2022)
Article
Polymer Science
Bagus Santoso, Paul R. Turner, Lyall R. Hanton, Stephen C. Moratti
Summary: A series of star and linear polymers based on a poly(ethylene oxide) core and poly(diethylene glycol ethyl ether acrylate) outer arms were synthesised by atom-transfer radical polymerization. These polymers exhibited low polydispersity and LCST behavior, with gelation occurring at different temperatures depending on the concentration.
Review
Engineering, Environmental
Mengqi Le, Wen Huang, Kai-Feng Chen, Caihong Lin, Lili Cai, Huatang Zhang, Yong-Guang Jia
Summary: Stimuli-responsive polymers are widely used as drug carriers in therapeutic applications. Upper critical solution temperature (UCST) polymeric carriers undergo a phase transition from hydrophobic to hydrophilic under the stimuli of temperature, near-infrared light, microwave, etc., thereby achieving a much more complete drug release. UCST polymeric carriers have recently emerged great potentials for controlled drug release, such as UCST polymeric micelles and hydrogels for cancer treatments and UCST polymeric surfaces for wound treatments, etc.. In this review, we mainly focus on UCST polymeric drug carriers based on different forms in recent five years.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Polymer Science
Guillaume Beaudoin, Anne Lasri, Chuanzhuang Zhao, Benoit Liberelle, Gregory De Crescenzo, Xiao-Xia Zhu
Summary: Homopolymers of acrylamide and acrylic acid are hydrophilic and soluble in water, while their copolymers can exhibit an upper critical solution temperature (UCST) behavior under acidic conditions. The thermoresponsive properties of the copolymers are influenced by their composition, molar mass, and concentration, as well as pH, salts, or urea additives.
Article
Polymer Science
Shohei Ida, Tenki Hikida, Atsumi Kawai, Tomonari Matsuda, Souma Suzuki, Hiroaki Imoto, Kensuke Naka, Shokyoku Kanaoka
Summary: Controlling the reversibility of property changes in stimuli-responsive polymer hydrogels is crucial for achieving sophisticated functions similar to those observed in natural soft tissues. By incorporating a highly hydrophobic component into a thermoresponsive hydrogel, we induced internal structural fixation through hydrophobic aggregation. The use of a polyhedral oligomeric silsesquioxane (POSS) compound as a crosslinker resulted in reproducible POSS-crosslinked PNIPAAm gels with reversible swelling/deswelling behavior. The gels exhibited irreversible turbidity changes due to the aggregation of the POSS moieties, leading to changes in mechanical properties.
Article
Chemistry, Multidisciplinary
Binoy Maiti, Mridula Nandi, Sebastian Bonardd, Lourdes Franco, Jordi Puiggali, Hamidreza Enshaei, Carlos Aleman, David Diaz Diaz
Summary: A series of thermoresponsive polyurethanes were synthesized through copolymerization of dicyclohexyl diisocyanate with glycerol ethoxylate in a single one-pot system, exhibiting an LCST of 57 degrees C. The ratio between hard and soft segments could tune the T-g values of the synthesized polyurethanes. An increase in soft segment content led to higher swelling ratios in the synthesized polyurethanes.
Article
Chemistry, Multidisciplinary
Kai-Feng Chen, Yiqing Zhang, Jiawei Lin, Jun-You Chen, Caihong Lin, Meng Gao, Yunhua Chen, Sa Liu, Lin Wang, Zhong-Kai Cui, Yong-Guang Jia
Summary: In this study, a method based on reversible addition and fragmentation chain transfer polymerization was described, which allows for the visualization of bacteria aggregation and control of bacteria-polyvalent scaffolds affinities under temperature stimulus through the decoration of aggregation-induced emission (AIE) molecules. The polyvalent scaffolds, composed of UCST block PATC and hydrophilic glucosamine modified polyacrylamide block GlcN, were found to induce the aggregation of E. coli ATCC8739 below UCST temperature, while beyond UCST temperature, the hydrophilic state of the scaffolds dissociated the bacteria aggregation. The specific recognition of the polyvalent scaffolds with bacteria enabled the targeted killing of E. coli ATCC8739 using the photothermal agent IR780 loaded PATC-GlcN under NIR radiation.
Article
Chemistry, Applied
Sarah Otto, Paula Facal Marina, Fiona Zhou, Anton Blencowe
Summary: This study successfully converted non-responsive polysaccharides into thermoresponsive polysaccharides with tuneable lower-critical solution temperatures (LCSTs) by functionalising dextran with alkylamide groups. The newly developed alkylamide-functionalised dextrans exhibited good solubility and tunable LCSTs, showing potential for biomedical applications such as drug-delivery.
CARBOHYDRATE POLYMERS
(2021)
Article
Polymer Science
Shuo Zhuo, Elaine Halligan, Billy Shu Hieng Tie, Colette Breheny, Luke M. Geever
Summary: This study explores the use of photopolymerisation process to simulate 4D printing process using poly (N-vinyl caprolactam) (PNVCL) hydrogels. The thermal behaviors of the novel photopolymerised NVCL-based hydrogels were analyzed. The results indicate that the phase transition temperature of the hydrogels can be controlled and the swelling and deswelling behavior depend on temperature and monomer feed ratio.
Article
Polymer Science
Feng Luo, Tao Lin Sun, Tasuku Nakajima, Daniel R. King, Takayuki Kurokawa, Yu Zhao, Abu Bin Ihsan, Xufeng Li, Honglei Guo, Jian Ping Gong
Article
Polymer Science
Feng Luo, Tao Lin Sun, Tasuku Nakajima, Takayuki Kurokawa, Xufeng Li, Honglei Guo, Yiwan Huang, Huijie Zhang, Jian Ping Gong
Article
Materials Science, Biomaterials
Yushui He, Xiao Wang, Yuanyuan He, Xin Zhao, Jingjing Lin, Yuan Feng, Jie Chen, Feng Luo, Zhen Li, Jiehua Li, Hong Tan
Summary: The bioinspired degradable polyurethane membrane with Janus surface morphology, integrating bioactive dopamine and an antibacterial Gemini quaternary ammonium salt, promotes periodontal tissue regeneration effectively by reducing cell adhesion and promoting bone tissue reconstruction, showing excellent antibacterial effect and antioxidant efficiency in in vivo research.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Polymer Science
Lin Tang, Shuren Shao, Ao Wang, Chenxu Tian, Feng Luo, Jiehua Li, Zhen Li, Hong Tan, Hengyu Zhang
Summary: By introducing a diol with fluorocarbon side chain as a second chain extender, the phase structure and chemical resistance of silicon-containing polycarbonate urethanes (SiPCUs) can be regulated. The fluorinated silicon-containing polyurethanes (FSiPCUs) exhibit stronger hydrogen bonding between carbonate and urethane groups, promoting miscibility between hard and soft segments and protecting carbonate groups from chain scission.
Article
Nanoscience & Nanotechnology
Juan -Juan Hu, Min Wang, Xiong-Xin Lei, Yan-Lin Jiang, Lei Yuan, Zhong-Jing Pan, Dan Lu, Feng Luo, Jie-Hua Li, Hong Tan
Summary: The study investigates the potential of using a hybrid hydrogel for treating vocal fold scarring. The hybrid hydrogel demonstrates excellent injectability and self-healing ability, promoting tissue regeneration and reducing inflammation. The treated vocal folds show vibration characteristics similar to normal vocal folds, achieving functional restoration.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Polymer Science
Hecheng Wu, Tianchen Dai, Wang Ao, Shuren Shao, Zhen Li, Feng Luo, Jiehua Li, Daiguo Zhao, Wanling Lan, Hengyu Zhang, Hong Tan
Summary: This study focuses on modifying the polarity of SiPEUs by using chain extenders with different dangling side chains, in order to improve their mechanical properties and stability in long-term implantation. The results show that the modified SiPEUs exhibit optimal interfacial miscibility, resulting in improved oxidative stability without sacrificing mechanical properties. This research provides valuable insights for developing biomedical materials with enhanced performance and stability.
Article
Polymer Science
Xueyu Li, Feng Luo, Tao Lin Sun, Kunpeng Cui, Reina Watanabe, Tasuku Nakajima, Jian Ping Gong
Summary: Understanding the mechanical behaviors of tough hydrogels with dynamic bonds in saline solution is crucial for applications, especially in the biomedical field.
Article
Materials Science, Biomaterials
Yangcen Ou, Xiaofei Wang, Nan He, Xiao Wang, Dan Lu, Zhen Li, Feng Luo, Jiehua Li, Hong Tan
Summary: The use of fluorescence imaging in tumor detection and resection assistance has become increasingly popular. This study introduces tetraphenyl ethylene (TPE) and phenylboronic acid (PBA) into polyurethane to synthesize a PU-TPE-PBA (PTP) fluorescent emulsion with aggregation-induced emission (AIE) for targeted tumor imaging. The PTP emulsion, with a size of less than 50 nm, shows excellent stability and high fluorescence sensitivity. The PTP nanoparticles can be enriched in tumors and retained for longer periods due to their ability to selectively recognize and bind to sialic acid (SA), which is overexpressed in tumor cells.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Nanoscience & Nanotechnology
Nan He, Ao Wang, Chenxu Tian, Yuanqing Song, Xiaolei Guo, Hao Ming, Mingming Ding, Feng Luo, Hong Tan, Jiehua Li
Summary: The study investigates the relationship between the spatial distributions of cationic groups and the endocytosis and tumor penetration of nanocarriers using quaternary ammonium salt (QAS) as a model. The results show that drug carriers with QAS extending to the micellar outer space can greatly enhance endocytosis compared to nanocarriers with QAS attached onto the micellar surface or shielded by a PEG corona. This study provides insights for the future development of tumor-penetrating drug delivery systems.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Materials Science, Biomaterials
Xiao Wang, Yangcen Ou, Xiaofei Wang, Lei Yuan, Nan He, Zhen Li, Feng Luo, Jiehua Li, Hong Tan
Summary: We designed a fluorescent polyurethane-oxidized dextran hydrogel with good injectability and self-healing properties. The hydrogel can be used as a visual platform for drug delivery and monitoring its own degradation. The network structure and acylhydrazone bond of the hydrogel enable drug loading and pH-responsive drug release.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Nanoscience & Nanotechnology
Min Wang, Juanjuan Hu, Yangcen Ou, Xueling He, Yanjun Wang, Chenyu Zou, Yanlin Jiang, Feng Luo, Dan Lu, Zhen Li, Jiehua Li, Hong Tan
Summary: There is an urgent need for wound dressings that can promote quick hemostasis and efficient wound healing in response to increasing clinical demands. This study presents a versatile method for constructing biodegradable hybrid cryogels that can rapidly stop bleeding. The cryogel's specific macroporous structure allows for stable fixation and quick swelling, making it ideal for minimally invasive surgery. Furthermore, the cryogel exhibits excellent biocompatibility and activates the endogenous coagulation system, leading to fast blood coagulation. In in vivo evaluations, the cryogel demonstrated great potential in promoting wound healing, reducing immune inflammation, and inducing angiogenesis and hair follicle regeneration. These findings highlight the high-performance capabilities of the cryogel as a wound dressing.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Materials Science, Biomaterials
Lin Tang, Xirui Long, Xueling He, Mingming Ding, Daiguo Zhao, Feng Luo, Jiehua Li, Zhen Li, Hong Tan, Hengyu Zhang
Summary: A fluorinated silicon-containing polyurethane (FSiPEU) with desirable surface properties and mechanical performance was developed in this study, demonstrating minimized inflammatory response and surface degradation after 6 months of implantation in mice, suggesting its potential as a promising candidate for long-term implantation.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Materials Science, Biomaterials
Yue Chen, Xirui Long, Weiwei Lin, Bohong Du, Hang Yin, Wanling Lan, Daiguo Zhao, Zhen Li, Jiehua Li, Feng Luo, Hong Tan
Summary: The hybrid cobalt-doped alginate/waterborne polyurethane 3D porous scaffold prepared in this study, with a nano-topology resembling a coral reef-like surface, showed promising potential for promoting neurite outgrowth and up-regulating synaptophysin expression of neuron-like cells PC12. Additionally, the scaffold could relieve inflammatory response of microglial cells BV2 and induce a transformation from pro-inflammatory to anti-inflammatory phenotype, suggesting its application in nerve repair and bright design inspiration for neural tissue engineering scaffolds.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Materials Science, Biomaterials
Yuanyuan He, Xinyuan Wan, Weiwei Lin, Jiehua Li, Zhen Li, Feng Luo, Jianshu Li, Hong Tan, Qiang Fu
BIOMATERIALS SCIENCE
(2020)
