Article
Engineering, Biomedical
Jinbin Qiu, Guorui Jin, Guoyou Huang, Haishui Huang, Feng Xu
Summary: In this study, an in vitro astrocyte culture system capable of precisely controlling culture temperature was developed to investigate the effects of clinically-relevant hyperthermic temperatures on astrocyte viability, morphology, and functions. It was found that high hyperthermia caused irreversible and permanent damages to astrocytes, while mild hyperthermia induced astrocyte activation and cytokine secretion without significant decreases in cell viability. This study provides new insights into fever-related symptoms and opens up possibilities for astrocyte-targeted therapy to treat brain diseases via hyperthermia.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Donghyuk Kim, Sukkyung Kang, Hyunjung Kim
Summary: Skin cancer incidence is on the rise due to increased UV exposure, prompting the exploration of photothermal therapy as a more effective treatment option. This study utilizes numerical analysis to determine the optimal conditions for photothermal therapy, aiming to minimize thermal damage to surrounding tissues while maximizing tumor cell apoptosis.
APPLIED SCIENCES-BASEL
(2021)
Article
Geosciences, Multidisciplinary
Miki Hondzo, Jiaqi You, Jackie Taylor, Garret Bartlet, Vaughan R. Voller
Summary: This study measured water temperature microprofiles at the air-water interface of a stratified lake under moderate wind speeds. The measurements revealed the cool skin effect and occurrence of natural convection. Proposed parameterization methods allow for estimation of diffusive thermal sublayer thickness and skin-to-bulk temperature difference, facilitating the validation and integration of satellite-derived lake surface temperatures.
GEOPHYSICAL RESEARCH LETTERS
(2022)
Article
Biology
James C. Short, Marc T. Freeman, Andrew E. McKechnie
Summary: The relationship between air temperature and avian physiology can be studied using respirometry, and both the stepped and steady-state protocols are suitable for quantifying avian thermal physiology during heat exposure. However, the stepped protocol has ethical and practical advantages.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Silvia Franze, Liliana Angelo, Antonella Casiraghi, Paola Minghetti, Francesco Cilurzo
Summary: The administration of drug fixed combinations by nanocarriers is an attractive approach to enhance the skin penetration and synergistic effects of drugs. This study investigated the use of deformable liposomes to deliver the combination of lidocaine and cannabidiol in the deeper layers of the skin. Results showed that the DiMiL formulation had higher skin permeation and dermal retention compared to the G-liposomes formulation, and both were more effective than control formulations carrying free drugs.
Article
Anesthesiology
Reiko Horishita, Yuichi Ogata, Ryo Fukui, Ryo Yamazaki, Kuniaki Moriwaki, Susumu Ueno, Nobuyuki Yanagihara, Yasuhito Uezono, Yuka Yokoyama, Kouichiro Minami, Takafumi Horishita
Summary: This study investigated the effects of local anesthetics on the 2-aminoethoxydiphenyl borate (2APB)-induced currents of the TRPV3 channel expressed in Xenopus oocytes. The results showed that clinically used local anesthetics inhibited the 2APB-activated currents from the TRPV3 channel in a concentration-dependent manner at pharmacologically relevant concentrations, possibly through extracellular interactions with the channel pore.
ANESTHESIA AND ANALGESIA
(2021)
Article
Dermatology
Johannes Wohlrab, Tim Mentel, Adina Eichner
Summary: This study demonstrates that the investigated medical device can safely and effectively activate heat-sensitive receptors in the skin to alleviate itch sensation. Clinical studies are needed to confirm its therapeutic efficacy in treating pruritus.
SKIN RESEARCH AND TECHNOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Megan L. Sullivan, Gene Wijffels, A. George, Yousef A. Al-Hosni, Joseph C. W. Olm, John B. Gaughan
Summary: This study conducted experiments in climate-controlled rooms and found that feedlot steers are physiologically capable of dealing with moderate heatwave conditions. The research is of great significance for managing feedlot animals after heatwaves.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Veterinary Sciences
Elisabeth-Lidwien J. M. M. Verdegaal, Gordon S. Howarth, Todd J. McWhorter, Catherine J. G. Delesalle
Summary: The study aimed to investigate the suitability of monitoring surface skin temperature (T-sk) as a metric of the thermoregulatory response in exercising horses. The results showed that there was no relationship between T-sk and core temperature (T-c) during exercise and recovery periods, and T-sk monitoring did not provide a reliable proxy for the thermoregulatory response and horse welfare.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Engineering, Biomedical
Rosa Orlacchio, Denys Nikolayev, Yann Le Page, Yves Le Drean, Maxim Zhadobov
Summary: This study assessed the cellular sensitivity of A375 melanoma cells to continuous millimeter-wave (MMW) induced heating and observed the cellular stress through the phosphorylation of heat shock protein 27 (HSP27). The results showed that phosphorylation of HSP27 is a valuable marker for cellular stress in A375 melanoma cells under MMW exposure, providing quantitative and spatial information about the distribution of thermal stress.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Article
Oncology
Agata Diakun, Tanja Khosrawipour, Agata Mikolajczyk-Martinez, Jakub Nicpon, Simon Thelen, Zdzislaw Kielbowicz, Przemyslaw Przadka, Bartlomiej Liszka, Joanna Kulas, Kacper Zielinski, Shiri Li, Hien Lau, Wojciech Kielan, Veria Khosrawipour
Summary: This study provides in-vivo data on the feasibility, safety, and efficacy of gas-based intraperitoneal hyperthermia beyond 43 degrees Celsius. The results show that gas-based hyperthermia between 48-50 degrees Celsius is safe without critical systemic temperature increase. Further studies are needed to evaluate its potential as a therapeutic option for peritoneal metastasis patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Alastair Carruthers, Jean Carruthers, Koenraad De Boulle, Nicholas Lowe, Elisabeth Lee, Mitchell F. Brin
Summary: Extrinsic and age-related intrinsic factors contribute to facial lines, including crow's feet lines (CFL) and forehead lines (FHL). OnabotulinumtoxinA is an effective treatment for facial lines, inhibiting acetylcholine release and reducing wrinkles. Clinical trials have demonstrated the efficacy and safety of onabotulinumtoxinA for CFL and FHL, meeting regulatory requirements globally. Adverse events are rare and well tolerated. OnabotulinumtoxinA treatment is now established as a minimally invasive and highly effective method for achieving a natural and youthful appearance.
Article
Chemistry, Physical
Fei Gao, Tingbin Zhang, Yuqing Miao, Huijun Ma, Hui Guo, Ruyi Jin, Zhi Li, Haifang Wang, Haiming Fan, Lingyun Zhao
Summary: A novel nanostructure, combining mild hyperthermia and chemotherapy, was designed to improve the efficacy of cancer treatment. Through exquisite microstructure design and physiochemical properties of the nanoplatform, the cancer therapeutic effect was significantly improved with minimal side effects.
Article
Thermodynamics
Aibing Zhang, Guangyong Li, Baolin Wang, Ji Wang, Jianke Du
Summary: This paper develops a biothermomechanical model of skin for hyperthermia treatment of cancer based on the non-Fourier bioheat transfer theory. The model considers skin as a three-layer tissue with homogeneous and linear thermoelasticity. Analytical solutions of temperature profile and stress distribution are derived considering different factors. Numerical results show the significant influence of blood perfusion and sweating on temperature, thermal damage, and stress. The findings provide insights into skin biothermomechanics and can guide the design of biomedical devices for hyperthermia treatment.
INTERNATIONAL COMMUNICATIONS IN HEAT AND MASS TRANSFER
(2023)
Review
Veterinary Sciences
Carla Marti Castello, Mara Tais de Carvalho, Andris Figueiroa Bakuzis, Simone Goncalves Fonseca, Marina Pacheco Miguel
Summary: Distinct thermal therapies like hyperthermia (HT) and ablation (AB) have shown significant cytotoxicity and immune response stimulation in cancer treatment. Nanotechnology-based thermal therapies and utilizing dogs with spontaneous tumors as models for cancer immunotherapies are of great interest.
VETERINARY AND COMPARATIVE ONCOLOGY
(2022)