Article
Biochemistry & Molecular Biology
Tao Fan, Shuofeng Li, Chu Xiao, He Tian, Yujia Zheng, Yu Liu, Chunxiang Li, Jie He
Summary: CCL20 plays a role in promoting lung adenocarcinoma progression, with high expression associated with poor prognosis and activation of EMT, inflammatory response, and TNF pathway. Knockdown of CCL20 inhibits EMT process and cell proliferation in lung adenocarcinoma. Low CCL20 expression improves response to anti-PD-L1 therapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Oncology
Chen Fang, Yingkuan Liang, Yong Huang, Dong Jiang, Jiaxi Li, Haitao Ma, Lingchuan Guo, Wei Jiang, Yu Feng
Summary: This study found that the P3H4 gene plays a role in promoting the metastasis and proliferation of LUAD, and its expression is positively correlated with TNM stage and survival time in LUAD. The study suggests that P3H4 may regulate metabolic substances through interaction with EGFR. This research is of great significance for further understanding the diagnostic and therapeutic role of LUAD.
Article
Oncology
Kaiyi Tao, JinShi Liu, JinXiao Liang, XiaoFang Xu, LiWei Xu, WeiMin Mao
Summary: The study investigated the molecular mechanism of lung adenocarcinoma (LUAD) progression and the communication between cancer cells and vascular endothelial cells. The findings demonstrated that miR-30a-5p could be delivered from vascular endothelial cells to LUAD cells via exosomes to inhibit tumor progression.
Article
Biochemistry & Molecular Biology
Shuohua Chen, Yang Tian, Anji Ju, Boya Li, Yan Fu, Yongzhang Luo
Summary: The study found that CCT3 is highly expressed in lung adenocarcinoma cells and is positively correlated with the malignancy of the tumor. Silencing CCT3 was shown to significantly inhibit tumor growth and metastasis in animal studies. CCT3 deficiency also resulted in suppressed proliferation, migration, and promoted apoptosis and cell cycle arrest in LUAD cells. Mechanistically, CCT3 deficiency inhibited glycolysis and reduced total intracellular ATP levels. Knockdown of CCT3 also decreased protein translation and led to a significant reduction in EIF3G protein, which interacts with CCT3. These findings suggest that CCT3 is critical for the growth and metastasis of lung adenocarcinoma and plays a role in maintaining intracellular ATP levels and cytoplasmic translation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Xin Peng, Xiaoli Liu, Wanshan Hu, Yanling Zhou, Lianlian Ouyang, Xintong Peng, Yao Long, Jingyue Sun, Tania Tao, Ling Chen, Ying Shi, Yongguang Tao, Desheng Xiao, Shuang Liu
Summary: In lung adenocarcinoma, overexpression of HOXC11 is associated with worse survival and is regulated by IKK alpha. HOXC11 promotes lung cancer progression by enhancing the expression of SPHK1 through directly binding to its promoter region.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Daniele Tavernari, Elena Battistello, Elie Dheilly, Aaron S. Petruzzella, Marco Mina, Jessica Sordet-Dessimoz, Solange Peters, Thorsten Krueger, David Gfeller, Nicolo Riggi, Elisa Oricchio, Igor Letovanec, Giovanni Ciriello
Summary: This study provides a detailed molecular map of intratumor spatial heterogeneity in lung adenocarcinoma, revealing non-genetic routes of cancer evolution. The transition from indolent to aggressive patterns in tumors is driven by epigenetic and transcriptional reprogramming reshaping cancer cell identity rather than genetic alterations. Highly multiplexed protein spatial profiling shows the coexistence of immune desert, inflamed, and excluded regions within individual tumors, matching histologic pattern composition.
Article
Genetics & Heredity
Ruijie Zhang, Shengjin Li, Jian Lan, Changyi Li, Xianzhi Du, Weijie Dong, Qian Yu, Daoxin Wang
Summary: This study found that low-dose cisplatin can activate the EMT process and promote malignant progression of lung adenocarcinoma cells through upregulating CNTN-1.
FRONTIERS IN GENETICS
(2022)
Article
Respiratory System
Chang Liu, Haifeng Li, Xiaojing Li, Xuejing Zhao, Xia Zhang
Summary: In lung adenocarcinoma (LUAD), the expression of lncRNA MANCR is significantly upregulated and is associated with poor prognosis. Downregulation of MANCR leads to decreased expression of proteins related to invasion, migration, cell cycle, and proliferation, while increasing apoptosis-related proteins. Silencing MANCR inhibits cancer cell functions, halts cell cycle progression, and promotes cell apoptosis in vitro experiments.
BMC PULMONARY MEDICINE
(2021)
Article
Oncology
Zijian Li, Tao Zeng, Chong Zhou, Yan Chen, Wu Yin
Summary: The risk model established in this study is more reliable than others in evaluating the prognosis of LUAD patients, and can more objectively describe the biological processes related to tumors and important molecular mechanisms.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Li Wang, Wangyang Liu, Kailai Liu, Lixia Wang, Xiangzhe Yin, Lin Bo, Haotian Xu, Shihua Lin, Ke Feng, Xinyu Zhou, Lin Lin, Meiting Fei, Caiyu Zhang, Shangwei Ning, Hongying Zhao
Summary: In this study, the researchers conducted a single-cell transcriptome analysis to investigate the dynamic gene regulation and molecular mechanism driving lung adenocarcinoma (LUAD) progression. They identified stage-specific risk genes and constructed a dysregulated network to understand the changes in gene regulation during LUAD progression. Additionally, they identified several genes as prognostic markers in LUAD.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Oncology
Yanting Dong, Tong Qiu, Yunpeng Xuan, Ao Liu, Xiao Sun, Zhangfeng Huang, Wenhao Su, Wenxing Du, Tianxiang Yun, Yang Wo, Alfons Navarro, Wenjie Jiao
Summary: In this study, circFBXW7 was found to inhibit proliferation and migration of LUAD cell lines by controlling the miR-942-5p/BARX2 axis, with its levels correlating with patient survival. This suggests that regulating circFBXW7 could have therapeutic value in treating LUAD patients.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Article
Oncology
Yang Zhou, Weitong Gao, Yu Xu, Jiale Wang, Xueying Wang, Liying Shan, Lijuan Du, Qingyu Sun, Hongyan Li, Fang Liu
Summary: This study established a cell death index (CDI) signature for lung adenocarcinoma (LUAD) using data from the TCGA and GEO databases, and investigated its relationship with patient prognosis, clinical variables, and biomarkers. The CDI signature was found to be a robust prognosis biomarker that can identify patients who may benefit from immunotherapy and improve diagnostic accuracy and patient outcomes.
NPJ PRECISION ONCOLOGY
(2023)
Article
Cell Biology
Nasser K. Altorki, Alain C. Borczuk, Sebron Harrison, Lauren K. Groner, Bhavneet Bhinder, Vivek Mittal, Olivier Elemento, Timothy E. McGraw
Summary: This study investigates the dynamic interaction between the tumor and its tumor microenvironment (TME) during lung cancer progression. Gene alterations in the extracellular matrix and fibroblasts are central in the preinvasive state. T-cell mediated immune suppression is initiated in preinvasive nodules and intensifies through progression to invasive tumors. Reduced T cell infiltration is more commonly associated with preinvasive cancers, while upregulation of immune checkpoints occurs only in invasive nodules. While an effector immune response is present throughout progression, it is effectively thwarted by immune-suppressive elements.
Article
Biochemistry & Molecular Biology
Hua Zhong, Wen Lu, Yong Tang, Clotilde Wiel, Yong Wei, Jian Cao, Gregory Riedlinger, Thales Papagiannakopoulos, Jessie Yanxiang Guo, Martin O. Bergo, Yibin Kang, Shridar Ganesan, Hatim E. Sabaawy, Sharon R. Pine
Summary: The SOX9 transcription factor plays important roles in tissue development and homeostasis, and has been implicated in tumor progression. However, its role in lung adenocarcinoma (LUAD) is not well understood. In this study, researchers used genetic knockout approaches in a mouse model of LUAD and found that loss of Sox9 significantly reduces lung tumor development and progression. They also demonstrated that SOX9 suppresses immune cell infiltration and function, which contributes to the inhibition of anti-tumor immunity. These findings suggest that SOX9 drives lung tumor progression by modulating the tumor microenvironment.
Article
Cell Biology
Wei Jiang, Yaozhou He, Zijian Ma, Yu Zhang, Chengpeng Zhang, Nianpeng Zheng, Xing Tang
Summary: circ_0008234 in LUAC inhibits disease progression through a competitive endogenous RNA mechanism, potentially serving as a biomarker and therapeutic target for LUAC treatment.
CELL DEATH DISCOVERY
(2021)
Article
Pathology
Tomoki Nakagawa, YunJung Kim, Junko Kano, Yoshihiko Murata, Zeinab Kosibaty, Masayuki Noguchi, Noriaki Sakamoto
Summary: The study found that high expression of RasGRF2 and pECT2 in lung adenocarcinomas is closely associated with poor prognosis, and patients with high expression of both have a much worse outcome than those negative for both.
PATHOLOGY INTERNATIONAL
(2021)
Article
Medicine, Research & Experimental
Marijn A. Scheijde-Vermeulen, Lennart A. Kester, Liset Westera, Bastiaan B. J. Tops, Friederike A. G. Meyer-Wentrup
Summary: This study aimed to evaluate the feasibility of integrating state-of-the-art sequencing techniques and flow cytometry into the diagnostic workup of pediatric lymphoma. The results showed that this integration is not only feasible but also provides additional diagnostic information.
LABORATORY INVESTIGATION
(2024)
Article
Medicine, Research & Experimental
Enrico Berrino, Sara Erika Bellomo, Anita Chesta, Paolo Detillo, Alberto Bragoni, Amedeo Gagliardi, Alessio Naccarati, Matteo Cereda, Gianluca Witel, Anna Sapino, Benedetta Bussolati, Gianni Bussolati, Caterina Marchi
Summary: Formalin-fixed paraffin-embedded (FFPE) samples are crucial for tissue-based analysis in precision medicine, but the quality of these samples can affect the reliability of sequencing data. The use of acid-deprived fixatives guarantees the highest DNA preservation and sequencing performance, enabling more complex molecular profiling of tissue samples.
LABORATORY INVESTIGATION
(2024)
Article
Medicine, Research & Experimental
Roope A. Kallionpaa, Sirkku Peltonen, Kim My Le, Eija Martikkala, Mira Jaaskelainen, Elnaz Fazeli, Pilvi Riihila, Pekka Haapaniemi, Anne Rokka, Marko Salmi, Ilmo Leivo, Juha Peltonen
Summary: This study investigated the immune microenvironment of cutaneous neurofibromas (cNFs) in patients with neurofibromatosis 1 (NF1). The results showed that cNFs have substantial populations of T cells and macrophages, which may be tumor-specific. T cell populations in cNFs were found to be different from those in the skin, and cNFs exhibited lower expression of proteins related to T cell-mediated immunity compared to the skin.
LABORATORY INVESTIGATION
(2024)