Article
Multidisciplinary Sciences
Beryl Mazel-Sanchez, Justyna Iwaszkiewicz, Joao P. P. Bonifacio, Filo Silva, Chengyue Niu, Shirin Strohmeier, Davide Eletto, Florian Krammer, Gene Tan, Vincent Zoete, Benjamin G. Hale, Mirco Schmolke
Summary: The excessive production of viral glycoproteins during infections can put a significant stress on the host cell's endoplasmic reticulum protein folding machinery. However, viruses have developed mechanisms to optimize this stress for their own replication by balancing folding capacity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biology
Tongtong Zhu, Guangyi Niu, Yuansheng Zhang, Ming Chen, Chuan-Yun Li, Lili Hao, Zhang Zhang
Summary: Viruses rely on hosts for life and reproduction, causing various symptoms and public health threats. RNA editing plays a crucial role in virus replication, protein synthesis, infectivity, and toxicity. Host-mediated RNA editing sites have been identified in different viruses, but there is still a lack of comprehensive understanding of the mechanisms and effects in different virus classes. This study synthesizes current knowledge of host-mediated RNA editing in viruses, presenting diverse editing mechanisms and effects between viruses and hosts.
Article
Chemistry, Medicinal
Yejin Jang, Jinhe Han, Xiaoli Li, Hyunjin Shin, Won-Jea Cho, Meehyein Kim
Summary: Influenza viruses are major pathogens causing respiratory infections in humans. A newly discovered isoquinolone compound showed potential in inhibiting influenza A and B viruses, but exhibited cytotoxic effects. Through chemical optimization, compound 21 was developed with improved antiviral activity and reduced cytotoxicity.
Article
Medicine, Research & Experimental
Won-Kyung Cho, Jin Yeul Ma
Summary: Epimedium koreanum Nakai (EKN) has shown significant inhibitory effects on influenza A virus infection by directly blocking viral attachment and having a virucidal effect. It can potentially be developed as a natural viral inhibitor against influenza virus infection.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Multidisciplinary Sciences
Nisrine Chelkha, Anthony Levasseur, Bernard La Scola, Philippe Colson
Summary: Giant viruses challenge the traditional view of the virosphere with their large size and complex interactions with hosts, exhibiting defense mechanisms against hosts and competing microorganisms. Comparative genomics may aid in identifying genes involved in defense strategies against giant viruses.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Antoine Guillon, Deborah Brea-Diakite, Adeline Cezard, Alan Wacquiez, Thomas Baranek, Jerome Bourgeais, Frederic Picou, Virginie Vasseur, Lea Meyer, Christophe Chevalier, Adrien Auvet, Jose M. Carballido, Lydie Nadal Desbarats, Florent Dingli, Andrei Turtoi, Audrey Le Gouellec, Florence Fauvelle, Amelie Donchet, Thibaut Crepin, Pieter S. Hiemstra, Christophe Paget, Damarys Loew, Olivier Herault, Nadia Naffakh, Ronan Le Goffic, Mustapha Si-Tahar
Summary: Research has shown that influenza virus infection causes significant changes in lung metabolism, leading to the accumulation of succinate in respiratory fluids. Succinate exhibits powerful antiviral activity by inhibiting influenza virus replication and reducing metabolic disruptions and inflammatory responses. Administering succinate intranasally to mice reduces viral loads in the lungs and improves survival rates. The antiviral mechanism involves succinylation of viral nucleoproteins, which alters their interactions with viral RNA.
Article
Microbiology
Paulina Koszalka, Ankita George, Vijaykrishna Dhanasekaran, Aeron C. Hurt, Kanta Subbarao
Summary: Combination therapy with influenza drugs baloxavir and oseltamivir can reduce the selection of viruses with reduced drug susceptibility. In animal models, combination therapy and monotherapy have similar effectiveness in reducing viral titers, but combination therapy can decrease the selection of viruses with reduced susceptibility to baloxavir.
Article
Multidisciplinary Sciences
Beryl Mazel-Sanchez, Chengyue Niu, Nathalia Williams, Michael Bachmann, Helena Choltus, Filo Silva, Veronique Serre-Beinier, Wolfram Karenovics, Justyna Iwaszkiewicz, Vincent Zoete, Laurent Kaiser, Oliver Hartley, Bernhard Wehrle-Haller, Mirco Schmolke
Summary: Using proximity ligation and mass spectrometry, transferrin receptor 1 (TfR1) was identified as a candidate entry protein for influenza A virus (IAV). Genetic and chemical inhibition experiments confirmed TfR1's functional involvement in IAV entry, with recycling being essential for this function. Even without its head, TfR1 promotes IAV particle uptake, confirming its role as a directly acting entry factor.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Biochemistry & Molecular Biology
Gayan Bamunuarachchi, Samuel Pushparaj, Lin Liu
Summary: Influenza virus infection through seasonal epidemics and occasional pandemics has been a major public health concern for decades. Incomplete protection from vaccination and increased antiviral resistance due to frequent mutations of influenza viruses have led to a continuous need for new therapeutic options. The functional significance of host protein and influenza virus interactions has been established, but relatively less is known about the interaction of host noncoding RNAs, including microRNAs and long noncoding RNAs, with influenza viruses.
Article
Engineering, Environmental
Chao Wang, Wenjiao Wu, Zefen Pang, Jiaxin Liu, Jianxiang Qiu, Tiangang Luan, Jiewei Deng, Zhixin Fang
Summary: Microplastics (MPs) are a type of emerging pollutants that pose a potential threat to human health. This study found that polystyrene microplastics (PS) can promote influenza A virus (IAV) infection. The PS can enrich the virus, enter cells through endocytosis, and downregulate the expression of IFITM3. Furthermore, PS can also down-regulate IRF3 and its active form P-IRF3 by inhibiting TBK1 phosphorylation activation, thereby reducing IFN-beta expression and affecting the cellular innate antiviral immune system.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Xue Wang, Yi Liu, Kaiyuan Li, Zhihui Hao
Summary: The SARS-CoV-2 coronavirus has attracted global attention due to its highly pathogenic nature and the resulting health crisis and economic burden. Developing effective anti-coronavirus drugs is challenging due to the virus's high mutation rate and unique exonuclease enzymes. The p53 tumor suppressor molecule represents a potential target for antiviral drugs due to its critical role in cell signaling pathways and stress responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Virology
Chuankuo Zhao, Juan Pu
Summary: Influenza viruses utilize sialic acid receptors to invade host cells, and factors such as sialic acid variants, glycan structural differences, and sulfation/fucosylation affect the specificity of viral host binding. Understanding these factors can contribute to the investigation of cross-species transmission of influenza viruses and the development of antiviral drugs.
Review
Microbiology
Chonghui Xu, Jizheng Chen, Xinwen Chen
Summary: Hepatitis viruses are the primary causative agents of hepatitis and pose a major public health issue globally. The host innate immune system acts as the first line of defense against these viruses. However, hepatitis viruses evade host immune surveillance through various strategies, compromising the innate immune response and creating a favorable environment for viral replication.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Honglei Sun, Fangtao Li, Qingzhi Liu, Jianyong Du, Litao Liu, Haoran Sun, Chong Li, Jiyu Liu, Xin Zhang, Jizhe Yang, Yuhong Duan, Yuhai Bi, Juan Pu, Yipeng Sun, Qi Tong, Yongqiang Wang, Xiangjun Du, Yuelong Shu, Kin-Chow Chang, Jinhua Liu
Summary: The study found that farmed minks are commonly infected with both human and avian influenza viruses. Human influenza viruses may be transmitted from humans to minks, while avian influenza viruses may be transmitted through feed to farmed minks. Therefore, feeding minks with raw poultry by-products should be prohibited to reduce the risk of novel pandemic virus emergence.
EMERGING MICROBES & INFECTIONS
(2021)
Article
Virology
Emi Takashita, Shin Murakami, Yoko Matsuzaki, Seiichiro Fujisaki, Hiroko Morita, Shiho Nagata, Misa Katayama, Katsumi Mizuta, Hidekazu Nishimura, Shinji Watanabe, Taisuke Horimoto, Hideki Hasegawa
Summary: To minimize public health risks, monitoring antiviral susceptibilities of influenza viruses is crucial. This study tested the susceptibility of influenza C and D viruses to RNA polymerase inhibitors and found that all tested viruses were susceptible without any associated amino acid substitutions. The combined use of focus reduction assay and genotypic assay has proven valuable for monitoring antiviral susceptibilities of influenza C and D viruses.
Article
Hematology
Elizabeta A. Rojas, Luis A. Corchete, Cristina De Ramon, Patryk Krzeminski, Dalia Quwaider, Ramon Garcia-Sanz, Joaquin Martinez-Lopez, Albert Oriol, Laura Rosinol, Joan Blade, Juan Jose Lahuerta, Jesus F. San Miguel, Marcos Gonzalez, Maria Victoria Mateos, Jean-Christophe Bourdon, Irena Misiewicz-Krzeminska, Norma C. Gutierrez
Summary: This study demonstrates for the first time the prognostic value of p53 isoforms in multiple myeloma patients, providing new insights into the role of p53 protein dysregulation in multiple myeloma biology.
AMERICAN JOURNAL OF HEMATOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Florence Cote, Guy Boivin, Vilayvong Loungnarath, Annie Ruest, Julie Bestman-Smith, Julie Carbonneau, Marie-Eve Hamelin, Marie-Claude Roy
Summary: This study describes 10 COVID-19 patients with severe symptoms who were treated with tocilizumab and dexamethasone. The duration of isolation, which exceeded 21 days for 7 patients, was correlated with the Ct values of nucleic acid amplification tests, clinical condition, and viral culture results.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Infectious Diseases
Etienne Racine, Guy Boivin, Yves Longtin, Deirdre McCormack, Helene Decaluwe, Patrice Savard, Matthew P. Cheng, Marie-Eve Hamelin, Julie Carbonneau, Fazia Tadount, Kelsey Adams, Benoite Bourdin, Sabryna Nantel, Vladimir Gilca, Jacques Corbeil, Gaston De Serres, Caroline Quach-Thanh
Summary: Among unvaccinated healthcare workers, reinfection with SARS-CoV-2 following a primary infection remained rare. The duration of seropositivity was significantly longer in symptomatic individuals compared to asymptomatic ones.
INFLUENZA AND OTHER RESPIRATORY VIRUSES
(2022)
Article
Infectious Diseases
Jean-Claude Tardif, Marieve Cossette, Marie-Claude Guertin, Nadia Bouabdallaoui, Marie-Pierre Dube, Guy Boivin
Summary: A predictive model for hospitalization or death due to COVID-19 was developed and identified risk factors and a threshold value. This model can be used to identify high-risk patients who will benefit from early colchicine therapy. Treatment with colchicine can significantly reduce the risk of hospitalization or death in high-risk patients.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Danny Bergeron, Hermes Paraqindes, Etienne Fafard-Couture, Gabrielle Deschamps-Francoeur, Laurence Faucher-Giguere, Philia Bouchard-Bourelle, Sherif Abou Elela, Frederic Catez, Virginie Marcel, Michelle S. Scott
Summary: snoDB is an interactive database providing up-to-date information on human small nucleolar RNAs (snoRNAs), including features, genomic location, conservation, host gene, snoRNA-RNA targets, and abundance. The second edition of snoDB introduces a new section on ribosomal RNA (rRNA) chemical modifications guided by snoRNAs, with easy navigation between different rRNA versions used in literature and experimentally measured modification levels. Additional information including snoRNA motifs, secondary structure prediction, snoRNA-protein interactions, and expression data in various tissues and cell lines has been included to enhance functional probing of snoRNA biology. Version 2.0 also features updated identifiers, more external resource links, and duplicate entry resolution.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Infectious Diseases
Elisabetta Colosi, Giulia Bassignana, Alain Barratt, Bruno Lina, Philippe Vanhems, Julia Bielicki, Vittoria Colizza
Summary: As the Omicron variant cases increased in early 2022, schools faced significant disruptions. A study compared reactive screening, regular screening, and reactive class closure protocols in France, Baselland (Switzerland), and Italy, respectively. The findings showed that reactive screening required more testing resources but had lower control compared to weekly screening. The study suggests optimizing school protocols based on incidence levels. Evaluation: 9 out of 10.
Article
Virology
Maria Gaudino, Adrien Lion, Eveline Sagne, Brandy Nagamine, Justine Oliva, Olivier Terrier, Elisabeth Errazuriz-Cerda, Anaelle Scribe, Fatima-Zohra Sikht, Elisa Simon, Charlotte Foret-Lucas, Blandine Gausseres, Julie Lion, Ana Moreno, Emilie Dordet-Frisoni, Eric Baranowski, Romain Volmer, Mariette F. Ducatez, Gilles Meyer
Summary: Since the spread of the respiratory influenza D virus (IDV) infection to the cattle population, the question about the impact of this virus on bovine respiratory disease (BRD) remains still unanswered. Animals affected by BRD are often coinfected with multiple pathogens, especially viruses and bacteria. This study used an ex vivo model of lung tissue to study the effects of IDV infection on bacterial superinfections. The results showed that IDV increases the susceptibility to the respiratory pathogen Mycoplasma bovis by impairing the innate immune response.
JOURNAL OF VIROLOGY
(2023)
Article
Oncology
Nour-El-Houda Mourksi, Cecile Dalban, Amelie Colombe-Vermorel, Laetitia Odeyer, Valentin Simioni, Jean-Sebastien Frenel, Michel Fabbro, Fernando Bazan, Sophie Abadie-Lacourtoisie, Elodie Coquan, Severine Martinez, Gwenaelle Garin, Severine Tabone-Eglinger, Isabelle Treilleux, Sylvie Chabaud, David Perol, Isabelle Ray-Coquard, Pierre-Etienne Heudel, Jean-Jacques Diaz, Virginie Marcel
Summary: The resistance of advanced hormone-dependent endometrial carcinoma to endocrine therapy is a global clinical issue. A recent study found that the combination of Vistusertib (a mTOR inhibitor) and Anastrozole (an aromatase inhibitor) improves progression-free rate compared to Anastrozole alone. This study evaluates the potential use of ribosome biogenesis (RiBi) factors as innovative markers for patient selection and treatment response prediction.
MOLECULAR ONCOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Jean-Sebastien Casalegno, Samantha Bents, John Paget, Yves Gillet, Dominique Ploin, Etienne Javouhey, Bruno Lina, Florence Morfin, Bryan T. Grenfell, Rachel Baker
Summary: The implementation of NPI during the COVID-19 pandemic had an impact on the circulation of RSV. A TSIR model was used to forecast the implications of this disruption on the future RSV epidemic. The model successfully captured the early start, peak timing, and end of the RSV epidemic, providing valuable information for mitigating the consequences of the outbreak.
JOURNAL OF GLOBAL HEALTH
(2023)
Review
Oncology
Margherita Puppo, Mariam Jaafar, Jean-Jacques Diaz, Virginie Marcel, Philippe Clezardin
Summary: This review discusses the roles of microRNAs and snoRNAs in the metastatic progression of cancer in bone. Dysregulation of microRNA and snoRNA expression in primary cancer cells leads to the acquisition of metastatic properties. Additionally, microRNAs and snoRNAs can act as intercellular mediators and remotely modulate the function of resident bone cells. Furthermore, the review explores the potential of microRNAs and snoRNAs as biomarkers and therapeutic targets in cancer treatments.
Article
Public, Environmental & Occupational Health
Christiana Kartsonaki, J. Kenneth Baillie, Noelia Garcia Barrio, Joaquin Baruch, Abigail Beane, Lucille Blumberg, Fernando Bozza, Tessa Broadley, Aidan Burrell, Gail Carson, Barbara Wanjiru Citarella, Andrew Dagens, Emmanuelle A. Dankwa, Christl A. Donnelly, Jake Dunning, Loubna Elotmani, Martina Escher, Nataly Farshait, Jean-Christophe Goffard, Bronner P. Goncalves, Matthew Hall, Madiha Hashmi, Benedict Sim Lim Heng, Antonia Ho, Waasila Jassat, Miguel Pedrera Jimenez, Cedric Laouenan, Samantha Lissauer, Ignacio Martin-Loeches, France Mentre, Laura Merson, Ben Morton, Daniel Munblit, Nikita A. Nekliudov, Alistair D. Nichol, Budha Charan Singh Oinam, David Ong, Prasan Kumar Panda, Michele Petrovic, Mark G. Pritchard, Nagarajan Ramakrishnan, Grazielle Viana Ramos, Claire Roger, Oana Sandulescu, Malcolm G. Semple, Pratima Sharma, Louise Sigfrid, Emily C. Somers, Anca Streinu-Cercel, Fabio Taccone, Pavan Kumar Vecham, Bharath Kumar Tirupakuzhi Vijayaraghavan, Jia Wei, Evert-Jan Wils, Xin Ci Wong, Peter Horby, Amanda Rojek, Piero L. Olliaro, Ali Abbas
Summary: This study analyzed demographic features, treatments, and clinical outcomes of hospitalized COVID-19 patients in 52 countries from January 2020 to January 2022. Age and male sex were associated with a higher risk of death. Symptoms, co-morbidities, and treatments were associated with clinical outcomes. This comprehensive international study provides valuable information for prioritizing treatment for COVID-19 patients at higher risk of death.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Chemistry, Physical
Lea Szpiro, Clara Bourgeay, Alexandre Loic Hoareau, Thomas Julien, Camille Menard, Yana Marie, Manuel Rosa-Calatrava, Vincent Moules
Summary: Environmental surfaces, especially high-touch surfaces, pose a high risk of becoming carriers of viruses and transmitting them to other individuals through direct contact. Consequently, there has been a growing interest in developing self-decontaminating materials to prevent viral transmission. This study compared the antiviral activities of three different experimental procedures on a reference surface and three active materials, highlighting the need for standardized testing conditions. Furthermore, an innovative approach based on finger-pad transfer was developed to evaluate the antiviral activity of high-touch surfaces under conditions resembling real-life exposure.
Article
Genetics & Heredity
Daniela Matuozzo, Estelle Talouarn, Astrid Marchal, Peng Zhang, Jeremy Manry, Yoann Seeleuthner, Yu Zhang, Alexandre Bolze, Matthieu Chaldebas, Baptiste Milisavljevic, Adrian Gervais, Paul Bastard, Takaki Asano, Lucy Bizien, Federica Barzaghi, Hassan Abolhassani, Ahmad Abou Tayoun, Alessandro Aiuti, Ilad Alavi Darazam, Luis M. Allende, Rebeca Alonso-Arias, Andres Augusto Arias, Gokhan Aytekin, Peter Bergman, Simone Bondesan, Yenan T. Bryceson, Ingrid G. Bustos, Oscar Cabrera-Marante, Sheila Carcel, Paola Carrera, Giorgio Casari, Khalil Chaibi, Roger Colobran, Antonio Condino-Neto, Laura E. Covill, Ottavia M. Delmonte, Loubna El Zein, Carlos Flores, Peter K. Gregersen, Marta Gut, Filomeen Haerynck, Rabih Halwani, Selda Hancerli, Lennart Hammarstroem, Nevin Hatipoglu, Adem Karbuz, Sevgi Keles, Christele Kyheng, Rafael Leon-Lopez, Jose Luis Franco, Davood Mansouri, Javier Martinez-Picado, Ozge Metin Akcan, Isabelle Migeotte, Pierre-Emmanuel Morange, Guillaume Morelle, Andrea Martin-Nalda, Giuseppe Novelli, Antonio Novelli, Tayfun Ozcelik, Figen Palabiyik, Qiang Pan-Hammarstroem, Rebeca Perez de Diego, Laura Planas-Serra, Daniel E. Pleguezuelo, Carolina Prando, Aurora Pujol, Luis Felipe Reyes, Jacques G. Riviere, Carlos Rodriguez-Gallego, Julian Rojas, Patrizia Rovere-Querini, Agatha Schlueter, Mohammad Shahrooei, Ali Sobh, Pere Soler-Palacin, Yacine Tandjaoui-Lambiotte, Imran Tipu, Cristina Tresoldi, Jesus Troya, Diederik van de Beek, Mayana Zatz, Pawel Zawadzki, Saleh Zaid Al-Muhsen, Mohammed Faraj Alosaimi, Fahad M. Alsohime, Hagit Baris-Feldman, Manish J. Butte, Stefan N. Constantinescu, Megan A. Cooper, Clifton L. Dalgard, Jacques Fellay, James R. Heath, Yu-Lung Lau, Richard P. Lifton, Tom Maniatis, Trine H. Mogensen, Horst von Bernuth, Alban Lermine, Michel Vidaud, Anne Boland, Jean-Francois Deleuze, Robert Nussbaum, Amanda Kahn-Kirby, France Mentre, Sarah Tubiana, Guy Gorochov, Florence Tubach, Pierre Hausfater, C. O. V. I. D. Human Genetic Effort, Isabelle Meyts, Shen-Ying Zhang, Anne Puel, Luigi D. Notarangelo, Stephanie Boisson-Dupuis, Helen C. Su, Bertrand Boisson, Emmanuelle Jouanguy, Jean-Laurent Casanova, Qian Zhang, Laurent Abel, Aurelie Cobat
Summary: Through a genome-wide rare variant burden association analysis, it was found that there is an association between at-risk variants in the TLR7 gene and rare loss-of-function variants in TLR3-dependent type I interferon immunity genes. These findings suggest that rare variants in TLR3- and TLR7-dependent type I interferon immunity genes may underlie life-threatening COVID-19 in patients under 60 years old.
Article
Immunology
Carla Saade, Bruno Pozzetto, Melyssa Yaugel-Novoa, Guy Oriol, Laurence Josset, Bruno Lina, Stephane Paul, Antonin Bal, Sophie Trouillet-Assant
Summary: This study examines the humoral immune response in vaccinated patients who are simultaneously infected with Delta and Omicron BA.1 variants of SARS-CoV-2. The findings indicate that exposure to both Delta and BA.1 S proteins does not provide an additional immune advantage compared to exposure to BA.1 S protein alone.
Article
Microbiology
Amel Saim-Mamoun, Julie Carbonneau, Chantal Rheaume, Yacine Abed, Guy Boivin
Summary: Baloxavir, the latest antiviral drug approved against seasonal influenza A and B viruses, shows low resistance against the PA-I38T substitution. This study evaluates the impact of this substitution on the fitness of contemporary influenza B viruses. The results indicate that influenza B viruses with the PA-I38T mutation may retain a significant level of fitness, emphasizing the importance of monitoring the emergence of such variant.