Article
Oncology
Qin Yang, Qing Miao, Hui Chen, Duo Li, Yongfeng Luo, Joanne Chiu, Hong-Jun Wang, Michael Chuvanjyan, Michael S. Parmacek, Wei Shi
Summary: Abnormal growth of airway smooth muscle cells is a key feature in asthmatic airway remodeling. The role of Myocd, a transcriptional coactivator, in this process has been investigated in a mouse model of chronic asthma. Deletion of Myocd mitigated airway smooth muscle cell hypertrophy and hyperplasia, reduced inflammation and collagen deposition, and attenuated abnormal mucin production. Myocd could be a potential therapeutic target for treating severe and persistent asthma.
JOURNAL OF PATHOLOGY
(2023)
Review
Physiology
Dora (Jun Ping) Xiong, James G. Martin, Anne-Marie Lauzon
Summary: Asthma is a common chronic inflammatory disease of the airways that varies in its presentation and severity. Airway smooth muscle is the major contributor to airway narrowing and asthma symptoms. Various factors can contribute to the dysfunction of airway smooth muscle. Methodological limitations in studying the airways have hindered our understanding of asthma mechanisms.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Anesthesiology
Tina H. Pedersen, Florian Ueltschi, Tobias Hornshaw, Robert Greif, Lorenz Theiler, Markus Huber, Maren Kleine-Brueggeney
Summary: The study found that implementing changes to departmental strategies for airway management significantly reduced the incidence of events related to airway management. Analyzing events and implementing strategies that specifically target identified issues may be key to improving airway management.
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Article
Medicine, General & Internal
Silvia De Rosa, Massimiliano Sorbello, Alessandro Rigobello, Lucia Cattin, Giuseppe Iannucci, Paolo Gennaro, Vinicio Danzi, Stefano Checcacci Carboni
Summary: This study provides the first radiologic images of Spritztube in situ in a living human, evaluating the depth of insertion and anatomical relationships. The results show that Spritztube can be helpful in maintaining an adequate airway during radiologic procedures.
Article
Anesthesiology
A. Sajayan, A. Nair, A. F. McNarry, F. Mir, I Ahmad, K. El-Boghdadly
Summary: Difficult airway management has a negative impact on patient care and clinical outcomes and is difficult to predict. However, despite airway assessment, unanticipated difficult airway management continues to occur. The rate of airway-related critical incidents is high, highlighting the need for improvement in airway management.
Editorial Material
Biochemistry & Molecular Biology
Ryan C. Hunter
Summary: Recent research suggests that glycan-based signaling through a carbohydrate-binding sensor kinase plays a crucial role in regulating pathogen behavior at the mucosal interface, providing robust protection against infection.
Review
Pharmacology & Pharmacy
Bo-wen Zhou, Hua-man Liu, Xin-hua Jia
Summary: Asthma as an individual disease remains a global health challenge. Traditional Chinese Medicine (TCM) has been shown to have anti-asthma effects, but its specific role and mechanism are still unclear. Animal studies have demonstrated that TCM formulas and natural compounds can significantly alleviate airway structural alterations and exhibit anti-inflammatory effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Wenxian Ma, Qiaoyan Jin, Haiqin Guo, Xinpeng Han, Lingbin Xu, Shemin Lu, Changgui Wu
Summary: This study demonstrates that metformin can alleviate airway inflammation and remodeling in an OVA-induced chronic asthmatic model. The protective effects of metformin may be associated with the restoration of AMPKα activity and decreased asthma-related angiogenesis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Food Science & Technology
Yao Lu, Yutao Zhou, Yingying Lin, Wusun Li, Shousheng Tian, Xianghui Hao, Huiyuan Guo
Summary: The study found that oral administration of donkey milk powder can improve asthma symptoms, alleviate airway injury and fibrosis, reduce mucin accumulation, goblet cell hyperplasia, and airway inflammation.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Otorhinolaryngology
Hannah N. Kuhar, Alessandra Bliss, Kimberly Evans, Beth Besecker, Carleen Spitzer, Michael Lyaker, Minka Schofield
Summary: To improve airway management, a multidisciplinary Difficult Airway Response Team (DART) was implemented at a tertiary care center. The study evaluated the feasibility of the DART program and found that it resulted in a decreased number of airway attempts in difficult airway patients.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Medicine, General & Internal
Jonghae Kim, Bum Young Park, Jung A. Lim
Summary: Awake bronchoscopy-guided intubation is a safe method for airway management in patients with endotracheal masses. Close cooperation between anesthesiologists and surgeons, as well as preoperative preparation for airway management, are essential. It is important to have alternative plans in place in case intubation and ventilation are not possible.
Article
Agriculture, Dairy & Animal Science
Alice Levy, Carol Reinero, Isabelle Masseau
Summary: This study investigated the detection and comparison of airway collapse in dogs using ventilator-assisted computed tomography (CT) and tracheobronchoscopy. The results showed that CT scans can detect both static and dynamic airway collapse, but there is limited agreement with tracheobronchoscopy results.
Article
Otorhinolaryngology
Roberto Saetti, Guglielmo Ronzani, Stefano Meneghesso, Marina Silvestrini
Summary: Tracheal stenosis is a rare condition where the trachea becomes narrow. A thorough preoperative evaluation is essential to determine the appropriate surgical procedure. Tracheal resection and anastomosis is a viable option, especially for extensive and high-grade lesions or failed endoscopic procedures. The patient in this case had undergone balloon dilatation and tracheal resection before, and was referred to our clinic with residual tracheal stenosis. We illustrate the surgical procedure and highlight a unique way to perform the anastomosis, particularly in a revision surgery.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Plant Sciences
Ibrahim Sulaiman, Emmanuel Oshiogwe Okwuofu, Norhafizah Mohtarrudin, Jonathan Chee Woei Lim, Johnson Stanslas
Summary: The standardized Andrographis paniculata 50% ethanol extract (APEE50) showed anti-inflammatory effects in a mouse asthma model by down-regulating Th2 cytokine gene expression and oxidative stress levels.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Medicine, General & Internal
Ioannis A. Tsolakis, Olga-Elpis Kolokitha
Summary: This study aimed to analyze the upper airway using cone-beam computed tomography at two different time points after rapid maxillary expansion (RPE) treatment. The results showed a significant increase in airway volume and minimal cross-sectional area immediately after RPE treatment and 6 months later.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Paul K. Henneberger, Jenil R. Patel, Gerda J. de Groene, Jeremy Beach, Susan M. Tarlo, Teake M. Pal, Stefania Curti
Summary: This study found that stopping or reducing exposure is more beneficial for improving symptoms of occupational asthma patients compared to continued exposure. Removal of exposure is more advantageous than reduction for patients exposed to low-molecular-weight agents, but may increase the risk of unemployment.
AMERICAN JOURNAL OF INDUSTRIAL MEDICINE
(2021)
Article
Environmental Sciences
Zhiwei Gao, James A. Dosman, Donna C. Rennie, David A. Schwartz, Ivana V. Yang, Jeremy Beach, Ambikaipakan Senthilselvan
Summary: The study found that certain polymorphisms in the TNF gene may increase the impact of smoking on lung function among workers in swine operations, especially for those with the rs1799724 polymorphism. This indicates that smokers may face a higher risk of respiratory problems, and smoking cessation should be emphasized for workers in terms of its effect on lung function.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2021)
Article
Public, Environmental & Occupational Health
Nicola Cherry, James R. Barrie, Jeremy Beach, Jean-Michel Galarneau, Trish Mhonde, Eric Wong
Summary: A study on firefighters attending a catastrophic wildfire found that they had an increased risk of asthma consultation post-fire, decreased lung function, and non-resolving airways damage associated with massive exposures during the wildfire.
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2021)
Article
Orthopedics
Brian H. Rowe, Esther H. Yang, Lindsay A. Gaudet, Justin Lowes, Leeor Eliyahu, Cristina Villa-Roel, Jeremy Beach, Martin Mrazik, Garnet Cummings, Donald Voaklander
Summary: This study aimed to document the occurrence and recovery outcomes of sports-related concussions (SRCs) in a community-based sample presenting to the Emergency Department (ED). While most patients returned to normal activities within 30 days, 40% still experienced persistent symptoms at 90 days of follow-up. Physically active individuals recover faster, but patients who return to physical activity before resolution of symptoms are at higher risk of persistent symptoms and further injury.
CLINICAL JOURNAL OF SPORT MEDICINE
(2022)
Article
Allergy
Ulfat A. Khanam, Zhiwei Gao, Darryl Adamko, Anthony Kusalik, Donna C. Rennie, Donna Goodridge, Luan Chu, Joshua A. Lawson
Summary: The objective of this study was to determine the extent of machine learning application in asthma research and to identify research gaps while mapping the existing literature. The study found that asthma episode prediction, asthma phenotype classification, and genetic profiling of asthma were the top three study topics. Cohort, cross-sectional, and case-control studies were the most frequently used study designs. The study also found that very few studies considered the location of residence factor.
Article
Public, Environmental & Occupational Health
Nicola Cherry, Jeremy Beach, Jean-Michel Galarneau
Summary: The study found that some firefighters experienced respiratory issues and mental health concerns after the fire, with symptoms related to particulate exposure being more significant.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Public, Environmental & Occupational Health
Nicola Cherry, Jeremy Beach, Jean-Michel Galarneau
Summary: This study examined the relationship between job demands and fetal loss in women with welding or electrical trade apprenticeships. The results showed no significant increase in fetal loss in welding trades compared to electrical work. However, vibration and extended work rotations were identified as potentially modifiable factors of importance.
AMERICAN JOURNAL OF INDUSTRIAL MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Jean-Michel Galarneau, Jeremy Beach, Nicola Cherry
Summary: A comparison of urinary metal concentrations in male and female workers in the welding and electrical trades found that welders had higher concentrations of aluminum and chromium. Male welders had higher estimated exposure to chromium and nickel than female welders, while female welders had higher urinary metal concentrations, which is of concern, particularly for women who may conceive while in the trade.
ANNALS OF WORK EXPOSURES AND HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Jean-Michel Galarneau, Jeremy Beach, Nicola Cherry
Summary: This study investigated the effects of work exposures during pregnancy on the outcome of pregnancy in female welders. The results showed that manipulating heavy objects, whole-body vibration, a higher rating for noise exposure intensity, and perceived heat intensity were associated with an increased risk of fetal loss, while the use of local exhaust ventilation was associated with a decreased risk of fetal loss. The study also found that perceived heat intensity and the number of previous pregnancies were associated with a shortened gestation period, and whole-body vibration and the welder's body mass index were negatively associated with birth weight. Exposure to metal fume constituents was not independently associated with pregnancy outcomes.
ANNALS OF WORK EXPOSURES AND HEALTH
(2022)
Article
Public, Environmental & Occupational Health
J. Beach, J-M Galarneau, N. Cherry
Summary: This study aimed to estimate the risk of sensitization to bakery allergens and allergic disease among trainee bakers in Alberta. The results showed that trainee bakers remain at risk of sensitization and occupational respiratory disease, suggesting the need for further control of exposure.
OCCUPATIONAL MEDICINE-OXFORD
(2022)
Article
Allergy
Edwina Veerasingam, Zhiwei Gao, Jeremy Beach, Ambikaipakan Senthilselvan
Summary: This study aimed to identify female and male-specific epidemiological and clinical characteristics associated with asthma + COPD. The results showed that the prevalence of asthma + COPD was significantly higher in females than males, and the association between smoking and asthma + COPD was influenced by age in females. In the asthma + COPD group, a higher proportion of respiratory symptoms associated with asthma was observed in females, while a higher proportion of respiratory symptoms associated with COPD was observed in males. The severity of airway obstruction was greater in males than females. These findings are important for the recognition and management of coexisting asthma and COPD in both females and males.
Article
Health Care Sciences & Services
Alicia Blackmore, Holly Etchegary, Leigh Anne Allwood-Newhook, Zhiwei Gao, Hai Van Nguyen, Kaylah Parsons-Mercer, Laurie Twells
Summary: By following the guiding principles of patient-oriented research and patient engagement, this study successfully engaged with mothers in discussions about the costs of infant feeding. The sessions covered topics such as monetary costs, workplace and environmental impacts, and evaluations were provided to gather feedback from the mothers.
PATIENT-RELATED OUTCOME MEASURES
(2022)
Article
Clinical Neurology
Brian H. Rowe, Esther H. Yang, Lindsay A. Gaudet, Leeor Eliyahu, Daniela R. Junqueira, Jeremy Beach, Martin Mrazik, Garnet Cummings, Donald Voaklander
Summary: This study compared male and female patients with concussion and found that female patients had more severe and prolonged symptoms during their visit to the emergency department. The study also revealed that women, patients with a history of sleep disorders, and those who presented with concussions after a motor vehicle collision were more likely to experience persistent symptoms.
JOURNAL OF NEUROSURGERY
(2022)
Review
Respiratory System
Ugochukwu Odimba, Ambikaipakan Senthilselvan, Jamie Farrell, Zhiwei Gao
Summary: Asthma-COPD overlap (ACO) is a newly identified phenotype of chronic obstructive airway diseases with shared asthma and COPD features. There is no clear definition for ACO, and the mechanisms underlying its development are not fully understood.
COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2021)
Article
Environmental Sciences
Maria Vitoria Takemura Mariano, Luana Paganotto Leandro, Karen Kich Gomes, Ana Beatriz dos Santos, Vitor Oliveira de Rosso, Alcir Luiz Dafre, Marcelo Farina, Thais Posser, Jeferson Luis Franco
Summary: This study evaluated the toxicity of copper at environmentally relevant concentrations on zebrafish larvae and found adverse effects on morphology, biochemistry, and behavior. Therefore, the permissible copper concentrations in Brazil need to be reevaluated.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2024)
