Journal
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
Volume 118, Issue 6, Pages 1047-1054Publisher
ELSEVIER TAIWAN
DOI: 10.1016/j.jfma.2018.10.012
Keywords
Diabetes; Type 1 diabetes mellitus (T1DM); Periodontal disease; Cohort study
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Funding
- Taiwan Ministry of Health and Welfare's Clinical Trial Center [MOHW107-TDU-B-212-123004]
- China Medical University Hospital [DMR-107-031, DMR-107-192]
- Academia Sinica Taiwan Biobank Stroke Biosignature Project [BM10501010037]
- NRPB Stroke Clinical Trial Consortium [MOST 105-2325-B-039-003]
- Tseng-Lien Lin Foundation, Taichung, Taiwan
- Taiwan Brain Disease Foundation, Taipei, Taiwan
- Katsuzo and Kiyo Aoshima Memorial Funds, Japan
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Background/purpose: Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease affecting oral health. Evidence shows possible association between T1DM and periodontal diseases (PDs). We conducted a nationwide population-based study in Taiwan, with a 14-year follow-up to investigate the risk of PDs in T1DM patients. Methods: We used data from the National Health Insurance Research Database in Taiwan. The T1DM cohort was identified with newly diagnosed T1DM from 1998 to 2011. The non-T1DM cohort was frequency matched with the T1DM cohort. Participants comprised 4248 patients in the T1DM cohort and 16992 persons in the non-T1DM cohort. Results: The T1DM patients showed an increased risk of PDs compared to non-T1DM individuals [adjusted hazard ratio (aHR) = 1.45]. T1DM patients who visited the emergency room more than twice per year had a higher aHR of 13.0 for developing PDs. The aHR for PDs was 13.2 in the T1DM patients who had been hospitalized more than twice per year. Conclusion: T1DM patients are at higher risk of developing PDs than non-T1DM individuals. Our results further showed that the number of T1DM interventions; that is, annual emergency visits and hospitalizations were associated with increased the risk of developing PDs. Copyright (C) 2018, Formosan Medical Association. Published by Elsevier Taiwan LLC.
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