Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 140, Issue 49, Pages 16967-16970Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.8b11547
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Funding
- MINECO [CTQ2017-87840-P, CTQ2017-87889-P, CTQ2015-65040-P]
- IRB Barcelona
- Spanish Ministry of Economy, Industry and Competitiveness (MINECO) through the Centers of Excellence Severo Ochoa award
- CERCA Programme of the Catalan Government
- MINECO
- UAB
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A novel cationic [IrH(THF)(P,N)-(imine)] [BArF] catalyst containing a P-stereogenic MaxPHOX ligand is described for the direct asymmetric hydrogenation of N-methyl and N-alkyl imines. This is the first catalytic system to attain high enantioselectivity (up to 94% ee) in this type of transformation. The labile tetrahydrofuran ligand allows for effective activation and reactivity, even at low temperatures. Density functional theory calculations allowed the rationalization of the stereochemical course of the reaction.
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