Review
Medicine, General & Internal
Christos Koutserimpas, Symeon Naoum, Vasileios Giovanoulis, Konstantinos Raptis, Kalliopi Alpantaki, Konstantinos Dretakis, Georgia Vrioni, George Samonis
Summary: Fungal hip prosthetic joint infections (PJIs) are rare but severe infections. This review analyzed all published cases of fungal hip PJIs to provide comprehensive information on demographics, causative fungi, treatment options, and infection outcomes.
Article
Orthopedics
H-Y. Yang, J-H. Cheon, D-M. Jung, J-K. Seon
Summary: This study investigated the clinical outcomes of patients with fungal periprosthetic joint infections (PJIs) treated with two-stage exchange knee arthroplasty combined with prolonged antifungal therapy. The results showed that fungal PJIs had a lower treatment success rate than non-fungal PJIs, and a higher rate of recurrent infections.
BONE & JOINT JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Irene K. Sigmund, Stephan E. Puchner, Reinhard Windhager
Summary: Accurate preoperative diagnosis of periprosthetic joint infections (PJIs) can be challenging, serum parameters such as CRP and ESR are commonly used to distinguish septic from aseptic failure, while novel serum biomarkers are being investigated to find a more specific and accurate diagnostic tool.
Review
Microbiology
Giulia Gatti, Francesca Taddei, Martina Brandolini, Andrea Mancini, Agnese Denicolo, Francesco Congestri, Martina Manera, Valentina Arfilli, Arianna Battisti, Silvia Zannoli, Maria Michela Marino, Anna Marzucco, Manuela Morotti, Laura Grumiro, Agata Scalcione, Giorgio Dirani, Monica Cricca, Vittorio Sambri
Summary: The incidence of total joint arthroplasty is increasing and is expected to exceed 4 million by 2030. As a result, the detection of infections associated with surgical interventions is also increasing, and prosthetic joint infections pose a challenging problem both clinically and economically. In recent years, the implementation of diagnostic methodologies has reduced errors and improved response time.
Article
Orthopedics
Robert A. McCulloch, Antony J. Palmer, James Donaldson, Benjamin J. Kendrick, Jonathan Miles, Adrian Taylor
Summary: This study retrospectively analyzed patients with fungal periprosthetic joint infection (PJI) who underwent revision surgery at two high-volume arthroplasty centers. The study found that less than half of the patients achieved eradication of fungal PJI, and the outcomes were comparable for total knee arthroplasty (TKA) and total hip arthroplasty (THA). Most patients with fungal PJI presented with open wounds or a history of sinus disease.
JOURNAL OF ARTHROPLASTY
(2023)
Article
Cell & Tissue Engineering
Y. Wang, G. Li, B. Ji, B. Xu, X. Zhang, A. Maimaitiyiming, L. Cao
Summary: This study investigated the optimal thresholds and diagnostic efficacy of commonly used serological and synovial fluid detection indexes for diagnosing periprosthetic joint infection (PJI) in patients with rheumatoid arthritis (RA). The results showed that synovial fluid white blood cell count (WBC) was the best detection index.
BONE & JOINT RESEARCH
(2023)
Article
Orthopedics
Carl L. Herndon, Taylor M. Rowe, Rory W. Metcalf, Susan M. Odum, Thomas K. Fehring, Bryan D. Springer, Jesse E. Otero
Summary: Fungal periprosthetic joint infection (PJI) is difficult to treat and has a high failure rate. This study represents the largest cohort of fungal PJIs reported in the literature, and more research is needed to improve care for these patients.
JOURNAL OF ARTHROPLASTY
(2023)
Article
Infectious Diseases
Sebastian Simon, Bernhard J. H. Frank, Susana Hartmann, Laetitia Hinterhuber, Michael Reitsamer, Alexander Aichmair, Martin Dominkus, Bo Soderquist, Jochen G. Hofstaetter
Summary: This study compared the treatment outcome of dalbavancin with Standard of Care (SoC) in hip and knee periprosthetic joint infections (PJIs). The results showed that dalbavancin treatment resulted in a similar outcome to SoC, with excellent safety and low rate of adverse effects.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Medicine, General & Internal
Marcel Niemann, Ellen Otto, Karl F. Braun, Frank Graef, Sufian S. Ahmad, Sebastian Hardt, Ulrich Stoeckle, Andrej Trampuz, Sebastian Meller
Summary: This study investigated the potential benefit of open incisional joint biopsy (OIB) in total hip (THA) and knee arthroplasty (TKA) patients with suspected periprosthetic joint infection (PJI) and ambiguous diagnostic results. The results showed that OIB had high specificity, positive predictive value (PPV), and negative predictive value (NPV) in cases where previous microbiological results were inconclusive, especially in TKA patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Serhat Akcaalan, Halil Ibrahim Ozaslan, Ceyhun Caglar, Mehmet Emin Simsek, Mustafa Citak, Mustafa Akkaya
Summary: Periprosthetic joint infection is a serious complication after joint arthroplasty, and its diagnosis is highly challenging for orthopedists. Currently used diagnostic criteria are unable to definitively diagnose infection, thus necessitating research into new biomarkers for improved diagnosis.
Article
Medicine, General & Internal
Mattia Loppini, Marco Di Maio, Roberta Avigni, Roberto Leone, Antonio Inforzato, Guido Grappiolo, Alberto Mantovani, Barbara Bottazzi
Summary: This study evaluated the diagnostic potential of synovial and plasmatic PTX3 in hip and knee periprosthetic joint infections (PJIs). The results showed that synovial PTX3 had high sensitivity and specificity in diagnosing PJI, while plasmatic PTX3 failed to differentiate infected from non-infected patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Orthopedics
Christopher E. Gross, Craig J. Della Valle, James C. Rex, Sophia A. Traven, Elizabeth C. Durante
Summary: Periprosthetic joint infection (PJI) caused by fungal pathogens is a serious complication of total joint arthroplasty, with patients often having comorbid conditions impairing immunity. Two-stage exchange is the preferred treatment method, with antifungal impregnated spacers showing promising success rates.
JOURNAL OF ARTHROPLASTY
(2021)
Article
Microbiology
Andreas Enz, Silke C. Mueller, Philipp Warnke, Martin Ellenrieder, Wolfram Mittelmeier, Annett Klinder
Summary: The treatment of fungal periprosthetic joint infections presents a special challenge in orthopaedic surgery, with mixed infections of bacteria and Candida albicans being common. The complexity and difficulty of treating fungal infections in joint revisions are highlighted in this study.
Review
Infectious Diseases
Konstantinos Tsikopoulos, Gabriele Meroni
Summary: Replacement of native joints aims to restore patients' quality of life. Periprosthetic joint infection (PJI) following joint replacement is a postoperative complication that necessitates hospitalisation, antibiotic treatment and further surgery. Establishing the correct diagnosis of PJI is critical in order to avoid unnecessary treatments in patients with aseptic failure. Intra-operative contamination and heterogeneity in infection period can confound the diagnosis.
Article
Infectious Diseases
Rares Mircea Birlutiu, Manuela Mihalache, Patricia Mihalache, Razvan Silviu Cismasiu, Victoria Birlutiu
Summary: PJIs are a serious complication of joint replacement surgeries, often leading to prolonged morbidity, increased costs, and mortality. This single-center observational study in Romania used sonication and bbFISH for bacterial detection and identification in PJI cases, with different surgical procedures showing similar survival rates after follow-up. Prospective randomized controlled trials are needed to determine the best management strategy for PJIs.
BMC INFECTIOUS DISEASES
(2021)