Article
Chemistry, Multidisciplinary
Ruoyu Shen, Lijun Peng, Wentao Zhou, Ding Wang, Qi Jiang, Jian Ji, Fuqiang Hu, Hong Yuan
Summary: Abnormal tumor vasculature leads to malignant tumor microenvironment and affects tumor progression. We developed a nano-delivery system that sustains the release of anti-angiogenic agents to stabilize tumor vascular normalization, improving tumor perfusion and reversing abnormalities in the tumor microenvironment, ultimately inhibiting tumor progression.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Nanoscience & Nanotechnology
Chia-Hao Huang, Kowit-Yu Chong, Kin Fong Lei
Summary: The research successfully reproduced an internal hypoxic environment in a paper-based solid tumor, demonstrating high levels of HIF1-alpha and VEGFA expression in the inner layer cells. This induced proliferation and migration of endothelial cells in the internal hypoxic environment. Additionally, the paper-based solid tumor was transplanted into nude mice for the study of hypoxic response and angiogenesis, providing a method for analyzing the interaction between cancer cells, hypoxia, and peripheral angiogenesis.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Materials Science, Biomaterials
Madhuri Dey, Bugra Ayan, Marina Yurieva, Derya Unutmaz, Ibrahim T. Ozbolat
Summary: The study of metastatic breast cancer micro-environment demonstrates that interactions with stromal components induce genetic and metabolic alterations conducive to tumor growth, impacting the transcriptional profile of genes involved in tumor angiogenesis and cancer invasion. Additionally, cancer-specific canonical pathways and activated upstream regulators can be identified through differential gene expression signatures.
Article
Biochemistry & Molecular Biology
Mira Suzuki, Masaki Nagane, Kazuhiro Kato, Akinori Yamauchi, Takuto Shimizu, Hiroko Yamashita, Naoyuki Aihara, Junichi Kamiie, Nagako Kawashima, Shokichi Naito, Tadashi Yamashita
Summary: This study demonstrates that endothelial ganglioside GM3 regulates tumor angiogenesis by suppressing cellular invasion and oxidative stress tolerance. Through experiments on a breast cancer model and GM3S-KO mice, the results show that GM3 expression can affect tumor growth and angiogenesis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Immunology
Julie Messiaen, Sandra A. Jacobs, Frederik De Smet
Summary: Brain tumors are a major cause of illness and death in children with cancer, especially high-grade glioma. Pediatric glioma differs significantly from adult glioma, making it difficult to make extrapolations. While there are currently few curative options for glioma, ongoing research is being conducted. The tumor micro-environment (TME) plays a crucial role in therapy resistance, but its interaction with tumor cells and the location of different cell types in the TME are not well understood. Understanding the TME in pediatric glioma is important for optimizing treatment outcomes. This review provides an overview of the composition and role of the TME in different types of pediatric glioma, and discusses how it may influence responses to conventional and immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Alain E. Andrea, Andrada Chiron, Sarah Mallah, Stephanie Bessoles, Guillaume Sarrabayrouse, Salima Hacein-Bey-Abina
Summary: CAR-T cell therapy has limited efficacy in solid tumors due to the immunosuppressive tumor microenvironment. To overcome this obstacle, researchers are designing new CAR-T cell engineering strategies to enhance the anti-cancer activity of CAR-T cells in hostile environments.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Floriane Racine, Christophe Louandre, Corinne Godin, Baptiste Chatelain, Stefan Prekovic, Wilbert Zwart, Antoine Galmiche, Zuzana Saidak
Summary: Human tumors often exhibit a hypercoagulant state that promotes vascular complications. The tumor coagulome, a repertoire of tumor-expressed genes that regulates coagulation and fibrinolysis, has been found to be linked with the tumor microenvironment. Glucocorticoids were discovered to regulate the coagulome through direct transcriptional and indirect effects, which have potential vascular consequences and impact on the tumor microenvironment.
Review
Chemistry, Physical
Jingjing Gu, Jiuyuan Sun, Ying Liu, Gaowei Chong, Yongyong Li, Haiqing Dong
Summary: Metabolic reprogramming leads to the preferential utilization of lactate produced by glycolysis as the main energy source by tumor cells, resulting in its accumulation in the tumor microenvironment. Lactate, which was previously considered a waste product, now plays a crucial role in tumor progression and modulation of lactate in the tumor microenvironment has become a potential target for cancer therapy. Nanomedicine offers advantages in drug delivery efficiency and treatment efficacy while minimizing damage to normal tissues, driving the development of lactate modulation-based nanosystems research.
Article
Physics, Fluids & Plasmas
Chien -Han Yen, Yi-Chieh Lai, Kuo-An Wu
Summary: We propose a phenomenological reaction-diffusion model to study the morphological instability of solid tumors during the avascular growth, which includes a nutrient-regulated growth rate of tumor cells. We find that tumor cells are more likely to induce surface instability in a harsher nutrient-deficient environment, while the instability is suppressed in a nutrient-rich environment due to nutrient-regulated proliferation. Additionally, the growth moving speed of tumor rims also influences the surface instability, with a larger growth movement resulting in a closer proximity to a nutrient-rich region and inhibiting the instability.
Article
Pharmacology & Pharmacy
Amber J. Abernethie, Annalisa Gastaldello, Giorgia Maltese, Ruth A. Morgan, Kerry J. McInnes, Gary R. Small, Brian R. Walker, Dawn EW. Livingstone, Patrick WF. Hadoke, Ruth Andrew
Summary: Compared with corticosterone, 5 alpha-tetrahydrocorticosterone (5 alpha THB) exhibits limited suppression of angiogenesis in mice, and this effect is probably independent of the glucocorticoid receptor. This finding may contribute to the development of safer topical anti-inflammatory drugs.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemical Research Methods
Ryan Cohen, Tracey Lee-Pullen, Timothy J. Miller, Katie Meehan, Kathy Fuller, Melanie J. McCoy
Summary: Exploring the tumour microenvironment provides insight into the unique interaction between the host and tumour. Immune biomarkers within the tumour microenvironment in colorectal cancer are more accurate in predicting disease recurrence than traditional histopathological staging. Multiplex immunofluorescence allows for simultaneous assessment of multiple markers to accurately classify immune cells and their spatial relationship to tumour tissue.
Article
Peripheral Vascular Disease
Jing Bai, Mehrdad Khajavi, Lufei Sui, Haojie Fu, Subrahmanian Tarakkad Krishnaji, Amy E. Birsner, Lauren Bazinet, Roger D. Kamm, Robert J. D'Amato
Summary: This study developed a novel microfluidic platform for studying angiogenesis, comparing angiogenic properties between different mouse strains, and mechanistically demonstrating that the Padi2 gene promotes angiogenesis through Notch1/Dll4 signaling. Analysis of the interactions between primary endothelial cells and pericytes in a 3D microfluidic environment helps elucidate the angiogenic response.
Article
Oncology
Alexis A. Vega, Erin A. Marshall, Avery J. C. Noonan, Fernando Sergio Leitao Filho, Julia Yang, Greg L. Stewart, Fraser D. Johnson, Emily A. Vucic, Michelle E. Pewarchuk, Parag P. Shah, Brian F. Clem, Corey Nislow, Stephen Lam, William W. Lockwood, Steven J. Hallam, Janice M. Leung, Levi J. Beverly, Wan L. Lam
Summary: This study reveals that bacteria present in the tumor microenvironment are enriched for methionine synthesis pathways and can provide essential nutrients, such as methionine, to cancer cells. The findings suggest a potential bi-directional cross-talk between the local microbiome and adjacent tumor cells, with implications for tumor development and progression.
Article
Chemistry, Physical
Xiao-Fei Yu, Wen-Cui Li, You-Ren Hu, Cheng-Yu Ye, An-Hui Lu
Summary: A new synthesis approach for internal gridded hollow carbon spheres is proposed in this study, which involves constructing a silica fence around solid polymer spheres to create the desired structure. These carbon spheres show good performance as sulfur hosts for Li-S batteries.
Review
Biochemistry & Molecular Biology
Chen Wang, Yumeng Shen, Jiaping Ni, Weiwei Hu, Yong Yang
Summary: Chronic stress affects tumor occurrence and development, but the exact molecular mechanisms are still not fully understood. This review summarizes the effects of chronic stress on various stages of tumor and provides an overview of the underlying molecular mechanisms. Additionally, available treatments and potential therapies for stressed patients with tumor are highlighted.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Maruf Hasan, Henry Reyer, Michael Oster, Nares Trakooljul, Siriluck Ponsuksilli, Elizabeth Magowan, Dagmar -Christiane Fischer, Klaus Wimmers
Summary: UVB exposure can increase the supply of vitamin D in pig husbandry and does not affect the growth performance of the pigs. After exposure, there are changes in gene expression in the liver, with the pathways for vitamin D synthesis being preferentially initiated.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Zhen Wang, Shu-ying Yi, Yuan-ying Zhang, Yu-di Wang, Han-lin Chen, Yi-jie Guo, Xin-ming Wei, Du-xiao Yang
Summary: Vitamin D can reverse S1P-induced cell death and alleviate EAE symptoms by regulating S1P levels and related signaling pathways.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2024)
Correction
Biochemistry & Molecular Biology
Haixiao Chen, Xing Ji, Xinhua Hu, Lihua Chen, Haiyan Lv, Chengyun Xu, Dun Hong, Ximei Wu
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2024)
