Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 8, Issue 16, Pages 10109-10120Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b11573
Keywords
morphology; biological effect; zinc oxide nanoflower; antibacterial; bacteria
Funding
- National Natural Science Foundation of China [21304044]
- Natural Science Foundation of Inner Mongolia Autonomous Region [2015MS0520]
- Program of Higher level Talents of Inner Mongolia University [30105-125136]
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Zinc oxides have gained exciting achievements in antimicrobial fields because of their advantageous properties, whereas their biological effects on bacteria are currently underexplored. In this study, biological effects of flower-shaped nano zinc oxides on bacteria were systematically investigated. Zinc oxide nanoflowers with controllable morphologies (viz., rod flowers, fusiform flowers, and petal flowers) were synthesized by modulating merely base type and concentration using the hydrothermal process. Their antibacterial power is in an order of petal flowers > fusiform flowers > rod flowers because of their differences in microscopic parameters such as specific surface area, pore size, and Zn-polar plane, etc. More importantly, the role of morphology in influencing biological effect on bacteria was examined; focusing on the morphology-induced effect on integrality of cell wall, permeability of cell membrane, DNA cleavage, etc. As for cytotoxicity, all petal flowers, fusiform flowers, and rod flowers show trivial cytotoxicity to the Hela cells. This work provides a guide for enhancing biological effect of the biocides on pathogenic bacteria by the morphological modulation.
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