RAAS inhibitors directly reduce diabetes-induced renal fibrosis via growth factor inhibition

US Renal Data System 2017 Annual Data Report: Epidemiology of Kidney Disease in the United States

(2018) Rajiv Saran et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Blockade of PDGF Receptors by Crenolanib Has Therapeutic Effect in Patient Fibroblasts and in Preclinical Models of Systemic Sclerosis

(2017) Katsunari Makino et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

High glucose induces HGF-independent activation of Met receptor in human renal tubular epithelium

(2017) Lucia Mesarosova et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Urinary collagen degradation products as early markers of progressive renal fibrosis

(2017) Ryanne S. Hijmans et al.   Journal of Translational Medicine

High resolution molecular and histological analysis of renal disease progression in ZSF1 fa/faCP rats, a model of type 2 diabetic nephropathy

(2017) Ken Dower et al.   PLoS One

Quantification of fibronectin as a method to assess ex vivo extracellular matrix remodeling

(2016) C.L. Bager et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Aldosterone induces NRK-52E cell apoptosis in acute kidney injury via rno-miR-203 hypermethylation and Kim-1 upregulation

(2016) Xiangcheng Xiao et al.   Experimental and Therapeutic Medicine

Turnover of type III collagen reflects disease severity and is associated with progression and microinflammation in patients with IgA nephropathy

(2015) Federica Genovese et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Serum and urine markers of collagen degradation reflect renal fibrosis in experimental kidney diseases

(2015) Marios Papasotiriou et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Nephropathy in Youth and Young Adults with Type 2 Diabetes

(2014) Carolina Solis-Herrera et al.   Current Diabetes Reports

Rho kinase pathway is likely responsible for the profibrotic actions of aldosterone in renal epithelial cells via inducing epithelial-mesenchymal transition and extracellular matrix excretion

(2013) Jiali Wei et al.   CELL BIOLOGY INTERNATIONAL

Angiotensin II Blockade and Renal Protection

(2013) Hiroyuki Kobori et al.   CURRENT PHARMACEUTICAL DESIGN

Angiotensin Receptor Blockers and Statins Could Alleviate Atrial Fibrosis via Regulating Platelet-Derived Growth Factor/Rac1 /Nuclear Factor-Kappa B Axis

(2013) Dongfang Yang et al.   International Journal of Medical Sciences

Antifibrotic, nephroprotective effects of paricalcitol versus calcitriol on top of ACE-inhibitor therapy in the COL4A3 knockout mouse model for progressive renal fibrosis

(2013) D. Rubel et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Association of Systemic Collagen Type IV Formation with Survival among Patients Undergoing Hemodialysis

(2013) Diana J. Leeming et al.   PLoS One

Anti-Fibrosis Therapy and Diabetic Nephropathy

(2012) Anil Karihaloo   Current Diabetes Reports

Diabetic Nephropathy and Extracellular Matrix

(2012) S. O. Kolset et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Involvement of matrix metalloproteinase-2 in the development of renal interstitial fibrosis in mouse obstructive nephropathy

(2012) Xuanyi Du et al.   LABORATORY INVESTIGATION

Experimental diabetic nephropathy is accelerated in matrix metalloproteinase-2 knockout mice

(2012) Yoshimi Takamiya et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Aldosterone Antagonists in Monotherapy Are Protective against Streptozotocin-Induced Diabetic Nephropathy in Rats

(2012) Nora F. Banki et al.   PLoS One

Chronic kidney disease growth factors in renal fibrosis

(2011) Peter Boor et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Renal (pro)renin receptor contributes to development of diabetic kidney disease through transforming growth factor-β1 - connective tissue growth factor signalling cascade

(2011) Jiqian Huang et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Connective tissue growth factor modulates podocyte actin cytoskeleton and extracellular matrix synthesis and is induced in podocytes upon injury

(2011) Rudolf Fuchshofer et al.   HISTOCHEMISTRY AND CELL BIOLOGY

The PDGF family in renal fibrosis

(2011) Tammo Ostendorf et al.   PEDIATRIC NEPHROLOGY

Pathologic Classification of Diabetic Nephropathy

(2010) T. W. C. Tervaert et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Sirolimus and everolimus reduce albumin endocytosis in proximal tubule cells via an angiotensin II-dependent pathway

(2010) Melinda Oroszlán et al.   TRANSPLANT IMMUNOLOGY

Losartan counteracts the hyper-reactivity to angiotensin II and ROCK1 over-activation in aortas isolated from streptozotocin-injected diabetic rats

(2009) Paola Failli et al.   Cardiovascular Diabetology

Angiotensin II Induces Connective Tissue Growth Factor and Collagen I Expression via Transforming Growth Factor–β–Dependent and –Independent Smad Pathways

(2009) Fuye Yang et al.   HYPERTENSION

Evidence of O-linked N-acetylglucosamine in diabetic nephropathy

(2009) Péter Degrell et al.   LIFE SCIENCES

Spironolactone exhibits direct renoprotective effects and inhibits renal renin–angiotensin–aldosterone system in diabetic rats

(2008) Masateru Taira et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Effects of Aliskiren on Blood Pressure, Albuminuria, and (Pro)Renin Receptor Expression in Diabetic TG(mRen-2)27 Rats

(2008) David L. Feldman et al.   HYPERTENSION

Effects of Spironolactone in an Experimental Model of Chronic Cyclosporine Nephrotoxicity

(2008) B. Macunluoglu et al.   TRANSPLANTATION PROCEEDINGS

Cellular and molecular mechanisms of fibrosis

(2007) TA Wynn   JOURNAL OF PATHOLOGY

A New Look at Platelet-Derived Growth Factor in Renal Disease

(2007) J. Floege et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY