Predicting the Changes in Oral Absorption of Weak Base Drugs Under Elevated Gastric pH Using an In Vitro–In Silico–In Vivo Approach: Case Examples—Dipyridamole, Prasugrel, and Nelfinavir

Published 2018 View Full Article

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Title
Predicting the Changes in Oral Absorption of Weak Base Drugs Under Elevated Gastric pH Using an In Vitro–In Silico–In Vivo Approach: Case Examples—Dipyridamole, Prasugrel, and Nelfinavir
Authors
Keywords
poorly water-soluble drugs, drug-drug interaction, dissolution, precipitation, oral absorption, pharmacokinetics, in silico, modeling, simulation
Journal
JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 108, Issue 1, Pages 584-591
Publisher
Elsevier BV
Online
2018-11-11
DOI
10.1016/j.xphs.2018.11.008

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