The Irrelevance of In Vitro Dissolution in Setting Product Specifications for Drugs Like Dextromethorphan That are Subject to Lysosomal Trapping

Published 2018 View Full Article

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Title
The Irrelevance of In Vitro Dissolution in Setting Product Specifications for Drugs Like Dextromethorphan That are Subject to Lysosomal Trapping
Authors
Keywords
absorption, bioequivalence, computational ADME, CYP enzymes, dissolution rate, genetic polymorphisms, metabolism, metabolite kinetics, pharmacokinetics
Journal
JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 108, Issue 1, Pages 268-278
Publisher
Elsevier BV
Online
2018-10-12
DOI
10.1016/j.xphs.2018.09.036

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