TNF-α enhances apoptosis by promoting chop expression in nucleus pulposus cells: role of the MAPK and NF-κB pathways

Functional self-assembled peptide scaffold inhibits tumor necrosis factor-alpha-induced inflammation and apoptosis in nucleus pulposus cells by suppressing nuclear factor-κB signaling

(2017) Xiaochuan Li et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

The unfolded protein response mediated by PERK is casually related to the pathogenesis of intervertebral disc degeneration

(2017) Takeshi Fujii et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Role of SHOX2 in the development of intervertebral disc degeneration

(2017) Fubiao Ye et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Non-specific low back pain

(2017) Chris Maher et al.   LANCET

GRP78 silencing enhances hyperoxia-induced alveolar epithelial cell apoptosis via CHOP pathway

(2017) Hong-Yan Lu et al.   Molecular Medicine Reports

Resistin promotes CCL4 expression through toll-like receptor-4 and activation of the p38-MAPK and NF-κB signaling pathways: implications for intervertebral disc degeneration

(2017) Z. Li et al.   OSTEOARTHRITIS AND CARTILAGE

Free fatty acid palmitate activates unfolded protein response pathway and promotes apoptosis in meniscus cells

(2016) J. Haywood et al.   OSTEOARTHRITIS AND CARTILAGE

TNF-αand TGF-β1 regulate Syndecan-4 expression in nucleus pulposus cells: role of the mitogen-activated protein kinase and NF-κB pathways

(2015) Hao Yang et al.   CONNECTIVE TISSUE RESEARCH

Salvianolic acid A attenuates TNF-α- and d-GalN-induced ER stress-mediated and mitochondrial-dependent apoptosis by modulating Bax/Bcl-2 ratio and calcium release in hepatocyte LO2 cells

(2015) Xiaojing Yan et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

The global burden of low back pain: estimates from the Global Burden of Disease 2010 study

(2014) Damian Hoy et al.   ANNALS OF THE RHEUMATIC DISEASES

Acetylcholine Inhibits Tumor Necrosis Factor α Activated Endoplasmic Reticulum Apoptotic Pathway via EGFR-PI3K Signaling in Cardiomyocytes

(2014) Yi Miao et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Azadirone, a Limonoid Tetranortriterpene, Induces Death Receptors and Sensitizes Human Cancer Cells to Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) through a p53 Protein-independent Mechanism

(2013) Subash C. Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor necrosis factor α- and interleukin-1β-dependent induction of CCL3 expression by nucleus pulposus cells promotes macrophage migration through CCR1

(2012) Jianru Wang et al.   ARTHRITIS AND RHEUMATISM

Simvastatin inhibition of mevalonate pathway induces apoptosis in human breast cancer cells via activation of JNK/CHOP/DR5 signaling pathway

(2012) Archana Gopalan et al.   CANCER LETTERS

Lentiviral shRNA silencing of CHOP inhibits apoptosis induced by cyclic stretch in rat annular cells and attenuates disc degeneration in the rats

(2011) Yue-Hui Zhang et al.   APOPTOSIS

Role of death receptor, mitochondrial and endoplasmic reticulum pathways in different stages of degenerative human lumbar disc

(2011) Hua Wang et al.   APOPTOSIS

TNF-α and IL-1β Promote a Disintegrin-like and Metalloprotease with Thrombospondin Type I Motif-5-mediated Aggrecan Degradation through Syndecan-4 in Intervertebral Disc

(2011) Jianru Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of CCAAT/Enhancer-binding Protein Homologous Protein (CHOP) Expression by Interleukin-1β in Pancreatic β Cells

(2010) Chunli Shao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modified expression of the ADAMTS enzymes and tissue inhibitor of metalloproteinases 3 during human intervertebral disc degeneration

(2009) Aneta J. Pockert et al.   ARTHRITIS AND RHEUMATISM