Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 83, Issue 22, Pages 14102-14109Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.8b02117
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Funding
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning [NRF-2018R1D1A1B07042179, 2017R1A4A1015594]
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A novel synthetic strategy employing benzyne and azomethine ylides for the construction of spiro[oxindole3,2'-pyrrolidine] derivatives has been achieved in good yields. The ketimines obtained from the condensation of isatins with CF3CH2NH2 react with benzyne in the presence of weak bases such as TBAF or TBAT. This mild practical 1,3-dipolar cycloaddition provides an efficient route to access biologically active compounds.
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