Article
Neurosciences
David K. Wright, Georgia F. Symons, William T. O'Brien, Stuart J. McDonald, Akram Zamani, Brendan Major, Zhibin Chen, Daniel Costello, Rhys D. Brady, Mujun Sun, Meng Law, Terence J. O'Brien, Richelle Mychasiuk, Sandy R. Shultz
Summary: The preliminary study showed that male athletes with SRC reported more severe symptoms compared to female athletes. dMRI revealed white matter differences between SRC athletes and non-concussed athletes at 48 hours post-injury, which persisted at 2 weeks post-injury. Furthermore, male SRC athletes exhibited significantly greater white matter disruption than female SRC athletes. These findings have implications for concussion management, including return-to-play decisions, and enhance our understanding of the role of sex in SRC outcomes.
Article
Clinical Neurology
Melanie A. Matyi, Jeffrey M. Spielberg
Summary: Deficits in negative emotion differentiation are associated with mental health outcomes, but the processes underlying individual differences in negative emotion differentiation are poorly understood. This study examines the relationship between white matter microstructure and negative emotion differentiation, providing insights into its component processes and its link to brain structure.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Juho Dahl, Olli Tenovuo, Jussi P. Posti, Jussi Hirvonen, Ari J. Katila, Janek Frantzen, Henna-Riikka Maanpaa, Riikka Takala, Eliisa Loyttyniemi, Jussi Tallus, Virginia Newcombe, David K. Menon, Peter J. Hutchinson, Mehrbod Mohammadian
Summary: Cerebral microbleeds are associated with the clinical severity of traumatic brain injury but have a weaker association with white matter integrity.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Nick Teller, Jordan A. Chad, Alexander Wong, Hayden Gunraj, Xiang Ji, Maged Goubran, Asaf Gilboa, Eugenie Roudaia, Allison Sekuler, Nathan Churchill, Tom Schweizer, Fuqiang Gao, Mario Masellis, Benjamin Lam, Chris Heyn, Ivy Cheng, Robert Fowler, Sandra E. Black, Bradley J. MacIntosh, Simon J. Graham, J. Jean Chen
Summary: By comparing simulation and experimental data, it is found that correlated diffusion imaging method performs better in detecting the effect of COVID-19, which reveals less restricted diffusion in the frontal lobe and more restricted diffusion in the cerebellar white matter in patients, consistent with existing studies.
HUMAN BRAIN MAPPING
(2023)
Article
Clinical Neurology
Letizia Squarcina, Susanna Lucini Paioni, Marcella Bellani, Maria Gloria Rossetti, Josselin Houenou, Mircea Polosan, Mary L. Phillips, Michele Wessa, Paolo Brambilla
Summary: In this study, the state of white matter structures in bipolar disorder patients was investigated using TBSS and FD analyses. The results showed diffusion abnormalities primarily located in the temporo-parietal network, while no significant differences were found in the morphological complexity of white matter structures. Individual patients showed localized significant deviations in fractal dimension values.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Review
Clinical Neurology
Xufang Ru, Ling Gao, Jiru Zhou, Qiang Li, Shilun Zuo, Yujie Chen, Zhi Liu, Hua Feng
Summary: Aneurysmal subarachnoid hemorrhage (SAH) is a special subtype of stroke with high mortality and disability rates. Survivors of SAH often experience neurological deficits and cognitive impairments, with white matter injuries being identified as a significant factor in long-term neurological deficits post-SAH. Mechanical damage from increased intracerebral pressure and metabolic damage from blood degradation and hypoxia are key factors in the pathophysiological processes leading to white matter injury after SAH.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Natalia Del Campo, Owen Phillips, Francoise Ory-Magne, Christine Brefel-Courbon, Monique Galitzky, Claire Thalamas, Katherine L. Narr, Shantanu Joshi, Manpreet K. Singh, Patrice Peran, Anne Pavy-LeTraon, Olivier Rascol
Summary: Multiple system atrophy (MSA) is a rare neurodegenerative disorder characterized by widespread accumulation of alpha-synuclein, primarily in oligodendrocytes. Whole brain deep and superficial white matter diffusivity abnormalities were observed in MSA patients but not in Parkinson's disease (PD) patients. These abnormalities were associated with motor and cognitive functions in MSA patients.
HUMAN BRAIN MAPPING
(2021)
Article
Clinical Neurology
Si-ping Luo, Fan-fan Chen, Han-wen Zhang, Fan Lin, Guo-dong Huang, Yi Lei
Summary: This study used DSI to quantitatively study the changes in the trigeminal cistern segment in patients with TN and found significant reductions in quantitative parameters on the affected side compared to the unaffected side. DSI, with its high-resolution fiber tracking technology, can provide valuable information about the integrity of trigeminal white matter in TN patients.
FRONTIERS IN NEUROLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Huawei Zhang, Huiru Li, Li Yin, Ziqi Chen, Baolin Wu, Xiaoqi Huang, Zhiyun Jia, Qiyong Gong
Summary: This study utilized MRI to explore white matter microstructure in patients with depression, revealing significant diffusion property differences in certain brain regions of depressed suicidal individuals. The findings suggest a close association between suicidal tendencies in depression and white matter abnormalities in the frontal cortex and limbic system.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Geriatrics & Gerontology
Stephanie Matijevic, Lee Ryan
Summary: The study found that age and sex have an impact on the cerebral white matter integrity of older adults, with a more significant effect on certain white matter tracts. Females exhibited lower global FA compared to males, but had higher MD in the anterior cingulum and superior longitudinal fasciculus. Age influenced both global FA and specific tract FA, while APOE epsilon 4 status did not show predictive power.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Clinical Neurology
Dong Dong, Koichi Hosomi, Nobuhiko Mori, Yoshi-ichiro Kamijo, Yohei Furotani, Daisuke Yamagami, Yu-ichiro Ohnishi, Yoshiyuki Watanabe, Takeshi Nakamura, Fumihiro Tajima, Haruhiko Kishima, Youichi Saitoh
Summary: Through contrastive analysis, we identified white matter brain regions that show microstructural changes in patients with neuropathic pain (NP) after spinal cord injury (SCI). The results showed that compared to the non-NP group, the NP group exhibited higher values of FA in the posterior body and splenium of the corpus callosum, which may be related to central sensitization or network hyperexcitability.
FRONTIERS IN NEUROLOGY
(2023)
Article
Anatomy & Morphology
Tory O. Frizzell, Elisha Phull, Mishaa Khan, Xiaowei Song, Lukas A. Grajauskas, Jodie Gawryluk, Ryan C. N. D'Arcy
Summary: This study evaluated white matter neuroplasticity in healthy adults pre-post motor training, specifically focusing on motor learning in the non-dominant hand. Changes in neuroplasticity were observed in the internal capsule and corpus callosum, with significant amplitude reductions in low-frequency oscillations implicating optimized transmission through altered myelination. The findings open new avenues for white matter investigations and advance MRI clinical applications.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zexuan Hu, Peng Sun, Ajit George, Xiangling Zeng, Mengyan Li, Tsen-Hsuan Lin, Zezhong Ye, Xinhua Wei, Xinqing Jiang, Sheng-Kwei Song, Ruimeng Yang
Summary: Using diffusion basis spectrum imaging (DBSI) to examine the microstructural changes in the substantia nigra (SN) and global white matter (WM) tracts of patients with early-stage PD. The results showed that DBSI could potentially detect and quantify inflammatory cell infiltration, fiber/dendrite loss, and edema in both SN and WM tracts in patients with early-stage PD.
EUROPEAN RADIOLOGY
(2023)
Article
Neurosciences
Fan Guo, Tian Zhang, Chen Wang, Ziliang Xu, Yingjuan Chang, Minwen Zheng, Peng Fang, Yuanqiang Zhu
Summary: This study used diffusion tensor imaging (DTI) to identify brain structural network differences contributing to individual differences in vulnerability to sleep deprivation (SD). The vulnerable group showed lower global efficiency, network strength, and local efficiency, as well as longer shortest path length. A disrupted subnetwork with widespread connections was observed in the vulnerable group. The strength of rich club connectivity was negatively correlated with performance on the psychomotor vigilance task (PVT).
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Computer Science, Interdisciplinary Applications
Temesgen Bihonegn, Sumit Kaushik, Avinash Bansal, Lubomir Vojtisek, Jan Slovak
Summary: The study aims to enhance the effectiveness of geodesic ray-tracing method in white matter fiber reconstruction by adjusting metrics on diffusion tensor spaces. By choosing appropriate metrics, enhancing robustness, and utilizing fourth order tensor data, more satisfactory results are achieved in white matter tract construction.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2021)
Article
Neurosciences
Amandine Jullienne, Mary Hamer, Elizabeth Haddad, Alexander Morita, Peter Gifford, Richard Hartman, William J. Pearce, Jiping Tang, John H. Zhang, Andre Obenaus
JOURNAL OF NEUROSCIENCE RESEARCH
(2020)
Article
Neurosciences
Jerome Badaut, Arash Adami, Lei Huang, Andre Obenaus
JOURNAL OF NEUROSCIENCE RESEARCH
(2020)
Article
Neurosciences
Amanda Q. Nguyen, Samantha Sutley, Jordan Koeppen, Karen Mina, Simone Woodruff, Sandy Hanna, Alekya Vengala, Peter W. Hickmott, Andre Obenaus, Iryna M. Ethell
JOURNAL OF NEUROSCIENCE
(2020)
Article
Biochemistry & Molecular Biology
Patsy Naomi Franco, Lara M. Durrant, Coleen Doan, Desirelys Carreon, Alejandra Beltran, Amandine Jullienne, Andre Obenaus, William J. Pearce
Summary: The study suggests that maternal undernutrition may impact neonatal cerebrovascular function through corticosteroid-dependent and -independent mechanisms, increasing vulnerability to hypoxic-ischemic injury and potentially leading to changes in neurobehavior and edema formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Steven J. Granger, Laura M. Glynn, Curt A. Sandman, Steven L. Small, Andre Obenaus, David B. Keator, Tallie Z. Baram, Hal Stern, Michael A. Yassa, Elysia Poggi Davis
Summary: Unpredictable maternal signals during infancy may affect the development of brain pathways, leading to aberrant cognitive and emotional outcomes. Studies have found that this maternal behavior pattern alters brain circuit maturation in animal models, but the association in humans is still uncertain.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Endocrinology & Metabolism
Jenny Szu, Andre Obenaus
Summary: Alzheimer's disease is a devastating neurological disorder characterized by memory and cognitive decline, with two main hypotheses proposed regarding its underlying mechanisms. The amyloid hypothesis suggests A beta accumulation as the basis of AD, while the vascular hypothesis links early vascular damage to increased A beta deposits in the brain. Studies have shown significant morphological changes in the cerebrovasculature associated with AD progression, highlighting the need for further research in this area.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Multidisciplinary Sciences
Yannick Fotio, Kwang-Mook Jung, Francesca Palese, Andre Obenaus, Alex Mabou Tagne, Lin Lin, Tarif Ibne Rashid, Romario Pacheco, Amandine Jullienne, Jade Ramirez, Marco Mor, Gilberto Spadoni, Cholsoon Jang, Andrea G. Hohmann, Daniele Piomelli
Summary: Chronic pain affects a large population worldwide and understanding the molecular events behind it is crucial for the development of effective therapies. The study highlights NAAA as a key control point in chronic pain progression that can be targeted with small-molecule therapeutics. Inhibiting NAAA can trigger a shift in local metabolism from aerobic glycolysis to mitochondrial respiration, effectively halting chronic pain development.
Article
Neurosciences
Kara M. Wendel, Annabel K. Short, Brenda P. Noarbe, Elizabeth Haddad, Anton M. Palma, Michael A. Yassa, Tallie Z. Baram, Andre Obenaus
Summary: The study found that there were brain-wide changes in the reward circuit of mice under early life adversity (ELA), with altered connectivity in the DR-VTA-NAcc pathway. ELA resulted in social anhedonia-like phenotype in adulthood, characterized by decreased social approach and interaction time with peers, but did not affect sucrose preference.
NEUROBIOLOGY OF STRESS
(2021)
Article
Biochemistry & Molecular Biology
Amandine Jullienne, Michelle V. Trinh, Andre Obenaus
Summary: MRI and PET technologies play important roles in the diagnosis and research of Alzheimer's Disease, with mouse models also contributing to our understanding of the disease on a cellular and molecular level. Researchers have focused on popular mouse models such as 3xTg-AD and 5xFAD, summarizing known MRI and PET imaging data. The goal is to provide a framework for future studies in AD mouse models and suggest improvements in rigor and reproducibility in future imaging studies.
Article
Neurosciences
Xiaoxiao Lin, Lujia Chen, Amandine Jullienne, Hai Zhang, Arjang Salehi, Mary Hamer, Todd C. Holmes, Andre Obenaus, Xiangmin Xu
Summary: This study longitudinally examined microvascular recovery and remodeling up to 2 months post injury using live brain miniscope and 2-photon microscopic imaging. The research found that new blood vessels began growing near the injury site shortly after the injury and peaked between 14 and 21 days post injury. The study concluded that morphological recovery events are closely linked to functional recovery of blood flow, which subsequently leads to improved behavioral outcomes.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Arjang Salehi, Sirus Salari, Amandine Jullienne, Jennifer Daglian, Kevin Chen, Tallie Z. Baram, Andre Obenaus
Summary: Febrile status epilepticus (FSE) is an important risk factor for temporal lobe epilepsy. In a rat model of FSE, an acute MRI signal in the basolateral amygdala (BLA) predicted epilepsy in adulthood. The reduced T2 relaxation values in the BLA may be influenced by vascular topology according to our hypothesis.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Amandine Jullienne, Ryan Quan, Jenny Szu, Michelle Trinh, Erik J. Behringer, Andre Obenaus
Summary: This study utilized the 3xTg-AD mouse model to examine the role of vascular dysfunction and structural abnormalities in the progression of Alzheimer's disease. The findings demonstrate progressive alterations in individual cortical vessels and the cortical vascular network, potentially identifying unique diagnostic signatures of AD progression.
Article
Neurosciences
Andre Obenaus, Beatriz Rodriguez-Grande, Jeong Bin Lee, Christophe J. Dubois, Marie-Line Fournier, Martine Cador, Stephanie Caille, Jerome Badaut
Summary: Traumatic brain injury (TBI) is most common among children and mild cases are the most frequent. Whether a single mild TBI sustained during childhood can cause long-lasting changes in the brain is still debated.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Andre Obenaus, Eli Kinney-Lang, Amandine Jullienne, Elizabeth Haddad, Kara M. M. Wendel, A. Duke Shereen, Ana Solodkin, Jeffrey F. F. Dunn, Tallie Z. Z. Baram
Summary: Previous neuroimaging techniques have struggled to accurately delineate the boundaries of the amygdaloid complex, specifically the basolateral nucleus (BLA), due to poor contrast. This study presents a novel diffusion tensor imaging (DTI) approach that enhances contrast, allowing for precise measurement and validation of BLA volumes using histological and cellular-identity techniques. The principles utilized in this study can be applied to other brain regions and various species.
Article
Neurosciences
Aleksandra Ichkova, Andrew M. Fukuda, Nina Nishiyama, Germaine Paris, Andre Obenaus, Jerome Badaut