Article
Neurosciences
Hongxiao Yu, Luo Shi, Jinting Chen, Shirui Jun, Yinchao Hao, Shuang Wang, Congrui Fu, Xiang Zhang, Haiyan Lu, Sheng Wang, Fang Yuan
Summary: The study demonstrates that neurons expressing LepRb in the nucleus tractus solitarii (NTS) play a key role in respiratory control, with leptin potentiating breathing via an NTS-LPBN-preBotC circuit. Stimulation of NTSLepRb neurons notably activates breathing, while ablation of NTSLepRb neurons projecting to the LPBN eliminates the enhanced effect.
NEUROSCIENCE BULLETIN
(2022)
Article
Neurosciences
Yinchao Hao, Ziqian Wei, Shuang Wang, Pei An, Yifei Huang, Lingxiao Yu, Mengchu Zhu, Hongxiao Yu, Fang Yuan, Sheng Wang
Summary: The disrupted medullary leptin signaling contributes to obesity-related hypoventilation, and inhibiting the upregulated SOCS3 in the NTS and RTN can alleviate this condition.
Article
Neurosciences
Shirui Jun, Xianhong Ou, Luo Shi, Hongxiao Yu, Tianjiao Deng, Jinting Chen, Xiaojun Nie, Yinchao Hao, Yishuo Shi, Wei Liu, Yanming Tian, Sheng Wang, Fang Yuan
Summary: The NTS is involved in the autonomic regulation of cardiovascular activity. NTSPNMT neurons have different effects on blood pressure depending on their projections. Stimulation of NTSPNMT neurons projecting to different areas can cause either a decrease or increase in blood pressure and heart rate. Ablation of NTSPNMT neurons and their projections to specific areas impairs the arterial baroreflex.
NEUROSCIENCE BULLETIN
(2023)
Article
Physiology
Elenia Cinelli, Ludovica Iovino, Fulvia Bongianni, Tito Pantaleo, Federico Lavorini, Claudia Mannini, Donatella Mutolo
Summary: It has been shown that muscarinic acetylcholine receptors (mAChRs) located within the caudal nucleus tractus solitarii (cNTS) mediate a cholinergic inhibitory control mechanism of the cough reflex. Identification of the involved mAChR subtypes could be of considerable interest for novel therapeutic strategies.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Article
Psychology, Biological
Winfried L. Neuhuber, Hans -Rudolf Berthoud
Summary: Due to its important role in autonomic networks and interoception, the vagus nerve continues to attract interest from both basic scientists and therapists. In addition to the classical vagal brainstem nuclei, the spinal trigeminal and paratrigeminal nuclei also play a role in vagal innervation. Furthermore, the nucleus of the solitary tract integrates not only visceral but also somatic sensory inputs.
BIOLOGICAL PSYCHOLOGY
(2022)
Article
Multidisciplinary Sciences
Zhe Chen, Ming-Tong Lin, Chen Zhan, Nan-Shan Zhong, Di Mu, Ke-Fang Lai, Mingzhe J. Liu
Summary: This study reveals that GABAergic neurons in the l/vlPAG region suppress cough processing through a descending pathway. Activation of these neurons decreases coughing-like behaviors, while suppression of these neurons enhances cough sensitivity. These findings provide important insights into the neural mechanisms underlying chronic cough.
Article
Neurosciences
Jekaterina Zyuzin, Nicholas Jendzjowsky
Summary: Sensory convergence of pulmonary vagal nociceptors and carotid chemoreceptors occurs in the nucleus tractus solitarius and nucleus ambiguus, leading to enhanced motor output for airway defense.
JOURNAL OF NEUROPHYSIOLOGY
(2022)
Article
Nutrition & Dietetics
Chieh-Jen Wu, Pei-Wen Cheng, Ming-Hsiang Kung, Chiu-Yi Ho, Jun-Yen Pan, Ching-Jiunn Tseng, Hsin-Hung Chen
Summary: This study investigated the impact of NTS Glut5 knockdown on fructose-induced hypertension. The results showed that Glut5 KD reduced sympathetic nerve hyperactivity, improved central insulin signaling, lowered blood pressure, restored signaling dependent on adenosine 5'-monophosphate-activated protein kinase, and reduced fructose-induced oxidative stress within the NTS.
JOURNAL OF NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Gwo-Ching Sun, Jockey Tse, Yung-Ho Hsu, Chiu-Yi Ho, Ching-Jiunn Tseng, Pei-Wen Cheng
Summary: Opioids play a role in the development of hypertension by causing inflammation and affecting blood pressure control. The formation of AT1R and mu OR heterodimers may contribute to the progression of hypertension.
Review
Physiology
Kevin Yackle
Summary: The rhythmicity of breath is essential for normal physiology, but breathing also possesses multifunctionality. External signals can alter breathing, such as stopping it underwater or deepening it during exertion. Internal cues utilize breath to express emotions and harmonize with other actions. The recent advancements in cellular and molecular tools have contributed to our understanding of the diversity of neuronal types in the breathing control circuit and how they confer its multifunctionality.
ANNUAL REVIEW OF PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Coralie Herent, Severine Diem, Giovanni Usseglio, Gilles Fortin, Julien Bouvier
Summary: Through neural circuit tracing and activity interference in mice, we have discovered two systems in the central locomotor network that enhance respiration in relation to running. One system involves the mesencephalic locomotor region (MLR) and the other involves the lumbar enlargement of the spinal cord. These findings expand our understanding of respiratory hyperpnea and the functional implications of cell types and pathways traditionally associated with locomotion or respiration.
NATURE COMMUNICATIONS
(2023)
Article
Neurosciences
Na Liu, Congrui Fu, Hongxiao Yu, Yakun Wang, Luo Shi, Yinchao Hao, Fang Yuan, Xiangjian Zhang, Sheng Wang
Summary: The study demonstrated that activation of Phox2b(LC) neurons can increase respiration, enhance ventilatory responses to high CO2, and boost activity of preBotzinger complex neurons, revealing a potential mechanism for respiratory control.
NEUROSCIENCE BULLETIN
(2021)
Article
Biology
Caroline B. Ferreira, Talita M. Silva, Phelipe E. Silva, Claudio L. Castro, Catherine Czeisler, Jose J. Otero, Ana C. Takakura, Thiago S. Moreira
Summary: Mutations in the Phox2b gene, specifically the non-polyalanine repeat expansion mutations (NPARM) form, were found to affect respiratory control and the number of certain neurons. This study contributes to our understanding of the neuropathology of congenital central hypoventilation syndrome (CCHS) and provides new evidence for the mechanisms underlying NPARM CCHS.
Article
Cell Biology
Grazyna Lietzau, Stelia Ntika, Hiranya Pintana, Linda Tracy, Thomas Klein, Thomas Nystrom, Vladimer Darsalia, Cesare Patrone, Camilla Krizhanovskii
Summary: GLP-1 is a peripheral incretin and centrally active peptide that regulates metabolism, improves cognition, and has neuroprotective effects. Obesity-induced type 2 diabetes may impair the function of GLP-1-producing neurons, but normalization of blood sugar levels may counteract this effect.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Review
Neurosciences
Jerome A. Dempsey, Travis D. Gibbons
Summary: This article examines the importance of three long-standing questions regarding the influence of chemoreceptors on cardiorespiratory function. It discusses the effects of chemoreceptor activity on ventilation and the role of chemoreception in the pathogenesis of obstructive sleep apnea. The findings highlight the significance of chemoreceptors in regulating breathing and airway function.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Neurosciences
Na Liu, Congrui Fu, Hongxiao Yu, Yakun Wang, Luo Shi, Yinchao Hao, Fang Yuan, Xiangjian Zhang, Sheng Wang
Summary: The study demonstrated that activation of Phox2b(LC) neurons can increase respiration, enhance ventilatory responses to high CO2, and boost activity of preBotzinger complex neurons, revealing a potential mechanism for respiratory control.
NEUROSCIENCE BULLETIN
(2021)
Article
Pharmacology & Pharmacy
Xuan Zhang, Gaohua Zhang, Wenjing Zhai, Zhijun Zhao, Sheng Wang, Jianfeng Yi
PHARMACOLOGICAL RESEARCH
(2020)
Article
Oncology
Cong Zhang, Lili Cui, Weiliang He, Xiangjian Zhang, Huaijun Liu
Summary: The study demonstrated that NBP promoted neurite development in both immature and mature neurons, improving the complexity and plasticity of neuronal development processes. Additionally, the data revealed that NBP promoted neurite extension and branching by activating the Shh signaling pathway in primary cortical neurons.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Peipei Zhang, Xiangjian Zhang, Yuanxiang Huang, Junmin Chen, Wenyan Shang, Guang Shi, Lan Zhang, Cong Zhang, Rong Chen
Summary: Atorvastatin significantly improved sensorimotor deficits and reduced neuroinflammation in mice with permanent middle cerebral artery occlusion (pMCAO), by modulating gut microbiota composition, enhancing intestinal barrier function, and regulating intestinal immune function. Transplantation of fecal microbiota from atorvastatin-treated mice attenuated neuroinflammation in pMCAO mice, suggesting a potential role of gut microbiota in the anti-inflammatory effects of atorvastatin in stroke.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Neurosciences
Yanming Tian, Danyang Geng, Yakun Wang, Luo Shi, Hongxiao Yu, Wei He, Yufang Zhu, Shirui Jun, Congrui Fu, Xin Wang, Xiangjian Zhang, Fang Yuan, Sheng Wang
Summary: This study shows that increased CO2-induced respiratory and cardiovascular responses in SHRs are associated with RTN neurons, particularly involving the activity of TASK-2 channels. The inhibition of TASK-2 channel activity by clofilium diminishes the amplified responses, indicating the important role played by RTN neurons in regulating these responses.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Cell Biology
Huaxing Zhang, Jing Dai, Danyang Tian, Lin Xiao, Hongmei Xue, Qi Guo, Xiangjian Zhang, Xu Teng, Sheng Jin, Yuming Wu
Summary: The disrupted diurnal variation in cardiac function in aging mice was associated with increased oxidative stress and decreased H2S levels. H2S could restore the diurnal variation in cardiac function of aging mice by reducing oxidative stress.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Review
Chemistry, Multidisciplinary
Hong-yun Wang, Jun-rui Ye, Li-yuan Cui, Shi-feng Chu, Nai-hong Chen
Summary: Recent evidence suggests that regulatory T (Treg) cells play a crucial role in immune regulation after ischemic stroke (IS), but their effects on IS outcomes remain controversial. Further research is needed to elucidate the mechanisms by which Treg cells modulate the immune responses induced by IS.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Physiology
Hua Chen, Bin Yu, Xinqi Guo, Hong Hua, Fang Cui, Yue Guan, Yanming Tian, Xiangjian Zhang, Yi Zhang, Huijie Ma
Summary: The study demonstrated that CIHH can reduce high blood pressure in SHR by modulating RAS activity, downregulating the ACE-Ang II-AT1 axis and upregulating the ACE2-(Ang1-7)-Mas axis, leading to reduced vascular remodeling and fibrosis, decreased inflammation, and enhanced vascular relaxation.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Neurosciences
Hongxiao Yu, Luo Shi, Jinting Chen, Shirui Jun, Yinchao Hao, Shuang Wang, Congrui Fu, Xiang Zhang, Haiyan Lu, Sheng Wang, Fang Yuan
Summary: The study demonstrates that neurons expressing LepRb in the nucleus tractus solitarii (NTS) play a key role in respiratory control, with leptin potentiating breathing via an NTS-LPBN-preBotC circuit. Stimulation of NTSLepRb neurons notably activates breathing, while ablation of NTSLepRb neurons projecting to the LPBN eliminates the enhanced effect.
NEUROSCIENCE BULLETIN
(2022)
Article
Pharmacology & Pharmacy
Xinhao Wang, Yize Zhao, Xiaorui Shi, Miao Gong, Ying Hao, Yaling Fu, Omar Israel Velez de-la-Paz, Xi Wang, Yuru Du, Xiangfei Guo, Li Song, Li Meng, Yuan Gao, Xi Yin, Sheng Wang, Yun Shi, Haishui Shi
Summary: This study found that the administration of exogenous SO2 derivatives has an effect on the formation of contextual fear memory, but no effect on reconsolidation and retention. This provides evidence for the development of new strategies for PTSD prevention and treatment.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Correction
Pharmacology & Pharmacy
Xinhao Wang, Yize Zhao, Xiaorui Shi, Miao Gong, Ying Hao, Yaling Fu, Omar Israel Velez de-la-Paz, Xi Wang, Yuru Du, Xiangfei Guo, Li Song, Li Meng, Yuan Gao, Xi Yin, Sheng Wang, Haishui Shi, Yun Shi
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Psychology, Biological
Miao Gong, Han Song, Yan Dong, Ziqing Huai, Yaling Fu, Panpan Yu, Boya Huang, Rui Yang, Yi Guo, Qian Meng, Yuan Gao, Li Song, Qingjun Guo, Qiang Gao, Xi Yin, Sheng Wang, Yun Shi, Haishui Shi
Summary: This study found that exposure to BPAF significantly affects emotional behaviors in adult and offspring mice in a sex-dependent manner. Adult male mice exposed to BPAF showed reduced anxiety and depression-like behaviors, while female mice showed increased anxiety and depression-like behaviors, as well as enhanced novel object recognition memory formation and impaired contextual fear conditioning memory formation. Maternal exposure to BPAF resulted in anxiety-like effects and anti-depression-like effects in male offspring mice during adulthood, while increasing anxiety and depression-like behaviors in female offspring mice during adulthood.
PHYSIOLOGY & BEHAVIOR
(2022)
Article
Biology
Junna He, Xiangjian Zhang, Weiliang He, Yanzhao Xie, Yanxia Chen, Yang Yang, Rong Chen
Summary: The study found that ZNS could inhibit neuronal apoptosis in cerebral ischemia by blocking reactive oxygen species, significantly improving neurological deficits and reducing infarct volumes in a cerebral ischemia mouse model. This suggests that ZNS may be a promising therapy for cerebral ischemia by exerting neuroprotective effects through inhibition of apoptosis in neuronal cells.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2021)