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Biochemistry & Molecular Biology
Yanlin He, Xing Cai, Hailan Liu, Krisitine M. Conde, Pingwen Xu, Yongxiang Li, Chunmei Wang, Meng Yu, Yang He, Hesong Liu, Chen Liang, Tingting Yang, Yongjie Yang, Kaifan Yu, Julia Wang, Rong Zheng, Feng Liu, Zheng Sun, Lora Heisler, Qi Wu, Qingchun Tong, Canjun Zhu, Gang Shu, Yong Xu
Summary: The translation discusses how obesity is primarily caused by consuming excessive calories beyond energetic requirements, while the underlying drivers have not been fully defined. The study found that activating specific neural pathways can regulate different types of feeding behavior, driven by either hunger or non-hunger cues.
MOLECULAR PSYCHIATRY
(2021)
Article
Psychology, Biological
Luciana Benedetto, Mayda Rivas, Florencia Pena, Diego Serantes, Annabel Ferreira, Pablo Torterolo
Summary: The disinhibition of the mPOA region increased active maternal behaviors and reduced nursing, while disinhibition of the VLPO region increased retrievals and mouthings. These findings suggest that the mPOA plays a key role in maternal behavior regulation, while the VLPO is involved in sleep promotion.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Psychiatry
Chunmei Wang, Wenjun Zhou, Yang He, Tiffany Yang, Pingwen Xu, Yongjie Yang, Xing Cai, Julia Wang, Hesong Liu, Meng Yu, Chen Liang, Tingting Yang, Hailan Liu, Makoto Fukuda, Qingchun Tong, Qi Wu, Zheng Sun, Yanlin He, Yong Xu
Summary: Sufficient feeding is essential for animals' survival, and the neurobiological processes regulating food seeking behavior have been partially understood, in which the AgRP -> PVT circuit is crucial for food seeking.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Psychology, Biological
Joseph S. Lonstein, Thierry D. Charlier, Jodi L. Pawluski, Nadege Aigueperse, Maryse Meurisse, Frederic Levy, Sophie Lumineau
Summary: The study investigates the neural mechanisms underlying maternal caregiving behavior in laboratory rodents and Japanese quail. The medial preoptic area (mPOA) plays a crucial role in maternal acceptance and motivation, while the nucleus accumbens (NAC) shows longer-term changes in response to maternal experience. The findings suggest a conserved role for mPOA and NAC in maternal caregiving across vertebrates.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Behavioral Sciences
Youjun Yang, Zhanqiong Zhong, Baojia Wang, Yili Wang, Weijun Ding
Summary: Lack of maternal care and attention during infancy and childhood can lead to neuropsychiatric disorders in adulthood, but the underlying neuroregulatory signaling has not been extensively studied. This study shows that unpredictable maternal separation in mice impairs neuronal development in the medial prefrontal cortex and causes long-lasting behavioral changes. The downregulation of dopamine D1 receptor in the mPFC appears to play a role in these abnormalities. Activating D1R signaling in the mPFC improves neuronal excitability and rescues the behavioral and cognitive dysfunction caused by maternal deprivation.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Neurosciences
Ying Han, Xing-Yu Li, Shao-Ran Wang, Yi-Chao Wei, Xiao-Hong Xu
Article
Multidisciplinary Sciences
Zheng-Dong Zhao, Wen Z. Yang, Cuicui Gao, Xin Fu, Wen Zhang, Qian Zhou, Wanpeng Chen, Xinyan Ni, Jun-Kai Lin, Juan Yang, Xiao-Hong Xu, Wei L. Shen
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Multidisciplinary Sciences
Yi-Chao Wei, Shao-Ran Wang, Zhuo-Lei Jiao, Wen Zhang, Jun-Kai Lin, Xing-Yu Li, Shuai-Shuai Li, Xin Zhang, Xiao-Hong Xu
NATURE COMMUNICATIONS
(2018)
Article
Neurosciences
Zheng-dong Zhao, Zongming Chen, Xinkuan Xiang, Mengna Hu, Hengchang Xie, Xiaoning Jia, Fang Cai, Yuting Cui, Zijun Chen, Lechen Qian, Jiashu Liu, Congping Shang, Yiqing Yang, Xinyan Ni, Wenzhi Sun, Ji Hu, Peng Cao, Haohong Li, Wei L. Shen
NATURE NEUROSCIENCE
(2019)
Article
Multidisciplinary Sciences
Wen Z. Yang, Xiaosa Du, Wen Zhang, Cuicui Gao, Hengchang Xie, Yan Xiao, Xiaoning Jia, Jiashu Liu, Jianhui Xu, Xin Fu, Hongqing Tu, Xiaoyu Fu, Xinyan Ni, Miao He, Jiajun Yang, Hong Wang, Haitao Yang, Xiao-hong Xu, Wei L. Shen
Review
Biology
Wei Xiao, Zhuo-Lei Jiao, Esra Senol, Jiwei Yao, Miao Zhao, Zheng-Dong Zhao, Xiaowei Chen, Peng Cao, Yu Fu, Zhihua Gao, Wei L. Shen, Xiao-Hong Xu
Summary: All animals exhibit innate behaviors crucial for survival, with modern techniques aiding in understanding neural circuits controlling various innate behaviors. Studies delve into the role of genetically-defined neurons in different behaviors, as well as the clinical significance and neural encoding of these behaviors. Exciting findings reveal divergence and convergence in neural circuits regulating innate behaviors, emphasizing the importance of multidisciplinary and cross-species approaches in research.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Article
Multidisciplinary Sciences
Hong Yu, Xinkuan Xiang, Zongming Chen, Xu Wang, Jiaqi Dai, Xinxin Wang, Pengcheng Huang, Zheng-dong Zhao, Wei L. Shen, Haohong Li
Summary: The study reveals that neuronal ensembles in the periaqueductal gray encode the sequential hunting motor program, providing a framework for decoding complex instinctive behaviors. LPAG(Vgat) neurons are essential for prey detection, chase and attack, while LPAG(Vglut2) neurons are selectively required for the attack.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Zheng-Dong Zhao, Xiao Han, Renchao Chen, Yiqiong Liu, Aritra Bhattacherjee, Wenqiang Chen, Yi Zhang
Summary: The striatum plays a critical role in regulating addiction-related behaviors. A subtype of D1 MSNs, Tac2+, demonstrates an unconventional and subtype/projection-specific negative regulatory function in drug addiction.
Article
Biochemical Research Methods
Jiaqi Shen, Lequn Geng, Xingyu Li, Catherine Emery, Kayla Kroning, Gwendolyn Shingles, Kerry Lee, Matthias Heyden, Peng Li, Wenjing Wang
Summary: We have developed a pair of chemically activated protein domains (CAPs) that can control the accessibility of short peptides. CAPs are applicable to a range of short peptides and have a chemical dependence up to 156-fold. Our study demonstrates the potential use of CAPs in cell cultures and multiple organs in living animals.
Article
Multidisciplinary Sciences
Wen Z. Yang, Hengchang Xie, Xiaosa Du, Qian Zhou, Yan Xiao, Zhengdong Zhao, Xiaoning Jia, Jianhui Xu, Wen Zhang, Shuang Cai, Zhangjie Li, Xin Fu, Rong Hua, Junhao Cai, Shuang Chang, Jing Sun, Hongbin Sun, Qingqing Xu, Xinyan Ni, Hongqing Tu, Ruimao Zheng, Xiaohong Xu, Hong Wang, Yu Fu, Liming Wang, Xi Li, Haitao Yang, Qiyuan Yao, Tian Yu, Qiwei Shen, Wei L. Shen
Summary: The neural pathways responsible for cold defense regulation are still unclear. In this study, the authors found that there are parallel thermogenic pathways from the brainstem to the hypothalamus that work together to enable resilience to cold temperature exposure and hypothermia. These pathways are crucial for cold defense and can induce strong cold-defense responses.
NATURE COMMUNICATIONS
(2023)