Article
Radiology, Nuclear Medicine & Medical Imaging
Hui Hong, Xinfeng Yu, Ruiting Zhang, Yeerfan Jiaerken, Shuyue Wang, Xiao Luo, Min Lou, Peiyu Huang, Minming Zhang
Summary: This study revealed that lacunar infarcts lead to decreased cortical thickness and reduced neurite orientation dispersion in the ipsilesional cortex. In patients with precentral gyrus involvement, correlations were found between neurite orientation dispersion in the ipsilesional cortex and cortical thickness, as well as between neurite orientation dispersion in the contralesional cortex and contralesional cortical thickness. The findings suggest that dendrites' loss may contribute to cortical atrophy following lacunar infarcts.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rifeng Jiang, Xiaomei Hu, Kaiji Deng, Shaofan Jiang, Weitao Chen, Zhongshuai Zhang
Summary: The study evaluated the application of NODDI in assessing brain glioma-induced CST injury. Results showed significant changes in CST features on the affected side for HGG patients, with track number, track volume, and FA decreasing, while MD and ICVF changed only in patients with motor weakness. The relative ICVF exhibited high sensitivity in diagnosing HGG-induced CST changes.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Immunology
Angela Radetz, Kalina Mladenova, Dumitru Ciolac, Gabriel Gonzalez-Escamilla, Vinzenz Fleischer, Erik Ellwardt, Julia Kraemer, Stefan Bittner, Sven G. Meuth, Muthuraman Muthuraman, Sergiu Groppa
Summary: The study investigated the microstructural integrity of the motor system in multiple sclerosis patients using advanced imaging techniques and found a link between microstructural characteristics, neural tissue excitability, and cognitive-motor performance. The NODDI parameters were more effective in detecting abnormalities in patients compared to healthy controls, suggesting the potential for using advanced biophysical models for predicting excitability alterations in neuroinflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Neurosciences
Matthew K. Defenderfer, Pinar Demirayak, Leland L. Fleming, Dawn K. DeCarlo, Paul Stewart, Kristina M. Visscher
Summary: Late-stage macular degeneration often impairs central vision, causing individuals to rely on peripheral vision. Patients with macular degeneration develop a preferred retinal locus to compensate for the loss of central vision. This study found that the thickness of the cortex associated with the preferred retinal locus was thinner in patients with macular degeneration compared to controls. However, there were no significant differences in cortical thickness, neurite density, or orientation dispersion between the preferred retinal locus and control regions.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Wenjun Wang, Qiaowen Yu, Wenjia Liang, Feifei Xu, Zhuoran Li, Yuchun Tang, Shuwei Liu
Summary: This study used advanced imaging techniques to examine the cortical microstructural alterations in preterm infants. The findings suggest that preterm infants have abnormal cortical development, particularly in terms of lower neurite density. These findings have significant clinical importance in understanding functional and behavioral variations in preterm population and guiding interventions for their brain development.
Article
Neurosciences
Nao-Xin Huang, Wen Qin, Jia-Hui Lin, Qiu-Yi Dong, Hua-Jun Chen
Summary: This study aimed to investigate the microstructural impairments of corticospinal tracts (CSTs) with different origins in amyotrophic lateral sclerosis (ALS) using neurite orientation dispersion and density imaging (NODDI). The results showed that ALS patients had microstructural impairments in CST subfibers, especially in those originating from the primary motor area (M1), which correlated with disease severity. The combination of NODDI and CST subfibers analysis may improve the diagnostic performance for ALS.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Oncology
Taoyang Yuan, Jianyou Ying, Chuzhong Li, Lu Jin, Jie Kang, Yuanyu Shi, Songbai Gui, Chunhui Liu, Rui Wang, Zhentao Zuo, Yazhuo Zhang
Summary: This study investigated microstructural pathology of the cortex and white matter in growth hormone-secreting pituitary adenoma, and found that these changes were associated with neuropsychological dysfunction in acromegaly.
FRONTIERS IN ONCOLOGY
(2021)
Article
Clinical Neurology
Jianqiao Tian, Sheelakumari Raghavan, Robert I. Reid, Scott A. Przybelski, Timothy G. Lesnick, Robel K. Gebre, Jonathan Graff-Radford, Christopher G. Schwarz, Val J. Lowe, Kejal Kantarci, David S. Knopman, Ronald C. Petersen, Clifford R. Jack, Prashanthi Vemuri
Summary: This study used neurite orientation dispersion and density imaging (NODDI) to investigate the association between white matter (WM) changes and Alzheimer disease (AD), and evaluated its relationship with cognitive performance. The results showed that the neurodegeneration of WM is spatially dependent and correlated with regional tau deposition in different stages of AD. Additionally, the WM changes explained a similar amount of cognitive performance variation as regional tau deposition and provided complementary information about disease staging and progression.
Article
Neurosciences
T. Demerath, C. Donkels, M. Reisert, M. Heers, A. Rau, N. Schroeter, A. Schulze-Bonhage, P. Reinacher, C. Scheiwe, M. J. Shah, J. Beck, A. Vlachos, C. A. Haas, H. Urbach
Summary: Hippocampal sclerosis with gray-white matter blurring in the anterior temporal lobe is associated with prolonged T1 relaxation and axonal loss. Patients without GMB in the temporal poles showed less reduction in axonal fraction on imaging compared to normal controls. Contralateral values did not differ significantly between patients and normal controls, but reduced axonal density and diameter were confirmed in the GMB-affected temporopolar white matter compared to temporal poles without GMB.
Article
Clinical Neurology
Jacqueline F. I. Anderson, Lucy E. Oehr, Jian Chen, Jerome J. Maller, Marc L. Seal, Joseph Yuan-Mou Yang
Summary: This study demonstrates that the predictive relationship between WMT microstructural organization and cognition is significantly disrupted 6-10 weeks after mTBI, suggesting different recovery trajectories for WMT microstructural organization and cognitive function.
FRONTIERS IN NEUROLOGY
(2023)
Article
Neurosciences
Nico Lehmann, Norman Aye, Joern Kaufmann, Hans-Jochen Heinze, Emrah Duezel, Gabriel Ziegler, Marco Taubert
Summary: The study used NODDI method to acquire multi-shell DWI data from 29 healthy young subjects twice, finding high test-retest reproducibility for the orientation dispersion index (ODI) and slightly worse results for the neurite density index (NDI). The choice of analysis approach was found to have significant consequences for the results, with voxel-based approach and ROI-averaging showing higher reproducibility.
Article
Neurosciences
Nils Schroeter, Michel Rijntjes, Horst Urbach, Cornelius Weiller, Martin Treppner, Elias Kellner, Wolfgang H. Jost, Bastian E. A. Sajonz, Marco Reisert, Jonas A. Hosp, Alexander Rau
Summary: This study investigated the pathophysiological significance of the substantia nigra (SN) and putamen in Parkinson's disease (PD) using diffusion microstructure imaging (DMI). The results showed that structural alterations in the SN and putamen were associated with motor impairment and the levodopa response in PD. The integrity of the putamen was crucial for the improvement of motor symptoms to dopaminergic medication.
NPJ PARKINSONS DISEASE
(2022)
Article
Clinical Neurology
Daphne Chylinski, Justinas Narbutas, Evelyne Balteau, Fabienne Collette, Christine Bastin, Christian Berthomier, Eric Salmon, Pierre Maquet, Julie Carrier, Christophe Phillips, Jean-Marc Lina, Gilles Vandewalle, Maxime Van Egroo
Summary: This study found that the complexity of neurite organization specifically influences the occurrence rate of fast switcher slow waves in healthy middle-aged individuals, and also found that the density of frontal neurites is closely related to neural synchronization during sleep.
Article
Clinical Neurology
Keejin Yoon, Derek B. Archer, Margareta A. Clarke, Seth A. Smith, Ipek Oguz, Gary Cutter, Junzhong Xu, Francesca Bagnato
Summary: In this study, the researchers propose that using the NODDI method and high-resolution probabilistic tractography, white matter tract templates can improve the assessment of regional axonal injury and its association with disability in pwMS. The results show that changes in IVF values are related to the disability status and lesion burden in pwMS.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Andrea Tedeschi, Molly J. E. Larson, Antonia Zouridakis, Lujia Mo, Arman Bordbar, Julia M. Myers, Hannah Y. Qin, Haven I. Rodocker, Fan Fan, John J. Lannutti, Craig A. McElroy, Shahid M. Nimjee, Juan Peng, W. David Arnold, Lawrence D. F. Moon, Wenjing Sun
Summary: The daily administration of gabapentin promotes structural and functional cortical plasticity in adult mice after a stroke. Gabapentin increases neuroplasticity and reduces maladaptive plasticity, leading to functional recovery. The findings suggest that repurposing gabapentinoids could be a promising treatment strategy for stroke repair.
Review
Neurosciences
Alberto Redolfi, Damiano Archetti, Silvia De Francesco, Claudio Crema, Fabrizio Tagliavini, Raffaele Lodi, Roberta Ghidoni, Claudia A. M. Gandini Wheeler-Kingshott, Daniel C. Alexander, Egidio D'Angelo
Summary: Neuroinformatics is a research field that focuses on software tools for identifying, analyzing, modeling, organizing, and sharing neuroscience data. With the emergence of big data, neuroinformatics has experienced rapid growth in the past two decades, enabling neuroscientists to acquire and process data faster and more cost-effectively. To address this, neuroimaging-focused neuroinformatics platforms have been developed, aiming to archive and organize data, develop data-driven models, and provide computational and storage resources.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Biophysics
Udunna C. Anazodo, Jinggang J. Ng, Boaz Ehiogu, Johnes Obungoloch, Abiodun Fatade, Henk J. M. M. Mutsaerts, Mario Forjaz Secca, Mamadou Diop, Abayomi Opadele, Daniel C. Alexander, Michael O. Dada, Godwin Ogbole, Rita Nunes, Patricia Figueiredo, Matteo Figini, Benjamin Aribisala, Bamidele O. Awojoyogbe, Harrison Aduluwa, Christian Sprenger, Rachel Wagner, Alausa Olakunle, Dominic Romeo, Yusha Sun, Francis Fezeu, Akintunde T. Orunmuyi, Sairam Geethanath, Vikas Gulani, Edward Chege Nganga, Sola Adeleke, Ntusi Ntobeuko, Frank J. Minja, Andrew G. Webb, Iris Asllani, Farouk Dako
Summary: Magnetic resonance imaging (MRI) technology has greatly impacted healthcare systems worldwide, but remains inaccessible in low-resource areas like Africa. The Consortium for Advancement of MRI Education and Research in Africa (CAMERA) is working to address this issue, conducting surveys and symposia to identify challenges and provide a framework for advancing MRI capacity in Africa.
NMR IN BIOMEDICINE
(2023)
Article
Behavioral Sciences
Lina I. Skora, James J. A. Livermore, Zoltan Dienes, Anil K. Seth, Ryan B. Scott
Summary: The extent to which high-level, complex functions can proceed unconsciously has been a topic of considerable debate. This study focuses on instrumental conditioning and aims to examine the feasibility of instrumental conditioning in the unconscious domain. The results suggest that complex forms of learning may rely on conscious access.
Article
Behavioral Sciences
Nourah M. M. Alruwais, Jenifer M. M. Rusted, Naji Tabet, Nicholas G. G. Dowell
Summary: This study investigated potential subtle differences in blood-brain barrier permeability in carriers of the APOE epsilon-4 genotype compared to carriers of the APOE epsilon-3 genotype. Although the differences were not statistically significant, they suggest early changes in BBB permeability in APOE epsilon-4 carriers, which may help identify at-risk populations and facilitate early interventions to change the trajectory of neurodegenerative decline.
BRAIN AND BEHAVIOR
(2022)
Article
Multidisciplinary Sciences
Ioanna Alicia Amaya, Nele Behrens, David John Schwartzman, Trevor Hewitt, Timo Torsten Schmidt
Summary: Flicker light stimulation induces transient visual hallucinatory phenomena, and this study found that the frequency and rhythmicity of the flickering significantly influenced the subjective experiences, especially the perception of Kluver forms and dynamics. Additionally, arrhythmic flicker stimulation reduced these effects compared to rhythmic stimulation. Therefore, flicker rhythmicity plays a critical role in driving the induced phenomenal experience.
Article
Multidisciplinary Sciences
Bojidar Rangelov, Alexandra Young, Watjana Lilaonitkul, Shahab Aslani, Paul Taylor, Eyjolfur Guomundsson, Qianye Yang, Yipeng Hu, John R. Hurst, David J. Hawkes, Joseph Jacob
Summary: The COVID-19 pandemic has presented a significant challenge to healthcare systems worldwide. This study developed an unsupervised data-driven model called SuStaIn, which can be used to predict short-term infectious diseases like COVID-19 based on commonly recorded clinical measures. The model identified three COVID-19 subtypes and introduced disease severity stages, both of which were predictive of in-hospital mortality or escalation of treatment. This model can be adapted for future outbreaks of COVID-19 or other infectious diseases.
SCIENTIFIC REPORTS
(2023)
Article
Psychiatry
Siegfried K. Wagner, Mario Cortina-Borja, Steven M. Silverstein, Yukun Zhou, David Romero-Bascones, Robbert R. Struyven, Emanuele Trucco, Muthu R. K. Mookiah, Tom MacGillivray, Stephen Hogg, Timing Liu, Dominic J. Williamson, Nikolas Pontikos, Praveen J. Patel, Konstantinos Balaskas, Daniel C. Alexander, Kelsey V. Stuart, Anthony P. Khawaja, Alastair K. Denniston, Jugnoo S. Rahi, Axel Petzold, Pearse A. Keane
Summary: This study found measurable differences in neural and vascular integrity of the retina in patients with schizophrenia, which were mostly secondary to the higher prevalence of diabetes and hypertension in these patients.
Article
Clinical Neurology
Fenglai Xiao, Lorenzo Caciagli, Britta Wandschneider, Daichi Sone, Alexandra L. Young, Sjoerd B. Vos, Gavin P. Winston, Yingying Zhang, Wenyu Liu, Dongmei An, Baris Kanber, Dong Zhou, Josemir W. Sander, Maria Thom, John S. Duncan, Daniel C. Alexander, Marian Galovic, Matthias J. Koepp
Summary: This study uses a machine learning algorithm to analyze structural MRI data of patients with epilepsy and control subjects, and identifies distinct subtypes of spatiotemporal progression of brain atrophy in different types of epilepsy. The findings suggest underlying processes in the progression of epilepsy-related brain atrophy and provide a novel MRI- and AI-guided epilepsy taxonomy for personalized prognosis and targeted therapeutics.
Article
Radiology, Nuclear Medicine & Medical Imaging
Saurabh Singh, Francesco Giganti, Louise Dickinson, Harriet Rogers, Baris Kanber, Joey Clemente, Hayley Pye, Susan Heavey, Urszula Stopka-Farooqui, Edward W. Johnston, Caroline M. Moore, Alex Freeman, Hayley C. Whitaker, Daniel C. Alexander, Eleftheria Panagiotaki, Shonit Punwani
Summary: This study aimed to assess the image quality of ADC and FIC maps derived from conventional diffusion-weighted MRI and VERDICT MRI in patients from the INNOVATE trial. The results showed that the image quality was comparable between FIC and ADC, but the image quality of ADC was higher than FIC when assessed using the Likert score.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrew R. H. Simpson, Edward H. Hughes, Lisa Mullen, Nicholas G. Dowell
Summary: The purpose of this study was to estimate vitreous oxygen concentration in ischemic eye disease by non-invasively performing MR T-1 mapping. The results showed that ischemic eye disease decreases vitreous T-1, potentially indicating an increase in vitreous partial pressure of oxygen (pO(2)) concentration. The study discusses potential theories for this unexpected result and highlights the potential clinical application of this technique in eye disease.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Psychology, Multidisciplinary
David J. Schwartzman, Ales Oblak, Nicolas Rothen, Daniel Bor, Anil K. Seth
Summary: This article investigates the similarities between induced and lifelong visual experiences and finds that training can alter the visual experiences of non-synaesthetes and produce phenomena similar to natural grapheme-colour synaesthesia.
COLLABRA-PSYCHOLOGY
(2023)
Meeting Abstract
Ophthalmology
Dominic Williamson, Robbert Struyven, Siegfried Wagner, David Romero-Bascones, Yukun Zhou, Mateo Gende Lozano, Timing Liu, Mario Cortina Borja, Jugnoo Rahi, Axel Petzold, Yue Wu, Cecilia S. Lee, Aaron Y. Lee, Alastair K. Denniston, Daniel Alexander, Pearse Keane
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Meeting Abstract
Ophthalmology
Yukun Zhou, Siegfried Wagner, Mark Chia, Dominic Williamson, Robbert Struyven, Timing Liu, Axel Petzold, Jugnoo Rahi, Mario Cortina Borja, Alastair K. Denniston, Daniel Alexander, Pearse Keane
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Meeting Abstract
Ophthalmology
Peter Lush, Anil K. Seth, Ryan B. Scott, Zoltan Dienes