Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 326, Issue -, Pages 55-61Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2018.11.008
Keywords
Sulfatides; Experimental autoimmune neuritis; Natural killer T cells
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Funding
- Taishan Scholars Construction Engineering of Shandong Province [ts20130914]
- National Natural Science Foundation of China [81471222, 81601040]
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Sulfatides have immunomodulatory functions, and play protective roles in multiple autoimmune diseases. In the present study, we showed that sulfatides ameliorated experimental autoimmune neuritis in Lewis rats induced with bovine peripheral myelin, which was associated with decreased proportions of Th1 and Th17 cells. Furthermore, compared control group, cells from sulfatide-treated rats exhibited lower potential in proliferation and IL-17 secretion in the presence of BPM or ConA in vitro. Moreover, sulfatides also reduced the proportions of NK and NKT cells. In summary, our study indicated that sulfatides might become a new therapeutic agent in Guillain-Barre syndrome in the future.
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