CNS-Wide over Expression of Fractalkine Improves Cognitive Functioning in a Tauopathy Model

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

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Neurotoxic reactive astrocytes are induced by activated microglia

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Metabolic changes over the course of aging in a mouse model of tau deposition

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Complement and microglia mediate early synapse loss in Alzheimer mouse models

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Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain

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Fractalkine Over Expression Suppresses α-Synuclein-mediated Neurodegeneration

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Partial rescue of memory deficits induced by calorie restriction in a mouse model of tau deposition

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Role of ADAM-17, p38 MAPK, Cathepsins, and the Proteasome Pathway in the Synthesis and Shedding of Fractalkine/CX3CL1 in Rheumatoid Arthritis

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Cathepsin S generates soluble CX3CL1 (fractalkine) in vascular smooth muscle cells

(2013) Urša Pečar Fonović et al.   BIOLOGICAL CHEMISTRY

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

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Aging enhances classical activation but mitigates alternative activation in the central nervous system

(2013) Daniel C. Lee et al.   NEUROBIOLOGY OF AGING

Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy

(2013) Kevin R. Nash et al.   NEUROBIOLOGY OF AGING

Ketogenic Diet Improves Motor Performance but Not Cognition in Two Mouse Models of Alzheimer’s Pathology

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VEGF significantly restores impaired memory behavior in Alzheimer's mice by improvement of vascular survival

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The Soluble Isoform of CX3CL1 Is Necessary for Neuroprotection in a Mouse Model of Parkinson's Disease

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Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

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In vivo structure/function and expression analysis of the CX3C chemokine fractalkine

(2011) K.-W. Kim et al.   BLOOD

Microglial signalling mechanisms: Cathepsin S and Fractalkine

(2011) Anna K. Clark et al.   EXPERIMENTAL NEUROLOGY

CX3CR1 Protein Signaling Modulates Microglial Activation and Protects against Plaque-independent Cognitive Deficits in a Mouse Model of Alzheimer Disease

(2011) Seo-Hyun Cho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blocking IL-1 Signaling Rescues Cognition, Attenuates Tau Pathology, and Restores Neuronal  -Catenin Pathway Function in an Alzheimer's Disease Model

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Are Tangles as Toxic as They Look?

(2011) Tara L. Spires-Jones et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

CX3CL1 reduces neurotoxicity and microglial activation in a rat model of Parkinson's disease

(2011) Mibel M Pabon et al.   Journal of Neuroinflammation

CX3CR1 Deficiency Leads to Impairment of Hippocampal Cognitive Function and Synaptic Plasticity

(2011) J. T. Rogers et al.   JOURNAL OF NEUROSCIENCE

CX3CR1 Deficiency Alters Microglial Activation and Reduces Beta-Amyloid Deposition in Two Alzheimer's Disease Mouse Models

(2010) Sungho Lee et al.   AMERICAN JOURNAL OF PATHOLOGY

LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 mice

(2010) Daniel C Lee et al.   Journal of Neuroinflammation

Convection-enhanced delivery and systemic mannitol increase gene product distribution of AAV vectors 5, 8, and 9 and increase gene product in the adult mouse brain

(2010) Nikisha Carty et al.   JOURNAL OF NEUROSCIENCE METHODS

AAV4-mediated Expression of IGF-1 and VEGF Within Cellular Components of the Ventricular System Improves Survival Outcome in Familial ALS Mice

(2010) James C Dodge et al.   MOLECULAR THERAPY

Regulation of Tau Pathology by the Microglial Fractalkine Receptor

(2010) Kiran Bhaskar et al.   NEURON

Controlling brain tumor growth by intraventricular administration of an AAV vector encoding IFN-β

(2009) D H Meijer et al.   CANCER GENE THERAPY

Fractalkine-induced activation of the phosphatidylinositol-3 kinase pathway attentuates microglial activationin vivoandin vitro

(2009) Anthony Lyons et al.   JOURNAL OF NEUROCHEMISTRY

The Liberation of Fractalkine in the Dorsal Horn Requires Microglial Cathepsin S

(2009) A. K. Clark et al.   JOURNAL OF NEUROSCIENCE

Fractalkine and CX3CR1 regulate hippocampal neurogenesis in adult and aged rats

(2009) Adam D. Bachstetter et al.   NEUROBIOLOGY OF AGING

Aging Analysis Reveals Slowed Tau Turnover and Enhanced Stress Response in a Mouse Model of Tauopathy

(2008) Chad Dickey et al.   AMERICAN JOURNAL OF PATHOLOGY

Analyzing real-time PCR data by the comparative CT method

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A Technique for Serial Collection of Cerebrospinal Fluid from the Cisterna Magna in Mouse

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