Journal
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
Volume 19, Issue 2, Pages 709-712Publisher
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jnn.2019.15912
Keywords
Platinum Nanoparticle; Platinum Nanocolloid; Raw 264.7 Cells; Nitric Oxide; AKT
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Funding
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education [2017R1D1A1B03029970]
- National Research Foundation of Korea [2017R1D1A1B03029970] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The cellular effects of platinum nanoparticle (PtNP) and platinum nanocolloid (PtNC) were investigated on murine leukemia Raw 264.7 cells. PtNP induced strong cytotoxic effects on Raw 264.7 cells while PtNC showed only mild cytotoxicity. Dramatic reduction in cell growth and morphological changes were observed for cells treated with PtNPs while PtNC did not show these effects. Both PtNPs and PtNC suppressed nitric oxide production, but PtNPs were superior to PtNC. PtNP strongly suppressed the expression of iNOS, COX-2 proteins and the phosphorylation of AKT on LPS-stimulated Raw 264.7 cells while PtNC showed only weak effects on these proteins. Our data showed that the preparation method of platinum nanoparticles may cause different cellular effects on cell growth and signaling.
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