Journal
JOURNAL OF MATERIALS RESEARCH
Volume 34, Issue 11, Pages 1845-1853Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1557/jmr.2018.452
Keywords
Alzheimer's disease; amyloid-beta 42; AuNP; biochemical pathway
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Funding
- Center for High Performance Computing, Shanghai Jiao Tong University
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Numerous studies have reported that amyloid-beta 42 (A beta-42) protein is a high-profile risk factor associated with the onset and progression of Alzheimer's disease (AD). Accumulation of extracellular senile plaques, synaptic degeneration, and intracellular neurofibrillary tangles were recorded as essential features that facilitate the onset of A beta-42, resulting in AD. Hence, we attempted a new screening technique to discover potential inhibitors against A beta-42 using an in silico deep neural network approach. We screened PubChem compounds library and found wgx-50 as a potential inhibitor of A beta-42. Also, synergistic effects of wgx-50-gold nanoparticles (AuNPs) complex induced significant inhibition of A beta-42, compared with those of wgx-50 alone. Further, molecular docking analysis, systems biology approach, and time course simulation confirmed that synergistic effects of wgx-50-AuNPs complex have potential application in the treatment for AD. Additionally, we proposed the biological circuit for AD induced by A beta-42 that can be used to monitor the effect of drugs on AD.
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