Thermodynamic destabilization and aggregation propensity as the mechanism behind the association of apoE3 mutants and lipoprotein glomerulopathy

The Novel Apolipoprotein E Mutation ApoE Chengdu (c.518T＞C, p.L173P) in a Chinese Patient with Lipoprotein Glomerulopathy

(2018) Hongyan Wu et al.   Journal of Atherosclerosis and Thrombosis

A mechanism for lipid binding to apoE and the role of intrinsically disordered regions coupled to domain–domain interactions

(2017) Carl Frieden et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Helical structure, stability, and dynamics in human apolipoprotein E3 and E4 by hydrogen exchange and mass spectrometry

(2017) Palaniappan S. Chetty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ability of apolipoprotein E fragments to promote intraneuronal accumulation of amyloid beta peptide 42 is both isoform and size-specific

(2016) Ioannis Dafnis et al.   Scientific Reports

Influence of Isoforms and Carboxyl-Terminal Truncations on the Capacity of Apolipoprotein E To Associate with and Activate Phospholipid Transfer Protein

(2015) Ioannis Dafnis et al.   BIOCHEMISTRY

Apolipoprotein E mutations: a comparison between lipoprotein glomerulopathy and type III hyperlipoproteinemia

(2014) Akira Matsunaga et al.   Clinical and Experimental Nephrology

Molecular Basis for Increased Risk for Late-onset Alzheimer Disease Due to the Naturally Occurring L28P Mutation in Apolipoprotein E4

(2014) Letta Argyri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A possible structural basis behind the pathogenic role of apolipoprotein E hereditary mutations associated with lipoprotein glomerulopathy

(2013) Efstratios Stratikos et al.   Clinical and Experimental Nephrology

Topics in lipoprotein glomerulopathy: an overview

(2013) Takao Saito et al.   Clinical and Experimental Nephrology

Signaling pathways of apoE and its role of gene expression in glomerulus diseases

(2013) Tian-Biao Zhou   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Hereditary features, treatment, and prognosis of the lipoprotein glomerulopathy in patients with the APOE Kyoto mutation

(2013) Zhangxue Hu et al.   KIDNEY INTERNATIONAL

Thermodynamic and structural destabilization of apoE3 by hereditary mutations associated with the development of lipoprotein glomerulopathy

(2012) Dimitra Georgiadou et al.   JOURNAL OF LIPID RESEARCH

Small-Molecule Structure Correctors Target Abnormal Protein Structure and Function: Structure Corrector Rescue of Apolipoprotein E4–Associated Neuropathology

(2012) Robert W. Mahley et al.   JOURNAL OF MEDICINAL CHEMISTRY

Hydrogen/Deuterium Exchange and Electron-Transfer Dissociation Mass Spectrometry Determine the Interface and Dynamics of Apolipoprotein E Oligomerization

(2011) Richard Y-C. Huang et al.   BIOCHEMISTRY

Mass Spectrometry-Based Protein Footprinting Characterizes the Structures of Oligomeric Apolipoprotein E2, E3, and E4

(2011) Brian Gau et al.   BIOCHEMISTRY

Lipoprotein glomerulopathy

(2011) Vasilis Tsimihodimos et al.   CURRENT OPINION IN LIPIDOLOGY

Apolipoprotein E4 Exaggerates Diabetic Dyslipidemia and Atherosclerosis in Mice Lacking the LDL Receptor

(2011) L. A. Johnson et al.   DIABETES

Human Apolipoprotein A-I-Derived Amyloid: Its Association with Atherosclerosis

(2011) Nahuel A. Ramella et al.   PLoS One

Biophysical Analysis of Apolipoprotein E3 Variants Linked with Development of Type III Hyperlipoproteinemia

(2011) Dimitra Georgiadou et al.   PLoS One

Topology of human apolipoprotein E3 uniquely regulates its diverse biological functions

(2011) J. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A new apolipoprotein E mutation, apoE Las Vegas, in a European-American with lipoprotein glomerulopathy

(2010) A. S. Bomback et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS

(2008) Robert W. Mahley et al.   JOURNAL OF LIPID RESEARCH

Successful treatment of patients with lipoprotein glomerulopathy by protein A immunoadsorption: a pilot study

(2008) Z. Xin et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION