Journal
JOURNAL OF INORGANIC BIOCHEMISTRY
Volume 189, Issue -, Pages 192-198Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2018.10.001
Keywords
Cationic phthalocyanine; Photosensitizer; Antimicrobial photodynamic therapy (aPDT); Bioluminescent bacteria; Synthesis
Funding
- National Key R&D Program of China [2017YFE0103200]
- National Natural Science Foundation of China [31370737, 31400637, 31570745, 31670739]
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Antimicrobial photodynamic therapy (aPDT) is an effective way to combat infectious diseases and antibiotic resistance. Photosensitizer is a key factor of aPDT and has triggered extensive research interest. In this study, a new asymmetric Zn(II) phthalocyanine mono-substituted with a triazatricyclodecane moiety (compound 3) and its cationic N-methylated derivative (compound 4) were synthesized. Their photodynamic antimicrobial activities were evaluated using bioluminescent bacterial strains. Compound 3 showed phototoxicity only toward the Gram-positive bacteria, whereas the cationic derivative compound 4 exhibited strong anti-bacterial activity against both Gram-positive and Gram-negative strains. These bacterial species were eradicated (> 4.0 logs or 99.99% killing) at appropriate concentrations of compound 4 with 12.7 J/cm(2) of red light, demonstrating compound 4 as a potent aPDT agent.
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