Journal
JOURNAL OF INNATE IMMUNITY
Volume 11, Issue 5, Pages 393-404Publisher
KARGER
DOI: 10.1159/000495115
Keywords
Metaorganism; Host; Microbiota; Microbiome; Physiology
Categories
Funding
- Deutsche Forschungsgemeinschaft [CRC 1182]
- intramural grant of the medical faculty of Kiel University
- Excellence Cluster Inflammation at Interfaces [EXC306]
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Animals are usually regarded as independent entities within their respective environments. However, within an organism, eukaryotes and prokaryotes interact dynamically to form the so-called metaorganism or holobiont, where each partner fulfils its versatile and crucial role. This review focuses on the interplay between microorganisms and multicellular eukaryotes in the context of host physiology, in particular aging and mucus-associated crosstalk. In addition to the interactions between bacteria and the host, we highlight the importance of viruses and nonmodel organisms. Moreover, we discuss current culturing and computational methodologies that allow a deeper understanding of underlying mechanisms controlling the physiology of metaorganisms. (C) 2018 The Author(s) Published by S. Karger AG, Basel
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