IL-6 Signaling Blockade during CD40-Mediated Immune Activation Favors Antitumor Factors by Reducing TGF-β, Collagen Type I, and PD-L1/PD-1

IL6 Blockade Reprograms the Lung Tumor Microenvironment to Limit the Development and Progression of K-ras-Mutant Lung Cancer

(2016) M. S. Caetano et al.   CANCER RESEARCH

Stromal biology and therapy in pancreatic cancer: a changing paradigm

(2015) Albrecht Neesse et al.   GUT

Negative immune checkpoints on T lymphocytes and their relevance to cancer immunotherapy

(2015) Anna Śledzińska et al.   Molecular Oncology

Characterization of Patients With Advanced Pancreatic Cancer and High Serum Interleukin-6 Levels

(2015) Tomofumi Miura et al.   PANCREAS

Galectin-3 Shapes Antitumor Immune Responses by Suppressing CD8+ T Cells via LAG-3 and Inhibiting Expansion of Plasmacytoid Dendritic Cells

(2015) T. Kouo et al.   Cancer Immunology Research

CD40L gene therapy tilts the myeloid cell profile and promotes infiltration of activated T lymphocytes

(2014) L Liljenfeldt et al.   CANCER GENE THERAPY

The role of the hepatocyte growth factor/c-MET pathway in pancreatic stellate cell–endothelial cell interactions: antiangiogenic implications in pancreatic cancer

(2014) Mishaal B. Patel et al.   CARCINOGENESIS

Pancreatic cancer stroma: Understanding biology leads to new therapeutic strategies

(2014) Agnieszka Anna Rucki   WORLD JOURNAL OF GASTROENTEROLOGY

Pancreatic Cancer-Associated Stellate Cells Promote Differentiation of Myeloid-Derived Suppressor Cells in a STAT3-Dependent Manner

(2013) T. A. Mace et al.   CANCER RESEARCH

Activated Pancreatic Stellate Cells Sequester CD8+ T Cells to Reduce Their Infiltration of the Juxtatumoral Compartment of Pancreatic Ductal Adenocarcinoma

(2013) Abasi Ene–Obong et al.   GASTROENTEROLOGY

Treatment Efficacy and Immune Stimulation by AdCD40L Gene Therapy of Spontaneous Canine Malignant Melanoma

(2013) Sara Westberg et al.   JOURNAL OF IMMUNOTHERAPY

Oncolytic viruses as therapeutic cancer vaccines

(2013) David L Bartlett et al.   Molecular Cancer

Pancreatic adenocarcinoma induces bone marrow mobilization of myeloid-derived suppressor cells which promote primary tumor growth

(2012) Matthew R. Porembka et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

The Pancreas Cancer Microenvironment

(2012) C. Feig et al.   CLINICAL CANCER RESEARCH

Flt3 ligand expands CD4+FoxP3+regulatory T cells in human subjects

(2012) Oliver Klein et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

(2012) Julie R. Brahmer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Overexpressed Galectin-3 in Pancreatic Cancer Induces Cell Proliferation and Invasion by Binding Ras and Activating Ras Signaling

(2012) Shumei Song et al.   PLoS One

Stat3 and MMP7 Contribute to Pancreatic Ductal Adenocarcinoma Initiation and Progression

(2011) Akihisa Fukuda et al.   CANCER CELL

Stat3/Socs3 Activation by IL-6 Transsignaling Promotes Progression of Pancreatic Intraepithelial Neoplasia and Development of Pancreatic Cancer

(2011) Marina Lesina et al.   CANCER CELL

Monocyte-derived DC maturation strategies and related pathways: a transcriptional view

(2011) Luciano Castiello et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Elevated myeloid-derived suppressor cells in pancreatic, esophageal and gastric cancer are an independent prognostic factor and are associated with significant elevation of the Th2 cytokine interleukin-13

(2011) Rachel F. Gabitass et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

AdCD40L Immunogene Therapy for Bladder Carcinoma--The First Phase I/IIa Trial

(2010) P.-U. Malmstrom et al.   CLINICAL CANCER RESEARCH

Characterization of Cytokine-Induced Myeloid-Derived Suppressor Cells from Normal Human Peripheral Blood Mononuclear Cells

(2010) M. G. Lechner et al.   JOURNAL OF IMMUNOLOGY

Phase 2 Trial of Single Agent Ipilimumab (Anti-CTLA-4) for Locally Advanced or Metastatic Pancreatic Adenocarcinoma

(2010) Richard E. Royal et al.   JOURNAL OF IMMUNOTHERAPY

Significance of M2-Polarized Tumor-Associated Macrophage in Pancreatic Cancer

(2009) Hiroshi Kurahara et al.   JOURNAL OF SURGICAL RESEARCH

Increased therapeutic efficacy of the prostate-specific oncolytic adenovirus Ad[I/PPT-E1A] by reduction of the insulator size and introduction of the full-length E3 region

(2008) A Danielsson et al.   CANCER GENE THERAPY

The Activated Stroma Index Is a Novel and Independent Prognostic Marker in Pancreatic Ductal Adenocarcinoma

(2008) Mert Erkan et al.   Clinical Gastroenterology and Hepatology

Pancreatic stellate cells promote proliferation and invasiveness of human pancreatic cancer cells via galectin-3

(2008) Hai-Biao Jiang et al.   WORLD JOURNAL OF GASTROENTEROLOGY