Sialic Acid–Dependent Inhibition of T Cells by Exosomal Ganglioside GD3 in Ovarian Tumor Microenvironments

Exosomes Associated with Human Ovarian Tumors Harbor a Reversible Checkpoint of T-cell Responses

(2018) Gautam N. Shenoy et al.   Cancer Immunology Research

Exosomes and tumor-mediated immune suppression

(2016) Theresa L. Whiteside   JOURNAL OF CLINICAL INVESTIGATION

Sialic acid-modified antigens impose tolerance via inhibition of T-cell proliferation and de novo induction of regulatory T cells

(2016) Maurizio Perdicchio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of human naïve Th cells increases surface expression of GD3 and induces neoexpression of GD2 that colocalize with TCR clusters

(2015) Tania M Villanueva-Cabello et al.   GLYCOBIOLOGY

Rapid and comprehensive ‘shotgun’ lipidome profiling of colorectal cancer cell derived exosomes

(2015) Todd A. Lydic et al.   METHODS

Extracellular Vesicles Present in Human Ovarian Tumor Microenvironments Induce a Phosphatidylserine-Dependent Arrest in the T-cell Signaling Cascade

(2015) R. J. Kelleher et al.   Cancer Immunology Research

Activated regulatory and memory T-cells accumulate in malignant ascites from ovarian carcinoma patients

(2014) Johannes Landskron et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Multifactorial T-cell Hypofunction That Is Reversible Can Limit the Efficacy of Chimeric Antigen Receptor-Transduced Human T cells in Solid Tumors

(2014) E. K. Moon et al.   CLINICAL CANCER RESEARCH

Ovarian Tumor Ascites CD14+ Cells Suppress Dendritic Cell–activated CD4+ T-cell Responses Through IL-10 Secretion and Indoleamine 2,3-Dioxygenase

(2014) Hannah E. Goyne et al.   JOURNAL OF IMMUNOTHERAPY

Exposure to Factor VIII Protein in the Presence of Phosphatidylserine Induces Hypo-responsiveness toward Factor VIII Challenge in Hemophilia A Mice

(2013) Puneet Gaitonde et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Identification of GD3 as a Suppressor of the Innate Immune Response in Ovarian Cancer

(2012) T. J. Webb et al.   CANCER RESEARCH

A hyphenated microLC-Q-TOF-MS platform for exosomal lipidomics investigations: Application to RCC urinary exosomes

(2012) Piero Del Boccio et al.   ELECTROPHORESIS

Ganglioside-binding specificities of E. coli enterotoxin LT-IIc: Importance of long-chain fatty acyl ceramide

(2012) C. S. Berenson et al.   GLYCOBIOLOGY

Ovarian cancer progression is controlled by phenotypic changes in dendritic cells

(2012) Uciane K. Scarlett et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Exosomes/microvesicles: mediators of cancer-associated immunosuppressive microenvironments

(2011) Douglas D. Taylor et al.   Seminars in Immunopathology

Blocking ovarian cancer progression by targeting tumor microenvironmental leukocytes

(2010) Juan R. Cubillos-Ruiz et al.   CELL CYCLE

Anti-GD3 Chimeric sFv-CD28/T-Cell Receptor   Designer T Cells for Treatment of Metastatic Melanoma and Other Neuroectodermal Tumors

(2010) A. S. Y. Lo et al.   CLINICAL CANCER RESEARCH

GD3, an Overexpressed Tumor-Derived Ganglioside, Mediates the Apoptosis of Activated but not Resting T Cells

(2009) G. Sa et al.   CANCER RESEARCH

In situ Stimulation of CD40 and Toll-like Receptor 3 Transforms Ovarian Cancer-Infiltrating Dendritic Cells from Immunosuppressive to Immunostimulatory Cells

(2009) U. K. Scarlett et al.   CANCER RESEARCH

Mammalian cell ganglioside-binding specificities of E. coli enterotoxins LT-IIb and variant LT-IIb(T13I)

(2009) C. S Berenson et al.   GLYCOBIOLOGY

Elevated Levels of Select Gangliosides in T Cells from Renal Cell Carcinoma Patients Is Associated with T Cell Dysfunction

(2009) S. Biswas et al.   JOURNAL OF IMMUNOLOGY

Depletion of Dendritic Cells Delays Ovarian Cancer Progression by Boosting Antitumor Immunity

(2008) E. Huarte et al.   CANCER RESEARCH