Integrated B Cell, Toll-like, and BAFF Receptor Signals Promote Autoantibody Production by Transitional B Cells

TACI deletion protects against progressive murine lupus nephritis induced by BAFF overexpression

(2018) Tanvi Arkatkar et al.   KIDNEY INTERNATIONAL

IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate

(2018) Mark Noviski et al.   eLife

Overexpression of the Cytokine BAFF and Autoimmunity Risk

(2017) Maristella Steri et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cutting Edge: BAFF Promotes Autoantibody Production via TACI-Dependent Activation of Transitional B Cells

(2016) Holly M. Jacobs et al.   JOURNAL OF IMMUNOLOGY

Blimp-1 controls plasma cell function through the regulation of immunoglobulin secretion and the unfolded protein response

(2016) Julie Tellier et al.   NATURE IMMUNOLOGY

Differential induction of plasma cells by isoforms of human TACI

(2015) Y. Garcia-Carmona et al.   BLOOD

BAFF-driven autoimmunity requires CD19 expression

(2015) Kirsten A. Fairfax et al.   JOURNAL OF AUTOIMMUNITY

Deleting the BAFF receptor TACI protects against systemic lupus erythematosus without extensive reduction of B cell numbers

(2015) William A. Figgett et al.   JOURNAL OF AUTOIMMUNITY

Opposing Impact of B Cell-Intrinsic TLR7 and TLR9 Signals on Autoantibody Repertoire and Systemic Inflammation

(2014) S. W. Jackson et al.   JOURNAL OF IMMUNOLOGY

The TACI Receptor Regulates T-Cell-Independent Marginal Zone B Cell Responses through Innate Activation-Induced Cell Death

(2013) William A. Figgett et al.   IMMUNITY

Effect of belimumab treatment on renal outcomes: results from the phase 3 belimumab clinical trials in patients with SLE

(2012) MA Dooley et al.   LUPUS

Endogenous antigen tunes the responsiveness of naive B cells but not T cells

(2012) Julie Zikherman et al.   NATURE

A phase III, randomized, placebo-controlled study of belimumab, a monoclonal antibody that inhibits B lymphocyte stimulator, in patients with systemic lupus erythematosus

(2011) Richard Furie et al.   ARTHRITIS AND RHEUMATISM

Development of autoimmune nephritis in genetically asplenic and splenectomized BAFF transgenic mice

(2011) Carrie A. Fletcher et al.   JOURNAL OF AUTOIMMUNITY

Mice overexpressing BAFF develop a commensal flora–dependent, IgA-associated nephropathy

(2011) Douglas D. McCarthy et al.   JOURNAL OF CLINICAL INVESTIGATION

Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial

(2011) Sandra V Navarra et al.   LANCET

BAFF Receptor Signaling Aids the Differentiation of Immature B Cells into Transitional B Cells following Tonic BCR Signaling

(2010) S. L. Rowland et al.   JOURNAL OF IMMUNOLOGY

The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88

(2010) Bing He et al.   NATURE IMMUNOLOGY

Transmembrane activator, calcium modulator, and cyclophilin ligand interactor drives plasma cell differentiation in LPS-activated B cells

(2009) Esra Ozcan et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Toll-like Receptors Activate Innate and Adaptive Immunity by using Dendritic Cell-Intrinsic and -Extrinsic Mechanisms

(2008) Baidong Hou et al.   IMMUNITY

Characterization of a late transitional B cell population highly sensitive to BAFF-mediated homeostatic proliferation

(2008) Almut Meyer-Bahlburg et al.   JOURNAL OF EXPERIMENTAL MEDICINE