Article
Infectious Diseases
Kazuma Sakaeda, Takuya Sadahira, Yuki Maruyama, Takehiro Iwata, Masami Watanabe, Koichiro Wada, Motoo Araki
Summary: We conducted a molecular biological analysis of ESBL-producing E. coli strains and their sensitivity to FMOX. Most of the strains belonged to the ST-131 sequence type and had CTX-M genotypes. The isolated strains were sensitive to FMOX in drug susceptibility tests. FMOX showed efficacy for perioperative prophylactic administration in urologic surgery and for therapeutic administration for urinary tract infections.
Article
Immunology
Bradley J. Langford, Kevin A. Brown, Christina Diong, Alex Marchand-Austin, Kwaku Adomako, Arezou Saedi, Kevin L. Schwartz, Jennie Johnstone, Derek R. MacFadden, Larissa M. Matukas, Samir N. Patel, Gary Garber, Nick Daneman
Summary: The study on antibiotic prophylaxis in older adults with UTI found that although it can reduce hospitalization or ED visits for some patients, it also increases the risk of antibiotic resistance and Clostridioides difficile infections, as well as general medication adverse events.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Guadalupe Miranda-Novales, Karen Flores-Moreno, Yolanda Lopez-Vidal, Samuel Ponce de Leon-Rosales
Summary: This study evaluated the antimicrobial susceptibility patterns of Escherichia coli and Klebsiella pneumoniae, and found that multidrug-resistant bacteria represented 61% of all isolates.
Article
Microbiology
Kayoko Hayakawa, Yasufumi Matsumura, Kohei Uemura, Shinya Tsuzuki, Aki Sakurai, Ryutaro Tanizaki, Koh Shinohara, Takehiro Hashimoto, Ryota Hase, Takashi Matono, Hideaki Kato, Momoko Mawatari, Hiroshi Hara, Yukihiro Hamada, Sho Saito, Norio Ohmagari, Yohei Doi
Summary: Cefmetazole showed clinical and bacteriological effectiveness comparable to meropenem against invasive urinary tract infection due to ESBLECs.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Immunology
Thijs ten Doesschate, Sander Kuiper, Cees van Nieuwkoop, Robert-Jan Hassing, Tom Ketels, Suzan P. van Mens, Wouter van den Bijllaardt, Akke K. van der Bij, Suzanne E. Geerlings, Ad Koster, Evert L. Koldewijn, Judith Branger, Andy I. M. Hoepelman, Cornelis H. van Werkhoven, Marc J. M. Bonten
Summary: Fosfomycin is noninferior to ciprofloxacin as oral step-down treatment for febrile urinary tract infections (fUTIs) caused by E. coli in women, but its use is associated with more gastrointestinal events.
CLINICAL INFECTIOUS DISEASES
(2022)
Review
Biochemistry & Molecular Biology
Maria Maisto, Fortuna Iannuzzo, Ettore Novellino, Elisabetta Schiano, Vincenzo Piccolo, Gian Carlo Tenore
Summary: Urinary tract infections (UTIs) are a common bacterial infection, especially in women. The main etiological agents are E. coli, Pseudomonas aeruginosa, and Proteus mirabilis. Due to the increase in antimicrobial resistance, there is a need for natural alternatives for UTI treatment. This review summarizes the potential therapeutic effects of natural polyphenol-based nutraceuticals and foods through in vitro and in vivo studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Geriatrics & Gerontology
Damir Krinitski, Rafal Kasina, Stefan Kloeppel, Eric Lenouvel
Summary: This study supports the association between delirium and urinary tract infection in older adults, but insufficient evidence was found for the association between delirium and asymptomatic bacteriuria in this age group. The limitations of the study include the moderate quality of included studies and a lack of available research on the association between delirium and asymptomatic bacteriuria. Future research should focus on using high-quality approaches to define delirium and UTI, and consider asymptomatic bacteriuria in their investigations.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Review
Infectious Diseases
Iain J. Abbott, Trisha N. Peel, Kelly A. Cairns, Andrew J. Stewardson
Summary: This article highlights the key clinical decisions involved in the diagnosis and treatment of urinary tract infections (UTIs) in adult women, emphasizing the importance of clinical effectiveness and antimicrobial stewardship in the post-antimicrobial era. The article discusses the diagnosis and treatment of UTIs, as well as emerging areas of research in this field.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Public, Environmental & Occupational Health
Erastus H. Haindongo, Binta Funtua, Boni Singu, Marius Hedimbi, Francis Kalemeera, Jana Hamman, Olli Vainio, Antti J. Hakanen, Jaana Vuopio
Summary: This study aimed to describe the national antimicrobial resistance situation of major bacterial uropathogens in females within the 14 Namibian regions. High resistance to ampicillin, quinolones, and sulfamethoxazole-trimethoprim among E. coli was reported, with concerning rates of resistance to third-generation cephalosporins at 22%.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2022)
Review
Infectious Diseases
Stefan Cox, Kelly Lo-A-Foe, Minke van Hoof, Geert-Jan Dinant, Guy Oudhuis, Paul Savelkoul, Jochen Cals, Eefje de Bont
Summary: Urinary tract infections (UTIs) are a common reason for women to visit a general practitioner, but there is often a discrepancy between prescribed antibiotics and established guidelines. Researchers have conducted interventions to improve GPs' prescribing behavior, and found that these interventions have some positive effects on antibiotic prescriptions for UTIs.
Article
Health Care Sciences & Services
Adil Abalkhail, Ahmad S. AlYami, Saeed F. Alrashedi, Khalid M. Almushayqih, Thamer Alslamah, Yasir Ahmed Alsalamah, Ayman Elbehiry
Summary: This study aims to investigate the antibiotic resistance of ESBL-E. coli among male and female patients with urinary tract infections in Riyadh, Saudi Arabia. The research found that most ESBL-E. coli isolates were resistant to cephalosporins and penicillin, but sensitive to carbapenems, aminoglycosides, and nitrofurantoins.
Article
Infectious Diseases
Leah J. Toombs-Ruane, Jonathan C. Marshall, Jackie Benschop, Dragana Drinkovi, Anne C. Midwinter, Patrick J. Biggs, Zoe Grange, Michael G. Baker, Jeroen Douwes, Mick G. Roberts, Nigel P. French, Sara A. Burgess
Summary: This study aimed to assess whether having a pet in the home is a risk factor for community-acquired urinary tract infections associated with extended-spectrum β-lactamase (ESBL)-or AmpC β-lactamase (ACBL)-producing Enterobacterales. Through telephone questionnaire and logistic regression analysis, it was found that pet ownership was not associated with ESBL-or ACBL-producing Enterobacterales-related urinary tract infections, while the main risk factors included recent antimicrobial treatment, travel to Asia in the previous year, and a doctor's visit in the last 6 months.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Review
Infectious Diseases
Gabriel Kambale Bunduki, Eva Heinz, Vincent Samuel Phiri, Patrick Noah, Nicholas Feasey, Janelisa Musaya
Summary: This study revealed an increasing antibiotic resistance of UPEC isolates, calling for a reassessment of treatment strategies. Additionally, this pathogen exhibited diverse surface and secreted virulence factors.
BMC INFECTIOUS DISEASES
(2021)
Article
Biochemical Research Methods
Kuo-Wei Hsu, Wen-Bin Lee, Huey-Ling You, Mel S. Lee, Gwo-Bin Lee
Summary: Urinary tract infections are common in females, posing risks to kidney function and often requiring broad-spectrum antibiotics. The rise of drug-resistant strains has led to high recurrence rates, emphasizing the need for accurate antibiotic selection. A newly developed portable system allows for rapid and precise measurement of antibiotic sensitivity in urine samples, offering promise for future personalized medicine.
Review
Infectious Diseases
Faiza Morado, Darren W. Wong
Summary: Urinary tract infection is a common bacterial infection with challenges in diagnosis. To limit unnecessary testing and antibiotic use, various diagnostic stewardship initiatives involving multidisciplinary approaches and education of healthcare providers are effective in decreasing inappropriate testing and prescribing.
Review
Psychology, Developmental
Bruna Costa, Maia Thornton, Ella Guest, Jane Meyrick, Heidi Williamson
Summary: This review finds moderate to strong evidence of effectiveness of the Triple P Positive Parenting Program, the Early Family Intervention Program, and general parent education/training interventions in supporting parents of children with AAHCs. These findings offer useful insights for current support delivery and future development of parent and family interventions. Recommendations for future intervention evaluation studies in this area are also made.
CHILD CARE HEALTH AND DEVELOPMENT
(2021)
Article
Infectious Diseases
Leah F. Jones, Heidi Williamson, Petronella Downing, Donna M. Lecky, Diana Harcourt, Cliodna McNulty
Summary: Urinary tract infections (UTIs) can be life-threatening in older adults. This study aimed to assess the acceptability and feasibility of using a UTI leaflet for older adults. Interviews and focus groups with 93 participants revealed that the leaflet was considered acceptable, but some older adults may find the information overwhelming. Care staff utilized the leaflet as an educational guide.
Article
Infectious Diseases
Nina J. Zhu, Monsey McLeod, Cliodna A. M. McNulty, Donna M. Lecky, Alison H. Holmes, Raheelah Ahmad
Summary: The study described the trend of antibiotic prescribing in out-of-hours general practices before and during the first wave of COVID-19 pandemic in England. It found that there was an increase in broad-spectrum antibiotic prescribing during the pandemic, while overall antibiotic prescribing volume decreased. The use of co-amoxiclav and doxycycline in out-of-hours settings peaked in March to May of 2020.
Review
Family Studies
Kevin Turner, Jane Meyrick, Danny Miller, Laura Stopgate
Summary: The evidence for psychosocial interventions supporting well-being in sex workers remains limited, with peer health initiatives showing potential in improving well-being for female street-based sex workers. Additionally, the use of ecological momentary assessment (EMA) can lead to increased self-esteem and behavior change intentions.
BMJ SEXUAL & REPRODUCTIVE HEALTH
(2022)
Review
Immunology
Uzochi Nwaosu, Rianna Raymond-Williams, Jane Meyrick
Summary: Studies investigating the effectiveness of psychosocial interventions to increase condom use among Black men in the UK are limited, with most evidence coming from the United States. Despite the disproportionate burden of STIs among Black men, successful elements of interventions remain unclear. Future research should focus on understanding the behavioral experiences and motivations of condom use among UK Black men to develop culturally relevant interventions.
INTERNATIONAL JOURNAL OF STD & AIDS
(2021)
Article
Medicine, General & Internal
Cliodna McNulty, Brieze Read, Anna Quigley, Neville Q. Verlander, Donna M. Lecky
Summary: This study aimed to investigate public attitudes and knowledge regarding antibiotic activity, resistance, and use. The findings revealed variations in knowledge and attitudes among the participants. The majority of respondents expressed trust in healthcare professionals' antibiotic decision-making, although only a small percentage would challenge such decisions. Individuals from lower socioeconomic backgrounds, ethnic minorities, and those with lower education levels demonstrated less understanding about antibiotics and resistance.
Article
Immunology
Eleonore Batteux, Freya Mills, Leah Ffion Jones, Charles Symons, Dale Weston
Summary: Vaccination is crucial in protecting the public from COVID-19. This systematic review aims to identify and evaluate the effectiveness of interventions to increase COVID-19 vaccine uptake. Personalized communication and text message reminders for appointments were found to be effective in increasing vaccine uptake, while the results on vaccination intention were mixed.
Article
Medicine, General & Internal
Cliodna McNulty, Eirwen Sides, Amy Thomas, Atiya Kamal, Rowshonara B. Syeda, Awatif Kaissi, Donna M. Lecky, Mahendra Patel, Ines Campos-Matos, Rashmi Shukla, Colin S. Brown, Manish Pareek, Loretta Sollars, Laura Nellums, Jane Greenway, Leah Ffion Jones
Summary: The public reactions to the COVID-19 pandemic were explored across diverse ethnic groups in England and Wales. The study found that dismay, frustration, and altruism were common among all ethnic groups during the first 6-9 months of the pandemic. Dismay was caused by perceived individual, family, and community risks, while frustration stemmed from the lack of recognition and action by the government in addressing COVID-19 and inequalities. Altruism was felt through the resilience of NHS staff and communities coming together. The study highlights the importance of clear communication, trust-building, and equality in healthcare across ethnicities.
Article
Public, Environmental & Occupational Health
Brieze Read, Cliodna A. M. McNulty, Neville Q. Verlander, Nicola Moss, Donna M. Lecky
Summary: The study showed that public knowledge of IPC measures has improved in 2021 compared to 2020, particularly in terms of infection transmission routes and hygiene habits. Future public health campaigns should further emphasize the importance of maintaining hygiene behaviors and vaccination.
Review
Gastroenterology & Hepatology
Cliodna A. M. McNulty
Summary: In the 1970s, dyspepsia affects 1% of the UK population. Fiberoptic gastroscopy allows systematic histopathology, leading to the discovery of flagellated bacteria (later known as H. pylori) closely associated with chronic active gastritis. Further research confirmed the association between H. pylori and gastritis.
Editorial Material
Family Studies
Jane Meyrick, Rachel Adams, Michelle Cutland
BMJ SEXUAL & REPRODUCTIVE HEALTH
(2023)
Article
Women's Studies
Jane Meyrick, Amelia Anning
Summary: This qualitative study explored survivors' experiences of group support services and their preferences for measuring recovery. The study found that survivors often experienced anger, preferred to recover in the company of others, and had different recovery goals. The findings highlight the importance of evaluating survivors and the potential of anger in group activism.
VIOLENCE AGAINST WOMEN
(2023)
Article
Health Care Sciences & Services
Catherine Hayes, Donna M. Lecky, Fionna Pursey, Amy Thomas, Diane Ashiru-Oredope, Ayoub Saei, Tracey Thornley, Philip Howard, Aimi Dickinson, Clare Ingram, Rosalie Allison, Cliodna A. M. McNulty
Summary: This study evaluated the impact of the community pharmacy antimicrobial stewardship intervention on staff's self-reported antimicrobial stewardship behaviors. The intervention was found to increase staff's antibiotic appropriateness checks and patient advice, and empowered them to query antibiotic appropriateness with prescribing clinicians.
Review
Psychology, Clinical
Jane Lomax, Jane Meyrick
Summary: Research shows that the effectiveness of psychosocial interventions for victims/survivors of sexual assault is uncertain and the evidence is weak, highlighting the need for higher quality studies. Further research is required to support the development of evidence-based interventions for victims/survivors of sexual assault.
JOURNAL OF HEALTH PSYCHOLOGY
(2022)
Review
Psychology, Clinical
Christine E. Ramsey-Wade, Heidi Williamson, Jane Meyrick
Summary: The systematic review suggests that therapeutic writing may improve outcomes for clients with disordered eating. The quantitative results indicate a positive trend, while the qualitative results highlight the depth of emotional experience accessed through brief therapeutic writing interventions. Further research in this area is encouraged.
JOURNAL OF CREATIVITY IN MENTAL HEALTH
(2021)