Article
Health Care Sciences & Services
Jason Joon Bock Lee, Jun Su Park, Hyun Pyo Hong, Myung Sub Kim, Dong-Hoe Koo, Hyebin Lee, Heerim Nam
Summary: This study analyzed the pretreatment albumin--bilirubin (ALBI) grade as a prognostic factor in hepatocellular carcinoma (HCC) patients undergoing combined transarterial chemoembolization (TACE) and radiotherapy (RT). The results showed that ALBI grades 2-3 were associated with worse progression-free survival (PFS) and overall survival (OS). The study suggests that ALBI grade may be a useful prognostic indicator for HCC patients treated with combined TACE-RT.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medicine, General & Internal
Wenhao Chen, Zijian Zhang, Xianrui Fang, Li Xiong, Yu Wen, Jiangjiao Zhou, Fanhua Kong, Heng Zou
Summary: The research found that the ALBI grading system can differentiate the long-term survival of HCC patients with different tumor sizes, and can serve as an important indicator for patient prognosis.
Article
Oncology
Arndt Vogel, Catherine Frenette, Max Sung, Bruno Daniele, Ari Baron, Stephen L. Chan, Jean Frederic Blanc, Toshiyuki Tamai, Min Ren, Howard J. Lim, Daniel H. Palmer, Yuko Takami, Masatoshi Kudo
Summary: Better baseline liver function, as measured by ALBI grade or CPS, may be associated with better survival outcomes in patients with unresectable hepatocellular carcinoma (uHCC) undergoing treatment with lenvatinib or sorafenib.
Article
Oncology
Ming-Hao Xu, Bin Xu, Chen-Hao Zhou, Zhong Xue, Zhao-Shuo Chen, Wen-Xin Xu, Cheng Huang, Xiao-Dong Zhu, Jian Zhou, Jia Fan, Hui-Chuan Sun, Ying-Hao Shen
Summary: This study aims to develop a nomogram for predicting PHLF grade B-C in patients with huge HCC, which can help identify patients at high risk of severe complications.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Review
Immunology
Bao-Wen Tian, Lun-Jie Yan, Zi-Niu Ding, Hui Liu, Cheng-Long Han, Guang-Xiao Meng, Jun-Shuai Xue, Zhao-Ru Dong, Yu-Chuan Yan, Jian-Guo Hong, Zhi-Qiang Chen, Dong-Xu Wang, Tao Li
Summary: Poor liver function is associated with a poor prognosis in HCC patients receiving ICIs. The ALBI score is a simpler and reliable method for evaluating liver function and determining treatment options. Despite the relatively short survival time of patients with impaired liver function, ICIs still show great potential for therapeutic applications.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Oncology
Jiayi Zhang, Lin Zhao, Yan Zhou, Jianmin Ding, Qian Zhang, Xiang Jing
Summary: In this study, ALBI grade demonstrated greater prognostic value than C-P grade for HCC patients undergoing thermal ablation, suggesting ALBI grade may be a more effective predictor of postoperative outcomes.
TRANSLATIONAL CANCER RESEARCH
(2022)
Article
Medicine, General & Internal
Po-Han Huang, Jen Yu, Yin-Yi Chu, Yang-Hsiang Lin, Chau-Ting Yeh
Summary: This study validated the independent prognostic value of CP score and ABCG2-rs2231142 genotype in advanced HCC patients receiving sorafenib treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Shu-Yein Ho, Po-Hong Liu, Chia-Yang Hsu, Yi-Hsiang Huang, Jia- Liao, Chien-Wei Su, Ming-Chih Hou, Teh-Ia Huo
Summary: This study developed a new prognostic model, the TBS-ALBI system, based on tumor burden score (TBS) and albumin-bilirubin (ALBI) grade, to predict the prognosis of hepatocellular carcinoma (HCC). The TBS-ALBI system showed significant survival differences in different patient groups, and had the lowest corrected Akaike information criterion (AICc) and the highest homogeneity compared to other staging models. The system was consistently stable across different viral etiologies, cancer stages, and treatment strategies.
Article
Gastroenterology & Hepatology
Takaaki Tanaka, Atsushi Hiraoka, Toshifumi Tada, Masashi Hirooka, Kazuya Kariyama, Joji Tani, Masanori Atsukawa, Koichi Takaguchi, Ei Itobayashi, Shinya Fukunishi, Kunihiko Tsuji, Toru Ishikawa, Kazuto Tajiri, Hironori Ochi, Satoshi Yasuda, Hidenori Toyoda, Chikara Ogawa, Takashi Nishimura, Takeshi Hatanaka, Satoru Kakizaki, Noritomo Shimada, Kazuhito Kawata, Atsushi Naganuma, Hisashi Kosaka, Hideko Ohama, Kazuhiro Nouso, Asahiro Morishita, Akemi Tsutsui, Takuya Nagano, Norio Itokawa, Tomomi Okubo, Taeang Arai, Michitaka Imai, Yohei Koizumi, Shinichiro Nakamura, Kouji Joko, Hiroko Iijima, Masaki Kaibori, Yoichi Hiasa, Masatoshi Kudo, Takashi Kumada
Summary: There was no significant difference in the best response between CP-A and -B patients treated with Atez/Bev. Analysis showed that CP-A patients had better progression-free survival (PFS) and overall survival (OS) rates compared to CP-B patients. The median PFS and OS were also significantly different between different Child-Pugh score (CPS) groups and modified albumin-bilirubin grade (mALBI) groups.
HEPATOLOGY RESEARCH
(2022)
Article
Oncology
Tae Hyun Kim, Bo Hyun Kim, Joong-Won Park, Yu Ri Cho, Young-Hwan Koh, Jung Won Chun, Eun Sang Oh, Do Yeul Lee, Sung Uk Lee, Yang-Gun Suh, Sang Myung Woo, Sung Ho Moon, Sang Soo Kim, Woo Jin Lee
Summary: In this study, the efficacy of PBT as an initial treatment in treatment-naive HCC patients was evaluated, and ALBI grade was found to be a useful predictor of overall survival.
Review
Gastroenterology & Hepatology
Coskun O. Demirtas, Antonio 'Alessio, Lorenza Rimassa, Rohini Sharma, David J. Pinato
Summary: The ALBI grade is an important tool for assessing liver functional reserve in patients with hepatocellular carcinoma, helping to categorize patients into subgroups with different prognoses and optimizing treatment selection and sequencing.
Article
Oncology
Robin Kate Kelley, Rebecca Miksad, Irfan Cicin, YenHsun Chen, Heinz-Josef Klumpen, Stefano Kim, Zhong-Zhe Lin, Jillian Youkstetter, Saswati Hazra, Suvajit Sen, Ann-Lii Cheng, Anthony B. El-Khoueiry, Tim Meyer, Ghassan K. Abou-Alfa
Summary: The study demonstrates the beneficial effects of cabozantinib in patients with advanced HCC, irrespective of ALBI grade 1 or 2.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
Masaki Kaibori, Kengo Yoshii, Kosuke Matsui, Hideyuki Matsushima, Hisashi Kosaka, Hidekazu Yamamoto, Kazunori Aoi, Takashi Yamaguchi, Katsunori Yoshida, Takeshi Hatanaka, Atsushi Hiraoka, Toshifumi Tada, Takashi Kumada, Mitsugu Sekimoto
Summary: The modified albumin-bilirubin grade and alpha-fetoprotein (mALF) score is a reliable prognostic tool for predicting postoperative complications and long-term survival in patients with hepatocellular carcinoma (HCC). Liver function deterioration and cancer progression were observed to increase with higher scores.
Review
Medicine, Research & Experimental
Wei Liu, Li-Juan Chen, Ying Jiang, Li-Juan Xu, Xuan Qiu
Summary: This study reports a rare case of combined HCC and ICG excretory defect, with preoperative ICG retention rate but no abnormal findings on Child-Pugh assessment and hepatobiliary-specific MRI. Despite the rarity of this condition, it is important to consider liver function tests when determining indications and procedures for hepatectomy.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Article
Oncology
Hung-Wei Wang, Po-Heng Chuang, Wen-Pang Su, Jung-Ta Kao, Wei-Fan Hsu, Chun-Che Lin, Guan-Tarn Huang, Jaw-Town Lin, Hsueh-Chou Lai, Cheng-Yuan Peng
Summary: The study showed that albumin-bilirubin grade and alpha-fetoprotein level before regorafenib therapy can serve as predictors of disease control and survival rates in patients with unresectable hepatocellular carcinoma.
Article
Gastroenterology & Hepatology
Andrea Benedetti Cacciaguerra, Burak Gorgec, Jacopo Lanari, Federica Cipriani, Nadia Russolillo, Federico Mocchegiani, Giuseppe Zimmitti, Adnan Alseidi, Andrea Ruzzenente, Bjorn Edwin, Mathieu D'Hondt, Marc G. Besselink, Felice Giuliante, David Fuks, Fernando Rotellar, Santiago Lopez-Ben, Alessandro Ferrero, Luca Aldrighetti, Umberto Cillo, Marco Vivarelli, Mohammed Abu Hilal
Summary: This study investigated the clinical impact of major hepatectomy in cirrhotic patients and found that laparoscopic major hepatectomy may have potential short-term benefits compared to open surgery, with fewer complications and reduced blood loss. Long-term survival outcomes following liver resection for hepatocellular carcinoma showed no significant difference between laparoscopic and open approaches.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Maurizio Iaria, Giorgio Bianchi, Federico Fazio, Francesco Ardito, Pasquale Perri, Nicholas Pontarolo, Simone Conci, Matteo Donadon, Matteo Zanello, Quirino Lai, Simone Famularo, Sarah Molfino, Ivano Sciannamea, Luca Fumagalli, Paola Germani, Antonio Floridi, Cecilia Ferrari, Giuseppe Zimmitti, Albert Troci, Mauro Zago, Valentina Ferraro, Federica Cipriani, Stefan Patauner, Giuliano La Barba, Maurizio Romano, Giacomo Zanus, Giorgio Ercolani, Antonio Frena, Luca Aldrighetti, Riccardo Memeo, Enrico Pinotti, Michele Crespi, Moh'd Abu Hilal, Guido Griseri, Paola Tarchi, Marco Chiarelli, Adelmo Antonucci, Gian L. Baiocchi, Fabrizio Romano, Massimo Rossi, Elio Jovine, Guido Torzilli, Andrea Ruzzenente, Marcello Maestri, Gian L. Grazi, Felice Giuliante, Alessandro Ferrero, Raffaele Dalla Valle
Summary: In this study, the perioperative and long-term oncological outcomes of salvage hepatectomy for recurrent hepatocellular carcinoma after primary hepatectomy or locoregional treatments were evaluated in a large Western cohort. The results showed that salvage hepatectomy is as safe, feasible, and effective as primary hepatectomy in terms of long-term outcomes.
Article
Gastroenterology & Hepatology
Mikhail Efanov, Diana Salimgereeva, Ruslan Alikhanov, Andrew G. R. Wu, David Geller, Federica Cipriani, Davit L. Aghayan, Asmund Avdem Fretland, Jasper Sijberden, Andrea Belli, Marco V. Marino, Vincenzo Mazzaferro, Adrian K. H. Chiow, Iswanto Sucandy, Arpad Ivanecz, Sung Hoon Choi, Jae Hoon Lee, Mikel Prieto, Marco Vivarelli, Felice Giuliante, Andrea Ruzzenente, Chee-Chien Yong, Constantino Fondevila, Fernando Rotellar, Gi-Hong Choi, Ricardo Robless Campos, Xiaoying Wang, Robert P. Sutcliffe, Johann Pratschke, Eric Lai, Charing C. Chong, Mathieu D'Hondt, Kazuteru Monden, Santiago Lopez-Ben, Paulo Herman, Fabrizio Di Benedetto, T. Peter Kingham, Rong Liu, Tran Cong Duy Long, Alessandro Ferrero, Giovanni Battista Levi Sandri, Daniel Cherqui, Olivier Scatton, Go Wakabayashi, Roberto I. Troisi, Tan-To Cheung, Atsushi Sugioka, Ho-Seong Han, Mohammad Abu Hilal, Olivier Soubrane, David Fuks, Luca Aldrighetti, Bjorn Edwin, Brian K. P. Goh
Summary: This study compares the outcomes of laparoscopic liver resection of segments 7 and 8 and finds that atypical resection of segment 7 is more difficult than segment 8, while segmentectomy 8 is more difficult than segmentectomy 7.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Carlo Sposito, Francesca Ratti, Alessandro Cucchetti, Francesco Ardito, Andrea Ruzzenente, Stefano Di Sandro, Marianna Maspero, Giorgio Ercolani, Fabrizio Di Benedetto, Alfredo Guglielmi, Felice Giuliante, Luca Aldrighetti, Vincenzo Mazzaferro
Summary: This study aimed to determine whether lymphadenectomy improves long-term outcomes in patients with clinically node-negative intrahepatic cholangiocarcinoma (iCCA). The results showed that adequate lymphadenectomy significantly improved survival outcomes for patients with clinically node-negative iCCA who were found to be node-positive at pathology. Therefore, routine use of adequate lymphadenectomy is recommended for patients with clinically node-negative iCCA.
JOURNAL OF HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Giada Aizza, Nadia Russolillo, Alessandro Ferrero, Nicholas L. Syn, Federica Cipriani, Davit Aghayan, Marco Marino, Riccardo Memeo, Vincenzo Mazzaferro, Adrian K. H. Chiow, Iswanto Sucandy, Arpad Ivanecz, Marco Vivarelli, Fabrizio Di Benedetto, Sung-Hoon Choi, Jae Hoon Lee, James O. Park, Mikel Gastaca, Constantino Fondevila, Mikhail Efanov, Fernando Rotellar, Gi-Hong Choi, Ricardo Robles-Campos, Xiaoying Wang, Robert P. Sutcliffe, Johann Pratschke, Chung Ngai Tang, Charing C. Chong, Mathieu D'Hondt, Chee Chien Yong, Andrea Ruzzenente, Paolo Herman, T. Peter Kingham, Olivier Scatton, Rong Liu, Giovanni Battista Levi Sandri, Olivier Soubrane, Alejandro Mejia, Santiago Lopez-Ben, Kazateru Monden, Go Wakabayashi, Daniel Cherqui, Roberto Troisi, Mengqiu Yin, Felice Giuliante, David Geller, Atsushi Sugioka, Bjorn Edwin, Tan-To Cheung, Tran Cong Duy Long, Mohammad Abu Hilal, David Fuks, Kuo-Hsin Chen, Luca Aldrighetti, Ho-Seong Han, Brian K. P. Goh
Summary: This study aimed to investigate the relationship between tumor size and the difficulty of laparoscopic left lateral sectionectomy (L-LLS). Three optimal tumor size cutoffs (40-, 70-, and 100-mm) were identified. As tumor size increased, there was a stepwise increase in the rates of open conversion, operative time, blood loss, intraoperative blood transfusion, Pringle maneuver use, major morbidity, and 30-day readmission.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Francesco Ardito, Quirino Lai, Alida Savelli, Simone Grassi, Elena Panettieri, Gennaro Clemente, Gennaro Nuzzo, Antonio Oliva, Felice Giuliante
Summary: The aim of this study was to evaluate the risk factors for malpractice litigation in patients with bile duct injury (BDI) referred to a tertiary care center. The results showed that patients in the late-referral group were more likely to have undergone surgical and endoscopic repair before referral. Prompt referral to experienced tertiary care centers without any attempt at repair may reduce the risk of litigation.
Editorial Material
Gastroenterology & Hepatology
Francesco Taliente, Agostino Maria De Rose, Francesco Ardito, Felice Giuliante
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2022)
Article
Surgery
Simone Famularo, Matteo Donadon, Federica Cipriani, Federico Fazio, Francesco Ardito, Maurizio Iaria, Pasquale Perri, Simone Conci, Tommaso Dominioni, Quirino Lai, Giuliano La Barba, Stefan Patauner, Sarah Molfino, Paola Germani, Giuseppe Zimmitti, Enrico Pinotti, Matteo Zanello, Luca Fumagalli, Cecilia Ferrari, Maurizio Romano, Antonella Delvecchio, Maria Grazia Valsecchi, Adelmo Antonucci, Fabio Piscaglia, Fabio Farinati, Yoshikuni Kawaguchi, Kiyoshi Hasegawa, Riccardo Memeo, Giacomo Zanus, Guido Griseri, Marco Chiarelli, Elio Jovine, Mauro Zago, Moh'd Abu Hilal, Paola Tarchi, Gian Luca Baiocchi, Antonio Frena, Giorgio Ercolani, Massimo Rossi, Marcello Maestri, Andrea Ruzzenente, Gian Luca Grazi, Raffaele Dalla Valle, Fabrizio Romano, Felice Giuliante, Alessandro Ferrero, Luca Aldrighetti, Davide P. Bernasconi, Guido Torzilli
Summary: This study aimed to create a machine learning predictive model to allocate patients with recurrent hepatocellular carcinoma (HCC) to their best potential treatment based on their specific characteristics. An individualized algorithm for treatment allocation was developed using factors such as age, cirrhosis, number and size of recurrent nodules, extrahepatic spread, and time to recurrence. The algorithm provides recommendations for the best potential treatment according to patients' profiles.
Review
Oncology
Roberto Iezzi, Afshin Gangi, Alessandro Posa, Uei Pua, Ping Liang, Ernesto Santos, Anil N. Kurup, Alessandro Tanzilli, Lorenzo Tenore, Davide De Leoni, Dimitrios Filippiadis, Felice Giuliante, Vincenzo Valentini, Antonio Gasbarrini, Shraga N. Goldberg, Martijn Meijerink, Riccardo Manfredi, Alexis Kelekis, Cesare Colosimo, David C. Madoff
Summary: Interventional oncology (IO) employs minimally invasive procedures to provide lower-risk alternatives to traditional medical and surgical therapies for cancer patients. This article aims to review new indications for locoregional IO treatments and summarize the expert discussion and report from the MIOLive Meets SIO session during the last Mediterranean Interventional Oncology Live congress held in Rome, Italy.
Article
Oncology
Andrea Dalbeni, Leonardo Antonio Natola, Marta Garbin, Mirko Zoncape, Filippo Cattazzo, Anna Mantovani, Antonio Vella, Stefania Cane, Jasmin Kassem, Michele Bevilacqua, Simone Conci, Tommaso Campagnaro, Andrea Ruzzenente, Alessandra Auriemma, Alessandro Drudi, Giovanna Zanoni, Alfredo Guglielmi, Michele Milella, David Sacerdoti
Summary: Hepatocellular carcinoma (HCC) is the leading cause of liver-related mortality worldwide, and interleukin 6 (IL-6) promotes the growth of the HCC microenvironment. The relationship between Child-Pugh (CP) score and HCC stage, as well as HCC stage and sarcopenia, is still unclear. This study aimed to investigate the correlation between IL-6 and HCC stage, and its potential as a diagnostic marker for sarcopenia.
Article
Biochemistry & Molecular Biology
Elisa Danese, Patricia M. -J. Lievens, Andrea Padoan, Denise Peserico, Roberta Galavotti, Davide Negrini, Matteo Gelati, Simone Conci, Andrea Ruzzenente, Gian Luca Salvagno, Giuseppe Lippi
Summary: Through a case-control study, it was found that the concentration of circulating bile acids (BAs) is significantly higher in patients with cholangiocarcinoma compared to those with benign biliary disease. The study also suggests that BAs may play a role in modulating the expression of the oncogenic mucin 5AC (MUC5AC) gene. In vitro experiments showed that primary conjugated BAs or TCDCA alone can result in the expression of a novel 230 kDa isoform of MUC5AC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Tommaso Campagnaro, Edoardo Poletto, Paola Tarchi, Simone Rattizzato, Giuseppe Verlato, Simone Conci, Corrado Pedrazzani, Nicolo De Manzini, Alfredo Guglielmi, Andrea Ruzzenente
Summary: The study evaluated the performance of the ACS-NSQIP SRC for patients undergoing surgery for colorectal liver metastases (CRLM). The results showed that the SRC only had good predicting capabilities for cardiac complications, but underestimated other complications and length of hospital stay.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Surgery
Felice Giuliante, Elena Panettieri, Agostino M. De Rose, Marino Murazio, Maria Vellone, Caterina Mele, Gennaro Clemente, Ivo Giovannini, Gennaro Nuzzo, Francesco Ardito
Summary: The impact of timing of repair on outcomes of patients with bile duct injury repaired with Hepp-Couinaud hepatico-jejunostomy (HC-HJ) remains controversial. This observational study showed that HC-HJ can be successfully performed regardless of the timing of repair, as long as the patients are stable and have dilated bile ducts without bile leak.
UPDATES IN SURGERY
(2023)
Article
Surgery
Jasper P. Sijberden, Federica Cipriani, Jacopo Lanari, Nadia Russolillo, Andrea Benedetti Cacciaguerra, Daniel Osei-Bordom, Simone Conci, Burak Gorgec, John N. Primrose, Bjorn Edwin, Santi Lopez-Ben, Mathieu D'Hondt, Fernando Rotellar, Marc G. Besselink, Ibrahim Dagher, Felice Giuliante, David Fuks, Renzo Rozzini, Andrea Ruzzenente, Robert P. Sutcliffe, Marco Vivarelli, Alessandro Ferrero, Umberto Cillo, Luca A. Aldrighetti, Mohammad Abu Hilal
BRITISH JOURNAL OF SURGERY
(2023)